| Kidney-Specific Membrane-Bound Serine Proteases CAP1/Prss8 and CAP3/St14 Affect ENaC Subunit Abundances but Not Its Activity. | Kidney-Specific Membrane-Bound Serine Proteases CAP1/Prss8 and CAP3/St14 Affect ENaC Subunit Abundances but Not Its Activity.
Ehret E, Stroh S, Auberson M, Ino F, Jäger Y, Maillard M, Szabo R, Bugge TH, Frateschi S, Hummler E., Free PMC Article | 11/28/2023 |
| Membrane protease prostasin promotes insulin secretion by regulating the epidermal growth factor receptor pathway. | Membrane protease prostasin promotes insulin secretion by regulating the epidermal growth factor receptor pathway.
Ishii T, Miyasato Y, Ichijo M, Uchimura K, Furuya F., Free PMC Article | 06/13/2023 |
| Sodium retention in nephrotic syndrome is independent of the activation of the membrane-anchored serine protease prostasin (CAP1/PRSS8) and its enzymatic activity. | Sodium retention in nephrotic syndrome is independent of the activation of the membrane-anchored serine protease prostasin (CAP1/PRSS8) and its enzymatic activity.
Essigke D, Bohnert BN, Janessa A, Wörn M, Omage K, Kalbacher H, Birkenfeld AL, Bugge TH, Szabo R, Artunc F., Free PMC Article | 05/28/2022 |
| Sodium absorption stimulator prostasin (PRSS8) has an anti-inflammatory effect via downregulation of TLR4 signaling in inflammatory bowel disease. | Sodium absorption stimulator prostasin (PRSS8) has an anti-inflammatory effect via downregulation of TLR4 signaling in inflammatory bowel disease.
Sugitani Y, Nishida A, Inatomi O, Ohno M, Imai T, Kawahara M, Kitamura K, Andoh A. | 09/18/2021 |
| Liver-Specific Overexpression of Prostasin Attenuates High-Fat Diet-Induced Metabolic Dysregulation in Mice. | Liver-Specific Overexpression of Prostasin Attenuates High-Fat Diet-Induced Metabolic Dysregulation in Mice.
Sekine T, Takizawa S, Uchimura K, Miyazaki A, Tsuchiya K., Free PMC Article | 08/14/2021 |
| Genetic Prss8 deficiency caused colitis and an inflamed rectum at an early age and intestinal tumors at a late age, with increased intestinal cell proliferation and migration but decreased cell differentiation. Increased PRSS8 inhibited cancer growth and metastasis in nude mice and inhibited cancer cell migration, invasion, colony and tumor sphere formation.PRSS8 targeted Wnt/beta-catenin, stem-cell, and EMT signaling. | PRSS8 suppresses colorectal carcinogenesis and metastasis.
Bao Y, Guo Y, Yang Y, Wei X, Zhang S, Zhang Y, Li K, Yuan M, Guo D, Macias V, Zhu X, Zhang W, Yang W. | 05/11/2019 |
| Studies in colonic T84 cell monolayers revealed that barrier disruption by the colitis-associated Th2-type cytokines, IL-4 and IL-13, down-regulates matriptase as well as prostasin through phosphorylation of the transcriptional regulator STAT6 | Inflammatory cytokines down-regulate the barrier-protective prostasin-matriptase proteolytic cascade early in experimental colitis.
Buzza MS, Johnson TA, Conway GD, Martin EW, Mukhopadhyay S, Shea-Donohue T, Antalis TM., Free PMC Article | 07/8/2017 |
| a proteolysis-dependent function of activated prostasin in hair follicles, dependent on zymogen conversion by matriptase. | Distinct Developmental Functions of Prostasin (CAP1/PRSS8) Zymogen and Activated Prostasin.
Friis S, Madsen DH, Bugge TH., Free PMC Article | 07/2/2016 |
| The claudin-4-mediated chloride conductance can be regulated endogenously by a protease-channel-activating protease 1 (cap1). | The Cap1-claudin-4 regulatory pathway is important for renal chloride reabsorption and blood pressure regulation.
Gong Y, Yu M, Yang J, Gonzales E, Perez R, Hou M, Tripathi P, Hering-Smith KS, Hamm LL, Hou J., Free PMC Article | 04/29/2016 |
| HAI-1 regulates the activity of activated matriptase, whereas HAI-2 has an essential role in regulating prostasin-dependent matriptase zymogen activation. | The protease inhibitor HAI-2, but not HAI-1, regulates matriptase activation and shedding through prostasin.
Friis S, Sales KU, Schafer JM, Vogel LK, Kataoka H, Bugge TH., Free PMC Article | 02/21/2015 |
| a novel inhibitory interaction between CAP1/Prss8 and nexin-1, opening the search for specific CAP1/Prss8 antagonists that are independent of its catalytic activity | The CAP1/Prss8 catalytic triad is not involved in PAR2 activation and protease nexin-1 (PN-1) inhibition.
Crisante G, Battista L, Iwaszkiewicz J, Nesca V, Mérillat AM, Sergi C, Zoete V, Frateschi S, Hummler E. | 01/31/2015 |
| Data indicate that liver-specific serine protease prostasin (PRSS8) knockout (LKO) mice develop insulin resistance associated with the increase in hepatic Toll-like receptor 4 (TLR4). | The serine protease prostasin regulates hepatic insulin sensitivity by modulating TLR4 signalling.
Uchimura K, Hayata M, Mizumoto T, Miyasato Y, Kakizoe Y, Morinaga J, Onoue T, Yamazoe R, Ueda M, Adachi M, Miyoshi T, Shiraishi N, Ogawa W, Fukuda K, Kondo T, Matsumura T, Araki E, Tomita K, Kitamura K., Free PMC Article | 12/6/2014 |
| Data indicate that serine protease prostasin (CAP1/PRSS8) supports terminal epidermal differentiation through a non-catalytic mechanism. | The membrane-anchored serine protease prostasin (CAP1/PRSS8) supports epidermal development and postnatal homeostasis independent of its enzymatic activity.
Peters DE, Szabo R, Friis S, Shylo NA, Uzzun Sales K, Holmbeck K, Bugge TH., Free PMC Article | 11/8/2014 |
| mutations in Prss8 restored placentation and normal development of HAI-1-deficient embryos and prevented early embryonic lethality, mid-gestation lethality due to placental labyrinth failure, and neural tube defects in HAI-2-deficient embryos. | Reduced prostasin (CAP1/PRSS8) activity eliminates HAI-1 and HAI-2 deficiency-associated developmental defects by preventing matriptase activation.
Szabo R, Uzzun Sales K, Kosa P, Shylo NA, Godiksen S, Hansen KK, Friis S, Gutkind JS, Vogel LK, Hummler E, Camerer E, Bugge TH., Free PMC Article | 01/5/2013 |
| Mutations of the serine protease CAP1/Prss8 lead to reduced embryonic viability, skin defects, and decreased ENaC activity. | Mutations of the serine protease CAP1/Prss8 lead to reduced embryonic viability, skin defects, and decreased ENaC activity.
Frateschi S, Keppner A, Malsure S, Iwaszkiewicz J, Sergi C, Merillat AM, Fowler-Jaeger N, Randrianarison N, Planès C, Hummler E. | 12/8/2012 |
| The T to A mutation at residue 170 (Val to Asp) in Prss8 is responsible for the mutant frizzy (fr) phenotype. | The mouse frizzy (fr) and rat 'hairless' (frCR) mutations are natural variants of protease serine S1 family member 8 (Prss8).
Spacek DV, Perez AF, Ferranti KM, Wu LK, Moy DM, Magnan DR, King TR. | 01/15/2011 |
| Deficiency of CAP1/Prss8 in alveolar epithelial cells induced in vitro a 40% decrease in epithelial sodium channel-mediated sodium currents. | ENaC-mediated alveolar fluid clearance and lung fluid balance depend on the channel-activating protease 1.
Planès C, Randrianarison NH, Charles RP, Frateschi S, Cluzeaud F, Vuagniaux G, Soler P, Clerici C, Rossier BC, Hummler E., Free PMC Article | 03/15/2010 |
| 546 backcross progeny were typed for linked markers to position fr centromeric of Fgfr2, between D7Csu5 and D7Mit165; an interval that contains only 2.7 Mb and fewer than 70 genes | The mouse frizzy mutation (fr) maps between D7Csu5 and D7Mit165.
Paul EL, Badal R, Thompson DS, Magnan DR, Soucy FM, Khan IM, Haughton RA, King TR. | 02/16/2010 |
| mutations in conserved residues of mCAP2 located in two protein-protein interacting domains significantly modulated ENaC activation | Activation of epithelial sodium channels by mouse channel activating proteases (mCAP) expressed in Xenopus oocytes requires catalytic activity of mCAP3 and mCAP2 but not mCAP1.
Andreasen D, Vuagniaux G, Fowler-Jaeger N, Hummler E, Rossier BC. | 01/21/2010 |
| Conclude that, at low concentrations, plasmin interacts with GPI-anchored prostasin, which leads to cleavage of the gamma-subunit and activation of ENaC, while at higher concentrations, plasmin directly activates ENaC. | Prostasin-dependent activation of epithelial Na+ channels by low plasmin concentrations.
Svenningsen P, Uhrenholt TR, Palarasah Y, Skjødt K, Jensen BL, Skøtt O. | 01/21/2010 |
| reduced activity of a matriptase-prostasin proteolytic cascade is the etiological origin of human ARIH and provides an important mouse model for the exploration of matriptase function in ARIH | Autosomal ichthyosis with hypotrichosis syndrome displays low matriptase proteolytic activity and is phenocopied in ST14 hypomorphic mice.
List K, Currie B, Scharschmidt TC, Szabo R, Shireman J, Molinolo A, Cravatt BF, Segre J, Bugge TH. | 01/21/2010 |
| data suggest that a matriptase-prostasin zymogen activation cascade may be functionally operative in multiple epithelial tissues, but matriptase promotes epithelial carcinogenesis independent of prostasin | Co-localization of the channel activating protease prostasin/(CAP1/PRSS8) with its candidate activator, matriptase.
List K, Hobson JP, Molinolo A, Bugge TH. | 01/21/2010 |
| matriptase acts upstream of prostasin in a zymogen activation cascade that regulates terminal epidermal differentiation and is required for prostasin zymogen activation | Evidence for a matriptase-prostasin proteolytic cascade regulating terminal epidermal differentiation.
Netzel-Arnett S, Currie BM, Szabo R, Lin CY, Chen LM, Chai KX, Antalis TM, Bugge TH, List K. | 01/21/2010 |
| findings demonstrate that prostasin is expressed in bladder epithelium; expression is downregulated during inflammation produced by intraperitoneal LPS injection; prostasin may play a role in bladder inflammatory response by modulating cytokine signaling | Prostasin attenuates inducible nitric oxide synthase expression in lipopolysaccharide-induced urinary bladder inflammation.
Chen LM, Wang C, Chen M, Marcello MR, Chao J, Chao L, Chai KX. | 01/21/2010 |
| conditional allelle mutations at Prss8 can be generated by Cre- and FLP-mediated recombination | A conditional allele at the mouse channel activating protease 1 (Prss8) gene locus.
Rubera I, Meier E, Vuagniaux G, Mérillat AM, Beermann F, Rossier BC, Hummler E. | 01/21/2010 |