| Role of Ubiquitin-conjugating enzyme E2 (UBE2) in two immune-mediated inflammatory skin diseases: a mendelian randomization analysis. | Role of Ubiquitin-conjugating enzyme E2 (UBE2) in two immune-mediated inflammatory skin diseases: a mendelian randomization analysis.
Wang X, Zhu Z., Free PMC Article | 06/3/2024 |
| UBE2L3 expression in human gastric cancer and its clinical significance. | UBE2L3 expression in human gastric cancer and its clinical significance.
Zhang X, Wei Y, Wu F, Li M, Han C, Huo C, Li Z, Tang F, He W, Zhao Y, Li Y., Free PMC Article | 05/30/2024 |
| The E3 ligase SMURF1 stabilizes p27 via UbcH7 catalyzed K29-linked ubiquitin chains to promote cell migration SMURF1-UbcH7 K29 ubiquitination of p27 and cell migration. | The E3 ligase SMURF1 stabilizes p27 via UbcH7 catalyzed K29-linked ubiquitin chains to promote cell migration SMURF1-UbcH7 K29 ubiquitination of p27 and cell migration.
Weinberg J, Whitcomb E, Bohm A, Chekkilla UK, Taylor A., Free PMC Article | 04/10/2024 |
| The membrane-associated ubiquitin ligase MARCHF8 stabilizes the human papillomavirus oncoprotein E7 by degrading CUL1 and UBE2L3 in head and neck cancer. | The membrane-associated ubiquitin ligase MARCHF8 stabilizes the human papillomavirus oncoprotein E7 by degrading CUL1 and UBE2L3 in head and neck cancer.
Khalil MI, Yang C, Vu L, Chadha S, Nabors H, James CD, Morgan IM, Pyeon D., Free PMC Article | 02/22/2024 |
| UBE2L3 Reduces TRIM21 Expression and IL-1beta Secretion in Epidermal Keratinocytes and Improves Psoriasis-Like Skin. | UBE2L3 Reduces TRIM21 Expression and IL-1β Secretion in Epidermal Keratinocytes and Improves Psoriasis-Like Skin.
Chen XY, Xu F, Chen JQ, Landeck L, Chen SQ, Zhou Y, Wang Z, Fu NC, Zheng M, Zhang X, Man XY. | 04/24/2023 |
| UBE2L3 regulates TLR7-induced B cell autoreactivity in Systemic Lupus Erythematosus. | UBE2L3 regulates TLR7-induced B cell autoreactivity in Systemic Lupus Erythematosus.
Mauro D, Manou-Stathopoulou S, Rivellese F, Sciacca E, Goldmann K, Tsang V, Lucey-Clayton I, Pagani S, Alam F, Pyne D, Rajakariar R, Gordon PA, Whiteford J, Bombardieri M, Pitzalis C, Lewis MJ. | 04/14/2023 |
| UBE2L3 promotes squamous cell carcinoma progression in the oral cavity and hypopharynx via activating the NF-kappaB signaling by increasing IkappaBalpha degradation. | UBE2L3 promotes squamous cell carcinoma progression in the oral cavity and hypopharynx via activating the NF-κB signaling by increasing IκBα degradation.
Cui Z, Sun S, Li J, Li J, Sha T, He J, Zuo L. | 04/30/2022 |
| Variants on the UBE2L3/YDJC Autoimmune Disease Risk Haplotype Increase UBE2L3 Expression by Modulating CCCTC-Binding Factor and YY1 Binding. | Variants on the UBE2L3/YDJC Autoimmune Disease Risk Haplotype Increase UBE2L3 Expression by Modulating CCCTC-Binding Factor and YY1 Binding.
Gopalakrishnan J, Tessneer KL, Fu Y, Pasula S, Pelikan RC, Kelly JA, Wiley GB, Gaffney PM., Free PMC Article | 02/19/2022 |
| Synergistic activation of NF-kappaB by TNFAIP3 (A20) reduction and UBE2L3 (UBCH7) augment that synergistically elevate lupus risk. | Synergistic activation of NF-κB by TNFAIP3 (A20) reduction and UBE2L3 (UBCH7) augment that synergistically elevate lupus risk.
Kim T, Bae SC, Kang C., Free PMC Article | 04/17/2021 |
| Overexpression of ubiquitin-conjugating enzyme E2 L3 in hepatocellular carcinoma potentiates apoptosis evasion by inhibiting the GSK3beta/p65 pathway. | Overexpression of ubiquitin-conjugating enzyme E2 L3 in hepatocellular carcinoma potentiates apoptosis evasion by inhibiting the GSK3β/p65 pathway.
Tao NN, Zhang ZZ, Ren JH, Zhang J, Zhou YJ, Wai Wong VK, Kwan Law BY, Cheng ST, Zhou HZ, Chen WX, Xu HM, Chen J. | 12/19/2020 |
| The rs59391722 allele in the promoter of the UBE2L3 gene was significantly associated with hepatitis B in both adults and children, and it increased the promoter activity of UBE2L3. Serum UBE2L3 protein levels were positively correlated with HBV viral load and hepatitis B e antigen levels in children with chronic hepatitis B. | A Functional Variant in Ubiquitin Conjugating Enzyme E2 L3 Contributes to Hepatitis B Virus Infection and Maintains Covalently Closed Circular DNA Stability by Inducing Degradation of Apolipoprotein B mRNA Editing Enzyme Catalytic Subunit 3A.
Zhou L, Ren JH, Cheng ST, Xu HM, Chen WX, Chen DP, Wong VKW, Law BYK, Liu Y, Cai XF, Tang H, Yu HB, Hu JL, Hu Y, Zhou HZ, Ren F, He L, Hu ZW, Jiang H, Xu HY, Huang AL, Chen J. | 06/20/2020 |
| Synergistic recruitment of UbcH7~Ub and phosphorylated Ubl domain triggers parkin activation. | Synergistic recruitment of UbcH7~Ub and phosphorylated Ubl domain triggers parkin activation.
Condos TE, Dunkerley KM, Freeman EA, Barber KR, Aguirre JD, Chaugule VK, Xiao Y, Konermann L, Walden H, Shaw GS., Free PMC Article | 10/5/2019 |
| UBCH7/UBE2L3 catalyzes the conjugation of heterotypic ubiquitin chains on p27(Kip1) that are proteolytically incompetent | Stabilization of p27(Kip1)/CDKN1B by UBCH7/UBE2L3 catalyzed ubiquitinylation: a new paradigm in cell-cycle control.
Whitcomb EA, Tsai YC, Basappa J, Liu K, Le Feuvre AK, Weissman AM, Taylor A., Free PMC Article | 09/21/2019 |
| The variant genotypes of rs4821116 in ubiquitin conjugating enzyme E2 L3 (UBE2L3) are associated with decreased risk for HBV-related hepatocellular carcinoma (HCC) and chronic hepatitis B virus (HBV) infection. Higher levels of UBE2L3 expression are correlated with higher tumor grade, advanced tumor stage and poor survival. In vitro analysis revealed that UBE2L3 may promote hepatocyte proliferation and migration. | UBE2L3, a susceptibility gene that plays oncogenic role in hepatitis B-related hepatocellular carcinoma.
Liu Y, Song C, Ni H, Jiao W, Gan W, Dong X, Liu J, Zhu L, Zhai X, Hu Z, Li J. | 09/7/2019 |
| The association between the genotype of rs4821116 in the UBE2L3 gene and the reduction in viral load in pregnant women needed to be confirmed by studies with a larger sample size. | [Predictive value of single nucleotide polymorphisms of HLA-C and UBE2L3 in evaluating the effect of telbivudine antiviral therapy during pregnancy].
Liu JF, Wang J, Guo DD, Qi CJ, Cao FR, Tian Z, Yao NJ, Wu YC, Yang Y, He YL, Zhao YR, Chen TY. | 03/30/2019 |
| Low UBE2L3 expression is associated with chikungunya fever. | Ubiquitin-Conjugating Enzyme E2 L3 is Downregulated by the Chikungunya Virus nsP2 Protease.
Ramphan S, Khongwichit S, Saisawang C, Kovanich D, Ketterman AJ, Ubol S, Auewarakul P, Roytrakul S, Smith DR, Kuadkitkan A. | 02/23/2019 |
| Crystal structure of HHARI and UbcH7 reveals UbcH7 approximately Ub binding RING1 domain of auto-inhibited HHARI. | Structural Studies of HHARI/UbcH7∼Ub Reveal Unique E2∼Ub Conformational Restriction by RBR RING1.
Dove KK, Olszewski JL, Martino L, Duda DM, Wu XS, Miller DJ, Reiter KH, Rittinger K, Schulman BA, Klevit RE., Free PMC Article | 03/24/2018 |
| Data suggest ordered binding of UBCH7-ubiquitin to E6AP Site 1 (for E6AP-Cys820/ubiquitin thioester formation) and E6AP Site 2 (for subsequent chain elongation); proximal indexation accounts for radially symmetric structure of E6AP, requirement for oligomerization in polyubiquitin chain formation, and mechanistic rationale for Cys820-ubiquitin thioester as platform in chain assembly. (E6AP = ubiquitin-protein ligase E6AP) | In silico modeling of the cryptic E2∼ubiquitin-binding site of E6-associated protein (E6AP)/UBE3A reveals the mechanism of polyubiquitin chain assembly.
Ronchi VP, Kim ED, Summa CM, Klein JM, Haas AL., Free PMC Article | 11/25/2017 |
| The TCGGC haplotype is associated with an increased risk of Hashimoto Thyroiditis(HT) and UBE2L3 gene is likely to be a susceptibility factor to HT in a Chinese Han population. | The haplotype of UBE2L3 gene is associated with Hashimoto's thyroiditis in a Chinese Han population.
Wang Y, Zhu YF, Wang Q, Xu J, Yan N, Xu J, Shi LF, He ST, Zhang JA., Free PMC Article | 10/22/2016 |
| together with UBE2N and UBE2D2, synergistically contribute to Parkin-mediated mitophagy | The ubiquitin-conjugating enzymes UBE2N, UBE2L3 and UBE2D2/3 are essential for Parkin-dependent mitophagy.
Geisler S, Vollmer S, Golombek S, Kahle PJ. | 10/24/2015 |
| The MAP1B-LC1 could interact with the ubiquitin-conjugating E2 enzyme UBE2L3 and that the ubiquitination/degradation mechanism triggered by MAP1B-LC1 could be prevented by inhibiting the ubiquitin-proteasome proteolytic pathway. | The MAP1B-LC1/UBE2L3 complex catalyzes degradation of cell surface CaV2.2 channels.
Gandini MA, Sandoval A, Zamponi GW, Felix R., Free PMC Article | 10/3/2015 |
| An interaction between LC1 and the ubiquitin-conjugating enzyme UBE2L3. | CaV2.2 channel cell surface expression is regulated by the light chain 1 (LC1) of the microtubule-associated protein B (MAP1B) via UBE2L3-mediated ubiquitination and degradation.
Gandini MA, Henríquez DR, Grimaldo L, Sandoval A, Altier C, Zamponi GW, Felix R, González-Billault C. | 06/27/2015 |
| UbcH7 has a role in regulating 53BP1 stability and DSB repair | UbcH7 regulates 53BP1 stability and DSB repair.
Han X, Zhang L, Chung J, Mayca Pozo F, Tran A, Seachrist DD, Jacobberger JW, Keri RA, Gilmore H, Zhang Y., Free PMC Article | 05/2/2015 |
| UBE2L3 polymorphism amplifies NF-kappaB activation and promotes plasma cell development, linking linear ubiquitination to multiple autoimmune diseases. | UBE2L3 polymorphism amplifies NF-κB activation and promotes plasma cell development, linking linear ubiquitination to multiple autoimmune diseases.
Lewis MJ, Vyse S, Shields AM, Boeltz S, Gordon PA, Spector TD, Lehner PJ, Walczak H, Vyse TJ., Free PMC Article | 04/11/2015 |
| Report role of UBE2L3 genetic variants in confering risk of systemic lupus erythematosus in Chinese population. | Variants in TNFSF4, TNFAIP3, TNIP1, BLK, SLC15A4 and UBE2L3 interact to confer risk of systemic lupus erythematosus in Chinese population.
Zuo XB, Sheng YJ, Hu SJ, Gao JP, Li Y, Tang HY, Tang XF, Cheng H, Yin XY, Wen LL, Sun LD, Yang S, Cui Y, Zhang XJ. | 01/31/2015 |