| ZIC1 Dictates Osteogenesis Versus Adipogenesis in Human Mesenchymal Progenitor Cells Via a Hedgehog Dependent Mechanism. | ZIC1 Dictates Osteogenesis Versus Adipogenesis in Human Mesenchymal Progenitor Cells Via a Hedgehog Dependent Mechanism.
Thottappillil N, Gomez-Salazar MA, Xu M, Qin Q, Xing X, Xu J, Broderick K, Yea JH, Archer M, Ching-Yun Hsu G, Péault B, James AW., Free PMC Article | 09/20/2023 |
| Common Variants Near ZIC1 and ZIC4 in Autopsy-Confirmed Multiple System Atrophy. | Common Variants Near ZIC1 and ZIC4 in Autopsy-Confirmed Multiple System Atrophy.
Hopfner F, Tietz AK, Ruf VC, Ross OA, Koga S, Dickson D, Aguzzi A, Attems J, Beach T, Beller A, Cheshire WP, van Deerlin V, Desplats P, Deuschl G, Duyckaerts C, Ellinghaus D, Evsyukov V, Flanagan ME, Franke A, Frosch MP, Gearing M, Gelpi E, van Gerpen JA, Ghetti B, Glass JD, Grinberg LT, Halliday G, Helbig I, Höllerhage M, Huitinga I, Irwin DJ, Keene DC, Kovacs GG, Lee EB, Levin J, Martí MJ, Mackenzie I, McKeith I, Mclean C, Mollenhauer B, Neumann M, Newell KL, Pantelyat A, Pendziwiat M, Peters A, Molina Porcel L, Rabano A, Matěj R, Rajput A, Rajput A, Reimann R, Scott WK, Seeley W, Selvackadunco S, Simuni T, Stadelmann C, Svenningsson P, Thomas A, Trenkwalder C, Troakes C, Trojanowski JQ, Uitti RJ, White CL, Wszolek ZK, Xie T, Ximelis T, Yebenes J, Alzheimer's Disease Genetics Consortium, Müller U, Schellenberg GD, Herms J, Kuhlenbäumer G, Höglinger G., Free PMC Article | 10/22/2022 |
| Age-Related DNA Methylation in Normal Kidney Tissue Identifies Epigenetic Cancer Risk Susceptibility Loci in the ANKRD34B and ZIC1 Genes. | Age-Related DNA Methylation in Normal Kidney Tissue Identifies Epigenetic Cancer Risk Susceptibility Loci in the ANKRD34B and ZIC1 Genes.
Serth J, Peters I, Hill B, Hübscher T, Hennenlotter J, Klintschar M, Kuczyk MA., Free PMC Article | 06/11/2022 |
| Mechanical-Stress-Related Epigenetic Regulation of ZIC1 Transcription Factor in the Etiology of Postmenopausal Osteoporosis. | Mechanical-Stress-Related Epigenetic Regulation of ZIC1 Transcription Factor in the Etiology of Postmenopausal Osteoporosis.
Datta HK, Kringen MK, Tuck SP, Salpingidou G, Olstad OK, Gautvik KM, Cockell SJ, Gautvik VT, Prediger M, Wu JJ, Birch MA, Reppe S., Free PMC Article | 04/16/2022 |
| Transcriptional expression of ZICs as an independent indicator of survival in gliomas. | Transcriptional expression of ZICs as an independent indicator of survival in gliomas.
Han Z, Jia J, Lv Y, Wang R, Cao K., Free PMC Article | 12/25/2021 |
| Roles and correlation of FOXA1 and ZIC1 in breast cancer. | Roles and correlation of FOXA1 and ZIC1 in breast cancer.
Zhang YW, Ma J, Shi CT, Han W, Gao XJ, Zhou MH, Ding HZ, Wang HN. | 09/4/2021 |
| LINC01419-mediated epigenetic silencing of ZIC1 promotes metastasis in hepatocellular carcinoma through the PI3K/Akt signaling pathway. | LINC01419-mediated epigenetic silencing of ZIC1 promotes metastasis in hepatocellular carcinoma through the PI3K/Akt signaling pathway.
Hou Y, Chen K, Liao R, Li Y, Yang H, Gong J. | 08/7/2021 |
| Zic1 suppresses gastric cancer metastasis by regulating Wnt/beta-catenin signaling and epithelial-mesenchymal transition. | Zic1 suppresses gastric cancer metastasis by regulating Wnt/β-catenin signaling and epithelial-mesenchymal transition.
Ge Q, Hu Y, He J, Chen F, Wu L, Tu X, Qi Y, Zhang Z, Xue M, Chen S, Zhong J, Wang L. | 10/3/2020 |
| A single factor induces neuronal differentiation to suppress glioma cell growth. | A single factor induces neuronal differentiation to suppress glioma cell growth.
Fu JQ, Chen Z, Hu YJ, Fan ZH, Guo ZX, Liang JY, Ryu BM, Ren JL, Shi XJ, Li J, Jia S, Wang J, Ke XS, Ma X, Tan X, Zhang T, Chen XZ, Zhang C., Free PMC Article | 09/12/2020 |
| this severe brain malformation indicates that premature closure of sutures can be independent of the abnormal brain development in subjects with pathogenic variants in ZIC1. | Mutated zinc finger protein of the cerebellum 1 leads to microcephaly, cortical malformation, callosal agenesis, cerebellar dysplasia, tethered cord and scoliosis.
Vandervore LV, Schot R, Hoogeboom AJM, Lincke C, de Coo IF, Lequin MH, Dremmen M, van Unen LMA, Saris JJ, Jansen AC, van Slegtenhorst MA, Wilke M, Mancini GMS. | 02/23/2019 |
| Study demonstrate that ZIC1 plays a tumor suppressive role in breast cancer, by targeting surviving, significantly downregulating its expression. | ZIC1 acts a tumor suppressor in breast cancer by targeting survivin.
Han W, Cao F, Gao XJ, Wang HB, Chen F, Cai SJ, Zhang C, Hu YW, Ma J, Gu X, Ding HZ., Free PMC Article | 12/1/2018 |
| Two proposed mechanisms for Zic-mediated cerebellar developmental control have been documented: regulation of neuronal progenitor proliferation-differentiation and the patterning of the cerebellar primordium. Clinical studies have also revealed that ZIC1 gain of function mutations contribute to coronal craniosynostosis, a rare skull malformation. | ZIC1 Function in Normal Cerebellar Development and Human Developmental Pathology.
Aruga J, Millen KJ. | 07/14/2018 |
| By unbiased genome-wide DNA methylation profiling and comprehensive stepwise verification and validation studies using in vitro and patient-derived samples, we identified 3 promising methylation markers (GHSR, SST, and ZIC1) associated with a 3q gain for the detection of cervical (pre)cancer | Genome-wide DNA Methylation Profiling Reveals Methylation Markers Associated with 3q Gain for Detection of Cervical Precancer and Cancer.
Verlaat W, Snijders PJF, Novianti PW, Wilting SM, De Strooper LMA, Trooskens G, Vandersmissen J, Van Criekinge W, Wisman GBA, Meijer CJLM, Heideman DAM, Steenbergen RDM. | 04/14/2018 |
| down-regulated expression of ZIC1 contributed to the inhibition of cell proliferation, and inhibited the growth of tumor | Clinicopathological significance of increased ZIC1 expression in human endometrial cancer.
Gu X, Liu Q, Yang N, Shen JF, Zhang XG, Cao F, Ding HZ. | 07/16/2016 |
| our results suggest that the Zic1 promoter methylation rate in plasma-derived DNA is of great significance for the early screening of gastric cancer and monitoring of tumorigenesis | Zic1 Promoter Hypermethylation in Plasma DNA Is a Potential Biomarker for Gastric Cancer and Intraepithelial Neoplasia.
Chen X, Lin Z, Xue M, Si J, Chen S., Free PMC Article | 05/14/2016 |
| Gain-of-Function Mutations in ZIC1 Are Associated with Coronal Craniosynostosis and Learning Disability. | Gain-of-Function Mutations in ZIC1 Are Associated with Coronal Craniosynostosis and Learning Disability.
Twigg SR, Forecki J, Goos JA, Richardson IC, Hoogeboom AJ, van den Ouweland AM, Swagemakers SM, Lequin MH, Van Antwerp D, McGowan SJ, Westbury I, Miller KA, Wall SA, WGS500 Consortium, van der Spek PJ, Mathijssen IM, Pauws E, Merzdorf CS, Wilkie AO., Free PMC Article | 12/12/2015 |
| ZIC1 might play a role in the development of Ovarian Cancer, and may be a therapeutic target in OC. | Screening the molecular targets of ovarian cancer based on bioinformatics analysis.
Du L, Qian X, Dai C, Wang L, Huang D, Wang S, Shen X. | 10/24/2015 |
| aberrant methylation is an important mechanism for ZIC1 inactivation in Hepatocellular carcinoma (HCC). | Role of ZIC1 methylation in hepatocellular carcinoma and its clinical significance.
Wang YY, Jiang JX, Ma H, Han J, Sun ZY, Liu ZM, Xu ZG. | 01/17/2015 |
| ZIC1 is frequently inactivated by promoter hypermethyaltion and functions as a tumor suppressor in thyroid cancer through modulating PI3K/Akt and MAPK signaling pathways and transcription factor FOXO3a. | ZIC1 is a putative tumor suppressor in thyroid cancer by modulating major signaling pathways and transcription factor FOXO3a.
Qiang W, Zhao Y, Yang Q, Liu W, Guan H, Lv S, Ji M, Shi B, Hou P. | 10/4/2014 |
| Loss of ZIC1 expression is associated with malignant pleural mesothelioma. | ZIC1 is silenced and has tumor suppressor function in malignant pleural mesothelioma.
Cheng YY, Kirschner MB, Cheng NC, Gattani S, Klebe S, Edelman JJ, Vallely MP, McCaughan BC, Jin HC, van Zandwijk N, Reid G. | 09/20/2014 |
| Methylation of ZIC1, a putative tumor suppressor, may be a novel determinant of ovarian cancer outcome | Comprehensive methylome analysis of ovarian tumors reveals hedgehog signaling pathway regulators as prognostic DNA methylation biomarkers.
Huang RL, Gu F, Kirma NB, Ruan J, Chen CL, Wang HC, Liao YP, Chang CC, Yu MH, Pilrose JM, Thompson IM, Huang HC, Huang TH, Lai HC, Nephew KP., Free PMC Article | 01/11/2014 |
| Zic transcription factors function in patterning hindbrain motor neurons through their regulation of embryonic retinoic acid signaling | The role of Zic transcription factors in regulating hindbrain retinoic acid signaling.
Drummond DL, Cheng CS, Selland LG, Hocking JC, Prichard LB, Waskiewicz AJ., Free PMC Article | 10/26/2013 |
| Overexpression of ZIC1 results in inactivation of Shh, PI(3)K and MAPK signaling pathways, as well as regulation of multiple downstream targets which are essential for the development and progression of gastric cancer. | ZIC1 modulates cell-cycle distributions and cell migration through regulation of sonic hedgehog, PI(3)K and MAPK signaling pathways in gastric cancer.
Zhong J, Chen S, Xue M, Du Q, Cai J, Jin H, Si J, Wang L., Free PMC Article | 12/22/2012 |
| ZIC1 may potentially function as a tumor suppressor gene | ZIC1 is downregulated through promoter hypermethylation, and functions as a tumor suppressor gene in colorectal cancer.
Gan L, Chen S, Zhong J, Wang X, Lam EK, Liu X, Zhang J, Zhou T, Yu J, Si J, Wang L, Jin H., Free PMC Article | 04/7/2012 |
| The down-regulated expression of ZIC1 and KLOTHO in colorectal carcinoma may relate to promoter methylation. | [DNA methylation of ZIC1 and KLOTHO gene promoters in colorectal carcinomas and its clinicopathological significance].
Gan LH, Pan J, Chen SJ, Zhong J, Wang LJ. | 10/1/2011 |