| Role of Ubiquitin-conjugating enzyme E2 (UBE2) in two immune-mediated inflammatory skin diseases: a mendelian randomization analysis. | Role of Ubiquitin-conjugating enzyme E2 (UBE2) in two immune-mediated inflammatory skin diseases: a mendelian randomization analysis.
Wang X, Zhu Z., Free PMC Article | 06/3/2024 |
| Hypoxia-induced long non-coding RNA LINC00460 promotes p53 mediated proliferation and metastasis of pancreatic cancer by regulating the miR-4689/UBE2V1 axis and sequestering USP10. | Hypoxia-induced long non-coding RNA LINC00460 promotes p53 mediated proliferation and metastasis of pancreatic cancer by regulating the miR-4689/UBE2V1 axis and sequestering USP10.
Zhang R, Wang X, Ying X, Huang Y, Zhai S, Shi M, Tang X, Liu J, Shi Y, Li F, Wang W, Deng X., Free PMC Article | 10/8/2023 |
| Ubiquitin-conjugating enzyme V variant 1 enables cellular responses toward fibroblast growth factor signaling in endothelium. | Ubiquitin-conjugating enzyme V variant 1 enables cellular responses toward fibroblast growth factor signaling in endothelium.
Elangovan M, Ka J, Pak B, Choi W, Oh SR, Jin SW, Yoo YJ. | 01/15/2022 |
| Uev1A amino terminus stimulates poly-ubiquitin chain assembly and is required for NF-kappaB activation. | Uev1A amino terminus stimulates poly-ubiquitin chain assembly and is required for NF-κB activation.
Wu Z, Andersen PL, Moraes T, McKenna SA, Zhang Y, Zhang W, Ellison MJ, Xiao W. | 10/23/2021 |
| Uev1A promotes breast cancer cell migration by up-regulating CT45A expression via the AKT pathway. | Uev1A promotes breast cancer cell migration by up-regulating CT45A expression via the AKT pathway.
Niu T, Wu Z, Xiao W., Free PMC Article | 10/16/2021 |
| Linkage-specific ubiquitin chain formation depends on a lysine hydrocarbon ruler. | Linkage-specific ubiquitin chain formation depends on a lysine hydrocarbon ruler.
Liwocha J, Krist DT, van der Heden van Noort GJ, Hansen FM, Truong VH, Karayel O, Purser N, Houston D, Burton N, Bostock MJ, Sattler M, Mann M, Harrison JS, Kleiger G, Ovaa H, Schulman BA., Free PMC Article | 04/3/2021 |
| Ube2v1 Positively Regulates Protein Aggregation by Modulating Ubiquitin Proteasome System Performance Partially Through K63 Ubiquitination. | Ube2v1 Positively Regulates Protein Aggregation by Modulating Ubiquitin Proteasome System Performance Partially Through K63 Ubiquitination.
Xu N, Gulick J, Osinska H, Yu Y, McLendon PM, Shay-Winkler K, Robbins J, Yutzey KE., Free PMC Article | 11/21/2020 |
| Ube2v1suppressed autophagy program and promoted epithelial mesenchymal transition (EMT) and metastasis of CRC cells in an autophagy-dependent pattern in vitro and in vivo. | Ube2v1-mediated ubiquitination and degradation of Sirt1 promotes metastasis of colorectal cancer by epigenetically suppressing autophagy.
Shen T, Cai LD, Liu YH, Li S, Gan WJ, Li XM, Wang JR, Guo PD, Zhou Q, Lu XX, Sun LN, Li JM., Free PMC Article | 11/23/2019 |
| Uev1A-Ubc13 complex catalyzes lysine63-linked ubiquitination of RHBDF2 to promote TACE maturation. | Uev1A-Ubc13 catalyzes K63-linked ubiquitination of RHBDF2 to promote TACE maturation.
Zhang Y, Li Y, Yang X, Wang J, Wang R, Qian X, Zhang W, Xiao W. | 07/21/2018 |
| Uev1A appears to be involved in the BMP signaling pathway in which it collaborates with a ubiquitin E3 ligase Smurf1 to promote Smad1 degradation in a Ubc13-independent manner. | Uev1A facilitates osteosarcoma differentiation by promoting Smurf1-mediated Smad1 ubiquitination and degradation.
Zhang W, Zhuang Y, Zhang Y, Yang X, Zhang H, Wang G, Yin W, Wang R, Zhang Z, Xiao W., Free PMC Article | 04/21/2018 |
| variants in CD101 and UBE2V1 associated with increased risk of sexually acquired HIV-1 | Whole genome sequencing of extreme phenotypes identifies variants in CD101 and UBE2V1 associated with increased risk of sexually acquired HIV-1.
Mackelprang RD, Bamshad MJ, Chong JX, Hou X, Buckingham KJ, Shively K, deBruyn G, Mugo NR, Mullins JI, McElrath MJ, Baeten JM, Celum C, Emond MJ, Lingappa JR, Partners in Prevention HSV/HIV Transmission Study and the Partners PrEP Study Teams., Free PMC Article | 12/9/2017 |
| Gene and protein expression of UBE2v1, a ubiquitin-conjugating E2-enzyme variant that mediates Lys63-linked ubiquitination, and Lys63-ubiquitinated proteins increased in HK2 tubular cells under high glucose; immunohistochemistry on diabtic kidney samples revealed an increase in UBE2v1- and Lys63-ubiquitinated proteins, particularly in kidneys of patients with diabetic nephropathy. | Lysine 63 ubiquitination is involved in the progression of tubular damage in diabetic nephropathy.
Pontrelli P, Conserva F, Papale M, Oranger A, Barozzino M, Vocino G, Rocchetti MT, Gigante M, Castellano G, Rossini M, Simone S, Laviola L, Giorgino F, Grandaliano G, Di Paolo S, Gesualdo L. | 09/2/2017 |
| Ubiquitin-conjugating enzyme complex Uev1A-Ubc13 promotes breast cancer metastasis through nuclear factor-small ka, CyrillicB mediated matrix metalloproteinase-1 gene regulation. | Ubiquitin-conjugating enzyme complex Uev1A-Ubc13 promotes breast cancer metastasis through nuclear factor-кB mediated matrix metalloproteinase-1 gene regulation.
Wu Z, Shen S, Zhang Z, Zhang W, Xiao W., Free PMC Article | 06/27/2015 |
| modification of proteins with Lys(63)-linked ubiquitin chains occurs through a UEV1A-independent substrate modification and UEV1A-dependent Lys(63)-linked ubiquitin chain synthesis mechanism | Substrate modification with lysine 63-linked ubiquitin chains through the UBC13-UEV1A ubiquitin-conjugating enzyme.
Petroski MD, Zhou X, Dong G, Daniel-Issakani S, Payan DG, Huang J. | 01/21/2010 |
| Data demonstrate that divergent activities of Ubc13 rely on its pairing with either of two Uevs, Uev1A or Mms2. | Distinct regulation of Ubc13 functions by the two ubiquitin-conjugating enzyme variants Mms2 and Uev1A.
Andersen PL, Zhou H, Pastushok L, Moraes T, McKenna S, Ziola B, Ellison MJ, Dixit VM, Xiao W., Free PMC Article | 01/21/2010 |
| A structural model for the Ub-hUev1a-hUbc13-Ub tetramer was developed to gain chemical insight into the synthesis of Lys(63)-linked Ubiquitin chains. | Structure and interactions of the ubiquitin-conjugating enzyme variant human Uev1a: implications for enzymatic synthesis of polyubiquitin chains.
Hau DD, Lewis MJ, Saltibus LF, Pastushok L, Xiao W, Spyracopoulos L. | 01/21/2010 |
| These data provide evidence that Uev1A is a critical regulatory component in the NF-kappaB signaling pathway in response to environmental stresses and identify UEV1A as a potential proto-oncogene. | Uev1A, a ubiquitin conjugating enzyme variant, inhibits stress-induced apoptosis through NF-kappaB activation.
Syed NA, Andersen PL, Warrington RC, Xiao W. | 01/21/2010 |