| MSK1 is required for the beneficial synaptic and cognitive effects of enriched experience across the lifespan. | MSK1 is required for the beneficial synaptic and cognitive effects of enriched experience across the lifespan.
Morè L, Privitera L, Cooper DD, Tsogka M, Arthur JSC, Frenguelli BG., Free PMC Article | 07/27/2023 |
| Hippocampal MSK1 regulates the behavioral and biological responses of mice to chronic social defeat stress: Involving of the BDNF-CREB signaling and neurogenesis. | Hippocampal MSK1 regulates the behavioral and biological responses of mice to chronic social defeat stress: Involving of the BDNF-CREB signaling and neurogenesis.
Ji CH, Gu JH, Liu Y, Tang WQ, Guan W, Huang J, Chen YM, Xu DW, Jiang B. | 01/22/2022 |
| Dual targeting of brain region-specific kinases potentiates neurological rescue in Spinocerebellar ataxia type 1. | Dual targeting of brain region-specific kinases potentiates neurological rescue in Spinocerebellar ataxia type 1.
Lee WS, Lavery L, Rousseaux MWC, Rutledge EB, Jang Y, Wan YW, Wu SR, Kim W, Al-Ramahi I, Rath S, Adamski CJ, Bondar VV, Tewari A, Soleimani S, Mota S, Yalamanchili HK, Orr HT, Liu Z, Botas J, Zoghbi HY., Free PMC Article | 10/23/2021 |
| Mitogen- and stress-activated protein kinase-1 activation is involved in melanocortin-induced BDNF expression in Neuro2a neuronal cells. | Mitogen- and stress-activated protein kinase-1 activation is involved in melanocortin-induced BDNF expression in Neuro2a neuronal cells.
Zhang W, Wu Y., Free PMC Article | 09/25/2021 |
| Mitogen and Stress-activated Protein Kinase 1 Negatively Regulates Hippocampal Neurogenesis. | Mitogen and Stress-activated Protein Kinase 1 Negatively Regulates Hippocampal Neurogenesis.
Olateju OI, Morè L, Arthur JSC, Frenguelli BG., Free PMC Article | 08/21/2021 |
| Overexpression of the MSK1 Kinase in Patients With Chronic Lung Allograft Dysfunction and Its Confirmed Role in a Murine Model. | Overexpression of the MSK1 Kinase in Patients With Chronic Lung Allograft Dysfunction and Its Confirmed Role in a Murine Model.
Nemska S, Daubeuf F, Obrecht A, Israel-Biet D, Stern M, Kessler R, Roux A, Tavakoli R, Villa P, Tissot A, Danger R, Reber L, Durand E, Foureau A, Brouard S, Magnan A, Frossard N, COLT consortium. | 07/31/2021 |
| Experience Recruits MSK1 to Expand the Dynamic Range of Synapses and Enhance Cognition. | Experience Recruits MSK1 to Expand the Dynamic Range of Synapses and Enhance Cognition.
Privitera L, Morè L, Cooper DD, Richardson P, Tsogka M, Hebenstreit D, Arthur JSC, Frenguelli BG., Free PMC Article | 10/31/2020 |
| These results indicate the relevance of CX3CL1 in the activation of the pro-inflammatory NF-kappaB signalling pathway through MSK1 in microglial cells. | Role of MSK1 in the Induction of NF-κB by the Chemokine CX3CL1 in Microglial Cells.
Galán-Ganga M, García-Yagüe ÁJ, Lastres-Becker I. | 05/11/2019 |
| These data suggest that the kinase activity of MSK1 is not directly required for several forms of synaptic plasticity or spatial learning and memory. | The Kinase Function of MSK1 Regulates BDNF Signaling to CREB and Basal Synaptic Transmission, But Is Not Required for Hippocampal Long-Term Potentiation or Spatial Memory.
Daumas S, Hunter CJ, Mistry RB, Morè L, Privitera L, Cooper DD, Reyskens KM, Flynn HT, Morris RG, Arthur JS, Frenguelli BG., Free PMC Article | 08/4/2018 |
| These data of this study provided important new insights into the mechanism by which the MAPK/MSK1 signaling cassette confers neuroprotection against excitotoxic insults. | Mitogen- and Stress-Activated Protein Kinase 1 Regulates Status Epilepticus-Evoked Cell Death in the Hippocampus.
Choi YS, Horning P, Aten S, Karelina K, Alzate-Correa D, Arthur JSC, Hoyt KR, Obrietan K., Free PMC Article | 05/5/2018 |
| Data suggest that expression of Rps6ka5 in gonadotroph cell line is up-regulated by GnRH signaling and is required for Cga expression; GnRH-activates Rps6ka5 targets at the first nucleosome just downstream from the transcriptional start site. (Rps6ka5= mitogen and stress-activated protein kinase 1; GnRH = gonadotropin-releasing hormone; Cga = gonadotropin alpha subunit) | Mitogen- and stress-activated protein kinase 1 is required for gonadotropin-releasing hormone-mediated activation of gonadotropin α-subunit expression.
Haj M, Wijeweera A, Rudnizky S, Taunton J, Pnueli L, Melamed P., Free PMC Article | 01/27/2018 |
| chromatin modifier, MSK1/2, has a role in suppressing endocrine and promoting acinar differentiation during pancreatic development | The Chromatin Modifier MSK1/2 Suppresses Endocrine Cell Fates during Mouse Pancreatic Development.
Bhat N, Park J, Zoghbi HY, Arthur JS, Zaret KS., Free PMC Article | 07/15/2017 |
| abnormal regulation of MSK1 contributes to the development of L-DOPA-induced dyskinesia and to the concomitant increase in striatal FosB, which may occur via increased histone H3 phosphorylation at the fosB promoter | A Role for Mitogen- and Stress-Activated Kinase 1 in L-DOPA-Induced Dyskinesia and ∆FosB Expression.
Feyder M, Södersten E, Santini E, Vialou V, LaPlant Q, Watts EL, Spigolon G, Hansen K, Caboche J, Nestler EJ, Fisone G., Free PMC Article | 10/22/2016 |
| Accelerated apoptotic death and in vivo turnover of erythrocytes have been found in mice lacking functional MSK1/MSK2. | Accelerated apoptotic death and in vivo turnover of erythrocytes in mice lacking functional mitogen- and stress-activated kinase MSK1/2.
Lang E, Bissinger R, Fajol A, Salker MS, Singh Y, Zelenak C, Ghashghaeinia M, Gu S, Jilani K, Lupescu A, Reyskens KM, Ackermann TF, Föller M, Schleicher E, Sheffield WP, Arthur JS, Lang F, Qadri SM., Free PMC Article | 09/24/2016 |
| Results suggest that MSK1/2 plays a significant role in the regulation of ischemia-induced progenitor cell proliferation and neurogenesis | Mitogen and stress-activated kinases 1/2 regulate ischemia-induced hippocampal progenitor cell proliferation and neurogenesis.
Karelina K, Liu Y, Alzate-Correa D, Wheaton KL, Hoyt KR, Arthur JS, Obrietan K., Free PMC Article | 01/2/2016 |
| MSK1 has a role in malignant transformation and skin cancer development, but is inhibited by chrysin derivative 69407 | A derivative of chrysin suppresses two-stage skin carcinogenesis by inhibiting mitogen- and stress-activated kinase 1.
Liu H, Hwang J, Li W, Choi TW, Liu K, Huang Z, Jang JH, Thimmegowda NR, Lee KW, Ryoo IJ, Ahn JS, Bode AM, Zhou X, Yang Y, Erikson RL, Kim BY, Dong Z., Free PMC Article | 09/13/2014 |
| the impact of MSK1 on glucocorticoid receptor-mediated transactivation | Mitogen- and stress-activated protein kinase 1 MSK1 regulates glucocorticoid response element promoter activity in a glucocorticoid concentration-dependent manner.
Beck IM, Clarisse D, Bougarne N, Okret S, Haegeman G, De Bosscher K. | 04/19/2014 |
| MSK1 is an important novel molecule involved in RANKL signaling and osteoclast differentiation | Mitogen- and stress-activated protein kinase 1 activates osteoclastogenesis in vitro and affects bone destruction in vivo.
Ha J, Kim HJ, Huang H, Lee ZH, Kim HH. | 10/26/2013 |
| MSK1/2 knockout results in reduced IL-10 secretion. | MSK1 and MSK2 inhibit lipopolysaccharide-induced prostaglandin production via an interleukin-10 feedback loop.
MacKenzie KF, Van Den Bosch MW, Naqvi S, Elcombe SE, McGuire VA, Reith AD, Blackshear PJ, Dean JL, Arthur JS., Free PMC Article | 08/3/2013 |
| MSK1-deficient mice exhibit a decreased capacity to entrain to a new light cycle, attenuated Period1 expression, histone phosporylation and CREB phosphorylation. | Mitogen- and stress-activated protein kinase 1 modulates photic entrainment of the suprachiasmatic circadian clock.
Cao R, Butcher GQ, Karelina K, Arthur JS, Obrietan K., Free PMC Article | 06/15/2013 |
| these data reveal that MSK1 serves as a critical regulator of hippocampal physiology and function | MSK1 regulates environmental enrichment-induced hippocampal plasticity and cognitive enhancement.
Karelina K, Hansen KF, Choi YS, DeVries AC, Arthur JS, Obrietan K., Free PMC Article | 04/27/2013 |
| data reveal a critical role for MSK1/2 as regulators of both basal and activity-dependent progenitor cell proliferation and morphological maturation in the subgranular zone | Mitogen- and stress-activated kinases regulate progenitor cell proliferation and neuron development in the adult dentate gyrus.
Choi YS, Karelina K, Alzate-Correa D, Hoyt KR, Impey S, Arthur JS, Obrietan K., Free PMC Article | 01/12/2013 |
| This study demonstrated that MSK1 is an integral part of a signaling pathway that underlies the adaptive response to synaptic and environmental experience. | MSK1 regulates homeostatic and experience-dependent synaptic plasticity.
Corrêa SA, Hunter CJ, Palygin O, Wauters SC, Martin KJ, McKenzie C, McKelvey K, Morris RG, Pankratov Y, Arthur JS, Frenguelli BG., Free PMC Article | 12/8/2012 |
| by suppression of both NF-kappaB and ERK1/2-MSK1 signaling, DMF inhibits maturation of DCs and subsequently Th1 and Th17 cell differentiation. | Dimethyl fumarate inhibits dendritic cell maturation via nuclear factor κB (NF-κB) and extracellular signal-regulated kinase 1 and 2 (ERK1/2) and mitogen stress-activated kinase 1 (MSK1) signaling.
Peng H, Guerau-de-Arellano M, Mehta VB, Yang Y, Huss DJ, Papenfuss TL, Lovett-Racke AE, Racke MK., Free PMC Article | 11/17/2012 |
| MSK1 is an important downstream kinase involved in CS-induced NF-kappaB activation | Mitogen- and stress-activated kinase 1 (MSK1) regulates cigarette smoke-induced histone modifications on NF-κB-dependent genes.
Sundar IK, Chung S, Hwang JW, Lapek JD Jr, Bulger M, Friedman AE, Yao H, Davie JR, Rahman I., Free PMC Article | 06/16/2012 |