| YWHAG promotes colorectal cancer progression by regulating the CTTN-Wnt/beta-catenin signaling axis. | YWHAG promotes colorectal cancer progression by regulating the CTTN-Wnt/β-catenin signaling axis.
Wang Y, Cao Y, Chen Y, Cheng H, Liu Z, Wang M, Feng Y, Fei B, Cui K, Huang Z. | 04/1/2024 |
| YWHAG Deficiency Disrupts the EMT-Associated Network to Induce Oxidative Cell Death and Prevent Metastasis. | YWHAG Deficiency Disrupts the EMT-Associated Network to Induce Oxidative Cell Death and Prevent Metastasis.
Lee JXT, Tan WR, Low ZS, Lee JQ, Chua D, Yeo WDC, See B, Vos MIG, Yasuda T, Nomura S, Cheng HS, Tan NS., Free PMC Article | 11/10/2023 |
| A heterozygous missense variant in the YWHAG gene causing developmental and epileptic encephalopathy 56 in a Chinese family. | A heterozygous missense variant in the YWHAG gene causing developmental and epileptic encephalopathy 56 in a Chinese family.
Yi Z, Song Z, Xue J, Yang C, Li F, Pan H, Feng X, Zhang Y, Pan H., Free PMC Article | 10/22/2022 |
| Myoclonic epilepsy of infancy related to YWHAG gene mutation: towards a better phenotypic characterization. | Myoclonic epilepsy of infancy related to YWHAG gene mutation: towards a better phenotypic characterization.
Iodice A, Giannelli C, Soli F, Riva A, Striano P. | 02/26/2022 |
| Long non-coding RNA NORAD protects against cerebral ischemia/reperfusion injury induced brain damage, cell apoptosis, oxidative stress and inflammation by regulating miR-30a-5p/YWHAG. | Long non-coding RNA NORAD protects against cerebral ischemia/reperfusion injury induced brain damage, cell apoptosis, oxidative stress and inflammation by regulating miR-30a-5p/YWHAG.
Zhou X, Wang Z, Xu B, Ji N, Meng P, Gu L, Li Y., Free PMC Article | 02/19/2022 |
| Genetic diagnosis of infantile-onset epilepsy in the clinic: Application of whole-exome sequencing following epilepsy gene panel testing. | Genetic diagnosis of infantile-onset epilepsy in the clinic: Application of whole-exome sequencing following epilepsy gene panel testing.
Kim SY, Jang SS, Kim H, Hwang H, Choi JE, Chae JH, Kim KJ, Lim BC. | 01/1/2022 |
| 14-3-3 proteins inactivate DAPK2 by promoting its dimerization and protecting key regulatory phosphosites. | 14-3-3 proteins inactivate DAPK2 by promoting its dimerization and protecting key regulatory phosphosites.
Horvath M, Petrvalska O, Herman P, Obsilova V, Obsil T., Free PMC Article | 12/4/2021 |
| The 14-3-3/SLP76 protein-protein interaction in T-cell receptor signalling: a structural and biophysical characterization. | The 14-3-3/SLP76 protein-protein interaction in T-cell receptor signalling: a structural and biophysical characterization.
Soini L, Leysen S, Davis J, Westwood M, Ottmann C. | 07/31/2021 |
| Epilepsy and electroencephalogram evolution in YWHAG gene mutation: A new phenotype and review of the literature. | Epilepsy and electroencephalogram evolution in YWHAG gene mutation: A new phenotype and review of the literature.
Stern T, Orenstein N, Fellner A, Lev-El Halabi N, Shuldiner AR, Gonzaga-Jauregui C, Lidzbarsky G, Basel-Salmon L, Goldberg-Stern H. | 07/24/2021 |
| 14-3-3gamma prevents centrosome duplication by inhibiting NPM1 function. | 14-3-3γ prevents centrosome duplication by inhibiting NPM1 function.
Bose A, Modi K, Dey S, Dalvi S, Nadkarni P, Sudarshan M, Kundu TK, Venkatraman P, Dalal SN. | 07/17/2021 |
| Functional genetic variants in centrosome-related genes CEP72 and YWHAG confer susceptibility to gastric cancer. | Functional genetic variants in centrosome-related genes CEP72 and YWHAG confer susceptibility to gastric cancer.
Ni J, Wang J, Fu Y, Yan C, Zhu M, Jiang Y, Chen J, Ding Y, Fan X, Li G, Jin G. | 07/17/2021 |
| 14-3-3 protein binding blocks the dimerization interface of caspase-2. | 14-3-3 protein binding blocks the dimerization interface of caspase-2.
Kalabova D, Filandr F, Alblova M, Petrvalska O, Horvath M, Man P, Obsil T, Obsilova V. | 05/22/2021 |
| Molecular basis for the recognition of steroidogenic acute regulatory protein by the 14-3-3 protein family. | Molecular basis for the recognition of steroidogenic acute regulatory protein by the 14-3-3 protein family.
Tugaeva KV, Titterington J, Sotnikov DV, Maksimov EG, Antson AA, Sluchanko NN. | 05/22/2021 |
| Human adipocyte differentiation and composition of disease-relevant lipids are regulated by miR-221-3p. | Human adipocyte differentiation and composition of disease-relevant lipids are regulated by miR-221-3p.
Ahonen MA, Asghar MY, Parviainen SJ, Liebisch G, Höring M, Leidenius M, Fischer-Posovszky P, Wabitsch M, Mikkola TS, Törnquist K, Savolainen-Peltonen H, Haridas PAN, Olkkonen VM. | 04/17/2021 |
| Expanding the genotype-phenotype correlation of de novo heterozygous missense variants in YWHAG as a cause of developmental and epileptic encephalopathy. | Expanding the genotype-phenotype correlation of de novo heterozygous missense variants in YWHAG as a cause of developmental and epileptic encephalopathy.
Kanani F, Titheradge H, Cooper N, Elmslie F, Lees MM, Juusola J, Pisani L, McKenna C, Mignot C, Valence S, Keren B, Lachlan K, DDD Study, Balasubramanian M. | 02/6/2021 |
| YWHA/14-3-3 proteins recognize phosphorylated TFEB by a noncanonical mode for controlling TFEB cytoplasmic localization and its activity. | YWHA/14-3-3 proteins recognize phosphorylated TFEB by a noncanonical mode for controlling TFEB cytoplasmic localization.
Xu Y, Ren J, He X, Chen H, Wei T, Feng W., Free PMC Article | 06/20/2020 |
| The role of 14-3-3gamma in breast cancer invasiveness to promote cell motility. Inhibition of 14-3-3gamma could, therefore, become a novel target of therapy to prevent invasion and metastasis in patients with breast cancers expressing 14-3-3gamma. | Breast cancer cell motility is promoted by 14-3-3γ.
Hiraoka E, Mimae T, Ito M, Kadoya T, Miyata Y, Ito A, Okada M. | 01/4/2020 |
| miR-222 inhibits cell proliferation and migration of osteosarcoma cells by down-regulating YWHAG expression. | MicroRNA-222 contributed to cell proliferation, invasion and migration via regulating YWHAG in osteosarcoma.
Chu YW, Wang CR, Weng FB, Yan ZJ, Wang C. | 12/14/2019 |
| The results in this report demonstrate that 14-3-3 epsilon and 14-3-3 gamma form a complex with Centrin2 and that the binding site is located in the N-terminal EF hand in Centrin2, EF1. | 14-3-3 proteins mediate the localization of Centrin2 to centrosome.
Bose A, Dalal SN. | 11/30/2019 |
| 14-3-3gamma associated primarily with cytoplasmic PKP1 phosphorylated at S155 and destabilized intercellular cohesion of keratinocytes by reducing its incorporation into desmosomes. | 14-3-3 proteins regulate desmosomal adhesion via plakophilins.
Rietscher K, Keil R, Jordan A, Hatzfeld M. | 11/2/2019 |
| Decreased expression of miR-182 in ESCC cells was accompanied by decreased cell invasion and proliferation, promotion of cell apoptosis and cell cycle arrest at G0/G1 phase. Dual-luciferase and western blot confirmed YWHAG as a target gene of miR-182. | MicroRNA-182 promoted esophageal squamous cell carcinoma cell growth and metastasis via targeting YWHAG.
Bai Q, Yu J, Li Y, Ma J, Gou Y. | 09/28/2019 |
| Overexpression of 14-3-3gamma in uterine leiomyoma cells resulted in reductions in the phosphorylations of multiple signaling molecules, including AKT, pan, ERK1/2, GSK-3 alpha/beta, MEK1/2, Foxo1 and Vimentin and may have causal effect of the growth of uterine leiomyoma. | Overexpression of the 14-3-3γ protein in uterine leiomyoma cells results in growth retardation and increased apoptosis.
Shen Q, Hu X, Zhou L, Zou S, Sun LZ, Zhu X. | 08/3/2019 |
| 14-3-3 beta and gamma function as positive regulators of GR transactivation and glucocorticoid-mediated hepatic gluconeogenesis. | Roles of 14-3-3β and γ in regulation of the glucocorticoid receptor transcriptional activation and hepatic gluconeogenesis.
Hwang Y, An HT, Kang M, Ko J. | 05/18/2019 |
| 14-3-3gamma protein directly interacts with the kinase domain of CaMKK2 and the region containing the inhibitory phosphorylation site Thr(145) within the N-terminal extension. CaMKK isoforms differ in their 14-3-3-mediated regulations and the interaction between 14-3-3 protein and the N-terminal 14-3-3-binding motif of CaMKK2 might be stabilized by small-molecule compounds. | 14-3-3 protein directly interacts with the kinase domain of calcium/calmodulin-dependent protein kinase kinase (CaMKK2).
Psenakova K, Petrvalska O, Kylarova S, Lentini Santo D, Kalabova D, Herman P, Obsilova V, Obsil T. | 08/18/2018 |
| Findings indicate the roles and molecular mechanisms of 14-3-3GAMMA protein (14-3-3gamma) in epithelial-mesenchymal transition (EMT), migration, and neoplasm invasion. | Knockdown of 14-3-3γ Suppresses Epithelial-Mesenchymal Transition and Reduces Metastatic Potential of Human Non-small Cell Lung Cancer Cells.
Raungrut P, Wongkotsila A, Champoochana N, Lirdprapamongkol K, Svasti J, Thongsuksai P. | 06/16/2018 |