| VAV2 orchestrates the interplay between regenerative proliferation and ribogenesis in both keratinocytes and oral squamous cell carcinoma. | VAV2 orchestrates the interplay between regenerative proliferation and ribogenesis in both keratinocytes and oral squamous cell carcinoma.
Fernández-Parejo N, Lorenzo-Martín LF, García-Pedrero JM, Rodrigo JP, Dosil M, Bustelo XR., Free PMC Article | 03/4/2024 |
| Vav2 promotes ductus arteriosus anatomic closure via the remodeling of smooth muscle cells by Rac1 activation. | Vav2 promotes ductus arteriosus anatomic closure via the remodeling of smooth muscle cells by Rac1 activation.
Chen Y, Wu Y, Feng W, Luo X, Xiao B, Ding X, Gu Y, Lu Y, Yu Y. | 12/15/2023 |
| AFAP1L1 promotes gastric cancer progression by interacting with VAV2 to facilitate CDC42-mediated activation of ITGA5 signaling pathway. | AFAP1L1 promotes gastric cancer progression by interacting with VAV2 to facilitate CDC42-mediated activation of ITGA5 signaling pathway.
Sun B, Ding B, Chen Y, Peng C, Chen X., Free PMC Article | 02/14/2023 |
| The tRNA-Cys-GCA Derived tsRNAs Suppress Tumor Progression of Gliomas via Regulating VAV2. | The tRNA-Cys-GCA Derived tsRNAs Suppress Tumor Progression of Gliomas via Regulating VAV2.
Ren J, Wu X, Shang FF, Qi Y, Tang Z, Wen C, Cao W, Cheng Q, Tan L, Chen H, Zhou HH, Zou H., Free PMC Article | 12/3/2022 |
| Potentially functional genetic variants of VAV2 and PSMA4 in the immune-activation pathway and non-small cell lung cancer survival. | Potentially functional genetic variants of VAV2 and PSMA4 in the immune-activation pathway and non-small cell lung cancer survival.
Bai Y, Zheng J, Cheng L, Liu Q, Zhao G, Li J, Gu Y, Xu W, Wang M, Wei Q, Zhang R. | 10/15/2022 |
| VAV2 is required for DNA repair and implicated in cancer radiotherapy resistance. | VAV2 is required for DNA repair and implicated in cancer radiotherapy resistance.
Liu W, Miao C, Zhang S, Liu Y, Niu X, Xi Y, Guo W, Chu J, Lin A, Liu H, Yang X, Chen X, Zhong C, Ma Y, Wang Y, Zhu S, Liu S, Tan W, Lin D, Wu C., Free PMC Article | 03/26/2022 |
| SNHG3 silencing suppresses the malignant development of triple-negative breast cancer cells by regulating miRNA-326/integrin alpha5 axis and inactivating Vav2/Rac1 signaling pathway. | SNHG3 silencing suppresses the malignant development of triple-negative breast cancer cells by regulating miRNA-326/integrin α5 axis and inactivating Vav2/Rac1 signaling pathway.
Wang P, Liu GZ, Wang JF, Du YY. | 04/3/2021 |
| Biochemical and NMR characterization of the interactions of Vav2-SH2 domain with lipids and the EphA2 juxtamembrane region on membrane. | Biochemical and NMR characterization of the interactions of Vav2-SH2 domain with lipids and the EphA2 juxtamembrane region on membrane.
Ge L, Wu B, Zhang Y, Wang J, Zhao H, Wang J. | 02/27/2021 |
| VAV2 signaling promotes regenerative proliferation in both cutaneous and head and neck squamous cell carcinoma. | VAV2 signaling promotes regenerative proliferation in both cutaneous and head and neck squamous cell carcinoma.
Lorenzo-Martín LF, Fernández-Parejo N, Menacho-Márquez M, Rodríguez-Fdez S, Robles-Valero J, Zumalave S, Fabbiano S, Pascual G, García-Pedrero JM, Abad A, García-Macías MC, González N, Lorenzano-Menna P, Pavón MA, González-Sarmiento R, Segrelles C, Paramio JM, Tubío JMC, Rodrigo JP, Benitah SA, Cuadrado M, Bustelo XR., Free PMC Article | 10/24/2020 |
| Both erb-b2 receptor tyrosine kinase 2 (ErbB2) and vav guanine nucleotide exchange factor 2 (VAV2 )are direct targets of miR-331-3p. | MicroRNA-331-3p inhibits epithelial-mesenchymal transition by targeting ErbB2 and VAV2 through the Rac1/PAK1/β-catenin axis in non-small-cell lung cancer.
Li X, Zhu J, Liu Y, Duan C, Chang R, Zhang C., Free PMC Article | 06/29/2019 |
| VAV2 polymorphisms associate with cardiovascular risk factors and target organ damage. | Association of VAV2 and VAV3 polymorphisms with cardiovascular risk factors.
Perretta-Tejedor N, Fernández-Mateos J, García-Ortiz L, Gómez-Marcos MA, Recio-Rodríguez JI, Agudo-Conde C, Rodriguez-Sánchez E, Morales AI, López-Hernández FJ, López-Novoa JM, González-Sarmiento R, Martínez-Salgado C., Free PMC Article | 10/27/2018 |
| Study found that Vav2, is overexpressed in human prostate cancer and enhanced AR and AR splicing variant activity. | Targeting AR Variant-Coactivator Interactions to Exploit Prostate Cancer Vulnerabilities.
Magani F, Peacock SO, Rice MA, Martinez MJ, Greene AM, Magani PS, Lyles R, Weitz JR, Burnstein KL., Free PMC Article | 06/16/2018 |
| High VAV2 expression is associated with breast cancer. | MST3 promotes proliferation and tumorigenicity through the VAV2/Rac1 signal axis in breast cancer.
Cho CY, Lee KT, Chen WC, Wang CY, Chang YS, Huang HL, Hsu HP, Yen MC, Lai MZ, Lai MD., Free PMC Article | 01/6/2018 |
| Manipulating steroidogenic factor-1 (SF-1) and nucleotide exchange factor VAV-2 (VAV2) abundance in cultured adrenocortical carcinoma (ACC) cells indicate that VAV2 was a critical factor for SF-1-induced cytoskeletal remodeling and invasion in culture and in vivo (chicken chorioallantoic membrane) models. | Dosage-dependent regulation of VAV2 expression by steroidogenic factor-1 drives adrenocortical carcinoma cell invasion.
Ruggiero C, Doghman-Bouguerra M, Sbiera S, Sbiera I, Parsons M, Ragazzon B, Morin A, Robidel E, Favier J, Bertherat J, Fassnacht M, Lalli E. | 12/2/2017 |
| Data indicate that phosphorylated cortactin recruits Vav2 to activate Rac3 and promote invadopodial maturation in invasive breast cancer cells. | Phosphorylated cortactin recruits Vav2 guanine nucleotide exchange factor to activate Rac3 and promote invadopodial function in invasive breast cancer cells.
Rosenberg BJ, Gil-Henn H, Mader CC, Halo T, Yin T, Condeelis J, Machida K, Wu YI, Koleske AJ., Free PMC Article | 10/7/2017 |
| autocrine VEGF and IL-8 promoted endothelial cell migration via the Src/Vav2/Rac1/PAK1 signaling pathway. | Autocrine VEGF and IL-8 Promote Migration via Src/Vav2/Rac1/PAK1 Signaling in Human Umbilical Vein Endothelial Cells.
Ju L, Zhou Z, Jiang B, Lou Y, Guo X. | 06/24/2017 |
| We concluded that Vav2 might promote invasion and metastasis of gastric cancer by regulating some invasion and metastasis-related genes. | Upregulated Vav2 in gastric cancer tissues promotes tumor invasion and metastasis.
Tan BB, Li Y, Fan LQ, Zhao Q, Liu QW, Liu Y, Wang D, Jia N. | 06/10/2017 |
| work suggested that EphB3 acted as a tumor promoter in Papillary Thyroid Cancer by increasing the in vitro migration as well as the in vivo metastasis of Papillary Thyroid Cancer cells through regulating the activities of Vav2 and Rho GTPases in a kinase-dependent manner. | EphB3 Stimulates Cell Migration and Metastasis in a Kinase-dependent Manner through Vav2-Rho GTPase Axis in Papillary Thyroid Cancer.
Li JJ, Sun ZJ, Yuan YM, Yin FF, Bian YG, Long LY, Zhang XL, Xie D., Free PMC Article | 06/3/2017 |
| The crystal structure of the complex between a phosphorylated PPxY motif of TXNIP and the SH2 domain of Vav2 reveals a conserved recognition mechanism. | Structural basis for a novel interaction between TXNIP and Vav2.
Liu S, Wu X, Zong M, Tempel W, Loppnau P, Liu Y. | 08/13/2016 |
| Our data provide the first evidence to implicate VAV2 in glucose-induced Rac1 activation, actin remodelling and glucose-stimulated insulin secretion in pancreatic beta cells. | VAV2, a guanine nucleotide exchange factor for Rac1, regulates glucose-stimulated insulin secretion in pancreatic beta cells.
Veluthakal R, Tunduguru R, Arora DK, Sidarala V, Syeda K, Vlaar CP, Thurmond DC, Kowluru A., Free PMC Article | 07/30/2016 |
| VAV2 is required for Met signaling in the perinuclear endosome. | Receptor tyrosine kinase c-Met controls the cytoskeleton from different endosomes via different pathways.
Ménard L, Parker PJ, Kermorgant S. | 07/25/2015 |
| Authors propose a model whereby vimentin promotes FAK stabilization through VAV2-mediated Rac1 activation. This model may explain why vimentin expressing metastatic lung cancer cells are more motile and invasive. | Vimentin regulates lung cancer cell adhesion through a VAV2-Rac1 pathway to control focal adhesion kinase activity.
Havel LS, Kline ER, Salgueiro AM, Marcus AI., Free PMC Article | 06/27/2015 |
| Data suggest a coordination between paxillin kinase linker (PKL)/Vav2 signaling and PKL/beta-PIX signaling during cell migration. | Paxillin kinase linker (PKL) regulates Vav2 signaling during cell spreading and migration.
Jones MC, Machida K, Mayer BJ, Turner CE., Free PMC Article | 01/18/2014 |
| the guanine nucleotide exchange factor (GEF) Vav2 is identified as a candidate partner for KCC3. | Potassium-chloride cotransporter 3 interacts with Vav2 to synchronize the cell volume decrease response with cell protrusion dynamics.
Salin-Cantegrel A, Shekarabi M, Rasheed S, Charron FM, Laganière J, Gaudet R, Dion PA, Lapointe JY, Rouleau GA., Free PMC Article | 01/11/2014 |
| Two variants of VAV2 and VAV3, rs2156323 and rs2801219, respectively, were identified in Japanese patients with primary open angle glaucoma, normal tension glaucoma, and developmental glaucoma. | Molecular genetic analysis of primary open-angle glaucoma, normal tension glaucoma, and developmental glaucoma for the VAV2 and VAV3 gene variants in Japanese subjects.
Shi D, Takano Y, Nakazawa T, Mengkegale M, Yokokura S, Nishida K, Fuse N. | 09/14/2013 |