| Human TYRP1: Two functions for a single gene? | Human TYRP1: Two functions for a single gene?
Gautron A, Migault M, Bachelot L, Corre S, Galibert MD, Gilot D. | 02/5/2022 |
| Association of TYRP1 with hypoxia and its correlation with patient outcome in uveal melanoma. | Association of TYRP1 with hypoxia and its correlation with patient outcome in uveal melanoma.
Jha J, Singh MK, Singh L, Pushker N, Lomi N, Meel R, Chosdol K, Sen S, Bakhshi S, Kashyap S. | 12/11/2021 |
| Identification of TYR, TYRP1, DCT and LARP7 as related biomarkers and immune infiltration characteristics of vitiligo via comprehensive strategies. | Identification of TYR, TYRP1, DCT and LARP7 as related biomarkers and immune infiltration characteristics of vitiligo via comprehensive strategies.
Zhang J, Yu R, Guo X, Zou Y, Chen S, Zhou K, Chen Y, Li Y, Gao S, Wu Y., Free PMC Article | 11/27/2021 |
| Tyrp1 Mutant Variants Associated with OCA3: Computational Characterization of Protein Stability and Ligand Binding. | Tyrp1 Mutant Variants Associated with OCA3: Computational Characterization of Protein Stability and Ligand Binding.
Patel MH, Dolinska MB, Sergeev YV., Free PMC Article | 10/30/2021 |
| Evaluation of the effect of narrow band-ultraviolet B on the expression of tyrosinase, TYRP-1, and TYRP-2 mRNA in vitiligo skin and their correlations with clinical improvement: A retrospective study. | Evaluation of the effect of narrow band-ultraviolet B on the expression of tyrosinase, TYRP-1, and TYRP-2 mRNA in vitiligo skin and their correlations with clinical improvement: A retrospective study.
Awad SS, Moftah NH, Rashed LA, Touni AA, Telep RAA. | 06/5/2021 |
| Association between brown eye colour in rs12913832:GG individuals and SNPs in TYR, TYRP1, and SLC24A4. | Association between brown eye colour in rs12913832:GG individuals and SNPs in TYR, TYRP1, and SLC24A4.
Meyer OS, Lunn MMB, Garcia SL, Kjærbye AB, Morling N, Børsting C, Andersen JD., Free PMC Article | 11/21/2020 |
| Protein Stability and Functional Characterization of Intra-Melanosomal Domain of Human Recombinant Tyrosinase-Related Protein 1. | Protein Stability and Functional Characterization of Intra-Melanosomal Domain of Human Recombinant Tyrosinase-Related Protein 1.
Dolinska MB, Young KL 2nd, Kassouf C, Dimitriadis EK, Wingfield PT, Sergeev YV., Free PMC Article | 09/12/2020 |
| the recombinant human intra-melanosomal domains of tyrosinase, TYRtr (19-469), and tyrosinase-related protein 1, TYRP1tr (25-472), were studied in vitro to define their functional relationship. | The TYRP1-mediated protection of human tyrosinase activity does not involve stable interactions of tyrosinase domains.
Dolinska MB, Wingfield PT, Young KL 2nd, Sergeev YV., Free PMC Article | 06/27/2020 |
| catalytic pathway starts with the tyrosinase HsTYR and two tyrosinase-related proteins HsTYRP1 and HsTYRP2. All three enzymes have the same active site but the latter two contain two zinc ions instead of copper ions | The Recent Crystal Structure of Human Tyrosinase Related Protein 1 (HsTYRP1) Solves an Old Problem and Poses a New One.
Decker H, Tuczek F. | 04/20/2019 |
| The rs387907171 SNP in TYRP1 exhibits strong allele frequency differences among islands in Northern Island Melanesia. Its absence from Bougainville, as well as the weak association with decreased hair color, indicates that additional alleles contribute to the blondism phenotype. | The rs387907171 SNP in TYRP1 is not associated with blond hair color on the Island of Bougainville.
Norton HL, Hanna M, Werren E, Friedlaender J. | 12/16/2017 |
| TYRP1-dependent miR-16 sequestration can also be overcome in vivo by using small oligonucleotides that mask miR-16-binding sites on TYRP1 mRNA. | A non-coding function of TYRP1 mRNA promotes melanoma growth.
Gilot D, Migault M, Bachelot L, Journé F, Rogiers A, Donnou-Fournet E, Mogha A, Mouchet N, Pinel-Marie ML, Mari B, Montier T, Corre S, Gautron A, Rambow F, El Hajj P, Ben Jouira R, Tartare-Deckert S, Marine JC, Felden B, Ghanem G, Galibert MD. | 11/11/2017 |
| The mRNA of TYRP1 is now found to sequester the tumour suppressor miR-16. | TYRP1 mRNA goes fishing for miRNAs in melanoma.
Soengas MS, Hernando E. | 11/11/2017 |
| DNA sequencing showed that the patient has carried compound heterozygous mutations of the tyrosinase related protein (TYRP1) gene, namely c.1214C>A (p.T405N) and c.1333dupG, which were inherited from his mother and father, respectively. | [Diagnosis of a case with oculocutaneous albinism type Ⅲ with next generation exome capture sequencing].
Lyu Y, Huang J, Zhang K, Liu G, Gao M, Gai Z, Liu Y. | 07/1/2017 |
| Single nucleotide polymorphisms in TYRP1 gene is associated with multiple primary melanoma. | Inherited genetic variants associated with occurrence of multiple primary melanoma.
Gibbs DC, Orlow I, Kanetsky PA, Luo L, Kricker A, Armstrong BK, Anton-Culver H, Gruber SB, Marrett LD, Gallagher RP, Zanetti R, Rosso S, Dwyer T, Sharma A, La Pilla E, From L, Busam KJ, Cust AE, Ollila DW, Begg CB, Berwick M, Thomas NE, GEM Study Group., Free PMC Article | 02/27/2016 |
| Mutation in TYRP1 is associated with oculocutaneous albinism. | [Suspected pathogenic mutation identified in two cases with oculocutaneous albinism].
He J, Zheng M, Zhang G, Hua A. | 11/21/2015 |
| Polymorphisms in 3'UTR of TYRP1 mRNA can affect TYRP1 mRNA regulation by miR-155 and its subsequent translation into protein. These SNPs can render TYRP1 mRNA and protein expression nonsusceptible to miR-155 activity | SNPs at miR-155 binding sites of TYRP1 explain discrepancy between mRNA and protein and refine TYRP1 prognostic value in melanoma.
El Hajj P, Gilot D, Migault M, Theunis A, van Kempen LC, Salés F, Fayyad-Kazan H, Badran B, Larsimont D, Awada A, Bachelot L, Galibert MD, Ghanem G, Journe F., Free PMC Article | 09/12/2015 |
| These data suggest that UVB-stimulated Ucn1 contributes to TRP1 production via the transcription of both Nurr-1 and Nur77. Ucn1, produced in melanoma cells, acts on melanoma cells themselves in an autocrine manner. | Ultraviolet B radiation-stimulated urocortin 1 is involved in tyrosinase-related protein 1 production in human melanoma HMV-II cells.
Watanuki Y, Kageyama K, Takayasu S, Matsuzaki Y, Iwasaki Y, Daimon M. | 08/1/2015 |
| These data indicate that galectin-3 is a regulatory component in melanin synthesis affecting the expression of Tyrp-1. | Melanocytic galectin-3 is associated with tyrosinase-related protein-1 and pigment biosynthesis.
Chalupa A, Koshoffer A, Galan E, Yu L, Liu FT, Boissy RE., Free PMC Article | 02/28/2015 |
| p53 regulation by TRP2 is not pervasive in melanoma. | p53 regulation by TRP2 is not pervasive in melanoma.
Houben R, Schmid CP, Maier M, Wobser M, Motschenbacher S, Becker JC, Vetter-Kauczok CS, Weyandt G, Hesbacher S, Haferkamp S., Free PMC Article | 10/4/2014 |
| Due to mutation in Tyrp1 protein, it became more rigid and might disturb the structural conformation and catalytic function of the structure and might also play a significant role in inducing oculocutaneous albinism type III. | In silico screening and molecular dynamics simulation of disease-associated nsSNP in TYRP1 gene and its structural consequences in OCA3.
Kamaraj B, Purohit R., Free PMC Article | 02/8/2014 |
| in human melanoma HMV-II cells both CRF and Ucn1 regulate TRP1 gene expression via Nurr-1/Nur77 production, independent of pro-opiomelanocortin or alpha-melanocyte-stimulating hormone stimulation. | Involvement of Nurr-1/Nur77 in corticotropin-releasing factor/urocortin1-induced tyrosinase-related protein 1 gene transcription in human melanoma HMV-II cells.
Watanuki Y, Takayasu S, Kageyama K, Iwasaki Y, Sakihara S, Terui K, Nigawara T, Suda T. | 12/14/2013 |
| High TYRP1/S100B mRNA expression in lymph node metastases from melanoma patients is associated with unfavourable clinical outcome. | Tyrosinase-related protein 1 mRNA expression in lymph node metastases predicts overall survival in high-risk melanoma patients.
El Hajj P, Journe F, Wiedig M, Laios I, Salès F, Galibert MD, Van Kempen LC, Spatz A, Badran B, Larsimont D, Awada A, Ghanem G., Free PMC Article | 07/20/2013 |
| We report four Pakistani albinism mutations, including three SLC45A2 alleles and one 22-nucleotide deletion in TYRP1. | Genetic studies of TYRP1 and SLC45A2 in Pakistani patients with nonsyndromic oculocutaneous albinism.
Kausar T, Jaworek TJ, Tariq N, Sadia S, Ali M, Shaikh RS, Ahmed ZM. | 05/11/2013 |
| The results suggested that the miRNAs may be involved in MITF regulation of TYR, TYRP1 and TYRP2, which provides a new clue for understanding the role of miRNAs in melanocyte dysfunctional disease. | The changes of microRNA expression profiles and tyrosinase related proteins in MITF knocked down melanocytes.
Wang P, Li Y, Hong W, Zhen J, Ren J, Li Z, Xu A. | 03/2/2013 |
| identifed an arginine-to-cysteine change at a highly conserved residue in TYRP1 as a major determinant of blond hair in Solomon Islanders; this missense mutation predicted to affect catalytic activity of TYRP1 and causes blond hair through a recessive mode of inheritance | Melanesian blond hair is caused by an amino acid change in TYRP1.
Kenny EE, Timpson NJ, Sikora M, Yee MC, Moreno-Estrada A, Eng C, Huntsman S, Burchard EG, Stoneking M, Bustamante CD, Myles S., Free PMC Article | 11/24/2012 |