| Suppressing UBE2N ameliorates Alzheimer's disease pathology through the clearance of amyloid beta. | Suppressing UBE2N ameliorates Alzheimer's disease pathology through the clearance of amyloid beta.
Zhang C, Jia Q, Zhu L, Hou J, Wang X, Li D, Zhang J, Zhang Y, Yang S, Tu Z, Yan XX, Yang W, Li S, Li XJ, Yin P., Free PMC Article | 10/31/2024 |
| UBE2N promotes cell viability and glycolysis by promoting Axin1 ubiquitination in prostate cancer cells. | UBE2N promotes cell viability and glycolysis by promoting Axin1 ubiquitination in prostate cancer cells.
Yang B, Chen W, Tao T, Zhang J, Kong D, Hao J, Yu C, Liao G, Gong H., Free PMC Article | 05/9/2024 |
| SET7 methylates the deubiquitinase OTUB1 at Lys [122] to impair its binding to E2 enzyme UBC13 and relieve its suppressive role on ferroptosis. | SET7 methylates the deubiquitinase OTUB1 at Lys (122) to impair its binding to E2 enzyme UBC13 and relieve its suppressive role on ferroptosis.
Deng H, Jia S, Tang J, Rong F, Xu C, Chen X, Wang Z, Zhu C, Sun X, Liao Q, Liu W, Li W, Xiao W, Liu X., Free PMC Article | 05/1/2023 |
| Blocking UBE2N abrogates oncogenic immune signaling in acute myeloid leukemia. | Blocking UBE2N abrogates oncogenic immune signaling in acute myeloid leukemia.
Barreyro L, Sampson AM, Ishikawa C, Hueneman KM, Choi K, Pujato MA, Chutipongtanate S, Wyder M, Haffey WD, O'Brien E, Wunderlich M, Ramesh V, Kolb EM, Meydan C, Neelamraju Y, Bolanos LC, Christie S, Smith MA, Niederkorn M, Muto T, Kesari S, Garrett-Bakelman FE, Bartholdy B, Will B, Weirauch MT, Mulloy JC, Gul Z, Medlin S, Kovall RA, Melnick AM, Perentesis JP, Greis KD, Nurmemmedov E, Seibel WL, Starczynowski DT. | 04/16/2022 |
| The lncRNA 'UCA1' modulates the response to chemotherapy of ovarian cancer through direct binding to miR-27a-5p and control of UBE2N levels. | The lncRNA 'UCA1' modulates the response to chemotherapy of ovarian cancer through direct binding to miR-27a-5p and control of UBE2N levels.
Wambecke A, Ahmad M, Morice PM, Lambert B, Weiswald LB, Vernon M, Vigneron N, Abeilard E, Brotin E, Figeac M, Gauduchon P, Poulain L, Denoyelle C, Meryet-Figuiere M., Free PMC Article | 04/16/2022 |
| Uev1A amino terminus stimulates poly-ubiquitin chain assembly and is required for NF-kappaB activation. | Uev1A amino terminus stimulates poly-ubiquitin chain assembly and is required for NF-κB activation.
Wu Z, Andersen PL, Moraes T, McKenna SA, Zhang Y, Zhang W, Ellison MJ, Xiao W. | 10/23/2021 |
| Functional interaction of ubiquitin ligase RNF167 with UBE2D1 and UBE2N promotes ubiquitination of AMPA receptor. | Functional interaction of ubiquitin ligase RNF167 with UBE2D1 and UBE2N promotes ubiquitination of AMPA receptor.
Ghilarducci K, Cabana VC, Desroches C, Chabi K, Bourgault S, Cappadocia L, Lussier MP. | 09/11/2021 |
| Ubc13-Mms2 cooperates with a family of RING E3 proteins in budding yeast membrane protein sorting. | Ubc13-Mms2 cooperates with a family of RING E3 proteins in budding yeast membrane protein sorting.
Renz C, Albanèse V, Tröster V, Albert TK, Santt O, Jacobs SC, Khmelinskii A, Léon S, Ulrich HD. | 07/31/2021 |
| Inhibiting ubiquitin conjugating enzyme E2 N by microRNA-590-3p reduced cell growth of cervical carcinoma. | Inhibiting ubiquitin conjugating enzyme E2 N by microRNA-590-3p reduced cell growth of cervical carcinoma.
Song TT, Xu F, Wang W. | 07/17/2021 |
| Linkage-specific ubiquitin chain formation depends on a lysine hydrocarbon ruler. | Linkage-specific ubiquitin chain formation depends on a lysine hydrocarbon ruler.
Liwocha J, Krist DT, van der Heden van Noort GJ, Hansen FM, Truong VH, Karayel O, Purser N, Houston D, Burton N, Bostock MJ, Sattler M, Mann M, Harrison JS, Kleiger G, Ovaa H, Schulman BA., Free PMC Article | 04/3/2021 |
| Legionella effector MavC targets the Ube2N~Ub conjugate for noncanonical ubiquitination. | Legionella effector MavC targets the Ube2N~Ub conjugate for noncanonical ubiquitination.
Puvar K, Iyer S, Fu J, Kenny S, Negrón Terón KI, Luo ZQ, Brzovic PS, Klevit RE, Das C., Free PMC Article | 09/5/2020 |
| Data show that miR-934 binds to a 3'-UTR of ubiquitin-conjugating enzyme 2N (ube2n) mRNA, down-regulated UBE2N protein expression; this, in turn, attenuated cyclin dependent kinase 6 (CDK6) protein degradation and led to CDK6 protein accumulation as well as the promotion of BC tumor growth. | Inhibition of UBE2N-dependent CDK6 protein degradation by miR-934 promotes human bladder cancer cell growth.
Yan H, Ren S, Lin Q, Yu Y, Chen C, Hua X, Jin H, Lu Y, Zhang H, Xie Q, Huang C, Huang H. | 06/13/2020 |
| Deamidation elicited by Shigella flexneri disrupts native and transient contacts to weaken the interaction between UBC13 and TRAF6 and to silence the host anti-inflammatory response. | Deamidation disrupts native and transient contacts to weaken the interaction between UBC13 and RING-finger E3 ligases.
Mohanty P, Agrata R, Habibullah BI, G S A, Das R., Free PMC Article | 05/9/2020 |
| Study reveals how TRIM21 facilitates ubiquitin transfer and differentiates this E2 from other closely related enzymes. A tri-ionic motif provides optimally distributed anchor points that allow TRIM21 to wrap an Ube2N~Ub complex around its RING domain. The tri-ionic motif is exclusively required for Ube2N but not Ube2D1 activity and provides a generic E2-specific catalysis mechanism for RING E3s. | A tri-ionic anchor mechanism drives Ube2N-specific recruitment and K63-chain ubiquitination in TRIM ligases.
Kiss L, Zeng J, Dickson CF, Mallery DL, Yang JC, McLaughlin SH, Boland A, Neuhaus D, James LC., Free PMC Article | 02/22/2020 |
| The protein expression of UBE2N was validated in an independent clinical cohort to distinguish euploid from aneuploid colorectal cancers cells. | Spatial UBE2N protein expression indicates genomic instability in colorectal cancers.
Gemoll T, Miroll E, Klein O, Lischka A, Eravci M, Thorns C, Habermann JK., Free PMC Article | 12/14/2019 |
| a novel function for UBC13 in regulating paclitaxel sensitivity through a DNMT1-CHFR-Aurora A pathway in ovarian cancer cells, is reported. | The inhibition of UBC13 expression and blockage of the DNMT1-CHFR-Aurora A pathway contribute to paclitaxel resistance in ovarian cancer.
Zhang X, Feng Y, Wang XY, Zhang YN, Yuan CN, Zhang SF, Shen YM, Fu YF, Zhou CY, Li X, Cheng XD, Lu WG, Xie X., Free PMC Article | 06/15/2019 |
| Study identified Ubc13 as a functional E2 for LNX1 and determined the complex structure of LNX1- Ubc13~ubiquitin (Ub). This structure uncovers a new interface between LNX1 and Ub, and unravels the mechanism by which Ub-loaded Ubc13 is recruited for Ub transfer via the E3 ligase activity of LNX1. | Structure of LNX1:Ubc13~Ubiquitin Complex Reveals the Role of Additional Motifs for the E3 Ligase Activity of LNX1.
Nayak D, Sivaraman J. | 05/11/2019 |
| RNF11 may regulate the activity of E3s that rely on Ubc13 for ubiquitin chain assembly by limiting the availability of Ubc13 and its conjugate. | The RING domain of RING Finger 11 (RNF11) protein binds Ubc13 and inhibits formation of polyubiquitin chains.
Budhidarmo R, Zhu J, Middleton AJ, Day CL. | 02/23/2019 |
| as a consequence of its high E2 affinity, an excess of ZNRF1 inhibits Ube2N-mediated ubiquitination at concentrations >/=500 nM instead of showing enhanced ubiquitination | Structural insights into the nanomolar affinity of RING E3 ligase ZNRF1 for Ube2N and its functional implications.
Behera AP, Naskar P, Agarwal S, Banka PA, Poddar A, Datta AB., Free PMC Article | 02/16/2019 |
| Together with Riplet, Ube2D3 promotes covalent conjugation of polyubiquitin chains to RIG-I, while Ube2N preferentially facilitates production of unanchored chains. In the presence of these chains, RIG-I induces MAVS aggregation directly on the mitochondria. Data thus reveal two essential mechanisms underlying the activation of RIG-I and MAVS for triggering innate immune signaling in response to viral infection in cells. | Ube2D3 and Ube2N are essential for RIG-I-mediated MAVS aggregation in antiviral innate immunity.
Shi Y, Yuan B, Zhu W, Zhang R, Li L, Hao X, Chen S, Hou F., Free PMC Article | 12/22/2018 |
| Uev1A-Ubc13 complex catalyzes lysine63-linked ubiquitination of RHBDF2 to promote TACE maturation. | Uev1A-Ubc13 catalyzes K63-linked ubiquitination of RHBDF2 to promote TACE maturation.
Zhang Y, Li Y, Yang X, Wang J, Wang R, Qian X, Zhang W, Xiao W. | 07/21/2018 |
| The malin-laforin complex interacts physically and functionally with the ubiquitin conjugating enzyme E2-N (UBE2N). | Ubiquitin conjugating enzyme E2-N and sequestosome-1 (p62) are components of the ubiquitination process mediated by the malin-laforin E3-ubiquitin ligase complex.
Sánchez-Martín P, Romá-Mateo C, Viana R, Sanz P. | 09/24/2016 |
| Data suggest that ubiquitin-conjugating enzyme E2 variant 2 (Ube2V2) and ring finger protein 4 (RNF4) together induce an active conformation of the ubiquitin-conjugating enzyme Ubc13-ubiquitin (Ubc13~Ub) thioester. | Structural basis for the RING-catalyzed synthesis of K63-linked ubiquitin chains.
Branigan E, Plechanovová A, Jaffray EG, Naismith JH, Hay RT., Free PMC Article | 11/28/2015 |
| together with UBE2L3 and UBE2D2, synergistically contribute to Parkin-mediated mitophagy | The ubiquitin-conjugating enzymes UBE2N, UBE2L3 and UBE2D2/3 are essential for Parkin-dependent mitophagy.
Geisler S, Vollmer S, Golombek S, Kahle PJ. | 10/24/2015 |
| MiR-205 inhibits DNA damage repair by targeting ZEB1 and Ubc13. | miR-205 acts as a tumour radiosensitizer by targeting ZEB1 and Ubc13.
Zhang P, Wang L, Rodriguez-Aguayo C, Yuan Y, Debeb BG, Chen D, Sun Y, You MJ, Liu Y, Dean DC, Woodward WA, Liang H, Yang X, Lopez-Berestein G, Sood AK, Hu Y, Ang KK, Chen J, Ma L., Free PMC Article | 10/17/2015 |