| Set7 deletion attenuates isoproterenol-induced cardiac fibrosis and delays cardiac dysfunction. | Set7 deletion attenuates isoproterenol-induced cardiac fibrosis and delays cardiac dysfunction.
Lunardon G, de Oliveira Silva T, Lino CA, Lu YW, Miranda JB, Asprino PF, de Almeida Silva A, Nepomuceno GT, Irigoyen MCC, Carneiro-Ramos MS, Takano APC, Martinho HDS, Barreto-Chaves MLM, Wang DZ, Diniz GP. | 01/28/2023 |
| LncRNA SNHG15 regulates hypoxic-ischemic brain injury via miR-153-3p/SETD7 axis. | LncRNA SNHG15 regulates hypoxic-ischemic brain injury via miR-153-3p/SETD7 axis.
Fu J, Huang Y, Xian L. | 12/17/2022 |
| Loss of SPTBN1 Suppresses Autophagy Via SETD7-mediated YAP Methylation in Hepatocellular Carcinoma Initiation and Development. | Loss of SPTBN1 Suppresses Autophagy Via SETD7-mediated YAP Methylation in Hepatocellular Carcinoma Initiation and Development.
Chen S, Wu H, Wang Z, Jia M, Guo J, Jin J, Li X, Meng D, Lin L, He AR, Zhou P, Zhi X., Free PMC Article | 04/9/2022 |
| SETD7 regulates chondrocyte differentiation and glycolysis via the Hippo signaling pathway and HIF1alpha. | SETD7 regulates chondrocyte differentiation and glycolysis via the Hippo signaling pathway and HIF‑1α.
Li M, Ning J, Wang J, Yan Q, Zhao K, Jia X., Free PMC Article | 02/12/2022 |
| IL-6 regulates the bone metabolism and inflammatory microenvironment in aging mice by inhibiting Setd7. | IL-6 regulates the bone metabolism and inflammatory microenvironment in aging mice by inhibiting Setd7.
Wang J, Chen J, Zhang B, Jia X. | 01/15/2022 |
| SetD7 (Set7/9) is a novel target of PPARgamma that promotes the adaptive pancreatic beta-cell glycemic response. | SetD7 (Set7/9) is a novel target of PPARγ that promotes the adaptive pancreatic β-cell glycemic response.
Jetton TL, Flores-Bringas P, Leahy JL, Gupta D., Free PMC Article | 12/18/2021 |
| SETD7 mediates the vascular invasion in articular cartilage and chondrocytes apoptosis in osteoarthriis. | SETD7 mediates the vascular invasion in articular cartilage and chondrocytes apoptosis in osteoarthriis.
Xiaoshi J, Maoquan L, Jiwei W, Jinqiu N, Ke Z. | 07/31/2021 |
| Murine peritoneal fibrosis was induced by intraperitoneal injection of methylglyoxal (MGO). SET7/9 expression was elevated in MGO-injected mice. | Inhibition of the H3K4 methyltransferase SET7/9 ameliorates peritoneal fibrosis.
Tamura R, Doi S, Nakashima A, Sasaki K, Maeda K, Ueno T, Masaki T., Free PMC Article | 08/11/2018 |
| spinal SET7/9 may contribute to the maintenance of CIBP | Spinal SET7/9 may contribute to the maintenance of cancer-induced bone pain in mice.
Hang LH, Xu ZK, Wei SY, Shu WW, Luo H, Chen J. | 05/5/2018 |
| the methyltransferase Set9 potentiates TGF-beta signaling by targeting Smad7, an inhibitory downstream effector. | SET9-Mediated Regulation of TGF-β Signaling Links Protein Methylation to Pulmonary Fibrosis.
Elkouris M, Kontaki H, Stavropoulos A, Antonoglou A, Nikolaou KC, Samiotaki M, Szantai E, Saviolaki D, Brown PJ, Sideras P, Panayotou G, Talianidis I., Free PMC Article | 10/14/2017 |
| SETD7 plays an important role in intestinal epithelial cell (IEC) biology during infection. | Intestinal Epithelial Cell-Intrinsic Deletion of Setd7 Identifies Role for Developmental Pathways in Immunity to Helminth Infection.
Oudhoff MJ, Antignano F, Chenery AL, Burrows K, Redpath SA, Braam MJ, Perona-Wright G, Zaph C., Free PMC Article | 09/30/2017 |
| We observe Set7-mediated modification of serum response factor (SRF) and mono-methylation of histone H4 lysine 4 (H3K4me1) regulate gene expression. We conclude the broad substrate specificity of Set7 serves to control key transcriptional networks in embryonic stem cells. | Set7 mediated interactions regulate transcriptional networks in embryonic stem cells.
Tuano NK, Okabe J, Ziemann M, Cooper ME, El-Osta A., Free PMC Article | 06/10/2017 |
| SETD7 is required for Wnt-driven intestinal tumorigenesis and regeneration. SETD7-dependent methylation of YAP facilitates Wnt-induced nuclear accumulation of beta-catenin. | SETD7 Controls Intestinal Regeneration and Tumorigenesis by Regulating Wnt/β-Catenin and Hippo/YAP Signaling.
Oudhoff MJ, Braam MJS, Freeman SA, Wong D, Rattray DG, Wang J, Antignano F, Snyder K, Refaeli I, Hughes MR, McNagny KM, Gold MR, Arrowsmith CH, Sato T, Rossi FMV, Tatlock JH, Owen DR, Brown PJ, Zaph C. | 08/20/2016 |
| SET7/9 regulates Nos2 expression through methylation of H3K4 in beta cells. | SET7/9 Enzyme Regulates Cytokine-induced Expression of Inducible Nitric-oxide Synthase through Methylation of Lysine 4 at Histone 3 in the Islet β Cell.
Fujimaki K, Ogihara T, Morris DL, Oda H, Iida H, Fujitani Y, Mirmira RG, Evans-Molina C, Watada H., Free PMC Article | 10/31/2015 |
| Data indicate that the ability of transcription factor Pdx1 to regulate genes in beta cells is partially dependent upon its methylation by methyltransferase Set7/9. | Transcriptional activity of the islet β cell factor Pdx1 is augmented by lysine methylation catalyzed by the methyltransferase Set7/9.
Maganti AV, Maier B, Tersey SA, Sampley ML, Mosley AL, Özcan S, Pachaiyappan B, Woster PM, Hunter CS, Stein R, Mirmira RG., Free PMC Article | 06/27/2015 |
| study found that Set7 is a modifier of the Hippo pathway. Mice that lack Set7 have a larger progenitor compartment in the intestine, coinciding with increased expression of Yes-associated protein target genes. | Control of the hippo pathway by Set7-dependent methylation of Yap.
Oudhoff MJ, Freeman SA, Couzens AL, Antignano F, Kuznetsova E, Min PH, Northrop JP, Lehnertz B, Barsyte-Lovejoy D, Vedadi M, Arrowsmith CH, Nishina H, Gold MR, Rossi FM, Gingras AC, Zaph C. | 11/2/2013 |
| The response to hyperglycemia in vascular endothelial cells involves Set7 mediated changes in chromatin remodeling and gene expression. | Distinguishing hyperglycemic changes by Set7 in vascular endothelial cells.
Okabe J, Orlowski C, Balcerczyk A, Tikellis C, Thomas MC, Cooper ME, El-Osta A. | 06/2/2012 |
| Set7/9 is dispensable for p53 function in the mouse. | The methyltransferase Set7/9 (Setd7) is dispensable for the p53-mediated DNA damage response in vivo.
Campaner S, Spreafico F, Burgold T, Doni M, Rosato U, Amati B, Testa G. | 11/5/2011 |
| Set7/9-mediated methylation of p53 does not represent a major regulatory event and does not appreciably control p53 activity in vivo. | p53-dependent transcription and tumor suppression are not affected in Set7/9-deficient mice.
Lehnertz B, Rogalski JC, Schulze FM, Yi L, Lin S, Kast J, Rossi FM. | 11/5/2011 |
| Define a biological function for Set7 in muscle differentiation and provide a molecular mechanism by which Set7 modulates myogenic transcription factors during muscle differentiation. | The histone methyltransferase Set7/9 promotes myoblast differentiation and myofibril assembly.
Tao Y, Neppl RL, Huang ZP, Chen J, Tang RH, Cao R, Zhang Y, Jin SW, Wang DZ., Free PMC Article | 10/15/2011 |
| Pdx1-dependent Set7/9 expression may be crucial to enhancing chromatin accessibility and transcription of beta-cell genes. | Expression and function of Set7/9 in pancreatic islets.
Ogihara T, Vanderford NL, Maier B, Stein RW, Mirmira RG., Free PMC Article | 04/9/2011 |
| Data conclude that Set7/9 is required for normal beta-cell function, likely through the maintenance of euchromatin structure at genes necessary for glucose-stimulated insulin secretion. | Methyltransferase Set7/9 maintains transcription and euchromatin structure at islet-enriched genes.
Deering TG, Ogihara T, Trace AP, Maier B, Mirmira RG., Free PMC Article | 01/21/2010 |
| ASCOM-MLL3 and ASCOM-MLL4 likely function as crucial but redundant H3K4MT complexes for PPARgamma-dependent adipogenesis | Targeted inactivation of MLL3 histone H3-Lys-4 methyltransferase activity in the mouse reveals vital roles for MLL3 in adipogenesis.
Lee J, Saha PK, Yang QH, Lee S, Park JY, Suh Y, Lee SK, Chan L, Roeder RG, Lee JW., Free PMC Article | 01/21/2010 |
| a novel role for SET7/9 in inflammation and diabetes. | Role of the histone H3 lysine 4 methyltransferase, SET7/9, in the regulation of NF-kappaB-dependent inflammatory genes. Relevance to diabetes and inflammation.
Li Y, Reddy MA, Miao F, Shanmugam N, Yee JK, Hawkins D, Ren B, Natarajan R., Free PMC Article | 01/21/2010 |
| Methylation of p53 by Set7 mediates p53 acetylation and activity in vivo. | Methylation of p53 by Set7/9 mediates p53 acetylation and activity in vivo.
Kurash JK, Lei H, Shen Q, Marston WL, Granda BW, Fan H, Wall D, Li E, Gaudet F. | 01/21/2010 |