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    XDH xanthine dehydrogenase [ Homo sapiens (human) ]

    Gene ID: 7498, updated on 3-Nov-2024

    GeneRIFs: Gene References Into Functions

    GeneRIFPubMed TitleDate
    Overnight changes in uric acid, xanthine oxidoreductase and oxidative stress levels and their relationships with sleep-disordered breathing in patients with coronary artery disease.

    Overnight changes in uric acid, xanthine oxidoreductase and oxidative stress levels and their relationships with sleep-disordered breathing in patients with coronary artery disease.
    Shimizu M, Kasai T, Naito R, Sato A, Ishiwata S, Yatsu S, Shitara J, Matsumoto H, Murata A, Kato T, Suda S, Hiki M, Kuwabara M, Murase T, Nakamura T, Daida H.

    11/28/2023
    Natural mutations of human XDH promote the nitrite (NO2[-])-reductase capacity of xanthine oxidoreductase: A novel mechanism to promote redox health?

    Natural mutations of human XDH promote the nitrite (NO(2)(-))-reductase capacity of xanthine oxidoreductase: A novel mechanism to promote redox health?
    Massimo G, Khambata RS, Chapman T, Birchall K, Raimondi C, Shabbir A, Dyson N, Rathod KS, Borghi C, Ahluwalia A., Free PMC Article

    10/30/2023
    Xanthine oxidoreductase gene polymorphisms are associated with high risk of sepsis and organ failure.

    Xanthine oxidoreductase gene polymorphisms are associated with high risk of sepsis and organ failure.
    Gao L, Rafaels N, Dudenkov TM, Damarla M, Damico R, Maloney JP, Moss M, Martin GS, Sevransky J, Shanholtz C, Herr DL, Garcia JGN, Hernandez-Beeftink T, Villar J, Flores C, Beaty TH, Brower R, Hassoun PM, Barnes KC., Free PMC Article

    07/12/2023
    The clinical value of serum xanthine oxidase levels in patients with acute ischemic stroke.

    The clinical value of serum xanthine oxidase levels in patients with acute ischemic stroke.
    Yu H, Chen X, Guo X, Chen D, Jiang L, Qi Y, Shao J, Tao L, Hang J, Lu G, Chen Y, Li Y., Free PMC Article

    03/5/2023
    XDH genotypes through gene-gene interactions with NUDT15 affect azathioprine-induced leukopenia in Chinese patients.

    XDH genotypes through gene-gene interactions with NUDT15 affect azathioprine-induced leukopenia in Chinese patients.
    Liu J, Wen Z, Huang S, Zhang X, Ai X, Qian J.

    09/3/2022
    Possible role of insulin resistance in activation of plasma xanthine oxidoreductase in health check-up examinees.

    Possible role of insulin resistance in activation of plasma xanthine oxidoreductase in health check-up examinees.
    Kurajoh M, Fukumoto S, Akari S, Murase T, Nakamura T, Takahashi K, Yoshida H, Nakatani S, Tsuda A, Morioka T, Mori K, Imanishi Y, Hirata K, Emoto M., Free PMC Article

    07/2/2022
    Racial Differences in XO (Xanthine Oxidase) and Mitochondrial DNA Damage-Associated Molecular Patterns in Resistant Hypertension.

    Racial Differences in XO (Xanthine Oxidase) and Mitochondrial DNA Damage-Associated Molecular Patterns in Resistant Hypertension.
    Butts B, Brown JA, Denney TS Jr, Ballinger S, Lloyd SG, Oparil S, Sanders P, Merriman TR, Gaffo A, Singh J, Kelley EE, Calhoun DA, Dell'Italia LJ., Free PMC Article

    05/14/2022
    Association of Plasma Xanthine Oxidoreductase with Arterial Stiffness in Type 2 Diabetes with Liver Dysfunction.

    Association of Plasma Xanthine Oxidoreductase with Arterial Stiffness in Type 2 Diabetes with Liver Dysfunction.
    Ohira M, Tanaka S, Watanabe Y, Nakamura S, Oka R, Yamaguchi T, Ban N, Saiki A, Ishihara N, Murano T, Murase T, Nakamura T, Tatsuno I.

    04/30/2022
    Relationship between xanthine oxidase gene polymorphisms and anti-tuberculosis drug-induced liver injury in a Chinese population.

    Relationship between xanthine oxidase gene polymorphisms and anti-tuberculosis drug-induced liver injury in a Chinese population.
    Ai X, Huang H, Miao Z, Zhou T, Wu H, Lai Y.

    03/19/2022
    Purine-Induced IFN-gamma Promotes Uric Acid Production by Upregulating Xanthine Oxidoreductase Expression.

    Purine-Induced IFN-γ Promotes Uric Acid Production by Upregulating Xanthine Oxidoreductase Expression.
    Wang H, Xie L, Song X, Wang J, Li X, Lin Z, Su T, Liang B, Huang D., Free PMC Article

    03/5/2022
    Plasma Xanthine Oxidoreductase Activity Associated with Glycemic Control in Patients with Pre-Dialysis Chronic Kidney Disease.

    Plasma Xanthine Oxidoreductase Activity Associated with Glycemic Control in Patients with Pre-Dialysis Chronic Kidney Disease.
    Nakatani S, Ishimura E, Murase T, Nakamura T, Nakatani A, Toi N, Nishide K, Uedono H, Tsuda A, Kurajoh M, Yamada S, Mori K, Inaba M, Emoto M.

    01/8/2022
    Plasma xanthine oxidoreductase activity in Japanese patients with type 2 diabetes across hospitalized treatment.

    Plasma xanthine oxidoreductase activity in Japanese patients with type 2 diabetes across hospitalized treatment.
    Kawachi Y, Fujishima Y, Nishizawa H, Nagao H, Nakamura T, Akari S, Murase T, Taya N, Omori K, Miyake A, Fukuda S, Takahara M, Kita S, Katakami N, Maeda N, Shimomura I., Free PMC Article

    01/1/2022
    Xanthine oxidoreductase promotes the progression of colitis-associated colorectal cancer by causing DNA damage and mediating macrophage M1 polarization.

    Xanthine oxidoreductase promotes the progression of colitis-associated colorectal cancer by causing DNA damage and mediating macrophage M1 polarization.
    Li H, Zhang C, Zhang H, Li H.

    12/18/2021
    Polymorphisms of the genes ABCG2, SLC22A12 and XDH and their relation with hyperuricemia and hypercholesterolemia in Mexican young adults.

    Polymorphisms of the genes ABCG2, SLC22A12 and XDH and their relation with hyperuricemia and hypercholesterolemia in Mexican young adults.
    Vargas-Morales JM, Guevara-Cruz M, Aradillas-García C, G Noriega L, Tovar A, Alegría-Torres JA., Free PMC Article

    10/30/2021
    Serum level of Xanthine oxidase, Uric Acid, and NADPH oxidase1 in Stage I of Multiple Myeloma.

    Serum level of Xanthine oxidase, Uric Acid, and NADPH oxidase1 in Stage I of Multiple Myeloma.
    Kohsari M, Khadem Ansari MH, Rasmi Y., Free PMC Article

    06/5/2021
    Local and Systemic Oxidative Stress in Balkan Endemic Nephropathy Is Not Associated with Xanthine Oxidase Activity.

    Local and Systemic Oxidative Stress in Balkan Endemic Nephropathy Is Not Associated with Xanthine Oxidase Activity.
    Veljković A, Hadži-Đokić J, Sokolović D, Čukuranović R, Čukuranović-Kokoris J, Bašić D, Đorđević B, Stojanović M, Šmelcerović A, Kocić G., Free PMC Article

    05/15/2021
    Uric acid increases IL-1beta secretion and Caspase-1 activation in PBMCs of Behcet's disease patients: The in vitro immunomodulatory effect of xanthine oxidase inhibitor Allopurinol.

    Uric acid increases IL-1β secretion and Caspase-1 activation in PBMCs of Behçet's disease patients: The in vitro immunomodulatory effect of xanthine oxidase inhibitor Allopurinol.
    Chekaoui A, Belguendouz H, Lahmar K, Mazari F, Terahi M, Hakem D, Youinou P, Touil-Boukoffa C.

    01/9/2021
    Plasma xanthine oxidoreductase (XOR) activity in patients who require cardiovascular intensive care.

    Plasma xanthine oxidoreductase (XOR) activity in patients who require cardiovascular intensive care.
    Shibata Y, Shirakabe A, Okazaki H, Matsushita M, Goda H, Shigihara S, Asano K, Kiuchi K, Tani K, Murase T, Nakamura T, Kobayashi N, Hata N, Asai K, Shimizu W.

    12/12/2020
    XOR activity is associated with glycemic control in patients with type 1 diabetes and that XOR activity is associated with vascular endothelial dysfunction.

    Xanthine oxidoreductase activity correlates with vascular endothelial dysfunction in patients with type 1 diabetes.
    Washio K, Kusunoki Y, Tsunoda T, Osugi K, Ohigashi M, Murase T, Nakamura T, Matsuo T, Konishi K, Katsuno T, Namba M, Koyama H.

    05/30/2020
    High serum xanthine oxidase levels are associated with increased sodium and left ventricular hypertrophy in resistant hypertension.

    Plasma xanthine oxidase activity is related to increased sodium and left ventricular hypertrophy in resistant hypertension.
    Butts B, Calhoun DA, Denney TS Jr, Lloyd SG, Gupta H, Gaddam KK, Aban I, Oparil S, Sanders PW, Patel R, Collawn JF, Dell'Italia LJ., Free PMC Article

    04/25/2020
    High Xanthine oxidase activity is associated with type 2 diabetes.

    Xanthine oxidase activity in type 2 diabetic Nigerians.
    Azenabor A, Erivona R, Adejumo E, Ozuruoke D, Azenabor R.

    12/21/2019
    Plasma XOR activity is a novel biomarker of metabolic disorders in a general population.

    Plasma Xanthine Oxidoreductase Activity as a Novel Biomarker of Metabolic Disorders in a General Population.
    Furuhashi M, Matsumoto M, Tanaka M, Moniwa N, Murase T, Nakamura T, Ohnishi H, Saitoh S, Shimamoto K, Miura T.

    10/19/2019
    The data suggests hyper-activity of xanthine oxidase in Duchenne muscular dystrophy (DMD), identifies xanthine oxidase activity as a contributing factor in eccentric contraction-induced force drop of dystrophin-deficient skeletal muscle and highlights the potential of isoxanthopterin as a noninvasive biomarker in DMD.

    Xanthine oxidase is hyper-active in Duchenne muscular dystrophy.
    Lindsay A, McCourt PM, Karachunski P, Lowe DA, Ervasti JM., Free PMC Article

    09/28/2019
    GLT would confer protection against renal injury by protecting against lipid accumulation and glutathionedepletion, at least in part, through suppression of ADA/XO/UA pathway.

    Glutamine confers renoprotection by normalizing lipid and glutathione content in insulin-resistant pregnant rats.
    Olaniyi KS, Olatunji LA.

    09/14/2019
    We found large differences between tumour types and individual tumours in their expression of XDH and APRT Variations in locus-specific DNA methylation and gene copy number correlated with the expression levels of XDH and APRT in human tumours respectively

    A pan-cancer study of the transcriptional regulation of uricogenesis in human tumours: pathological and pharmacological correlates.
    Saidak Z, Louandre C, Dahmani S, Sauzay C, Guedda S, Chauffert B, Chatelain D, Ceballos-Picot I, Galmiche A., Free PMC Article

    05/18/2019
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