| UCHL-3 as a potential biomarker of ovarian cancer. | UCHL-3 as a potential biomarker of ovarian cancer.
Yang Q, Peng X, Nian Z, Yuan S, Wang Z, Song Y, Shamsnur R, Wang H, Yi T. | 03/27/2024 |
| CircMTA2 Drives Gastric Cancer Progression through Suppressing MTA2 Degradation via Interacting with UCHL3. | CircMTA2 Drives Gastric Cancer Progression through Suppressing MTA2 Degradation via Interacting with UCHL3.
Xie G, Lei B, Yin Z, Xu F, Liu X., Free PMC Article | 03/14/2024 |
| UCHL3 inhibits ferroptosis by stabilizing beta-catenin and maintains stem-like properties of hepatocellular carcinoma cells. | UCHL3 inhibits ferroptosis by stabilizing β-catenin and maintains stem-like properties of hepatocellular carcinoma cells.
Long G, Wu Z, Wang D, Mi X, Hu K, Zhou L, Tang J. | 01/29/2024 |
| Activation of CTNNB1 by deubiquitinase UCHL3-mediated stabilization facilitates bladder cancer progression. | Activation of CTNNB1 by deubiquitinase UCHL3-mediated stabilization facilitates bladder cancer progression.
Liu T, Fan MQ, Xie XX, Shu QP, Du XH, Qi LZ, Zhang XD, Zhang MH, Shan G, Du RL, Li SZ., Free PMC Article | 09/26/2023 |
| The deubiquitinase UCHL3 mediates p300-dependent chemokine signaling in alveolar type II cells to promote pulmonary fibrosis. | The deubiquitinase UCHL3 mediates p300-dependent chemokine signaling in alveolar type II cells to promote pulmonary fibrosis.
Lee SY, Park SY, Lee SH, Kim H, Kwon JH, Yoo JY, Kim K, Park MS, Lee CG, Elias JA, Sohn MH, Shim HS, Yoon HG., Free PMC Article | 09/8/2023 |
| Rational Development and Characterization of a Ubiquitin Variant with Selectivity for Ubiquitin C-Terminal Hydrolase L3. | Rational Development and Characterization of a Ubiquitin Variant with Selectivity for Ubiquitin C-Terminal Hydrolase L3.
Hewitt CS, Das C, Flaherty DP., Free PMC Article | 04/2/2022 |
| Knockdown of UCHL3 inhibits esophageal squamous cell carcinoma progression by reducing CRY2 methylation. | Knockdown of UCHL3 inhibits esophageal squamous cell carcinoma progression by reducing CRY2 methylation.
Xue J, Yi J, Zhu X. | 03/5/2022 |
| UCHL3 promotes aerobic glycolysis of pancreatic cancer through upregulating LDHA expression. | UCHL3 promotes aerobic glycolysis of pancreatic cancer through upregulating LDHA expression.
Fan Y, Hu D, Li D, Ma C, Tang Y, Tao Q, Deng L, Tang D. | 12/4/2021 |
| The deubiquitylase UCHL3 maintains cancer stem-like properties by stabilizing the aryl hydrocarbon receptor. | The deubiquitylase UCHL3 maintains cancer stem-like properties by stabilizing the aryl hydrocarbon receptor.
Ouyang L, Yan B, Liu Y, Mao C, Wang M, Liu N, Wang Z, Liu S, Shi Y, Chen L, Wang X, Cheng Y, Cao Y, Xiao D, Zhang L, Liu S, Tao Y., Free PMC Article | 10/9/2021 |
| K27-Linked Diubiquitin Inhibits UCHL3 via an Unusual Kinetic Trap. | K27-Linked Diubiquitin Inhibits UCHL3 via an Unusual Kinetic Trap.
van Tilburg GBA, Murachelli AG, Fish A, van der Heden van Noort GJ, Ovaa H, Sixma TK. | 09/4/2021 |
| Silencing UCHL3 enhances radio-sensitivity of non-small cell lung cancer cells by inhibiting DNA repair. | Silencing UCHL3 enhances radio-sensitivity of non-small cell lung cancer cells by inhibiting DNA repair.
Liu M, Chen H, Chen X, Xiong J, Song Z., Free PMC Article | 07/24/2021 |
| UCH-L3 promotes non-small cell lung cancer proliferation via accelerating cell cycle and inhibiting cell apoptosis. | UCH-L3 promotes non-small cell lung cancer proliferation via accelerating cell cycle and inhibiting cell apoptosis.
Li G, Jin X, Zheng J, Jiang N, Shi W. | 07/10/2021 |
| Ubiquitin Carboxyl-Terminal Hydrolases (UCHs): Potential Mediators for Cancer and Neurodegeneration. | Ubiquitin Carboxyl-Terminal Hydrolases (UCHs): Potential Mediators for Cancer and Neurodegeneration.
Sharma A, Liu H, Tobar-Tosse F, Chand Dakal T, Ludwig M, Holz FG, Loeffler KU, Wüllner U, Herwig-Carl MC., Free PMC Article | 04/3/2021 |
| Deubiquitylase UCHL3 regulates bi-orientation and segregation of chromosomes during mitosis. | Deubiquitylase UCHL3 regulates bi-orientation and segregation of chromosomes during mitosis.
Jerabkova K, Liao Y, Kleiss C, Fournane S, Durik M, Agote-Arán A, Brino L, Sedlacek R, Sumara I. | 03/13/2021 |
| Our results indicate that highly expressed UCHL3 enhances inflammation by stabilizing TRAF2, which in turn facilitates tumourigenesis in ovarian cancer, and that UCHL3 is a potential target for ovarian cancer patients with increased inflammation. | UCHL3 promotes ovarian cancer progression by stabilizing TRAF2 to activate the NF-κB pathway.
Zhang MH, Zhang HH, Du XH, Gao J, Li C, Shi HR, Li SZ. | 04/18/2020 |
| UCH-L3 might play a role in epithelial ovarian cancer pathogenesis and progression | [UCH-L3 Expression in Epithelial Ovarian Cancer and Its Clinical Significance].
Li TT, Wang HJ. | 11/16/2019 |
| Depletion of UCHL3 increases TDP1 ubiquitylation and turnover rate and sensitizes cells to TOP1 poisons. Overexpression of UCHL3, but not a catalytically inactive mutant, suppresses TDP1 ubiquitylation and turnover rate. | UCHL3 Regulates Topoisomerase-Induced Chromosomal Break Repair by Controlling TDP1 Proteostasis.
Liao C, Beveridge R, Hudson JJR, Parker JD, Chiang SC, Ray S, Ashour ME, Sudbery I, Dickman MJ, El-Khamisy SF., Free PMC Article | 11/9/2019 |
| UCHL3 facilitates cellular viability after DSB induction by antagonizing Ku80 ubiquitylation to enhance Ku80 retention at sites of damage. | The deubiquitylating enzyme UCHL3 regulates Ku80 retention at sites of DNA damage.
Nishi R, Wijnhoven PWG, Kimura Y, Matsui M, Konietzny R, Wu Q, Nakamura K, Blundell TL, Kessler BM., Free PMC Article | 10/19/2019 |
| The authors find that UCHL3 regulates COPS5-dependent deneddylation of Cullin1, which is an essential component of SCF(beta-TrCP) complex and associated with SCF(beta-TrCP) activities. The authors further demonstrate that UCHL3 upregulates the levels of SCF(beta-TrCP) substrates including IFN-I receptor IFNAR1, which enhances IFN-I mediated signaling pathway and antiviral activity. | Ubiquitin C-terminal hydrolase-L3 promotes interferon antiviral activity by stabilizing type I-interferon receptor.
Zhao P, Guo T, Qian L, Wang X, Yuan Y, Cheng Q, Zuo Y, Liu J, Miao Y, Feng Q, Zhang L, Wu S, Zheng H. | 03/31/2018 |
| Study demonstrated positive correlations between the level and activity of UCHL3 and sperm characteristics and function suggesting that UCHL3 may play a role in male infertility. | Ubiquitin Carboxy-Terminal HydrolaseL3 Correlates with Human Sperm Count, Motility and Fertilization.
Wang M, Yu T, Hu L, Cheng Z, Li M., Free PMC Article | 06/10/2017 |
| Using a series of engineered protein substrates, which are similar in size yet differ in secondary structure, we demonstrate that thermal stability is a key factor that significantly affects UCH-L3 hydrolysis. | Characterizing substrate selectivity of ubiquitin C-terminal hydrolase-L3 using engineered α-linked ubiquitin substrates.
Navarro MF, Carmody L, Romo-Fewell O, Lokensgard ME, Love JJ. | 04/25/2015 |
| UCH-L3 is a novel regulator of epithelial-mesenchymal transition and cell migration in prostate cancer cells. | Ubiquitin C-terminal hydrolase-L3 regulates EMT process and cancer metastasis in prostate cell lines.
Song HM, Lee JE, Kim JH. | 02/28/2015 |
| Data identified of UCHL3 as an essential deubiquitinase in adipogenesis. | A novel RNAi lethality rescue screen to identify regulators of adipogenesis.
van Beekum O, Gao Y, Berger R, Koppen A, Kalkhoven E., Free PMC Article | 10/6/2012 |
| impaired UCH-L3 function may contribute to the accumulation of full length UBB(+1) in various pathologie | Mutant ubiquitin (UBB+1) associated with neurodegenerative disorders is hydrolyzed by ubiquitin C-terminal hydrolase L3 (UCH-L3).
Dennissen FJ, Kholod N, Hermes DJ, Kemmerling N, Steinbusch HW, Dantuma NP, van Leeuwen FW. | 10/15/2011 |
| identification and the sequence-specific assignments for 186 out of the 218 UCH-L3 (230 less 12 prolines) backbone 15N and amide proton resonances | Backbone 1H, 13C, and 15N resonance assignments for the 26-kD human de-ubiquitinating enzyme UCH-L3.
Harris R, Eidhoff U, Vinzenz D, Renatus M, Gerhartz B, Hommel U, Driscoll PC. | 01/21/2010 |