| The RNA-binding protein Msi2 regulates autophagy during myogenic differentiation. | The RNA-binding protein Msi2 regulates autophagy during myogenic differentiation.
Wang R, Kato F, Watson RY, Beedle AM, Call JA, Tsunoda Y, Noda T, Tsuchiya T, Kashima M, Hattori A, Ito T., Free PMC Article | 02/21/2024 |
| Musashi-2 causes cardiac hypertrophy and heart failure by inducing mitochondrial dysfunction through destabilizing Cluh and Smyd1 mRNA. | Musashi-2 causes cardiac hypertrophy and heart failure by inducing mitochondrial dysfunction through destabilizing Cluh and Smyd1 mRNA.
Singh S, Gaur A, Sharma RK, Kumari R, Prakash S, Kumari S, Chaudhary AD, Prasun P, Pant P, Hunkler H, Thum T, Jagavelu K, Bharati P, Hanif K, Chitkara P, Kumar S, Mitra K, Gupta SK. | 11/8/2023 |
| Musashi-2 binds with Fbxo6 to induce Rnaset2 ubiquitination and chemokine signaling pathway during vascular smooth muscle cell phenotypic switch in atherosclerosis. | Musashi-2 binds with Fbxo6 to induce Rnaset2 ubiquitination and chemokine signaling pathway during vascular smooth muscle cell phenotypic switch in atherosclerosis.
Zhang T, Wu S, Xu R, Zhang S, Wang M, Li J. | 10/10/2023 |
| Lack of Musashi-2 induces type IIa fiber-dominated muscle atrophy. | Lack of Musashi-2 induces type IIa fiber-dominated muscle atrophy.
Furuichi Y, Furutani A, Tamura K, Manabe Y, Fujii NL. | 08/25/2023 |
| ADAR1-dependent miR-3144-3p editing simultaneously induces MSI2 expression and suppresses SLC38A4 expression in liver cancer. | ADAR1-dependent miR-3144-3p editing simultaneously induces MSI2 expression and suppresses SLC38A4 expression in liver cancer.
Kim HS, Na MJ, Son KH, Yang HD, Kim SY, Shin E, Ha JW, Jeon S, Kang K, Moon K, Park WS, Nam SW., Free PMC Article | 02/25/2023 |
| Tumorigenic role of Musashi-2 in aggressive mantle cell lymphoma. | Tumorigenic role of Musashi-2 in aggressive mantle cell lymphoma.
Sureda-Gómez M, Balsas P, Rodríguez ML, Nadeu F, De Bolòs A, Eguileor Á, Kulis M, Castellano G, López C, Giné E, Demajo S, Jares P, Martín-Subero JI, Beà S, Campo E, Amador V., Free PMC Article | 02/14/2023 |
| MSI2 deficiency in ILC3s attenuates DSS-induced colitis by affecting the intestinal microbiota. | MSI2 deficiency in ILC3s attenuates DSS-induced colitis by affecting the intestinal microbiota.
Li N, Xu S, Zhang S, Zhu Q, Meng X, An W, Fu B, Zhong M, Yang Y, Lin Z, Liu X, Xia J, Wang J, You T, Yan C, Tang H, Zhuang G, Peng Z., Free PMC Article | 02/4/2023 |
| Msi2-mediated MiR7a-1 processing repression promotes myogenesis. | Msi2-mediated MiR7a-1 processing repression promotes myogenesis.
Yang W, Yang L, Wang J, Zhang Y, Li S, Yin Q, Suo J, Ma R, Ye Y, Cheng H, Li J, Hui J, Hu P., Free PMC Article | 03/26/2022 |
| Myofibroblast-Specific Msi2 Knockout Inhibits HCC Progression in a Mouse Model. | Myofibroblast-Specific Msi2 Knockout Inhibits HCC Progression in a Mouse Model.
Qu C, He L, Yao N, Li J, Jiang Y, Li B, Peng S, Hu K, Chen D, Chen G, Huang W, Cao M, Fan J, Yuan Y, Ye W, Hong J. | 01/8/2022 |
| Assessment of MUSASHI 1 and MUSASHI 2 expression in spermatozoa and testicular tissue. | Assessment of MUSASHI 1 and MUSASHI 2 expression in spermatozoa and testicular tissue.
Talebi-Yazdabadi Z, Jahanbakhsh N, Dormiani K, Forouzanfar M, Lachinani L, Zohrabi D, Tavalaee M, Nasr-Esfahani MH. | 10/9/2021 |
| The Musashi proteins MSI1 and MSI2 are required for photoreceptor morphogenesis and vision in mice. | The Musashi proteins MSI1 and MSI2 are required for photoreceptor morphogenesis and vision in mice.
Sundar J, Matalkah F, Jeong B, Stoilov P, Ramamurthy V., Free PMC Article | 08/7/2021 |
| Study reveals a unique MUSASHI-2 (MSI2) mRNA binding network in hematopoietic stem cells that changes during transition to multipotent progenitors and discovers a significant increase in RNA binding activity of MSI2 in leukemic stem cells compared with normal hematopoietic stem and progenitor cells, resulting in selective regulation of MSI2's oncogenic targets. | HyperTRIBE uncovers increased MUSASHI-2 RNA binding activity and differential regulation in leukemic stem cells.
Nguyen DTT, Lu Y, Chu EL, Yang X, Park SM, Choo ZN, Chin CR, Prieto C, Schurer A, Barin E, Savino AM, Gourkanti S, Patel P, Vu LP, Leslie CS, Kharas MG., Free PMC Article | 08/15/2020 |
| Immunostained brain sections and bioinformatics supported the view that MSI2 regulates immature properties of SCN neurons, potentially providing flexibility in SCN neural circuits. | Musashi-2 and related stem cell proteins in the mouse suprachiasmatic nucleus and their potential role in circadian rhythms.
Beligala DH, De A, Malik A, Silver R, Rimu K, LeSauter J, McQuillen HJ, Geusz ME. | 12/21/2019 |
| the testis-expressed transcription factor, Tbx1, and the piRNA regulator of gamete development, Piwil1, were both found to be targeted for translational repression by MSI2. | RNA binding protein Musashi-2 regulates PIWIL1 and TBX1 in mouse spermatogenesis.
Sutherland JM, Sobinoff AP, Fraser BA, Redgrove KA, Siddall NA, Koopman P, Hime GR, McLaughlin EA. | 12/22/2018 |
| Absence of Musashi2 in osteoclast precursors promotes apoptosis and inhibits RANKL-induced NF-kappaB activation, which is essential for osteoclast survival. | RNA-binding protein Musashi2 induced by RANKL is critical for osteoclast survival.
Fujiwara T, Zhou J, Ye S, Zhao H., Free PMC Article | 10/28/2017 |
| Msi2 primarily recognizes mRNA 3'UTRs at sites enriched in multiple copies of UAG motifs in epithelial progenitor cells. | Genome-wide analysis of Musashi-2 targets reveals novel functions in governing epithelial cell migration.
Bennett CG, Riemondy K, Chapnick DA, Bunker E, Liu X, Kuersten S, Yi R., Free PMC Article | 06/10/2017 |
| Msi proteins are dispensable for normal homeostasis and self-renewal of the active intestinal stem cell. | Msi RNA-binding proteins control reserve intestinal stem cell quiescence.
Yousefi M, Li N, Nakauka-Ddamba A, Wang S, Davidow K, Schoenberger J, Yu Z, Jensen ST, Kharas MG, Lengner CJ., Free PMC Article | 06/3/2017 |
| our findings reveal the importance of Msi2 in suppressing hair regeneration and maintaining hair follicle stem cells quiescence | Msi2 Maintains Quiescent State of Hair Follicle Stem Cells by Directly Repressing the Hh Signaling Pathway.
Ma X, Tian Y, Song Y, Shi J, Xu J, Xiong K, Li J, Xu W, Zhao Y, Shuai J, Chen L, Plikus MV, Lengner CJ, Ren F, Xue L, Yu Z., Free PMC Article | 04/29/2017 |
| studies highlight Msi reporters as a unique tool to identify therapy resistance, and define Msi signalling as a central regulator of pancreatic cancer | Image-based detection and targeting of therapy resistance in pancreatic adenocarcinoma.
Fox RG, Lytle NK, Jaquish DV, Park FD, Ito T, Bajaj J, Koechlein CS, Zimdahl B, Yano M, Kopp J, Kritzik M, Sicklick J, Sander M, Grandgenett PM, Hollingsworth MA, Shibata S, Pizzo D, Valasek M, Sasik R, Scadeng M, Okano H, Kim Y, MacLeod AR, Lowy AM, Reya T., Free PMC Article | 07/2/2016 |
| MSI1 and MSI2 display distinct expression profiles during mammalian folliculogenesis and that MSI2 is required for pre-antral follicle development | Knockout of RNA Binding Protein MSI2 Impairs Follicle Development in the Mouse Ovary: Characterization of MSI1 and MSI2 during Folliculogenesis.
Sutherland JM, Sobinoff AP, Gunter KM, Fraser BA, Pye V, Bernstein IR, Boon E, Siddall NA, De Andres LI, Hime GR, Holt JE, Graf T, McLaughlin EA., Free PMC Article | 03/26/2016 |
| Through expression studies and utilizing a transgenic Msi1 testis-specific overexpression model, we have identified 2 unique RNA-binding targets of MSI1 in spermatogonia, Msi2 and Erh, and have demonstrated a role for MSI1 in translational regulation. | RNA binding protein Musashi-1 directly targets Msi2 and Erh during early testis germ cell development and interacts with IPO5 upon translocation to the nucleus.
Sutherland JM, Sobinoff AP, Fraser BA, Redgrove KA, Davidson TL, Siddall NA, Koopman P, Hime GR, McLaughlin EA. | 09/26/2015 |
| Msi proteins contribute to an epithelial gene expression program in neural and mammary cell types. | Musashi proteins are post-transcriptional regulators of the epithelial-luminal cell state.
Katz Y, Li F, Lambert NJ, Sokol ES, Tam WL, Cheng AW, Airoldi EM, Lengner CJ, Gupta PB, Yu Z, Jaenisch R, Burge CB., Free PMC Article | 08/15/2015 |
| Msi2 is an important regulator of the hematopoietic stem cell (HSC) translatome and balances HSC homeostasis and lineage bias. | Musashi-2 controls cell fate, lineage bias, and TGF-β signaling in HSCs.
Park SM, Deering RP, Lu Y, Tivnan P, Lianoglou S, Al-Shahrour F, Ebert BL, Hacohen N, Leslie C, Daley GQ, Lengner CJ, Kharas MG., Free PMC Article | 03/15/2014 |
| Ectopic expression of Musashi 2 isoform 1, but not isoform 2, enhanced the cloning efficiency of embryonic stem cells, but both isoforms were required for the self-renewal of embryonic stem cells. | Musashi2 is required for the self-renewal and pluripotency of embryonic stem cells.
Wuebben EL, Mallanna SK, Cox JL, Rizzino A., Free PMC Article | 08/25/2012 |
| Our data indicate that Msi2 maintains the stem cell compartment mainly by regulating the proliferation of primitive progenitors downstream of long term hematopoietic stem cells | Musashi 2 is a regulator of the HSC compartment identified by a retroviral insertion screen and knockout mice.
de Andrés-Aguayo L, Varas F, Kallin EM, Infante JF, Wurst W, Floss T, Graf T. | 10/8/2011 |