| A novel polypeptide encoded by the circular RNA ZKSCAN1 suppresses HCC via degradation of mTOR. | A novel polypeptide encoded by the circular RNA ZKSCAN1 suppresses HCC via degradation of mTOR.
Song R, Ma S, Xu J, Ren X, Guo P, Liu H, Li P, Yin F, Liu M, Wang Q, Yu L, Liu J, Duan B, Rahman NA, Wołczyński S, Li G, Li X., Free PMC Article | 02/4/2023 |
| CircZKSCAN1 Suppresses Hepatocellular Carcinoma Tumorigenesis by Regulating miR-873-5p/Downregulation of Deleted in Liver Cancer 1. | CircZKSCAN1 Suppresses Hepatocellular Carcinoma Tumorigenesis by Regulating miR-873-5p/Downregulation of Deleted in Liver Cancer 1.
Li J, Bao S, Wang L, Wang R. | 12/11/2021 |
| The results revealed that ZKSCAN1 circular RNA exerted its inhibitive role by competitively binding FMRP, therefore, block the binding between FMRP and beta-catenin-binding protein-cell cycle and apoptosis regulator 1 (CCAR1) mRNA, and subsequently restrain the transcriptional activity of Wnt signaling. | Circular RNAs negatively regulate cancer stem cells by physically binding FMRP against CCAR1 complex in hepatocellular carcinoma.
Zhu YJ, Zheng B, Luo GJ, Ma XK, Lu XY, Lin XM, Yang S, Zhao Q, Wu T, Li ZX, Liu XL, Wu R, Liu JF, Ge Y, Yang L, Wang HY, Chen L., Free PMC Article | 06/27/2020 |
| These results reveal that Circ-ZKSCAN1 acts as a tumor suppressor via a novel circ-ZKSCAN1/miR-1178-3p/p21 axis, which have the important role in the proliferation, migration and invasion ablitities of BCa cells and provide a novel perspective on circRNAs in BCa progression. | Circular RNA circ-ZKSCAN1 inhibits bladder cancer progression through miR-1178-3p/p21 axis and acts as a prognostic factor of recurrence.
Bi J, Liu H, Dong W, Xie W, He Q, Cai Z, Huang J, Lin T., Free PMC Article | 04/4/2020 |
| Dual luciferase activity assay demonstrated that ZNF139 inhibited transcriptional activities of miR-185's promoter in cells transfected with the reporter plasmid encompassing the upstream promoter region of miR-185 along with pcDNA-ZNF139. Our data reveal that ZNF139 might promote MDR gene MDR1/P-gp, MRP-1 and Bcl-2 by prohibiting miR-185 | ZNF139 increases multidrug resistance in gastric cancer cells by inhibiting miR-185.
Tan B, Li Y, Zhao Q, Fan L, Wang D., Free PMC Article | 05/18/2019 |
| High ZNF139 expression is associated with low chemosensitivity in gastric cancer. | miR‑195‑5p regulates multi‑drug resistance of gastric cancer cells via targeting ZNF139.
Nie H, Mu J, Wang J, Li Y., Free PMC Article | 11/10/2018 |
| ZKSCAN1, a zinc finger family gene, is expressed in both linear and circular (circZKSCAN1) forms of RNA in human hepatocellular carcinoma (HCC) tissues and cell lines. | ZKSCAN1 gene and its related circular RNA (circZKSCAN1) both inhibit hepatocellular carcinoma cell growth, migration, and invasion but through different signaling pathways.
Yao Z, Luo J, Hu K, Lin J, Huang H, Wang Q, Zhang P, Xiong Z, He C, Huang Z, Liu B, Yang Y., Free PMC Article | 11/4/2017 |
| ZNF139 functions to promote apoptosis resistance of gastric cancer cells by regulating some apoptosis related genes. | Silencing of ZNF139-siRNA induces apoptosis in human gastric cancer cell line BGC823.
Fan L, Tan B, Li Y, Zhao Q, Liu Y, Wang D, Zhang Z., Free PMC Article | 10/8/2016 |
| ZNF139 expression is related to clinicopathologic characteristics and prognosis of gastric cancer. It is overexpressed and involved in apoptosis in GC tissues by regulating caspase-3. | Zinc finger protein 139 expression in gastric cancer and its clinical significance.
Li Y, Zhao Q, Fan LQ, Wang LL, Tan BB, Leng YL, Liu Y, Wang D., Free PMC Article | 09/26/2015 |
| ZNF139 was involved in GC MDR by promoting expressions of MDR1/P-gp, MRP1 and Bcl-2 and inhibiting Bax simultaneously. | Regulatory mechanism of ZNF139 in multi-drug resistance of gastric cancer cells.
Li Y, Tan BB, Zhao Q, Fan LQ, Liu Y, Wang D. | 02/14/2015 |
| ZNF139 gene may influence the biological behavior of gastric cancer cells in many ways by regulating multiple proteins. | Comparative proteomics in gastric cancer cell line BGC823 after ZNF139 gene inhibited with RNA interference.
Fan LQ, Li Y, Zhao Q, Tan BB, Ma LG, Liu Y, Wang D. | 01/3/2015 |
| Knocking down ZNF139 expression in gastric cancer cells could effectively reduce gastric cancer cell invasion and migration ability | ZNF139 promotes tumor metastasis by increasing migration and invasion in human gastric cancer cells.
Li Y, Tan BB, Zhao Q, Fan LQ, Wang D, Liu Y. | 08/9/2014 |