Ubiquitin Carboxyl-Terminal Hydrolase L1 and Its Role in Parkinson's Disease. | Ubiquitin Carboxyl-Terminal Hydrolase L1 and Its Role in Parkinson's Disease. Buneeva O, Medvedev A., Free PMC Article | 06/21/2024 |
Proximity proteomics reveals UCH-L1 as an essential regulator of NLRP3-mediated IL-1beta production in human macrophages and microglia. | Proximity proteomics reveals UCH-L1 as an essential regulator of NLRP3-mediated IL-1β production in human macrophages and microglia. Liang Z, Damianou A, Vendrell I, Jenkins E, Lassen FH, Washer SJ, Grigoriou A, Liu G, Yi G, Lou H, Cao F, Zheng X, Fernandes RA, Dong T, Tate EW, Di Daniel E, Kessler BM. | 06/14/2024 |
Digenic FLNA and UCHL1 variants resulting in a complex phenotype. | Digenic FLNA and UCHL1 variants resulting in a complex phenotype. Pernice HF, O'Donnell LF, Rossor AM, Laura M, Record CJ, Skorupinska M, Blake J, Poh R, Polke J, Reilly MM. | 03/6/2024 |
UCHL1 is a potential molecular indicator and therapeutic target for neuroendocrine carcinomas. | UCHL1 is a potential molecular indicator and therapeutic target for neuroendocrine carcinomas. Liu S, Chai T, Garcia-Marques F, Yin Q, Hsu EC, Shen M, Shaw Toland AM, Bermudez A, Hartono AB, Massey CF, Lee CS, Zheng L, Baron M, Denning CJ, Aslan M, Nguyen HM, Nolley R, Zoubeidi A, Das M, Kunder CA, Howitt BE, Soh HT, Weissman IL, Liss MA, Chin AI, Brooks JD, Corey E, Pitteri SJ, Huang J, Stoyanova T., Free PMC Article | 02/24/2024 |
Changes in Serum LncRNA MEG3/miR-181b and UCH-L1 Levels in Patients with Moderate and Severe Intracerebral Hemorrhage. | Changes in Serum LncRNA MEG3/miR-181b and UCH-L1 Levels in Patients with Moderate and Severe Intracerebral Hemorrhage. Wang H, Wang L, Shi Q. | 02/7/2024 |
Targeted epigenetic silencing of UCHL1 expression suppresses collagen-1 production in human lung epithelial cells. | Targeted epigenetic silencing of UCHL1 expression suppresses collagen-1 production in human lung epithelial cells. Wu DD, Lau ATY, Xu YM, Reinders-Luinge M, Koncz M, Kiss A, Timens W, Rots MG, Hylkema MN., Free PMC Article | 12/1/2023 |
Elevated cerebrospinal fluid ubiquitin C-terminal hydrolase-L1 levels correlate with phenotypic severity and therapeutic response in Niemann-Pick disease, type C1. | Elevated cerebrospinal fluid ubiquitin C-terminal hydrolase-L1 levels correlate with phenotypic severity and therapeutic response in Niemann-Pick disease, type C1. Cawley NX, Giddens S, Farhat NM, Luke RA, Scott KEJ, Mohamed HO, Dang Do A, Berry-Kravis E, Cologna SM, Liu F, Porter FD., | 11/16/2023 |
UCHL1-PKM2 axis dysregulation is associated with promoted proliferation and invasiveness of urothelial bladder cancer cells. | UCHL1-PKM2 axis dysregulation is associated with promoted proliferation and invasiveness of urothelial bladder cancer cells. Zheng Y, Shi D, Chen L, Yang Y, Yao M., Free PMC Article | 10/24/2023 |
UCHL1 facilitates protein aggregates clearance to enhance neural stem cell activation in spinal cord injury. | UCHL1 facilitates protein aggregates clearance to enhance neural stem cell activation in spinal cord injury. Ding L, Chu W, Xia Y, Shi M, Li T, Zhou FQ, Deng DYB., Free PMC Article | 08/14/2023 |
Ubiquitin C-terminal hydrolase L1 after out-of-hospital cardiac arrest. | Ubiquitin C-terminal hydrolase L1 after out-of-hospital cardiac arrest. Wihersaari L, Reinikainen M, Tiainen M, Bendel S, Kaukonen KM, Vaahersalo J, Romppanen J, Pettilä V, Skrifvars MB, FINNRESUSCI Study Group. | 07/20/2023 |
UCHL1 aggravates skin fibrosis through an IGF-1-induced Akt/mTOR/HIF-1alpha pathway in keloid. | UCHL1 aggravates skin fibrosis through an IGF-1-induced Akt/mTOR/HIF-1α pathway in keloid. Guo C, Liang L, Zheng J, Xie Y, Qiu X, Tan G, Huang J, Wang L. | 06/3/2023 |
Associations of blood UCH-L1 and NfL levels with cognitive dysfunction in Parkinson's disease patients. | Associations of blood UCH-L1 and NfL levels with cognitive dysfunction in Parkinson's disease patients. Dong L, Chang Q, Ma J, Liu C, Guo D, Li X, Yang D, Fan Y, Liang K, Li D, Gu Q. | 04/19/2023 |
Ubiquitin C-terminal hydrolase 1 is increased in migraine attack. | Ubiquitin C-terminal hydrolase 1 is increased in migraine attack. Atescelik M, Yilmaz M. | 03/17/2023 |
Role of UCHL1 in the pathogenesis of neurodegenerative diseases and brain injury. | Role of UCHL1 in the pathogenesis of neurodegenerative diseases and brain injury. Mi Z, Graham SH., Free PMC Article | 03/8/2023 |
Pivotal Role of Ubiquitin Carboxyl-Terminal Hydrolase L1 (UCHL1) in Uterine Leiomyoma. | Pivotal Role of Ubiquitin Carboxyl-Terminal Hydrolase L1 (UCHL1) in Uterine Leiomyoma. Suzuki T, Dai Y, Ono M, Kojima J, Sasaki T, Fujiwara H, Kuji N, Nishi H., Free PMC Article | 03/1/2023 |
UCHL1 promotes cancer stemness in triple-negative breast cancer. | UCHL1 promotes cancer stemness in triple-negative breast cancer. Tian C, Liu Y, Liu Y, Hu P, Xie S, Guo Y, Wang H, Zhang Z, Du L, Lei B, Wang Y, Xue L, Zhang D, Su J, Zhang X, Zhang R, Chen J, Zhang X, Chen L, Li M, Jia Q, Song J, Liu J. | 12/17/2022 |
MMP-1, UCH-L1, and 20S Proteasome as Potential Biomarkers Supporting the Diagnosis of Brain Glioma. | MMP-1, UCH-L1, and 20S Proteasome as Potential Biomarkers Supporting the Diagnosis of Brain Glioma. Oldak L, Chludzinska-Kasperuk S, Milewska P, Grubczak K, Reszec J, Gorodkiewicz E., Free PMC Article | 11/5/2022 |
Structural basis for specific inhibition of the deubiquitinase UCHL1. | Structural basis for specific inhibition of the deubiquitinase UCHL1. Grethe C, Schmidt M, Kipka GM, O'Dea R, Gallant K, Janning P, Gersch M., Free PMC Article | 10/22/2022 |
Heterozygous UCHL1 loss-of-function variants cause a neurodegenerative disorder with spasticity, ataxia, neuropathy, and optic atrophy. | Heterozygous UCHL1 loss-of-function variants cause a neurodegenerative disorder with spasticity, ataxia, neuropathy, and optic atrophy. Park J, Tucci A, Cipriani V, Demidov G, Rocca C, Senderek J, Butryn M, Velic A, Lam T, Galanaki E, Cali E, Vestito L, Maroofian R, Deininger N, Rautenberg M, Admard J, Hahn GA, Bartels C, van Os NJH, Horvath R, Chinnery PF, Tiet MY, Hewamadduma C, Hadjivassiliou M, Tofaris GK, Genomics England Research Consortium, Wood NW, Hayer SN, Bender F, Menden B, Cordts I, Klein K, Nguyen HP, Krauss JK, Blahak C, Strom TM, Sturm M, van de Warrenburg B, Lerche H, Maček B, Synofzik M, Ossowski S, Timmann D, Wolf ME, Smedley D, Riess O, Schöls L, Houlden H, Haack TB, Hengel H. | 10/15/2022 |
Prognostic value of day-of-injury plasma GFAP and UCH-L1 concentrations for predicting functional recovery after traumatic brain injury in patients from the US TRACK-TBI cohort: an observational cohort study. | Prognostic value of day-of-injury plasma GFAP and UCH-L1 concentrations for predicting functional recovery after traumatic brain injury in patients from the US TRACK-TBI cohort: an observational cohort study. Korley FK, Jain S, Sun X, Puccio AM, Yue JK, Gardner RC, Wang KKW, Okonkwo DO, Yuh EL, Mukherjee P, Nelson LD, Taylor SR, Markowitz AJ, Diaz-Arrastia R, Manley GT, TRACK-TBI Study Investigators., Free PMC Article | 08/27/2022 |
Ubiquitin carboxyl-terminal esterase L1 is not elevated in the serum of concussed rugby players: an observational cross-sectional study. | Ubiquitin carboxyl-terminal esterase L1 is not elevated in the serum of concussed rugby players: an observational cross-sectional study. Harrell JO, Morgan JE, Beck SD, Scobercea IC, Baker JS, Knox A, Serrador JM, Rogatzki MJ., Free PMC Article | 07/30/2022 |
Predicting Clinical Outcomes 7-10 Years after Severe Traumatic Brain Injury: Exploring the Prognostic Utility of the IMPACT Lab Model and Cerebrospinal Fluid UCH-L1 and MAP-2. | Predicting Clinical Outcomes 7-10 Years after Severe Traumatic Brain Injury: Exploring the Prognostic Utility of the IMPACT Lab Model and Cerebrospinal Fluid UCH-L1 and MAP-2. Svingos AM, Robicsek SA, Hayes RL, Wang KK, Robertson CS, Brophy GM, Papa L, Gabrielli A, Hannay HJ, Bauer RM, Heaton SC. | 07/23/2022 |
Association of Ubiquitin C-Terminal Hydrolase-L1 (Uch-L1) serum levels with cognition and brain energy metabolism. | Association of Ubiquitin C-Terminal Hydrolase-L1 (Uch-L1) serum levels with cognition and brain energy metabolism. Zhang M, Chen MY, Wang SL, Ding XM, Yang R, Li J, Jiang GH. | 06/11/2022 |
UCHL1 acts as a potential oncogene and affects sensitivity of common anti-tumor drugs in lung adenocarcinoma. | UCHL1 acts as a potential oncogene and affects sensitivity of common anti-tumor drugs in lung adenocarcinoma. Yao J, Reyimu A, Sun A, Duoji Z, Zhou W, Liang S, Hu S, Wang X, Dai J, Xu X., Free PMC Article | 06/11/2022 |
UCHL1 promotes proliferation and metastasis in head and neck squamous cell carcinoma and could be a potential therapeutic target. | UCHL1 promotes proliferation and metastasis in head and neck squamous cell carcinoma and could be a potential therapeutic target. Zhang D, Fu Y, Tian G, Li J, Shang D, Zhou S. | 05/21/2022 |