| Sp4 Regulates PTTG1IP Gene Transcription and Expression. | Sp4 Regulates PTTG1IP Gene Transcription and Expression.
Dai X, Luo S, Guo S, Zhou W, Song W. | 12/24/2022 |
| CircPTTG1IP knockdown suppresses rheumatoid arthritis progression by targeting miR-431-5p/FSTL1 axis. | CircPTTG1IP knockdown suppresses rheumatoid arthritis progression by targeting miR-431-5p/FSTL1 axis.
Yang C, Liu Q, Jiang Z. | 12/3/2022 |
| PTTG and PBF interact in head and neck squamous cell carcinoma to reduce p53 stability and function | PTTG and PBF Functionally Interact with p53 and Predict Overall Survival in Head and Neck Cancer.
Read ML, Modasia B, Fletcher A, Thompson RJ, Brookes K, Rae PC, Nieto HR, Poole VL, Roberts S, Campbell MJ, Boelaert K, Turnell AS, Smith VE, Mehanna H, McCabe CJ., Free PMC Article | 10/12/2019 |
| PBF is a novel AR target gene and plays a role in androgen-induced proliferation and metastatic functions | Pituitary tumor transforming gene binding factor (PBF) is required for androgen-induced prostate cancer proliferation and invasion.
Huang SQ, Wang B, Liao QJ, Shen CX, Li WB. | 09/14/2019 |
| Nnegative pituitary tumor-transforming gene 1 protein-interacting protein (PTTG1IP) immunoexpression predicted a 1.5-fold risk of breast cancer death. | PTTG1-interacting protein (PTTG1IP/PBF) predicts breast cancer survival.
Repo H, Gurvits N, Löyttyniemi E, Nykänen M, Lintunen M, Karra H, Kurki S, Kuopio T, Talvinen K, Söderström M, Kronqvist P., Free PMC Article | 06/23/2018 |
| data reveal new insight into PBF function and confirm that, rather than being oncogenic, mutations in PBF are likely to be passenger effects, with overexpression of PBF the more important etiological event in human cancer | Functional consequences of the first reported mutations of the proto-oncogene PTTG1IP/PBF.
Imruetaicharoenchoke W, Fletcher A, Lu W, Watkins RJ, Modasia B, Poole VL, Nieto HR, Thompson RJ, Boelaert K, Read ML, Smith VE, McCabe CJ., Free PMC Article | 04/28/2018 |
| PTTG1IP and MAML3 are associated with BHR severity in adult asthma. The relevance of these genes is supported by the eQTL analyses and co-expression of PTTG1lP with vimentin and E-cadherin1, and MAML3 with MAML2. | PTTG1IP and MAML3, novel genomewide association study genes for severity of hyperresponsiveness in adult asthma.
Nieuwenhuis MA, Vonk JM, Himes BE, Sarnowski C, Minelli C, Jarvis D, Bouzigon E, Nickle DC, Laviolette M, Sin D, Weiss ST, van den Berge M, Koppelman GH, Postma DS. | 12/9/2017 |
| Findings indicate that PBF and PTTG have a critical role in promoting thyroid cancer that is predictive of poorer patient outcome. | Elevated PTTG and PBF predicts poor patient outcome and modulates DNA damage response genes in thyroid cancer.
Read ML, Fong JC, Modasia B, Fletcher A, Imruetaicharoenchoke W, Thompson RJ, Nieto H, Reynolds JJ, Bacon A, Mallick U, Hackshaw A, Watkinson JC, Boelaert K, Turnell AS, Smith VE, McCabe CJ., Free PMC Article | 10/14/2017 |
| Unique role for PBF in regulating CTTN function to promote endocrine cell invasion and migration. | Pro-invasive Effect of Proto-oncogene PBF Is Modulated by an Interaction with Cortactin.
Watkins RJ, Imruetaicharoenchoke W, Read ML, Sharma N, Poole VL, Gentilin E, Bansal S, Bosseboeuf E, Fletcher R, Nieto HR, Mallick U, Hackshaw A, Mehanna H, Boelaert K, Smith VE, McCabe CJ., Free PMC Article | 07/1/2017 |
| these results demonstrate an emerging role for PBF in colorectal tumorigenesis through regulating p53 activity, with implications for PBF as a prognostic indicator for invasive tumors. | The proto-oncogene PBF binds p53 and is associated with prognostic features in colorectal cancer.
Read ML, Seed RI, Modasia B, Kwan PP, Sharma N, Smith VE, Watkins RJ, Bansal S, Gagliano T, Stratford AL, Ismail T, Wakelam MJ, Kim DS, Ward ST, Boelaert K, Franklyn JA, Turnell AS, McCabe CJ. | 05/28/2016 |
| These findings indicate that miR-584 suppresses glioma cell growth by negatively regulating the expression of PTTG1IP, suggesting that miR-584 has a tumor suppressive role in human glioma pathogenesis. | MicroRNA-584 functions as a tumor suppressor and targets PTTG1IP in glioma.
Wang XP, Deng XL, Li LY., Free PMC Article | 10/31/2015 |
| protooncogene PBF is a negative regulator of p53 function in thyroid tumorigenesis, in which PBF is generally overexpressed and p53 mutations are rare compared with other tumor types | The PTTG1-binding factor (PBF/PTTG1IP) regulates p53 activity in thyroid cells.
Read ML, Seed RI, Fong JC, Modasia B, Ryan GA, Watkins RJ, Gagliano T, Smith VE, Stratford AL, Kwan PK, Sharma N, Dixon OM, Watkinson JC, Boelaert K, Franklyn JA, Turnell AS, McCabe CJ., Free PMC Article | 05/24/2014 |
| Data from mutant recombinant proteins suggest that proto-oncogene PBF is a phosphoprotein and highlight importance of tyrosine residue Y174 in both endocytosis of PBF and its interaction/co-localization with NIS/SLC5A5 (sodium-iodide symporter). | Manipulation of PBF/PTTG1IP phosphorylation status; a potential new therapeutic strategy for improving radioiodine uptake in thyroid and other tumors.
Smith VE, Sharma N, Watkins RJ, Read ML, Ryan GA, Kwan PP, Martin A, Watkinson JC, Boelaert K, Franklyn JA, McCabe CJ., Free PMC Article | 10/19/2013 |
| PBF expression may be a promising biomarker for prognostic and therapeutic purposes in papillary thyroid carcinoma patients. | Prognostic significance of pituitary tumour-transforming gene-binding factor (PBF) expression in papillary thyroid carcinoma.
Hsueh C, Lin JD, Chang YS, Hsueh S, Chao TC, Yu JS, Jung SM, Tseng NM, Sun JH, Kuo SY, Ueng SH. | 06/8/2013 |
| Authors identified pituitary tumor-transforming gene 1 (PTTG1) binding factor (PBF) as a target of miR-122 and demonstrated that hepatitis B virus replication causes an obvious increase in PBF levels. | Hepatitis B virus mRNA-mediated miR-122 inhibition upregulates PTTG1-binding protein, which promotes hepatocellular carcinoma tumor growth and cell invasion.
Li C, Wang Y, Wang S, Wu B, Hao J, Fan H, Ju Y, Ding Y, Chen L, Chu X, Liu W, Ye X, Meng S., Free PMC Article | 03/23/2013 |
| The present study provides the first epidemiological evidence that functional regulatory variants of PTTG1IP were associated with the risk of ER-positive breast cancer, further supporting its relevance as one proto-oncogene in breast cancer. | Functional variable number of tandem repeats variation in the promoter of proto-oncogene PTTG1IP is associated with risk of estrogen receptor-positive breast cancer.
Xiang C, Gao H, Meng L, Qin Z, Ma R, Liu Y, Jiang Y, Dang C, Jin L, He F, Wang H., Free PMC Article | 09/1/2012 |
| overexpression of PBF causes thyroid cell proliferation, macrofollicular lesions, and hyperplasia, as well as repression of the critical therapeutic route for radioiodide uptake | Proto-oncogene PBF/PTTG1IP regulates thyroid cell growth and represses radioiodide treatment.
Read ML, Lewy GD, Fong JC, Sharma N, Seed RI, Smith VE, Gentilin E, Warfield A, Eggo MC, Knauf JA, Leadbeater WE, Watkinson JC, Franklyn JA, Boelaert K, McCabe CJ., Free PMC Article | 12/17/2011 |
| PBF's role in endocrine cancer is discussed. [review] | Pituitary tumor-transforming gene and its binding factor in endocrine cancer.
Smith VE, Franklyn JA, McCabe CJ. | 03/5/2011 |
| PTTG expression was higher in malignant cells than in primary astrocytes, whereas PTTG-binding factor was not in astrocytoma | Expression of pituitary tumor transforming gene (PTTG) and its binding protein in human astrocytes and astrocytoma cells: function and regulation of PTTG in U87 astrocytoma cells.
Tfelt-Hansen J, Yano S, Bandyopadhyay S, Carroll R, Brown EM, Chattopadhyay N. | 01/21/2010 |
| overexpression of PTTG and PBF in differentiated thyroid cancer has profound implications for activity of the NIS gene, and hence significantly impacts upon the efficacy of radioiodine treatment. | PTTG and PBF repress the human sodium iodide symporter.
Boelaert K, Smith VE, Stratford AL, Kogai T, Tannahill LA, Watkinson JC, Eggo MC, Franklyn JA, McCabe CJ. | 01/21/2010 |