| The P53-P21-RB1 pathway promotes BRD4 degradation in liver cancer through USP1. | The P53-P21-RB1 pathway promotes BRD4 degradation in liver cancer through USP1.
Li N, Zhang E, Li Z, Lv S, Zhao X, Ke Q, Zou Q, Li W, Wang Y, Guo H, Song T, Sun L., Free PMC Article | 04/15/2024 |
| USP1-dependent nucleolytic expansion of PRIMPOL-generated nascent DNA strand discontinuities during replication stress. | USP1-dependent nucleolytic expansion of PRIMPOL-generated nascent DNA strand discontinuities during replication stress.
Nusawardhana A, Pale LM, Nicolae CM, Moldovan GL., Free PMC Article | 03/25/2024 |
| A genome-wide CRISPR screen identifies USP1 as a novel regulator of the mammalian circadian clock. | A genome-wide CRISPR screen identifies USP1 as a novel regulator of the mammalian circadian clock.
Hu Y, Li X, Zhang J, Liu D, Lu R, Li JD. | 02/7/2024 |
| The UAF1-USP1 Deubiquitinase Complex Stabilizes cGAS and Facilitates Antiviral Responses. | The UAF1-USP1 Deubiquitinase Complex Stabilizes cGAS and Facilitates Antiviral Responses.
Yu Z, Tong L, Ma C, Song H, Wang J, Chai L, Wang C, Wang M, Wang C, Yan R, Fu Y, Jia M, Zhao W, Zhao C. | 01/9/2024 |
| USP1 promotes cholangiocarcinoma progression by deubiquitinating PARP1 to prevent its proteasomal degradation. | USP1 promotes cholangiocarcinoma progression by deubiquitinating PARP1 to prevent its proteasomal degradation.
Zhang DY, Zhu Y, Wu Q, Ma S, Ma Y, Shen ZC, Wang Z, Sun W, Zhou YC, Wang D, Zhou S, Liu Z, Kwong LN, Lu Z., Free PMC Article | 10/13/2023 |
| USP1 promotes the aerobic glycolysis and progression of T-cell acute lymphoblastic leukemia via PLK1/LDHA axis. | USP1 promotes the aerobic glycolysis and progression of T-cell acute lymphoblastic leukemia via PLK1/LDHA axis.
Liu S, Xiang Y, Wang B, Gao C, Chen Z, Xie S, Wu J, Liu Y, Zhao X, Yang C, Yue Z, Wang L, Wen X, Zhang R, Zhang F, Xu H, Zhai X, Zheng H, Zhang H, Qian M., Free PMC Article | 07/6/2023 |
| USP1 modulates hepatocellular carcinoma progression via the Hippo/TAZ axis. | USP1 modulates hepatocellular carcinoma progression via the Hippo/TAZ axis.
Liu D, Li Q, Zang Y, Li X, Li Z, Zhang P, Feng C, Yang P, Cui J, Sun Y, Wei T, Su P, Zhao X, Yang H, Ding Y., Free PMC Article | 04/14/2023 |
| USP1-regulated reciprocal differentiation of Th17 cells and Treg cells by deubiquitinating and stabilizing TAZ. | USP1-regulated reciprocal differentiation of Th17 cells and Treg cells by deubiquitinating and stabilizing TAZ.
Zhu X, Wang P, Zhan X, Zhang Y, Sheng J, He S, Chen Y, Nie D, You X, Mai H, Yu Q, Li L, Jie L, Hu S., Free PMC Article | 03/2/2023 |
| Ubiquitinated PCNA Drives USP1 Synthetic Lethality in Cancer. | Ubiquitinated PCNA Drives USP1 Synthetic Lethality in Cancer.
Simoneau A, Engel JL, Bandi M, Lazarides K, Liu S, Meier SR, Choi AH, Zhang H, Shen B, Martires L, Gotur D, Pham TV, Li F, Gu L, Gong S, Zhang M, Wilker E, Pan X, Whittington DA, Throner S, Maxwell JP, Chen Y, Yu Y, Huang A, Andersen JN, Feng T., Free PMC Article | 02/11/2023 |
| Inhibition of USP1 enhances anticancer drugs-induced cancer cell death through downregulation of survivin and miR-216a-5p-mediated upregulation of DR5. | Inhibition of USP1 enhances anticancer drugs-induced cancer cell death through downregulation of survivin and miR-216a-5p-mediated upregulation of DR5.
Woo SM, Kim S, Seo SU, Kim S, Park JW, Kim G, Choi YR, Hur K, Kwon TK., Free PMC Article | 10/15/2022 |
| USP1 inhibition suppresses the progression of osteosarcoma via destabilizing TAZ. | USP1 inhibition suppresses the progression of osteosarcoma via destabilizing TAZ.
Yuan P, Feng Z, Huang H, Wang G, Chen Z, Xu G, Xie Z, Jie Z, Zhao X, Ma Q, Wang S, Shen Y, Huang Y, Han Y, Ye H, Wang J, Shi P, Sun X., Free PMC Article | 06/11/2022 |
| Ubiquitin-specific protease 1 overexpression indicates poor prognosis and promotes proliferation, migration, and invasion of gastric cancer cells. | Ubiquitin-specific protease 1 overexpression indicates poor prognosis and promotes proliferation, migration, and invasion of gastric cancer cells.
Meng D, Li D. | 03/26/2022 |
| USP1 Promotes GC Metastasis via Stabilizing ID2. | USP1 Promotes GC Metastasis via Stabilizing ID2.
Li N, Wu L, Zuo X, Luo H, Sheng Y, Yan J., Free PMC Article | 03/12/2022 |
| USP1-dependent RPS16 protein stability drives growth and metastasis of human hepatocellular carcinoma cells. | USP1-dependent RPS16 protein stability drives growth and metastasis of human hepatocellular carcinoma cells.
Liao Y, Shao Z, Liu Y, Xia X, Deng Y, Yu C, Sun W, Kong W, He X, Liu F, Guo Z, Chen G, Tang D, Gan H, Liu J, Huang H., Free PMC Article | 01/1/2022 |
| A new role of GRP75-USP1-SIX1 protein complex in driving prostate cancer progression and castration resistance. | A new role of GRP75-USP1-SIX1 protein complex in driving prostate cancer progression and castration resistance.
Liao Y, Liu Y, Shao Z, Xia X, Deng Y, Cai J, Yao L, He J, Yu C, Hu T, Sun W, Liu F, Tang D, Liu J, Huang H. | 12/25/2021 |
| USP1-WDR48 deubiquitinase complex enhances TGF-beta induced epithelial-mesenchymal transition of TNBC cells via stabilizing TAK1. | USP1-WDR48 deubiquitinase complex enhances TGF-β induced epithelial-mesenchymal transition of TNBC cells via stabilizing TAK1.
Han D, Wang L, Chen B, Zhao W, Liang Y, Li Y, Zhang H, Liu Y, Wang X, Chen T, Li C, Song X, Luo D, Li Z, Yang Q., Free PMC Article | 12/4/2021 |
| Inhibition of USP1 induces apoptosis via ID1/AKT pathway in B-cell acute lymphoblastic leukemia cells. | Inhibition of USP1 induces apoptosis via ID1/AKT pathway in B-cell acute lymphoblastic leukemia cells.
Kuang X, Xiong J, Lu T, Wang W, Zhang Z, Wang J., Free PMC Article | 09/11/2021 |
| Mutation of aspartic acid 199 in USP1 disrupts its deubiquitinating activity and impairs DNA repair. | Mutation of aspartic acid 199 in USP1 disrupts its deubiquitinating activity and impairs DNA repair.
Jang SW, Kim JM. | 08/28/2021 |
| Structural basis of FANCD2 deubiquitination by USP1-UAF1. | Structural basis of FANCD2 deubiquitination by USP1-UAF1.
Rennie ML, Arkinson C, Chaugule VK, Toth R, Walden H. | 06/26/2021 |
| Inhibition of USP1, a new partner of Bcr-Abl, results in decrease of Bcr-Abl level in K562 cells. | Inhibition of USP1, a new partner of Bcr-Abl, results in decrease of Bcr-Abl level in K562 cells.
Antonenko SV, Telegeev GD. | 05/8/2021 |
| Comprehensive analysis of ubiquitin-specific protease 1 reveals its importance in hepatocellular carcinoma. | Comprehensive analysis of ubiquitin-specific protease 1 reveals its importance in hepatocellular carcinoma.
Zhao Y, Xue C, Xie Z, Ouyang X, Li L., Free PMC Article | 10/31/2020 |
| USP1 (ubiquitin specific peptidase 1) has been identified as a key player in the modulation of ULK1 K63-linked deubiquitination. | USP1 (ubiquitin specific peptidase 1) targets ULK1 and regulates its cellular compartmentalization and autophagy.
Raimondi M, Cesselli D, Di Loreto C, La Marra F, Schneider C, Demarchi F., Free PMC Article | 05/16/2020 |
| USP1 is phosphorylated by ATM and ATR and binds to Snail. Knockout or pharmacological inhibition of USP1 increased platinum sensitivity and decreased metastatic dissemination in a Snail-dependent manner. | USP1 links platinum resistance to cancer cell dissemination by regulating Snail stability.
Sonego M, Pellarin I, Costa A, Vinciguerra GLR, Coan M, Kraut A, D'Andrea S, Dall'Acqua A, Castillo-Tong DC, Califano D, Losito S, Spizzo R, Couté Y, Vecchione A, Belletti B, Schiappacassi M, Baldassarre G., Free PMC Article | 05/9/2020 |
| High USP1 expression is associated with Glioma Tumorigenesis. | Aberrant Activation of β-Catenin Signaling Drives Glioma Tumorigenesis via USP1-Mediated Stabilization of EZH2.
Ma L, Lin K, Chang G, Chen Y, Yue C, Guo Q, Zhang S, Jia Z, Huang TT, Zhou A, Huang S., Free PMC Article | 10/26/2019 |
| USP1 exhibits DNA-mediated activation at the replication fork, protects the fork, and promotes survival in BRCA1-deficient tumor cells. | USP1 Is Required for Replication Fork Protection in BRCA1-Deficient Tumors.
Lim KS, Li H, Roberts EA, Gaudiano EF, Clairmont C, Sambel LA, Ponnienselvan K, Liu JC, Yang C, Kozono D, Parmar K, Yusufzai T, Zheng N, D'Andrea AD., Free PMC Article | 06/1/2019 |