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    VEGFB vascular endothelial growth factor B [ Homo sapiens (human) ]

    Gene ID: 7423, updated on 2-Nov-2024

    GeneRIFs: Gene References Into Functions

    GeneRIFPubMed TitleDate
    Chondroitin polymerizing factor promotes development and progression of colorectal cancer via facilitating transcription of VEGFB.

    Chondroitin polymerizing factor promotes development and progression of colorectal cancer via facilitating transcription of VEGFB.
    Huang Y, Zhang Z, Tong H, Qin W, Li Q, Ma L, Ren Z, Chen W, Zhang Y, Zhong Y, Yao L, Zhou P., Free PMC Article

    06/7/2024
    Sorcin promotes proliferation of hepatocellular carcinoma by regulating VEGFA/B via PI3K pathway.

    Sorcin promotes proliferation of hepatocellular carcinoma by regulating VEGFA/B via PI3K pathway.
    Zhang H, Hu S, Sanches JGP, Li Y, Wei Y, Pu C, Zhang J.

    05/31/2024
    VEGF-B prevents excessive angiogenesis by inhibiting FGF2/FGFR1 pathway.

    VEGF-B prevents excessive angiogenesis by inhibiting FGF2/FGFR1 pathway.
    Lee C, Chen R, Sun G, Liu X, Lin X, He C, Xing L, Liu L, Jensen LD, Kumar A, Langer HF, Ren X, Zhang J, Huang L, Yin X, Kim J, Zhu J, Huang G, Li J, Lu W, Chen W, Liu J, Hu J, Sun Q, Lu W, Fang L, Wang S, Kuang H, Zhang Y, Tian G, Mi J, Kang BA, Narazaki M, Prodeus A, Schoonjans L, Ornitz DM, Gariepy J, Eelen G, Dewerchin M, Yang Y, Ou JS, Mora A, Yao J, Zhao C, Liu Y, Carmeliet P, Cao Y, Li X., Free PMC Article

    08/23/2023
    Increased Serum VEGF-B Level Is Associated With Renal Function Impairment in Patients With Type 2 Diabetes.

    Increased Serum VEGF-B Level Is Associated With Renal Function Impairment in Patients With Type 2 Diabetes.
    Wei Y, Han S, Zhou R, Xu P, Zhou L, Zhu Z, Kan Y, Yang X, Xiang Y, Cao Y, Jin Y, Yan J, Yu X, Wang X, Shang W., Free PMC Article

    04/23/2022
    The Aryl Hydrocarbon Receptor-Dependent TGF-alpha/VEGF-B Ratio Correlates With Disease Subtype and Prognosis in Multiple Sclerosis.

    The Aryl Hydrocarbon Receptor-Dependent TGF-α/VEGF-B Ratio Correlates With Disease Subtype and Prognosis in Multiple Sclerosis.
    Cirac A, Tsaktanis T, Beyer T, Linnerbauer M, Andlauer T, Grummel V, Nirschl L, Loesslein L, Quintana FJ, Hemmer B, Rothhammer V., Free PMC Article

    03/5/2022
    Peptides Derived from Vascular Endothelial Growth Factor B Show Potent Binding to Neuropilin-1.

    Peptides Derived from Vascular Endothelial Growth Factor B Show Potent Binding to Neuropilin-1.
    Mota F, Yelland T, Hutton JA, Parker J, Patsiarika A, Chan AWE, O'Leary A, Fotinou C, Martin JF, Zachary IC, Djordjevic S, Frankel P, Selwood DL., Free PMC Article

    02/26/2022
    Co-expression of VEGF-B and FLT-1 correlates with malignancy and prognosis of gastric cancer.

    Co-expression of VEGF-B and FLT-1 correlates with malignancy and prognosis of gastric cancer.
    Ma Y, Wang W, Liu L, Liu Y, Bi W.

    02/12/2022
    Molecular docking, synthesis and biological evaluation of Vascular Endothelial Growth Factor (VEGF) B based peptide as antiangiogenic agent targeting the second domain of the Vascular Endothelial Growth Factor Receptor 1 (VEGFR1D2) for anticancer application.

    Molecular docking, synthesis and biological evaluation of Vascular Endothelial Growth Factor (VEGF) B based peptide as antiangiogenic agent targeting the second domain of the Vascular Endothelial Growth Factor Receptor 1 (VEGFR1D2) for anticancer application.
    Sadremomtaz A, Ali AM, Jouyandeh F, Balalaie S, Navari R, Broussy S, Mansouri K, Groves MR, Asghari SM., Free PMC Article

    10/9/2021
    Identification of a Tumor Microenvironment-relevant Gene set-based Prognostic Signature and Related Therapy Targets in Gastric Cancer.

    Identification of a Tumor Microenvironment-relevant Gene set-based Prognostic Signature and Related Therapy Targets in Gastric Cancer.
    Cai WY, Dong ZN, Fu XT, Lin LY, Wang L, Ye GD, Luo QC, Chen YC., Free PMC Article

    05/22/2021
    Results found that VEGF-B expressions levels were higher in Behcet's disease (BD) patients than those in the healthy group, but this difference did not reach statistical significance. Also, VEGF-B gene expression is significantly higher in patients with vascular involvement (DVT/thrombophlebitis).

    The Evaluation of the Relationship between sTREM-1, VEGF-B, and VEGF Gene Expression Levels with Disease Activity of Behçet's Patients.
    Harmanci K, Akan OY, Pirildar T, Ortan P, Ulman C., Free PMC Article

    03/30/2019
    vitreous levels increased in neovascular retinal diseases

    Evaluation of the growth factors VEGF-a and VEGF-B in the vitreous and serum of patients with macular and retinal vascular diseases.
    Mesquita J, Castro-de-Sousa JP, Vaz-Pereira S, Neves A, Passarinha LA, Tomaz CT.

    01/26/2019
    High plasma VEGF-B levels are associated with type 2 diabetes mellitus.

    Plasma vascular endothelial growth factor B levels are increased in patients with newly diagnosed type 2 diabetes mellitus and associated with the first phase of glucose-stimulated insulin secretion function of β-cell.
    Wu J, Wei H, Qu H, Feng Z, Long J, Ge Q, Deng H.

    06/30/2018
    Data from clinical studies point out the changes in circulating or tissue expression levels of VEGF-B in obese compared with lean patients.

    The role of vascular endothelial growth factor-B in metabolic homoeostasis: current evidence.
    Zafar MI, Zheng J, Kong W, Ye X, Gou L, Regmi A, Chen LL., Free PMC Article

    05/5/2018
    Cardiac transgenic vascular endothelial growth factor-B overexpression failed to protect heart transplants from ischemia-reperfusion injury.

    Vascular Endothelial Growth Factor-B Overexpressing Hearts Are Not Protected From Transplant-Associated Ischemia-Reperfusion Injury.
    Raissadati A, Tuuminen R, Dashkevich A, Bry M, Kivelä R, Anisimov A, Syrjälä S, Arnaudova R, Rouvinen E, Keränen MA, Krebs R, Nykänen AI, Lemström KB.

    10/14/2017
    renal VEGF-B expression correlates with the severity of Diabetic Kidney Disease.

    Reducing VEGF-B Signaling Ameliorates Renal Lipotoxicity and Protects against Diabetic Kidney Disease.
    Falkevall A, Mehlem A, Palombo I, Heller Sahlgren B, Ebarasi L, He L, Ytterberg AJ, Olauson H, Axelsson J, Sundelin B, Patrakka J, Scotney P, Nash A, Eriksson U.

    07/15/2017
    Data show that metformin treatment reduces serum vascular endothelial growth factor B (VEGF-B) levels and ameliorates insulin resistance.

    Serum vascular endothelial growth factor B is elevated in women with polycystic ovary syndrome and can be decreased with metformin treatment.
    Cheng F, Zhao L, Wu Y, Huang T, Yang G, Zhang Z, Wu Y, Jia F, Wu J, Chen C, Liu D.

    12/17/2016
    VEGFA and VEGFB associated sub-network, kinase insert domain receptor (KDR), fibronectin 1 (FN1), transforming growth factor beta induced (TGFBI) and proliferating cell nuclear antigen (PCNA) found to interact with at least two of the three hub genes.

    Bioinformatics Analyses of the Role of Vascular Endothelial Growth Factor in Patients with Non-Small Cell Lung Cancer.
    Wang Y, Huang L, Wu S, Jia Y, Yang Y, Luo L, Bi A, Fang M., Free PMC Article

    04/2/2016
    Frameshift mutations of VEGFB gene is associated with stomach and colorectal cancers.

    Frameshift mutation of an angiogenesis factor VEGFB and its mutational heterogeneity in colorectal cancers.
    Choi MR, Yoo NJ, Lee SH, An CH.

    03/12/2016
    plasma VEGF levels before treatment were lower in patients with schizophrenia and that their VEGF levels increased after treatment.

    Alterations in plasma vascular endothelial growth factor levels in patients with schizophrenia before and after treatment.
    Lee BH, Hong JP, Hwang JA, Ham BJ, Na KS, Kim WJ, Trigo J, Kim YK.

    01/2/2016
    fluid shear stress induces the synthesis of Insulin growth factor-2 and vascular endothelial growth factor (VEGF) B and D, which in turn transactivate MMP-12.

    Fluid shear promotes chondrosarcoma cell invasion by activating matrix metalloproteinase 12 via IGF-2 and VEGF signaling pathways.
    Wang P, Chen SH, Hung WC, Paul C, Zhu F, Guan PP, Huso DL, Kontrogianni-Konstantopoulos A, Konstantopoulos K., Free PMC Article

    11/28/2015
    MMP9 may activate VEGF-B via PI3K/Akt signaling pathway.

    Vascular endothelial growth factor B coordinates metastasis of non-small cell lung cancer.
    Liu G, Xu S, Jiao F, Ren T, Li Q.

    06/20/2015
    Roles of vascular endothelial growth factor in amyotrophic lateral sclerosis.

    Roles of vascular endothelial growth factor in amyotrophic lateral sclerosis.
    Pronto-Laborinho AC, Pinto S, de Carvalho M., Free PMC Article

    02/14/2015
    Low VEGFB and VEGFD gene expression is associated with early-stage non-small cell lung cancer.

    A gene signature combining the tissue expression of three angiogenic factors is a prognostic marker in early-stage non-small cell lung cancer.
    Sanmartín E, Sirera R, Usó M, Blasco A, Gallach S, Figueroa S, Martínez N, Hernando C, Honguero A, Martorell M, Guijarro R, Rosell R, Jantus-Lewintre E, Camps C.

    11/8/2014
    Our study suggested that VEGF-B was an angiogenesis factor in vitro and that ERK1/2 and p38-related signaling pathways were involved in these VEGF-B activities.

    Effects of vascular endothelial growth factor B on proliferation and migration in EA.Hy926 cells.
    Zhang GH, Qin R, Zhang SH, Zhu H.

    10/4/2014
    VEGF-B has possible roles in cardiac protection, energy metabolism support, and neuroprotectin [review]

    Vascular endothelial growth factor-B in physiology and disease.
    Bry M, Kivelä R, Leppänen VM, Alitalo K.

    09/6/2014
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