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    VCL vinculin [ Homo sapiens (human) ]

    Gene ID: 7414, updated on 3-Nov-2024

    GeneRIFs: Gene References Into Functions

    GeneRIFPubMed TitleDate
    Effect of Focal Adhesion Kinase and Vinculin Expression on Migration Parameters of Normal and Tumor Epitheliocytes.

    Effect of Focal Adhesion Kinase and Vinculin Expression on Migration Parameters of Normal and Tumor Epitheliocytes.
    Solomatina ES, Kovaleva AV, Tvorogova AV, Vorobjev IA, Saidova AA.

    05/7/2024
    Heart Failure with Recovered Ejection Fraction in Patients with Vinculin Loss-of-function Variants.

    Heart Failure with Recovered Ejection Fraction in Patients with Vinculin Loss-of-function Variants.
    Zahavich L, Akilen R, George K, Mital S., Free PMC Article

    12/22/2023
    Serum claudin-5, claudin-11, occludin, vinculin, paxillin, and beta-catenin levels in preschool children with autism spectrum disorder.

    Serum claudin-5, claudin-11, occludin, vinculin, paxillin, and beta-catenin levels in preschool children with autism spectrum disorder.
    Bilgiç A, Ferahkaya H, Karagöz H, Kılınç İ, Energin VM.

    10/26/2023
    Vinculin Y822 is an important determinant of ligand binding.

    Vinculin Y822 is an important determinant of ligand binding.
    DeWane G, Cronin NM, Dawson LW, Heidema C, DeMali KA., Free PMC Article

    06/22/2023
    [No Effect of the p.Arg230His Variant Of The VCL Protein on the Course of the Hypertrophic Cardiomyopathy In Russian Family Carrying The p.Gln1233Ter Pathogenic Variant In The MYBPC3 Gene].

    [No Effect of the p.Arg230His Variant Of The VCL Protein on the Course of the Hypertrophic Cardiomyopathy In Russian Family Carrying The p.Gln1233Ter Pathogenic Variant In The MYBPC3 Gene].
    Filatova EV, Krylova NS, Klass AL, Kovalevskaya EA, Maslova MY, Shadrina MI, Poteshkina NG, Slominsky PA.

    04/19/2023
    Expression of the phagocytic receptors alphaMbeta2 and alphaXbeta2 is controlled by RIAM, VASP and Vinculin in neutrophil-differentiated HL-60 cells.

    Expression of the phagocytic receptors α(M)β(2) and α(X)β(2) is controlled by RIAM, VASP and Vinculin in neutrophil-differentiated HL-60 cells.
    Torres-Gomez A, Fiyouzi T, Guerra-Espinosa C, Cardeñes B, Clares I, Toribio V, Reche PA, Cabañas C, Lafuente EM., Free PMC Article

    10/22/2022
    Study of Antibodies to Cytolethal Distending Toxin B (CdtB) and Antibodies to Vinculin in Patients with Irritable Bowel Syndrome.

    Study of Antibodies to Cytolethal Distending Toxin B (CdtB) and Antibodies to Vinculin in Patients with Irritable Bowel Syndrome.
    Zaki MES, Elhammady D, Foda Salama M, Abdelsalam M, Osman AOB., Free PMC Article

    12/4/2021
    An assessment of the role of vinculin loss of function variants in inherited cardiomyopathy.

    An assessment of the role of vinculin loss of function variants in inherited cardiomyopathy.
    Hawley MH, Almontashiri N, Biesecker LG, Berger N, Chung WK, Garcia J, Grebe TA, Kelly MA, Lebo MS, Macaya D, Mei H, Platt J, Richard G, Ryan A, Thomson KL, Vatta M, Walsh R, Ware JS, Wheeler M, Zouk H, Mason-Suares H, Funke B., Free PMC Article

    11/13/2021
    Vinculin orchestrates prostate cancer progression by regulating tumor cell invasion, migration, and proliferation.

    Vinculin orchestrates prostate cancer progression by regulating tumor cell invasion, migration, and proliferation.
    Zheng X, Xu H, Gong L, Cao D, Jin T, Wang Y, Pi J, Yang Y, Yi X, Liao D, Jin X, Wei Q, Yang L, Li H, Ai J.

    08/28/2021
    High expression of vinculin predicts poor prognosis and distant metastasis and associates with influencing tumor-associated NK cell infiltration and epithelial-mesenchymal transition in gastric cancer.

    High expression of vinculin predicts poor prognosis and distant metastasis and associates with influencing tumor-associated NK cell infiltration and epithelial-mesenchymal transition in gastric cancer.
    Li H, Wang C, Lan L, Behrens A, Tomaschko M, Ruiz J, Su Q, Zhao G, Yuan C, Xiao X, Li B, Yan L, Wu W, Li W, Chen J, He Y, Zhang C., Free PMC Article

    08/14/2021
    Loss-of-function or gain-of-function variations in VINCULIN (VCL) are risk factors of human neural tube defects.

    Loss-of-function or gain-of-function variations in VINCULIN (VCL) are risk factors of human neural tube defects.
    Wang Y, Qin Y, Peng R, Wang H., Free PMC Article

    08/7/2021
    Identification of Vinculin as a Potential Diagnostic Biomarker for Acute Aortic Dissection Using Label-Free Proteomics.

    Identification of Vinculin as a Potential Diagnostic Biomarker for Acute Aortic Dissection Using Label-Free Proteomics.
    Wang HQ, Yang H, Tang Q, Gong YC, Fu YH, Wan F, Yang B, Guo R, Zhong YL, Zhu JM, Zhang Z., Free PMC Article

    05/15/2021
    Talin-activated vinculin interacts with branched actin networks to initiate bundles.

    Talin-activated vinculin interacts with branched actin networks to initiate bundles.
    Boujemaa-Paterski R, Martins B, Eibauer M, Beales CT, Geiger B, Medalia O., Free PMC Article

    03/28/2021
    Phosphoinositides regulate force-independent interactions between talin, vinculin, and actin.

    Phosphoinositides regulate force-independent interactions between talin, vinculin, and actin.
    Kelley CF, Litschel T, Schumacher S, Dedden D, Schwille P, Mizuno N., Free PMC Article

    02/27/2021
    Vinculin expression in non-small cell lung cancer.

    Vinculin expression in non-small cell lung cancer.
    Yu Q, Xu L, Chen L, Sun B, Yang Z, Lu K, Yang Z., Free PMC Article

    11/21/2020
    Talin dissociates from RIAM and associates to vinculin sequentially in response to the actomyosin force.

    Talin dissociates from RIAM and associates to vinculin sequentially in response to the actomyosin force.
    Vigouroux C, Henriot V, Le Clainche C., Free PMC Article

    08/29/2020
    Irritable bowel syndrome patients with diarrhea had higher anti-vinculin and anti-CdtB titers than irritable bowel syndrome subjects.

    Second-Generation Biomarker Testing for Irritable Bowel Syndrome Using Plasma Anti-CdtB and Anti-Vinculin Levels.
    Morales W, Rezaie A, Barlow G, Pimentel M.

    05/9/2020
    Metavinculin cardiomyopathy mutants induce higher-order F-actin assemblies.

    Cardiomyopathy Mutations in Metavinculin Disrupt Regulation of Vinculin-Induced F-Actin Assemblies.
    Sarker M, Lee HT, Mei L, Krokhotin A, de Los Reyes SE, Yen L, Costantini LM, Griffith J, Dokholyan NV, Alushin GM, Campbell SL., Free PMC Article

    03/28/2020
    Findings indicate that vinculin resists mechanical fluctuations to maintain the tight junctions paracellular barrier function for ions in epithelial cell sheets.

    Vinculin is critical for the robustness of the epithelial cell sheet paracellular barrier for ions.
    Konishi S, Yano T, Tanaka H, Mizuno T, Kanoh H, Tsukita K, Namba T, Tamura A, Yonemura S, Gotoh S, Matsumoto H, Hirai T, Tsukita S., Free PMC Article

    01/18/2020
    EGFR-mediated kinase cascade controls the force-dependent recruitment of vinculin to stressed E-cadherin complexes - a key early signature of cadherin-based mechanotransduction.

    Epidermal growth factor receptor and integrins control force-dependent vinculin recruitment to E-cadherin junctions.
    Sehgal P, Kong X, Wu J, Sunyer R, Trepat X, Leckband D., Free PMC Article

    10/26/2019
    Study find that Vinculin is a key downstream target of Linc01060. Vinculin overexpression inhibited Linc01060KD-mediated increases in FAK and paxillin phosphorylation, whereas vinculin knockdown reversed the Linc01060-mediated repression of FAK and inactivation of focal adhesion turnover. Vinculin knockdown also accelerated pancreatic cancer cell proliferation by upregulating ERK activity.

    Loss of Linc01060 induces pancreatic cancer progression through vinculin-mediated focal adhesion turnover.
    Shi X, Guo X, Li X, Wang M, Qin R.

    08/24/2019
    Integrin engagement during cell attachment activates Poldip2/Nox4 to oxidize actin, which modulates filamentous actin assembly and its interaction with vinculin.

    NOX4 (NADPH Oxidase 4) and Poldip2 (Polymerase δ-Interacting Protein 2) Induce Filamentous Actin Oxidation and Promote Its Interaction With Vinculin During Integrin-Mediated Cell Adhesion.
    Vukelic S, Xu Q, Seidel-Rogol B, Faidley EA, Dikalova AE, Hilenski LL, Jorde U, Poole LB, Lassègue B, Zhang G, Griendling KK., Free PMC Article

    08/10/2019
    Vinculin is necessary to maintain the integrity of the glomerular filtration barrier by modulating podocyte foot processes and stabilizing intercellular junctions.

    Vinculin is required to maintain glomerular barrier integrity.
    Lausecker F, Tian X, Inoue K, Wang Z, Pedigo CE, Hassan H, Liu C, Zimmer M, Jinno S, Huckle AL, Hamidi H, Ross RS, Zent R, Ballestrem C, Lennon R, Ishibe S., Free PMC Article

    12/22/2018
    ERalpha upregulates vinculin expression in breast cancer cells; Loss of vinculin promotes amoeboid features of cancer cells

    Loss of ERα induces amoeboid-like migration of breast cancer cells by downregulating vinculin.
    Gao Y, Wang Z, Hao Q, Li W, Xu Y, Zhang J, Zhang W, Wang S, Liu S, Li M, Xue X, Zhang W, Zhang C, Zhang Y., Free PMC Article

    11/10/2018
    We report that polyoma small T antigen leads to upregulation of tubulin and vinculin in a time dependent manner with tubulin expression being most significantly affected.

    Polyoma small T upregulates the expression of cytoskeletal proteins in mammalian cells during mitosis.
    Reshi I, Sarwar Z, Bhat SA, Gillani SQ, Shah M, Fazili KM, Andrabi S.

    07/28/2018
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