| Repression of the SUMO-conjugating enzyme UBC9 is associated with lowered double minutes and reduced tumor progression. | Repression of the SUMO-conjugating enzyme UBC9 is associated with lowered double minutes and reduced tumor progression.
Wang Y, Zou H, Ji W, Huang M, You B, Sun N, Qiao Y, Liu P, Xu L, Zhang X, Cai M, Kuang Y, Fu S, Sun W, Jia X, Wu J., Free PMC Article | 03/14/2024 |
| The Interaction between SARS-CoV-2 Nucleocapsid Protein and UBC9 Inhibits MAVS Ubiquitination by Enhancing Its SUMOylation. | The Interaction between SARS-CoV-2 Nucleocapsid Protein and UBC9 Inhibits MAVS Ubiquitination by Enhancing Its SUMOylation.
Huang C, Yin Y, Pan P, Huang Y, Chen S, Chen J, Wang J, Xu G, Tao X, Xiao X, Li J, Yang J, Jin Z, Li B, Tong Z, Du W, Liu L, Liu Z., Free PMC Article | 01/11/2024 |
| Stabilization of Pin1 by USP34 promotes Ubc9 isomerization and protein sumoylation in glioma stem cells. | Stabilization of Pin1 by USP34 promotes Ubc9 isomerization and protein sumoylation in glioma stem cells.
Zhu Q, Liang P, Meng H, Li F, Miao W, Chu C, Wang W, Li D, Chen C, Shi Y, Yu X, Ping Y, Niu C, Wu HB, Zhang A, Bian XW, Zhou W., Free PMC Article | 01/5/2024 |
| Knockdown of UBE2I inhibits tumorigenesis and enhances chemosensitivity of cholangiocarcinoma via modulating p27kip1 nuclear export. | Knockdown of UBE2I inhibits tumorigenesis and enhances chemosensitivity of cholangiocarcinoma via modulating p27kip1 nuclear export.
Huang J, Tan X, Liu Y, Jiang K, Luo J. | 04/19/2023 |
| Upregulation of miRNA-10a-5p promotes tumor progression in cervical cancer by suppressing UBE2I signaling. | Upregulation of miRNA-10a-5p promotes tumor progression in cervical cancer by suppressing UBE2I signaling.
Gu Y, Feng X, Jin Y, Liu Y, Zeng L, Zhou D, Feng Y. | 02/9/2023 |
| Combined Evaluation of mRNA and Protein Expression, Promoter Methylation, and Immune Infiltration of UBE2I in Pan-Digestive System Tumors. | Combined Evaluation of mRNA and Protein Expression, Promoter Methylation, and Immune Infiltration of UBE2I in Pan-Digestive System Tumors.
Huang S, Wang X, Luo K, Zhang X, Liu Z, Li R., Free PMC Article | 10/15/2022 |
| SUMOylation stabilizes hSSB1 and enhances the recruitment of NBS1 to DNA damage sites. | SUMOylation stabilizes hSSB1 and enhances the recruitment of NBS1 to DNA damage sites.
Zhou L, Zheng L, Hu K, Wang X, Zhang R, Zou Y, Zhong L, Wang S, Wu Y, Kang T., Free PMC Article | 10/9/2021 |
| Adipose-specific knockout of ubiquitin-conjugating enzyme E2L6 (Ube2l6) reduces diet-induced obesity, insulin resistance, and hepatic steatosis. | Adipose-specific knockout of ubiquitin-conjugating enzyme E2L6 (Ube2l6) reduces diet-induced obesity, insulin resistance, and hepatic steatosis.
Wei W, Li Y, Li Y, Li D. | 09/11/2021 |
| HRM screening of the UBC9 gene encoding the SUMO-E2-conjugating enzyme - case-control study in breast cancer. | HRM screening of the UBC9 gene encoding the SUMO-E2-conjugating enzyme - case-control study in breast cancer.
Bialik P, Wysokinski D, Slomka M, Morawiec Z, Strapagiel D, Wozniak K. | 05/8/2021 |
| UBC9 coordinates inflammation affecting development of bladder cancer. | UBC9 coordinates inflammation affecting development of bladder cancer.
Huang X, Tao Y, Gao J, Zhou X, Tang S, Deng C, Lai Z, Lin X, Wang Q, Li T., Free PMC Article | 03/20/2021 |
| SUMOylation of the transcription factor ZFHX3 at Lys-2806 requires SAE1, UBC9, and PIAS2 and enhances its stability and function in cell proliferation. | SUMOylation of the transcription factor ZFHX3 at Lys-2806 requires SAE1, UBC9, and PIAS2 and enhances its stability and function in cell proliferation.
Wu R, Fang J, Liu M, A J, Liu J, Chen W, Li J, Ma G, Zhang Z, Zhang B, Fu L, Dong JT., Free PMC Article | 12/26/2020 |
| UBC9 regulates Nav1.5 expression levels in a SUMOylation-independent manner. | UBC9 regulates cardiac sodium channel Na(v)1.5 ubiquitination, degradation and sodium current density.
Tang B, Hu Y, Wang Z, Cheng C, Wang P, Liang L, Xiong H, Luo C, Xu C, Chen Q, Wang QK., Free PMC Article | 06/27/2020 |
| The results indicate that SUMO interacts with VP24 and promotes its USP7-mediated deubiquitination, playing a key role in the interference with the innate immune response mediated by the viral protein. | Regulation of the Ebola Virus VP24 Protein by SUMO.
Vidal S, El Motiam A, Seoane R, Preitakaite V, Bouzaher YH, Gómez-Medina S, San Martín C, Rodríguez D, Rejas MT, Baz-Martínez M, Barrio R, Sutherland JD, Rodríguez MS, Muñoz-Fontela C, Rivas C., Free PMC Article | 06/13/2020 |
| The Ubc9 modulates the function of SLP-76 in T cell activation both by direct interaction and by SUMOylation of SLP-76 and that the Ubc9-SLP-76 module acts as a novel regulatory complex in the control of T cell activation. | Ubc9 Interacts with and SUMOylates the TCR Adaptor SLP-76 for NFAT Transcription in T Cells.
Xiong Y, Yi Y, Wang Y, Yang N, Rudd CE, Liu H. | 05/30/2020 |
| With the aim of investigating RHES 3D structure and function, bioinformatic analyses and molecular modelling have been performed in the present study, based on which, RHES regions predicted to be involved in the interaction with mHtt or the SUMOE2 ligase Ubc9 have been identified. | Bioinformatics analysis of Ras homologue enriched in the striatum, a potential target for Huntington's disease therapy.
Carbo M, Brandi V, Pascarella G, Staid DS, Colotti G, Polticelli F, Ilari A, Morea V., Free PMC Article | 04/18/2020 |
| It demonstrates the enzyme/substrate nature of Ubc9/CRMP2 binding and identify hot spots on CRMP2 that may form the basis of future drug discovery campaigns disrupting the CRMP2-Ubc9 interaction to recapitulate allosteric regulation of NaV1.7 for pain relief. | Chemical shift perturbation mapping of the Ubc9-CRMP2 interface identifies a pocket in CRMP2 amenable for allosteric modulation of Nav1.7 channels.
François-Moutal L, Scott DD, Perez-Miller S, Gokhale V, Khanna M, Khanna R., Free PMC Article | 08/17/2019 |
| Detailed structural, thermodynamic, and kinetics results of the interactions between Ubc9 and its K65 acetylated variant (Ac-Ubc9(K65)) with three NDSMs derived from Elk1, CBP, and Calpain2 were shown to rationalize the mechanism beneath this reduced binding. | Molecular mechanism of K65 acetylation-induced attenuation of Ubc9 and the NDSM interaction.
Naik MT, Kang M, Ho CC, Liao PH, Hsieh YL, Naik NM, Wang SH, Chang I, Shih HM, Huang TH., Free PMC Article | 08/17/2019 |
| Findings suggest that nuclear DNA leakage activates nucleophagy through UBC9-mediated SUMOylation of lamin A/C, leading to degradation of nuclear components including lamin A/C and leaked nuclear DNA. | Nuclear accumulation of UBC9 contributes to SUMOylation of lamin A/C and nucleophagy in response to DNA damage.
Li Y, Jiang X, Zhang Y, Gao Z, Liu Y, Hu J, Hu X, Li L, Shi J, Gao N., Free PMC Article | 06/29/2019 |
| Study demonstrated overexpression of Ubc9 protein in osteosarcoma. Silencing Ubc9 in osteosarcoma cell lines induced decoupling of SUMO1 from Cx43, generating increased free Cx43 levels, which is important for reconstructing gap junction intercellular communication and recovering cellular functions. | Silencing Ubc9 expression suppresses osteosarcoma tumorigenesis and enhances chemosensitivity to HSV-TK/GCV by regulating connexin 43 SUMOylation.
Zhang D, Yu K, Yang Z, Li Y, Ma X, Bian X, Liu F, Li L, Liu X, Wu W. | 12/1/2018 |
| Data show that the forkhead Box Protein P3 (FOXP3) response element at the -310 bp region, but not the -2182 bp region, is mainly required for ubiquitin conjugating enzyme 9 (UBC9) activation by FOXP3. | FOXP3 Activates SUMO-Conjugating UBC9 Gene in MCF7 Breast Cancer Cells.
Wang CM, Yang WH, Liu R, Wang L, Yang WH., Free PMC Article | 11/10/2018 |
| Study provides an insight into the role of the RNF4 to balance the role of SUMO signaling by directly targeting Ubc9 and SUMO E3 ligases. | The STUbL RNF4 regulates protein group SUMOylation by targeting the SUMO conjugation machinery.
Kumar R, González-Prieto R, Xiao Z, Verlaan-de Vries M, Vertegaal ACO., Free PMC Article | 09/22/2018 |
| The SUMO1/UBC9 axis may regulate Nox1mediated diabetic retinopathy by inhibiting reactive oxygen species generation and apoptosis. | SUMO1/UBC9‑decreased Nox1 activity inhibits reactive oxygen species generation and apoptosis in diabetic retinopathy.
Hu J, Xue P, Mao X, Xie L, Li G, You Z., Free PMC Article | 07/21/2018 |
| our results indicate that down-regulation of UBC9 sensitizes cells to anticancer drugs, is possibly associated with the regulation of ERK1/2 and P38 activation and interacts with the intrinsic apoptosis pathway. | Down-regulation of UBC9 increases the sensitivity of hepatocellular carcinoma to doxorubicin.
Fang S, Qiu J, Wu Z, Bai T, Guo W., Free PMC Article | 04/28/2018 |
| Ubc9 is an essential regulator of ADAP where it is required for TCR-induced membrane recruitment of the small GTPase Rap1 and its effector protein RapL and for activation of the small GTPase Rac1 in T cell adhesion. | Ubc9 Binds to ADAP and Is Required for Rap1 Membrane Recruitment, Rac1 Activation, and Integrin-Mediated T Cell Adhesion.
Xiong Y, Ye C, Yang N, Li M, Liu H. | 12/30/2017 |
| Listeriolysin O -induced down-regulation of Ubc9 is independent of Ubc9-SUMO interaction, however, it may involve phosphorylation signaling. | Degradation of nuclear Ubc9 induced by listeriolysin O is dependent on K(+) efflux.
Li J, Lam WW, Lai TW, Au SW. | 10/28/2017 |