N-Acetyltransferase 10 represses Uqcr11 and Uqcrb independently of ac4C modification to promote heart regeneration. | N-Acetyltransferase 10 represses Uqcr11 and Uqcrb independently of ac4C modification to promote heart regeneration. Ma W, Tian Y, Shi L, Liang J, Ouyang Q, Li J, Chen H, Sun H, Ji H, Liu X, Huang W, Gao X, Jin X, Wang X, Liu Y, Yu Y, Guo X, Tian Y, Yang F, Li F, Wang N, Cai B., Free PMC Article | 03/13/2024 |
Disruption of mitochondrial complex III in cap mesenchyme but not in ureteric progenitors results in defective nephrogenesis associated with amino acid deficiency. | Disruption of mitochondrial complex III in cap mesenchyme but not in ureteric progenitors results in defective nephrogenesis associated with amino acid deficiency. Guan N, Kobayashi H, Ishii K, Davidoff O, Sha F, Ikizler TA, Hao CM, Chandel NS, Haase VH., Free PMC Article | 07/2/2022 |
MiR-4435 is an UQCRB-related circulating miRNA in human colorectal cancer. | MiR-4435 is an UQCRB-related circulating miRNA in human colorectal cancer. Hong JW, Kim JM, Kim JE, Cho H, Kim D, Kim W, Oh JW, Kwon HJ., Free PMC Article | 11/21/2020 |
our present study revealed that hsa-miR-10a-5p is associated with genes involved in the cholesterol synthesis pathway in mutant UQCRB-expressing cells. | Hsa-miR-10a-5p downregulation in mutant UQCRB-expressing cells promotes the cholesterol biosynthesis pathway. Kim JE, Hong JW, Lee HS, Kim W, Lim J, Cho YS, Kwon HJ., Free PMC Article | 10/26/2019 |
Our results provide novel insights into the critical role of UQCRB in regulating CRC, supporting UQCRB as a new candidate for the development of diagnostics for CRC patients. | Mitochondrial UQCRB as a new molecular prognostic biomarker of human colorectal cancer. Kim HC, Chang J, Lee HS, Kwon HJ., Free PMC Article | 07/7/2018 |
The knockdown of UQCRB gene by UQCRB siRNA significantly inhibited the cancer stem cell-like phenotypes as well as the expression of stemness markers by blocking mitochondrial ROS/HIF1alpha/cMet pathway in U87MG GSCs. | Downregulation of mitochondrial UQCRB inhibits cancer stem cell-like properties in glioblastoma. Jung N, Kwon HJ, Jung HJ. | 06/9/2018 |
UQCRB gene mutation is associated with mitochondrial complex III deficiency in a Chinese family. | [Analysis of UQCRB gene mutation in a child with mitochondrial complex III deficiency]. Zhang T, Hong F, Qian G, Tong F, Zhou X, Huang X, Yang R, Huang X. | 09/16/2017 |
a UQCRB mutation promotes angiogenesis through the generation of mitochondrial reactive oxygen species | A mutation in the mitochondrial protein UQCRB promotes angiogenesis through the generation of mitochondrial reactive oxygen species. Chang J, Jung HJ, Jeong SH, Kim HK, Han J, Kwon HJ. | 02/14/2015 |
Mitochondrial UQCRB regulates VEGFR2 signaling in endothelial cells. | Mitochondrial UQCRB regulates VEGFR2 signaling in endothelial cells. Jung HJ, Kim Y, Chang J, Kang SW, Kim JH, Kwon HJ. | 03/15/2014 |
Studies indicate that mitochondrial oxygen sensor ubiquinol-cytochrome c reductase binding protein (UQCRB) as a terpestacin-binding protein. | Exploring the role of mitochondrial UQCRB in angiogenesis using small molecules. Jung HJ, Kwon HJ. | 10/19/2013 |
Two SNPs in the 3' untranslated region of UQCRB (complex III), rs7836698 and rs10504961, were associated with overall survival. | Polymorphisms in the mitochondrial oxidative phosphorylation chain genes as prognostic markers for colorectal cancer. Lascorz J, Bevier M, Schönfels WV, Kalthoff H, Aselmann H, Beckmann J, Egberts J, Buch S, Becker T, Schreiber S, Hampe J, Hemminki K, Försti A, Schafmayer C., Free PMC Article | 10/27/2012 |
Observational study of gene-disease association. (HuGE Navigator) | See all PubMed (2) articlesGenetic variants in nuclear-encoded mitochondrial genes influence AIDS progression. Hendrickson SL, Lautenberger JA, Chinn LW, Malasky M, Sezgin E, Kingsley LA, Goedert JJ, Kirk GD, Gomperts ED, Buchbinder SP, Troyer JL, O'Brien SJ. Polymorphisms in mitochondrial genes and prostate cancer risk. Wang L, McDonnell SK, Hebbring SJ, Cunningham JM, St Sauver J, Cerhan JR, Isaya G, Schaid DJ, Thibodeau SN. | 09/20/2009 |