| UBE2V2 promotes metastasis by regulating EMT and predicts a poor prognosis in lung adenocarcinoma. | UBE2V2 promotes metastasis by regulating EMT and predicts a poor prognosis in lung adenocarcinoma.
Yang Z, Wu G, Zhao J, Shi G, Zhou J, Zhou X., Free PMC Article | 11/1/2023 |
| UBE2V2 Positively Correlates With PD-L1 Expression and Confers Poor Patient Survival in Lung Adenocarcinoma. | UBE2V2 Positively Correlates With PD-L1 Expression and Confers Poor Patient Survival in Lung Adenocarcinoma.
Hua ZD, Liu XB, Sheng JH, Li C, Li P, Cai XQ, Han ZQ. | 02/5/2022 |
| Uev1A amino terminus stimulates poly-ubiquitin chain assembly and is required for NF-kappaB activation. | Uev1A amino terminus stimulates poly-ubiquitin chain assembly and is required for NF-κB activation.
Wu Z, Andersen PL, Moraes T, McKenna SA, Zhang Y, Zhang W, Ellison MJ, Xiao W. | 10/23/2021 |
| Ubc13-Mms2 cooperates with a family of RING E3 proteins in budding yeast membrane protein sorting. | Ubc13-Mms2 cooperates with a family of RING E3 proteins in budding yeast membrane protein sorting.
Renz C, Albanèse V, Tröster V, Albert TK, Santt O, Jacobs SC, Khmelinskii A, Léon S, Ulrich HD. | 07/31/2021 |
| Data suggest that ubiquitin-conjugating enzyme E2 variant 2 (Ube2V2) and ring finger protein 4 (RNF4) together induce an active conformation of the ubiquitin-conjugating enzyme Ubc13-ubiquitin (Ubc13~Ub) thioester. | Structural basis for the RING-catalyzed synthesis of K63-linked ubiquitin chains.
Branigan E, Plechanovová A, Jaffray EG, Naismith JH, Hay RT., Free PMC Article | 11/28/2015 |
| Functional analysis of selected regulated proteins revealed that knockdown of HNRPD, PHB2 and UB2V2 can increase HCMV replication, while knockdown of A4 and KSRP resulted in decreased HCMV replication. | Subcellular quantitative proteomic analysis reveals host proteins involved in human cytomegalovirus infection.
Chai F, Li HY, Wang W, Zhu XJ, Li Y, Wang S, Guo L, Zhang LK, Xiao G. | 08/22/2015 |
| suppression of hMMS2 reverses L-OHP tolerance in differentiated human colorectal carcinoma cells by promoting apoptosis | [Roles of hMMS2 gene in reversing the oxaliplatin tolerance of human colon carcinoma cells].
Zhang L, Sui Y, Wang T, Li L, Li Y, Jin C, Xu F. | 06/14/2014 |
| Data show RING finger (RNF) E3 ubiquitin ligase RNF8 dimerizes and binds to E2 ubiquitin-conjugating complex Ubc13/Mms2 with formation of Lys-63 ubiquitin chains, whereas the RNF168 RING domain is a monomer and does not catalyze Lys-6 ubiquitylation. | Molecular insights into the function of RING finger (RNF)-containing proteins hRNF8 and hRNF168 in Ubc13/Mms2-dependent ubiquitylation.
Campbell SJ, Edwards RA, Leung CC, Neculai D, Hodge CD, Dhe-Paganon S, Glover JN., Free PMC Article | 10/13/2012 |
| the crystal structure of human OTUB1 in complex with human UBC13 and MMS2 | Molecular basis of Lys-63-linked polyubiquitination inhibition by the interaction between human deubiquitinating enzyme OTUB1 and ubiquitin-conjugating enzyme UBC13.
Sato Y, Yamagata A, Goto-Ito S, Kubota K, Miyamoto R, Nakada S, Fukai S., Free PMC Article | 10/13/2012 |
| entire coding region and splice junctions of RNF8, UBC13 and MMS2 genes were screened for mutations in affected index cases from 123 Northern Finnish breast cancer families | Mutation screening of the RNF8, UBC13 and MMS2 genes in Northern Finnish breast cancer families.
Vuorela M, Pylkäs K, Winqvist R., Free PMC Article | 10/8/2011 |
| These results point to a high level of redundancy in the DNA damage tolerance pathway and suggest the existence of another hMMS2 variant (hMMSv) or complex that can compensate for its loss. | hMMS2 serves a redundant role in human PCNA polyubiquitination.
Brun J, Chiu R, Lockhart K, Xiao W, Wouters BG, Gray DA., Free PMC Article | 01/21/2010 |
| Mms2 physical association with ubiquitin is correlated with its ability to promote Lys63-linked ubiquitin chain assembly | Two Mms2 residues cooperatively interact with ubiquitin and are critical for Lys63 polyubiquitination in vitro and in vivo.
Pastushok L, Spyracopoulos L, Xiao W. | 01/21/2010 |
| Data demonstrate that divergent activities of Ubc13 rely on its pairing with either of two Uevs, Uev1A or Mms2. | Distinct regulation of Ubc13 functions by the two ubiquitin-conjugating enzyme variants Mms2 and Uev1A.
Andersen PL, Zhou H, Pastushok L, Moraes T, McKenna S, Ziola B, Ellison MJ, Dixit VM, Xiao W., Free PMC Article | 01/21/2010 |
| The results in this study allowed identification of important residues of the Ubc13-Mms2 interface, determine a correlation between heterodimer formation and function, and conclude why Mms2 forms a specific complex with Ubc13 but not other Ubc proteins. | A single Mms2 "key" residue insertion into a Ubc13 pocket determines the interface specificity of a human Lys63 ubiquitin conjugation complex.
Pastushok L, Moraes TF, Ellison MJ, Xiao W. | 01/21/2010 |
| Ubc13-Mms2 and Lys63-polyubiquitin chains are associated with signaling cellular stress | The Chfr mitotic checkpoint protein functions with Ubc13-Mms2 to form Lys63-linked polyubiquitin chains.
Bothos J, Summers MK, Venere M, Scolnick DM, Halazonetis TD. | 01/21/2010 |
| UBE2v2 signalling through PCNA ubiquitination is not required for immunoglobulin diversification in DT40 cells. | UBE2V2 (MMS2) is not required for effective immunoglobulin gene conversion or DNA damage tolerance in DT40.
Simpson LJ, Sale JE. | 01/21/2010 |
| Insight into the influence of protein dynamics on the affinity of ubiquitin for Mms2. | Main chain and side chain dynamics of the ubiquitin conjugating enzyme variant human Mms2 in the free and ubiquitin-bound States.
Spyracopoulos L, Lewis MJ, Saltibus LF. | 01/21/2010 |