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    UPK3A uroplakin 3A [ Homo sapiens (human) ]

    Gene ID: 7380, updated on 2-Nov-2024

    GeneRIFs: Gene References Into Functions

    GeneRIFPubMed TitleDate
    High Expression of UPK3A Promotes the Progression of Gastric Cancer Cells by Inactivating p53 Pathway.

    High Expression of UPK3A Promotes the Progression of Gastric Cancer Cells by Inactivating p53 Pathway.
    Xu D, Guo J, Xu H., Free PMC Article

    07/16/2022
    UPIIIa is a biomarker for bladder cancer that is unrelated to chemical carcinogenesis

    Uroplakin IIIa Is a Marker in Bladder Cancer but Seems Not to Reflect Chemical Carcinogenesis.
    Szymańska B, Matuszewski M, Dembowski J, Zdrojowy R, Długosz A., Free PMC Article

    03/2/2019
    High expression level of preoperative serum Uroplakin III is associated with biologically aggressive bladder cancer.

    High expression level of preoperative serum Uroplakin III is associated with biologically aggressive bladder cancer.
    Tsumura H, Matsumoto K, Ikeda M, Yanagita K, Hirano S, Hagiwara M, Nagashio R, Fujita T, Sato Y, Iwamura M.

    12/12/2015
    High Uroplakin III expression is associated with bladder urothelial carcinoma from malignancy metastatic to the urinary bladder.

    Value of uroplakin III in distinguishing variants of primary bladder urothelial carcinoma from malignancy metastatic to the urinary bladder.
    Klopfer K, Delahunt B, Adamson M, Samaratunga H.

    01/10/2015
    a strong association between UPIII and in the group with tumor recurrence

    Significance of uroplakin III expression in recurrence of solitary muscle non-invasive bladder cancer.
    Tadin T, Krpina K, Štifter S, Babarović E, Jonjić N.

    12/27/2014
    studies suggest that bacteria-induced UPIIIa signaling is a critical mediator of bladder responses to insult by uropathogenic E. coli

    Bacteria-induced uroplakin signaling mediates bladder response to infection.
    Thumbikat P, Berry RE, Zhou G, Billips BK, Yaggie RE, Zaichuk T, Sun TT, Schaeffer AJ, Klumpp DJ., Free PMC Article

    01/21/2010
    Uroplakin III plays a pivotal role in Eshcerichia coli UTI pathogenesis.

    Differentiation-induced uroplakin III expression promotes urothelial cell death in response to uropathogenic E. coli.
    Thumbikat P, Berry RE, Schaeffer AJ, Klumpp DJ., Free PMC Article

    01/21/2010
    Loss of UP III expression is associated with established markers of biologically aggressive bladder cancer

    Loss expression of uroplakin III is associated with clinicopathologic features of aggressive bladder cancer.
    Matsumoto K, Satoh T, Irie A, Ishii J, Kuwao S, Iwamura M, Baba S.

    01/21/2010
    Not a useful immunohistochemical marker for detection of pleural malignant mesothelioma.

    Uroplakin is not a reliable immunohistochemical marker for malignant mesothelioma of the pleura.
    Butnor KJ, Ordonez NG.

    01/21/2010
    Observational study of gene-disease association. (HuGE Navigator)See all PubMed (2) articles

    Whole-genome linkage and association scan in primary, nonsyndromic vesicoureteric reflux.
    Cordell HJ, Darlay R, Charoen P, Stewart A, Gullett AM, Lambert HJ, Malcolm S, Feather SA, Goodship TH, Woolf AS, Kenda RB, Goodship JA, UK VUR Study Group.

    No pathogenic mutations in the uroplakin III gene of 25 patients with primary vesicoureteral reflux.
    Giltay JC, van de Meerakker J, van Amstel HK, de Jong TP.

    03/13/2008
    Uroplakin III mRNA is up-regulated to a greater extent in vesicoureteral reflux than in control exfoliated urinary cells.

    Up-regulation of urinary UPIII mRNA levels in vesicoureteral reflux patients: potential application as a screening test for vesicoureteral reflux.
    Iwaki H, Johnin K, Kageyama S, Kim CJ, Isono T, Yoshiki T.

    01/21/2010
    uroplakin III and III-delta4 genes were significantly up-regulated only in patients with nonulcerative interstitial cystitis

    Uroplakin III-delta4 messenger RNA as a promising marker to identify nonulcerative interstitial cystitis.
    Zeng Y, Wu XX, Homma Y, Yoshimura N, Iwaki H, Kageyama S, Yoshiki T, Kakehi Y.

    01/21/2010
    Loss of p63 expression is a prerequisite for uroplakin III expression in urothelial bladder cancer.

    Impaired p63 expression associates with poor prognosis and uroplakin III expression in invasive urothelial carcinoma of the bladder.
    Koga F, Kawakami S, Fujii Y, Saito K, Ohtsuka Y, Iwai A, Ando N, Takizawa T, Kageyama Y, Kihara K.

    01/21/2010
    Our results indicate that de novo mutations in UPIIIA can be involved in defective early kidney development, but probably constitute only a rare cause of human renal hypodysplasia in a minor subset of individuals [UPIIIA].

    Mutations in Uroplakin IIIA are a rare cause of renal hypodysplasia in humans.
    Schönfelder EM, Knüppel T, Tasic V, Miljkovic P, Konrad M, Wühl E, Antignac C, Bakkaloglu A, Schaefer F, Weber S, ESCAPE Trial Group.

    01/21/2010
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