| Exercise-induced circular RNA circUtrn is required for cardiac physiological hypertrophy and prevents myocardial ischaemia-reperfusion injury. | Exercise-induced circular RNA circUtrn is required for cardiac physiological hypertrophy and prevents myocardial ischaemia-reperfusion injury.
Wang L, Feng J, Feng X, Meng D, Zhao X, Wang J, Yu P, Xu GE, Hu M, Wang T, Lehmann HI, Li G, Sluijter JPG, Xiao J. | 04/8/2024 |
| Regulation of Drp1 and enhancement of mitochondrial fission by the deubiquitinating enzyme PSMD14 facilitates the proliferation of bladder cancer cells. | Regulation of Drp1 and enhancement of mitochondrial fission by the deubiquitinating enzyme PSMD14 facilitates the proliferation of bladder cancer cells.
Song W, Li Z, Xia M, Xiao W., Free PMC Article | 11/30/2023 |
| Mitochondrial dynamics-related genes DRP1 and OPA1 contributes to early diagnosis of cognitive impairment in diabetes. | Mitochondrial dynamics-related genes DRP1 and OPA1 contributes to early diagnosis of cognitive impairment in diabetes.
Liu M, Gong C, Shen X, Jiang Y, Xu Y, Zhong W, Chen Y, Dong N, Liao J, Yin N., Free PMC Article | 08/16/2023 |
| Ischemia/reperfusion-induced MiD51 upregulation recruits Drp1 to mitochondria and contributes to myocardial injury. | Ischemia/reperfusion-induced MiD51 upregulation recruits Drp1 to mitochondria and contributes to myocardial injury.
Gao T, Shi R, Liu Z, De D, Li R, Chen Y, Pei J, Ding M. | 06/13/2023 |
| Exercise activates Sirt1-mediated Drp1 acetylation and inhibits hepatocyte apoptosis to improve nonalcoholic fatty liver disease. | Exercise activates Sirt1-mediated Drp1 acetylation and inhibits hepatocyte apoptosis to improve nonalcoholic fatty liver disease.
Hu Z, Zhang H, Wang Y, Li B, Liu K, Ran J, Li L., Free PMC Article | 03/9/2023 |
| DRP-1 inhibition is a promising adjuvant for BH3 mimetics in melanoma treatment. | BH3 mimetics induce apoptosis independent of DRP-1 in melanoma.
Mukherjee N, Strosnider A, Vagher B, Lambert KA, Slaven S, Robinson WA, Amato CM, Couts KL, Bemis JGT, Turner JA, Norris DA, Shellman YG., Free PMC Article | 11/16/2019 |
| clarify the role of Opa-1 and Drp-1 in mitochondrial dynamics and cell survival, a controversial alpha-synuclein research issue | Drp-1 dependent mitochondrial fragmentation and protective autophagy in dopaminergic SH-SY5Y cells overexpressing alpha-synuclein.
Martinez JH, Alaimo A, Gorojod RM, Porte Alcon S, Fuentes F, Coluccio Leskow F, Kotler ML. | 02/2/2019 |
| In aortas of CKD rats and hippurate-treated rats, we observed an increase in Drp1 protein levels and mitochondrial fission. Inhibition of Drp1 improved endothelial function in both rat models. These results indicate that hippurate, by itself, can cause endothelial dysfunction. Increased mitochondrial fission plays an active role in hippurate-induced endothelial dysfunction via an increase in mitoROS | The uremic toxin hippurate promotes endothelial dysfunction via the activation of Drp1-mediated mitochondrial fission.
Huang M, Wei R, Wang Y, Su T, Li P, Chen X., Free PMC Article | 10/13/2018 |
| findings demonstrate that Drp1-mediated mitochondrial fission plays a critical role in the regulation of cell cycle progression and hepatocellular carcinoma cell proliferation | Drp1-mediated mitochondrial fission promotes cell proliferation through crosstalk of p53 and NF-κB pathways in hepatocellular carcinoma.
Zhan L, Cao H, Wang G, Lyu Y, Sun X, An J, Wu Z, Huang Q, Liu B, Xing J., Free PMC Article | 02/24/2018 |
| Knockdown of UTRN expression by shRNA evidently inhibited cell proliferation and promoted cell apoptosis in glioma cells. | Inhibition of Human Glioma Cell Proliferation Caused by Knockdown of Utrophin Using a Lentivirus-Mediated System.
Shen SH, Yu N, Xu H, Liu XY, Tan GW, Wang ZX. | 02/18/2017 |
| Correlation of Utrophin Levels with the Dystrophin Protein Complex and Muscle Fibre Regeneration in Duchenne and Becker Muscular Dystrophy Muscle Biopsies. | Correlation of Utrophin Levels with the Dystrophin Protein Complex and Muscle Fibre Regeneration in Duchenne and Becker Muscular Dystrophy Muscle Biopsies.
Janghra N, Morgan JE, Sewry CA, Wilson FX, Davies KE, Muntoni F, Tinsley J., Free PMC Article | 08/6/2016 |
| there is an inverse correlation between the level of muscle fibrosis and the level of utrophin and that of the number of revertant myofibers in Duchenne muscular dystrophy | Inhibition of muscle fibrosis results in increases in both utrophin levels and the number of revertant myofibers in Duchenne muscular dystrophy.
Levi O, Genin O, Angelini C, Halevy O, Pines M., Free PMC Article | 08/6/2016 |
| probed the role of N-terminal CH1 and C-terminal CH2 domains in the structure and function of dystrophin tandem CH domain and compared with earlier results on utrophin to understand the unifying principles of how tandem CH domains work | The N- and C-Terminal Domains Differentially Contribute to the Structure and Function of Dystrophin and Utrophin Tandem Calponin-Homology Domains.
Singh SM, Bandi S, Mallela KM. | 04/23/2016 |
| targeting Drp1-dependent mitochondrial dynamics may provide a novel strategy to suppress breast cancer metastasis and improve the chemotherapeutic effect in the future | Mitochondrial dynamics regulates hypoxia-induced migration and antineoplastic activity of cisplatin in breast cancer cells.
Han XJ, Yang ZJ, Jiang LP, Wei YF, Liao MF, Qian Y, Li Y, Huang X, Wang JB, Xin HB, Wan YY. | 08/22/2015 |
| The actin binding affinity of the utrophin tandem calponin-homology domain (CH) is determined by its CH1 domain, when compared to its CH2 domain. | The actin binding affinity of the utrophin tandem calponin-homology domain is primarily determined by its N-terminal domain.
Singh SM, Bandi S, Winder SJ, Mallela KM. | 05/17/2014 |
| this study demonstrated a pathway for Drp1 autophagic degradation. Chemical inhibition of lysosomal degradation and ATG7 knockdown increased Drp1 levels. | Autophagy-mediated turnover of dynamin-related protein 1.
Purnell PR, Fox HS., Free PMC Article | 11/2/2013 |
| UtroUp recognises 18 base pairs of the utrophin promoter and efficiently drives utrophin upregulation. | UtroUp is a novel six zinc finger artificial transcription factor that recognises 18 base pairs of the utrophin promoter and efficiently drives utrophin upregulation.
Onori A, Pisani C, Strimpakos G, Monaco L, Mattei E, Passananti C, Corbi N., Free PMC Article | 08/3/2013 |
| This family study showed that the 6q24.2 mircoduplication of the utrophin gene is a potential risk factor for the development of annular pancreas. | A rare microduplication in a familial case of annular pancreas and duodenal stenosis.
Markljung E, Adamovic T, Ortqvist L, Wester T, Nordenskjöld A. | 05/4/2013 |
| The present findings demonstrate that genotoxic stress in neurons results in p53-dependent declines in Drp1 and parkin levels contribute to altered mitochondrial morphology and cell death. | Declines in Drp1 and parkin expression underlie DNA damage-induced changes in mitochondrial length and neuronal death.
Wang DB, Garden GA, Kinoshita C, Wyles C, Babazadeh N, Sopher B, Kinoshita Y, Morrison RS., Free PMC Article | 03/23/2013 |
| UAPC located in caveolae and non-caveolae lipid raft domains of HUVECs may have a mechanosensory function that could participate in the control of eNOS activity | Caveolae and non-caveolae lipid raft microdomains of human umbilical vein endothelial cells contain utrophin-associated protein complexes.
Ramírez-Sánchez I, Mendoza-Lorenzo P, Zentella-Dehesa A, Méndez-Bolaina E, Lara-Padilla E, Ceballos-Reyes G, Canto P, Palma-Flores C, Coral-Vázquez RM. | 11/24/2012 |
| Examined the thermodynamic stability and aggregation of utrophin N-ABD and compared with that of dystrophin. Utrophin N-ABD has decreased denaturant and thermal stability, unfolds faster, and is correspondingly more susceptible to proteolysis. | Thermodynamic stability, unfolding kinetics, and aggregation of the N-terminal actin-binding domains of utrophin and dystrophin.
Singh SM, Molas JF, Kongari N, Bandi S, Armstrong GS, Winder SJ, Mallela KM., Free PMC Article | 09/22/2012 |
| Homeobox protein engrailed-1 protein regulates transcription of the utrophin gene. | A method of utrophin up-regulation through RNAi-mediated knockdown of the transcription factor EN1.
Wang Q, Cao DH, Jin CL, Lin CK, Ma HW, Wu YY. | 10/8/2011 |
| These results indicate that Drp1-dependent mitochondrial positioning and activity controls T-cell activation by fuelling central supramolecular activation cluster assembly at the immune synapse. | The mitochondrial fission factor dynamin-related protein 1 modulates T-cell receptor signalling at the immune synapse.
Baixauli F, Martín-Cófreces NB, Morlino G, Carrasco YR, Calabia-Linares C, Veiga E, Serrador JM, Sánchez-Madrid F., Free PMC Article | 06/18/2011 |
| EN1 might be a negative regulatory factor for UTROPHIN. | [The regulation of UTROPHIN expression by EN1].
Wang Q, Cao DH, Lin CK, Wang ZD, Cui WT, Jin CL. | 05/28/2011 |
| The structural and functional properties of dystrophins and utrophins in brain, the consequences of dystrophins loss-of-function, are discussed. | Dystrophins, utrophins, and associated scaffolding complexes: role in mammalian brain and implications for therapeutic strategies.
Perronnet C, Vaillend C., Free PMC Article | 10/23/2010 |