| LncRNA SLC1A5-AS/MZF1/ASCT2 Axis Contributes to Malignant Progression of Hepatocellular Carcinoma. | LncRNA SLC1A5-AS/MZF1/ASCT2 Axis Contributes to Malignant Progression of Hepatocellular Carcinoma.
Jiang J, Dong W, Zhang W, Wang Q, Wang R, Wang J, Wu H, Dong H, Zhao RC, Wang J, Li Z. | 12/18/2023 |
| MZF1 alleviates oxidative stress and apoptosis induced by rotenone in SH-SY5Y cells by promoting RBM3 transcription. | MZF1 alleviates oxidative stress and apoptosis induced by rotenone in SH-SY5Y cells by promoting RBM3 transcription.
Zhang J, Chai W, Xiang Z, Zhou X, Zhang P. | 06/11/2022 |
| MZF1 mediates oncogene-induced senescence by promoting the transcription of p16(INK4A). | MZF1 mediates oncogene-induced senescence by promoting the transcription of p16(INK4A).
Wu D, Tan H, Su W, Cheng D, Wang G, Wang J, Ma DA, Dong GM, Sun P., Free PMC Article | 02/19/2022 |
| Cigarette smoke modulates binding of the transcription factor MZF1 to the VEGF promoter and regulates VEGF expression in dependence of genetic variation SNP 405. | Cigarette smoke modulates binding of the transcription factor MZF1 to the VEGF promoter and regulates VEGF expression in dependence of genetic variation SNP 405.
Krüger M, Metzger C, Al-Nawas B, Kämmerer PW, Brieger J. | 12/26/2020 |
| Metallothionein 2A (MT2A)/myeloid zinc-finger 1 (MZF1) may serve as a prognostic marker and a therapeutic target for human gastric cancer. | Transcription Factor Myeloid Zinc-Finger 1 Suppresses Human Gastric Carcinogenesis by Interacting with Metallothionein 2A.
Lin S, Wang X, Pan Y, Tian R, Lin B, Jiang G, Chen K, He Y, Zhang L, Zhai W, Jin P, Yang L, Li G, Wu Y, Hu J, Gong W, Chang Z, Sheng JQ, Lu Y, Wang JM, Huang J. | 04/18/2020 |
| Exogenous expression of the acidic domain of MZF1 repressed the binding of endogenous MZF1 to IGF1R promoter via blocking the interaction with ETS-like gene 1 (ELK1). This blockage not only caused MZF1 protein degradation, but also restrained ELK1 nuclear localization in high-level MZF1-expressing TNBC cells. MZF1, but not ELK1, was necessary for the retention of mesenchymal phenotype by repressing IGF1R promoter activity | Myeloid Zinc Finger 1 (MZF1) Maintains the Mesenchymal Phenotype by Down-regulating IGF1R/p38 MAPK/ERα Signaling Pathway in High-level MZF1-expressing TNBC cells.
Yue CH, Liu JY, Chi CS, Hu CW, Tan KT, Huang FM, Pan YR, Lin KI, Lee CJ. | 08/10/2019 |
| Mechanistically, FTO enhanced MZF1 expression by reducing m(6)A levels and mRNA stability in MZF1 mRNA transcript, leading to oncogenic functions. | m(6)A demethylase FTO facilitates tumor progression in lung squamous cell carcinoma by regulating MZF1 expression.
Liu J, Ren D, Du Z, Wang H, Zhang H, Jin Y. | 11/10/2018 |
| MZF1 gene expression was not significantly correlated with PYROXD2 protein expression in the samples of resected tumor tissues, which revealed that the PYROXD2 promoter transcription activity was determined by the aggregated effect of numerous transcription factors. This finding may be helpful in understanding the underlying mechanism which regulates the PYROXD2 expression. | Myeloid zinc finger 1 protein is a key transcription stimulating factor of PYROXD2 promoter.
Liu H, Jiang X, Wang T, Yu F, Wang X, Chen J, Xie X, Fan H. | 07/7/2018 |
| PAX2 is involved in the carcinogenesis of endometrial cancer by stimulating cell growth and promoting cell motility; the overexpression of PAX2 in endometrial cancer is regulated by promoter hypermethylation and the transcription factor MZF1 | DNA methylation promotes paired box 2 expression via myeloid zinc finger 1 in endometrial cancer.
Jia N, Wang J, Li Q, Tao X, Chang K, Hua K, Yu Y, Wong KK, Feng W., Free PMC Article | 02/24/2018 |
| miR-337-3p directly binds to the MMP-14 promoter to repress MZF1-facilitatd MMP-14 expression, thus suppressing the progression of gastric cancer | miRNA-337-3p inhibits gastric cancer progression through repressing myeloid zinc finger 1-facilitated expression of matrix metalloproteinase 14.
Zheng L, Jiao W, Mei H, Song H, Li D, Xiang X, Chen Y, Yang F, Li H, Huang K, Tong Q., Free PMC Article | 01/20/2018 |
| TGF-beta1-induced CK17 enhances cancer stem cell-like properties rather than epithelial-mesenchymal transition in promoting cervical cancer metastasis via the ERK1/2-MZF1 signaling pathway. | TGF-β1-induced CK17 enhances cancer stem cell-like properties rather than EMT in promoting cervical cancer metastasis via the ERK1/2-MZF1 signaling pathway.
Wu L, Han L, Zhou C, Wei W, Chen X, Yi H, Wu X, Bai X, Guo S, Yu Y, Liang L, Wang W. | 10/7/2017 |
| SIRT6 over-expression establishes a condition whereby reconfiguration of the Hexokinase 2 promoter chromatin structure makes it receptive to interaction with MZF1/SIRT6 complex, thereby favouring a regulatory state conducive to diminished transcription | SIRT6 regulated nucleosomal occupancy affects Hexokinase 2 expression.
Gupta P, Sheikh T, Sen E. | 10/7/2017 |
| Tumor antigen PRAME is up-regulated by MZF1 in cooperation with DNA hypomethylation in melanoma cells. | Tumor antigen PRAME is up-regulated by MZF1 in cooperation with DNA hypomethylation in melanoma cells.
Lee YK, Park UH, Kim EJ, Hwang JT, Jeong JC, Um SJ. | 09/30/2017 |
| MZF1 has a role in cellular migration of gastric cancer cells via promoting an increase in intracellular SMAD4 levels. This study might provide new evidence for the molecular basis of the tumor suppressive effect of the MZF1-SMAD4 axis, a new therapeutic target in advanced human gastric cancer. | Upregulation of SMAD4 by MZF1 inhibits migration of human gastric cancer cells.
Lee JH, Kim SS, Lee HS, Hong S, Rajasekaran N, Wang LH, Choi JS, Shin YK. | 04/8/2017 |
| Here we discuss the regulation of MZF1 that mediated its recruitment and activation in cancer, concentrating on posttranslational modification by phosphorylation, and sumoylation | Role and Regulation of Myeloid Zinc Finger Protein 1 in Cancer.
Eguchi T, Prince T, Wegiel B, Calderwood SK., Free PMC Article | 06/4/2016 |
| These findings suggest that PKCalpha expression in HCC could be stimulated by the formation of MZF-1/Elk-1 complex, which directly binds to the PKCalpha promoter. | MZF-1/Elk-1 Complex Binds to Protein Kinase Cα Promoter and Is Involved in Hepatocellular Carcinoma.
Yue CH, Huang CY, Tsai JH, Hsu CW, Hsieh YH, Lin H, Liu JY., Free PMC Article | 04/23/2016 |
| our results revealed that the loss of nuclear expression of MZF1 in oral squamous cell carcinoma (OSCC) samples can predict the progression of OSCC and the survival of OSCC patients in Taiwan | Expression of myeloid zinc finger 1 and the correlation to clinical aspects of oral squamous cell carcinoma.
Ko CP, Yang LC, Chen CJ, Yeh KT, Lin SH, Yang SF, Chen MK, Lin CW. | 02/27/2016 |
| The aberrant decreases in Ik-1 and MZF1 contribute significantly to the pathogenesis of NPM-ALK(+) T-cell lymphoma through the upregulation of IGF-IR expression. | The transcription factors Ik-1 and MZF1 downregulate IGF-IR expression in NPM-ALK⁺ T-cell lymphoma.
Vishwamitra D, Curry CV, Alkan S, Song YH, Gallick GE, Kaseb AO, Shi P, Amin HM., Free PMC Article | 01/16/2016 |
| our results argue that MZF-1 regulates the CTGF and NOV genes in the hematopoietic compartment, and may be involved in their respective functions in the stroma. | Myeloid Zinc Finger 1 (MZF-1) Regulates Expression of the CCN2/CTGF and CCN3/NOV Genes in the Hematopoietic Compartment.
Piszczatowski RT, Rafferty BJ, Rozado A, Parziale JV, Lents NH. | 10/17/2015 |
| Data indicate that elevated miR-492 expression in prostate tumors that resulted in diminished myeloid zinc-finger 1 (MZF-1) and ferroportin (FPN). | Myeloid zinc-finger 1 (MZF-1) suppresses prostate tumor growth through enforcing ferroportin-conducted iron egress.
Chen Y, Zhang Z, Yang K, Du J, Xu Y, Liu S. | 10/17/2015 |
| Data suggest that induction of foxhead box M1(FOXM1) by E6 oncoprotein through the transcription factors MZF1/NKX2-1 axis may be responsible for human papillomavirus 16/18-mediated tumor progression. | Up-regulation of FOXM1 by E6 oncoprotein through the MZF1/NKX2-1 axis is required for human papillomavirus-associated tumorigenesis.
Chen PM, Cheng YW, Wang YC, Wu TC, Chen CY, Lee H., Free PMC Article | 07/25/2015 |
| MZF1-mediated MYC expression may promote tumor progression, resulting in poor outcomes in cases of lung adenocarcinoma with low-wild-type-LKB1 tumors. | The MZF1/c-MYC axis mediates lung adenocarcinoma progression caused by wild-type lkb1 loss.
Tsai LH, Wu JY, Cheng YW, Chen CY, Sheu GT, Wu TC, Lee H. | 06/6/2015 |
| MZF-1 binds to and positively regulates the GAPDH promoter. | The glyceraldehyde 3-phosphate dehydrogenase gene (GAPDH) is regulated by myeloid zinc finger 1 (MZF-1) and is induced by calcitriol.
Piszczatowski RT, Rafferty BJ, Rozado A, Tobak S, Lents NH. | 12/20/2014 |
| p55PIK is transcriptionally activated by MZF1, resulting in increased proliferation of colorectal cancer cells | p55PIK transcriptionally activated by MZF1 promotes colorectal cancer cell proliferation.
Deng Y, Wang J, Wang G, Jin Y, Luo X, Xia X, Gong J, Hu J., Free PMC Article | 11/16/2013 |
| Selected single nucleotide polymorphisms in the MZF-1 gene exert a minor effect on the risk of Alzheimer's disease. | Haplotype of single nucleotide polymorphisms in exon 6 of the MZF-1 gene and Alzheimer's disease.
Porcellini E, Carbone I, Martelli PL, Ianni M, Casadio R, Pession A, Licastro F. | 11/2/2013 |