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    Slc38a3 solute carrier family 38, member 3 [ Mus musculus (house mouse) ]

    Gene ID: 76257, updated on 28-Oct-2024

    GeneRIFs: Gene References Into Functions

    GeneRIFPubMed TitleDate
    Choroid plexus LAT2 and SNAT3 as partners in CSF amino acid homeostasis maintenance.

    Choroid plexus LAT2 and SNAT3 as partners in CSF amino acid homeostasis maintenance.
    Dolgodilina E, Camargo SM, Roth E, Herzog B, Nunes V, Palacín M, Verrey F., Free PMC Article

    11/21/2020
    the results demonstrate the regulatory role of Sp1 in regulation of SN1 expression and activity in ammonia-treated astrocytes and implicate altered Sp1 phosphorylation status in this capacity.

    Silencing of Transcription Factor Sp1 Promotes SN1 Transporter Regulation by Ammonia in Mouse Cortical Astrocytes.
    Dąbrowska K, Zielińska M., Free PMC Article

    04/27/2019
    This indicates a role for PKC in dynamically controlling the trafficking of SNAT3 transporters in astrocytes in situ.

    PKC-Mediated Modulation of Astrocyte SNAT3 Glutamine Transporter Function at Synapses in Situ.
    Dong W, Todd AC, Bröer A, Hulme SR, Bröer S, Billups B., Free PMC Article

    09/8/2018
    SNAT3 is required for amino acid homeostasis and determines critical functions in various organs. Loss of Snat3 cannot be compensated.

    Loss of function mutation of the Slc38a3 glutamine transporter reveals its critical role for amino acid metabolism in the liver, brain, and kidney.
    Chan K, Busque SM, Sailer M, Stoeger C, Bröer S, Daniel H, Rubio-Aliaga I, Wagner CA.

    10/8/2016
    acid loading increased urinary ammonium excretion in all groups, but to a lesser extent in the O-GI group. SNAT3 mRNA expression was enhanced in both obese groups

    Dysregulation of the glutamine transporter Slc38a3 (SNAT3) and ammoniagenic enzymes in obese, glucose-intolerant mice.
    Busque SM, Stange G, Wagner CA.

    04/18/2015
    Regulation of SNAT3 gene expression by extracellular pH involves post-transcriptional and transcriptional mechanisms, the latter being distinct from the mechanisms that control the tissue-specific expression of the gene

    Expression of glutamine transporter Slc38a3 (SNAT3) during acidosis is mediated by a different mechanism than tissue-specific expression.
    Balkrishna S, Bröer A, Welford SM, Hatzoglou M, Bröer S., Free PMC Article

    04/18/2015
    In this study, the in vivo endothelial membrane localization of the sodium-dependent glutamine transporters Snat3 (Slc38a3) and Snat1 (Slc38a1) was investigated in the mouse brain microvasculature.

    Differential axial localization along the mouse brain vascular tree of luminal sodium-dependent glutamine transporters Snat1 and Snat3.
    Ruderisch N, Virgintino D, Makrides V, Verrey F., Free PMC Article

    09/17/2011
    Potassium restriction, high protein intake, and metabolic acidosis increase expression of the glutamine transporter SNAT3 (Slc38a3) in mouse kidney.

    Potassium restriction, high protein intake, and metabolic acidosis increase expression of the glutamine transporter SNAT3 (Slc38a3) in mouse kidney.
    Busque SM, Wagner CA.

    01/21/2010
    ISH and IF revealed SN1 and SN2 expression in the ganglion, inner nuclear, and photoreceptor cell layers.

    Expression and function of system N glutamine transporters (SN1/SN2 or SNAT3/SNAT5) in retinal ganglion cells.
    Umapathy NS, Dun Y, Martin PM, Duplantier JN, Roon P, Prasad P, Smith SB, Ganapathy V., Free PMC Article

    01/21/2010
    selective regulation of SNAT3 and y(+)LAT1 expression may serve a major role in the renal adaptation to acid secretion and thus for systemic acid-base balance.

    Regulation of renal amino acid transporters during metabolic acidosis.
    Moret C, Dave MH, Schulz N, Jiang JX, Verrey F, Wagner CA.

    01/21/2010
    differential regulation of SNAT3 by insulin and serum starvation reinforces the functional significance of this transporter in liver physiology

    Differential regulation of amino acid transporter SNAT3 by insulin in hepatocytes.
    Gu S, Villegas CJ, Jiang JX.

    01/21/2010
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