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    YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein zeta [ Homo sapiens (human) ]

    Gene ID: 7534, updated on 12-Sep-2024

    GeneRIFs: Gene References Into Functions

    GeneRIFPubMed TitleDate
    Deregulated 14-3-3zeta and methionine adenosyltransferase alpha1 interplay promotes liver cancer tumorigenesis in mice and humans.

    Deregulated 14-3-3ζ and methionine adenosyltransferase α1 interplay promotes liver cancer tumorigenesis in mice and humans.
    Lu L, Zhang J, Fan W, Li Y, Wang J, Li TWH, Barbier-Torres L, Mato JM, Liu T, Seki E, Matsuda M, Tomasi ML, Bhowmick NA, Yang H, Lu SC., Free PMC Article

    08/28/2024
    Structural Features and Physiological Associations of Human 14-3-3zeta Pseudogenes.

    Structural Features and Physiological Associations of Human 14-3-3ζ Pseudogenes.
    Lughmani H, Patel H, Chakravarti R., Free PMC Article

    05/20/2024
    14-3-3 interaction with phosphodiesterase 8A sustains PKA signaling and downregulates the MAPK pathway.

    14-3-3 interaction with phosphodiesterase 8A sustains PKA signaling and downregulates the MAPK pathway.
    Mukherjee S, Roy S, Mukherjee S, Harikishore A, Bhunia A, Mandal AK., Free PMC Article

    04/11/2024
    TMEM65 promotes gastric tumorigenesis by targeting YWHAZ to activate PI3K-Akt-mTOR pathway and is a therapeutic target.

    TMEM65 promotes gastric tumorigenesis by targeting YWHAZ to activate PI3K-Akt-mTOR pathway and is a therapeutic target.
    Shi L, Wang X, Guo S, Gou H, Shang H, Jiang X, Wei C, Wang J, Li C, Wang L, Zhao Z, Yu W, Yu J., Free PMC Article

    03/27/2024
    CSF 14-3-3 zeta(zeta) isoform is associated with tau pathology and cognitive decline in Alzheimer's disease.

    CSF 14-3-3 zeta(ζ) isoform is associated with tau pathology and cognitive decline in Alzheimer's disease.
    Qiang Q, Skudder-Hill L, Toyota T, Huang Z, Wei W, Adachi H, Alzheimer's Disease Neuroimaging Initiative.

    02/22/2024
    High-throughput functional screen identifies YWHAZ as a key regulator of pancreatic cancer metastasis.

    High-throughput functional screen identifies YWHAZ as a key regulator of pancreatic cancer metastasis.
    Cao F, Jiang Y, Chang L, Du H, Chang D, Pan C, Huang X, Yu D, Zhang M, Fan Y, Bian X, Li K., Free PMC Article

    09/9/2023
    Molecular basis and dual ligand regulation of tetrameric estrogen receptor alpha/14-3-3zeta protein complex.

    Molecular basis and dual ligand regulation of tetrameric estrogen receptor α/14-3-3ζ protein complex.
    Somsen BA, Sijbesma E, Leysen S, Honzejkova K, Visser EJ, Cossar PJ, Obšil T, Brunsveld L, Ottmann C., Free PMC Article

    08/4/2023
    Discovery of 14-3-3 zeta as a potential biomarker for cardiac hypertrophy.

    Discovery of 14-3-3 zeta as a potential biomarker for cardiac hypertrophy.
    Mahmud J, Thi My Ong H, Ates E, Seo HS, Kang MJ., Free PMC Article

    06/29/2023
    YWHAZ variation causes intellectual disability and global developmental delay with brain malformation.

    YWHAZ variation causes intellectual disability and global developmental delay with brain malformation.
    Wan RP, Liu ZG, Huang XF, Kwan P, Li YP, Qu XC, Ye XG, Chen FY, Zhang DW, He MF, Wang J, Mao YL, Qiao JD., Free PMC Article

    01/28/2023
    Expression of PD-L1 and YWHAZ in Patients with Diffuse Large B Cell Lymphoma: A Possible Association with the Prognosis of Lymphoma.

    Expression of PD-L1 and YWHAZ in Patients with Diffuse Large B Cell Lymphoma: A Possible Association with the Prognosis of Lymphoma.
    Yan S, Shang Q, Fan Z, Yang Y, Liu Y, Gao H, Chen K, Liang F, Li X, Zhang Q, Yan H., Free PMC Article

    10/15/2022
    hucMSC-sEVs-Derived 14-3-3zeta Serves as a Bridge between YAP and Autophagy in Diabetic Kidney Disease.

    hucMSC-sEVs-Derived 14-3-3ζ Serves as a Bridge between YAP and Autophagy in Diabetic Kidney Disease.
    Yin S, Liu W, Ji C, Zhu Y, Shan Y, Zhou Z, Chen W, Zhang L, Sun Z, Zhou W, Qian H., Free PMC Article

    10/15/2022
    Overexpression of 14-3-3zeta primes disease recurrence, metastasis and resistance to chemotherapy by inducing epithelial-mesenchymal transition in NSCLC.

    Overexpression of 14-3-3ζ primes disease recurrence, metastasis and resistance to chemotherapy by inducing epithelial-mesenchymal transition in NSCLC.
    Wei L, Hu N, Ye M, Xi Z, Wang Z, Xiong L, Yang N, Shen Y., Free PMC Article

    08/20/2022
    Quantitation of Human 14-3-3zeta Dimerization and the Effect of Phosphorylation on Dimer-monomer Equilibria.

    Quantitation of Human 14-3-3ζ Dimerization and the Effect of Phosphorylation on Dimer-monomer Equilibria.
    Trošanová Z, Louša P, Kozeleková A, Brom T, Gašparik N, Tungli J, Weisová V, Župa E, Žoldák G, Hritz J.

    05/14/2022
    TBP, PPIA, YWHAZ and EF1A1 Are the Most Stably Expressed Genes during Osteogenic Differentiation.

    TBP, PPIA, YWHAZ and EF1A1 Are the Most Stably Expressed Genes during Osteogenic Differentiation.
    Franko N, Vrščaj LA, Zore T, Ostanek B, Marc J, Lojk J., Free PMC Article

    04/30/2022
    Loss of ubiquitin-specific peptidase 18 destabilizes 14-3-3zeta protein and represses lung cancer metastasis.

    Loss of ubiquitin-specific peptidase 18 destabilizes 14-3-3ζ protein and represses lung cancer metastasis.
    Chen Z, Zheng L, Chen Y, Liu X, Kawakami M, Mustachio LM, Roszik J, Ferry-Galow KV, Parchment RE, Liu X, Andresson T, Duncan G, Kurie JM, Rodriguez-Canales J, Liu X, Dmitrovsky E., Free PMC Article

    04/16/2022
    Structural insights on the effects of mutation of a charged binding pocket residue on phosphopeptide binding to 14-3-3zeta protein.

    Structural insights on the effects of mutation of a charged binding pocket residue on phosphopeptide binding to 14-3-3ζ protein.
    T S S, Dalvi S, Venkatraman P, Vemparala S.

    04/16/2022
    PRDM5 suppresses oesophageal squamous carcinoma cells and modulates 14-3-3zeta/Akt signalling pathway.

    PRDM5 suppresses oesophageal squamous carcinoma cells and modulates 14-3-3zeta/Akt signalling pathway.
    Zhang C, Liu Z, Sheng Y, Wu B, Song Y, Ye G, Qi Y, Zhao S.

    03/26/2022
    CircCDK17 knockdown inhibits tumor progression and cell glycolysis by downregulaing YWHAZ expression through sponging miR-1294 in cervical cancer.

    CircCDK17 knockdown inhibits tumor progression and cell glycolysis by downregulaing YWHAZ expression through sponging miR-1294 in cervical cancer.
    Chen R, Liang F, Yan J, Wang Y., Free PMC Article

    03/12/2022
    14-3-3zeta promoted invasion and lymph node metastasis of breast invasive ductal carcinoma with HER2 overexpression.

    14-3-3ζ promoted invasion and lymph node metastasis of breast invasive ductal carcinoma with HER2 overexpression.
    Wan D, Zhang Y, Yu Q, Li F, Zhuo J.

    03/5/2022
    Structural insights into the BRAF monomer-to-dimer transition mediated by RAS binding.

    Structural insights into the BRAF monomer-to-dimer transition mediated by RAS binding.
    Martinez Fiesco JA, Durrant DE, Morrison DK, Zhang P., Free PMC Article

    02/19/2022
    FOXD1-AS1 promotes malignant behaviours of prostate cancer cells via the miR-3167/YWHAZ axis.

    FOXD1-AS1 promotes malignant behaviours of prostate cancer cells via the miR-3167/YWHAZ axis.
    Qu W, Wei X, Zhang H, Hou J.

    01/15/2022
    Circular RNA Paired-Related Homeobox 1 Promotes Gastric Carcinoma Cell Progression via Regulating MicroRNA-665/YWHAZ Axis.

    Circular RNA Paired-Related Homeobox 1 Promotes Gastric Carcinoma Cell Progression via Regulating MicroRNA-665/YWHAZ Axis.
    Liu W, Hu W, Hou K, Zhu S.

    12/4/2021
    Enhancement of cisplatin sensitivity in human breast cancer MCF-7 cell line through BiP and 14-3-3zeta co-knockdown.

    Enhancement of cisplatin sensitivity in human breast cancer MCF-7 cell line through BiP and 14-3-3ζ co-knockdown.
    Kashkoulinejad-Kouhi T, Safarian S, Arnaiz B, Saa L., Free PMC Article

    11/22/2021
    Cautions should be taken when using cell models for gastric cancer research.

    Cautions should be taken when using cell models for gastric cancer research.
    Cai S, Yao D, Zhang Y, Li Z, Li X, Li L.

    09/25/2021
    Down-regulation of 14-3-3zeta reduces proliferation and increases apoptosis in human glioblastoma.

    Down-regulation of 14-3-3zeta reduces proliferation and increases apoptosis in human glioblastoma.
    Yang X, Cao W, Wang X, Zhang X, Zhang W, Li Z, Fu H.

    08/21/2021
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