| Histone chaperone HIRA, promyelocytic leukemia protein, and p62/SQSTM1 coordinate to regulate inflammation during cell senescence. | Histone chaperone HIRA, promyelocytic leukemia protein, and p62/SQSTM1 coordinate to regulate inflammation during cell senescence.
Dasgupta N, Lei X, Shi CH, Arnold R, Teneche MG, Miller KN, Rajesh A, Davis A, Anschau V, Campos AR, Gilson R, Havas A, Yin S, Chua ZM, Liu T, Proulx J, Alcaraz M, Rather MI, Baeza J, Schultz DC, Yip KY, Berger SL, Adams PD., | 09/16/2024 |
| Histone H3.3 chaperone HIRA renders stress-responsive genes poised for prospective lethal stresses in acquired tolerance. | Histone H3.3 chaperone HIRA renders stress-responsive genes poised for prospective lethal stresses in acquired tolerance.
Nagagaki Y, Kozakura Y, Mahandaran T, Fumoto Y, Nakato R, Shirahige K, Ishikawa F. | 09/13/2024 |
| Disparity of gene expression in coronary artery disease: insights from MEIS1, HIRA, and Myocardin. | Disparity of gene expression in coronary artery disease: insights from MEIS1, HIRA, and Myocardin.
Javanshir E, Ebrahimi ZJ, Mirzohreh ST, Ghaffari S, Banisefid E, Alamdari NM, Roshanravan N. | 06/10/2024 |
| HIRA-mediated loading of histone variant H3.3 controls androgen-induced transcription by regulation of AR/BRD4 complex assembly at enhancers. | HIRA-mediated loading of histone variant H3.3 controls androgen-induced transcription by regulation of AR/BRD4 complex assembly at enhancers.
Morozov VM, Riva A, Sarwar S, Kim WJ, Li J, Zhou L, Licht JD, Daaka Y, Ishov AM., Free PMC Article | 11/1/2023 |
| Interplay between PML NBs and HIRA for H3.3 dynamics following type I interferon stimulus. | Interplay between PML NBs and HIRA for H3.3 dynamics following type I interferon stimulus.
Kleijwegt C, Bressac F, Seurre C, Bouchereau W, Cohen C, Texier P, Simonet T, Schaeffer L, Lomonte P, Corpet A., Free PMC Article | 06/12/2023 |
| HIRA Supports Hepatitis B Virus Minichromosome Establishment and Transcriptional Activity in Infected Hepatocytes. | HIRA Supports Hepatitis B Virus Minichromosome Establishment and Transcriptional Activity in Infected Hepatocytes.
Locatelli M, Quivy JP, Chapus F, Michelet M, Fresquet J, Maadadi S, Aberkane AN, Diederichs A, Lucifora J, Rivoire M, Almouzni G, Testoni B, Zoulim F., Free PMC Article | 09/3/2022 |
| Haploinsufficiency of the HIRA gene may not always produce severe neurodevelopmental consequences. | Haploinsufficiency of the HIRA gene may not always produce severe neurodevelopmental consequences.
Curtis D. | 01/22/2022 |
| HIRA contributes to zygote formation in mice and is implicated in human 1PN zygote phenotype. | HIRA contributes to zygote formation in mice and is implicated in human 1PN zygote phenotype.
Smith R, Pickering SJ, Kopakaki A, Thong KJ, Anderson RA, Lin CJ., Free PMC Article | 01/8/2022 |
| DNA methylation mediated downregulation of histone H3 variant H3.3 affects cell proliferation contributing to the development of HCC. | DNA methylation mediated downregulation of histone H3 variant H3.3 affects cell proliferation contributing to the development of HCC.
Reddy D, Bhattacharya S, Shah S, Rashid M, Gupta S. | 01/1/2022 |
| Dissecting regulatory pathways for transcription recovery following DNA damage reveals a non-canonical function of the histone chaperone HIRA. | Dissecting regulatory pathways for transcription recovery following DNA damage reveals a non-canonical function of the histone chaperone HIRA.
Bouvier D, Ferrand J, Chevallier O, Paulsen MT, Ljungman M, Polo SE., Free PMC Article | 07/24/2021 |
| Histone Loaders CAF1 and HIRA Restrict Epstein-Barr Virus B-Cell Lytic Reactivation. | Histone Loaders CAF1 and HIRA Restrict Epstein-Barr Virus B-Cell Lytic Reactivation.
Zhang Y, Jiang C, Trudeau SJ, Narita Y, Zhao B, Teng M, Guo R, Gewurz BE., Free PMC Article | 07/24/2021 |
| Haploinsufficiency of the HIRA gene located in the 22q11 deletion syndrome region is associated with abnormal neurodevelopment and impaired dendritic outgrowth. | Haploinsufficiency of the HIRA gene located in the 22q11 deletion syndrome region is associated with abnormal neurodevelopment and impaired dendritic outgrowth.
Jeanne M, Vuillaume ML, Ung DC, Vancollie VE, Wagner C, Collins SC, Vonwill S, Haye D, Chelloug N, Pfundt R, Kummeling J, Moizard MP, Marouillat S, Kleefstra T, Yalcin B, Laumonnier F, Toutain A. | 05/15/2021 |
| Two HIRA-dependent pathways mediate H3.3 de novo deposition and recycling during transcription. | Two HIRA-dependent pathways mediate H3.3 de novo deposition and recycling during transcription.
Torné J, Ray-Gallet D, Boyarchuk E, Garnier M, Le Baccon P, Coulon A, Orsi GA, Almouzni G. | 02/2/2021 |
| H3.3 chaperones HIRA and DAXX promote ectopic CENP-A deposition. | HJURP antagonizes CENP-A mislocalization driven by the H3.3 chaperones HIRA and DAXX.
Nye J, Sturgill D, Athwal R, Dalal Y., Free PMC Article | 04/6/2019 |
| analysis of the trimeric HIRA, UBN1 and CABIN1 H3.3 histone chaperone complex | Functional activity of the H3.3 histone chaperone complex HIRA requires trimerization of the HIRA subunit.
Ray-Gallet D, Ricketts MD, Sato Y, Gupta K, Boyarchuk E, Senda T, Marmorstein R, Almouzni G., Free PMC Article | 01/12/2019 |
| These data show that HIRA phosphorylation limits the expression of myogenic genes, while the dephosphorylation of HIRA is required for proficient H3.3 deposition and gene activation, demonstrating that the phosphorylation switch is exploited to modulate HIRA/H3.3-mediated muscle gene regulation during myogenesis. | Differential regulation of the histone chaperone HIRA during muscle cell differentiation by a phosphorylation switch.
Yang JH, Song TY, Jo C, Park J, Lee HY, Song I, Hong S, Jung KY, Kim J, Han JW, Youn HD, Cho EJ., Free PMC Article | 01/20/2018 |
| Data show that histone chaperone HIRA co-localizes with viral genomes, binds to incoming viral and deposits histone H3.3 onto these. | Histone chaperone HIRA deposits histone H3.3 onto foreign viral DNA and contributes to anti-viral intrinsic immunity.
Rai TS, Glass M, Cole JJ, Rather MI, Marsden M, Neilson M, Brock C, Humphreys IR, Everett RD, Adams PD., Free PMC Article | 12/16/2017 |
| Chromatin reassembly during double-strand break repair was dependent on the HIRA histone chaperone that is specific to the replication-independent histone variant H3.3 and on CAF-1 that is specific to the replication-dependent canonical histones H3.1/H3.2. | Nucleosome disassembly during human non-homologous end joining followed by concerted HIRA- and CAF-1-dependent reassembly.
Li X, Tyler JK., Free PMC Article | 11/25/2017 |
| RPA, best known for its role in DNA replication and repair, recruits HIRA to promoters and enhancers and regulates deposition of newly synthesized H3.3 to these regulatory elements for gene regulation. | RPA Interacts with HIRA and Regulates H3.3 Deposition at Gene Regulatory Elements in Mammalian Cells.
Zhang H, Gan H, Wang Z, Lee JH, Zhou H, Ordog T, Wold MS, Ljungman M, Zhang Z., Free PMC Article | 10/7/2017 |
| H3.Y discriminates between HIRA and DAXX chaperone complexes and reveals unexpected insights into human DAXX-H3.3-H4 binding and deposition requirements. | H3.Y discriminates between HIRA and DAXX chaperone complexes and reveals unexpected insights into human DAXX-H3.3-H4 binding and deposition requirements.
Zink LM, Delbarre E, Eberl HC, Keilhauer EC, Bönisch C, Pünzeler S, Bartkuhn M, Collas P, Mann M, Hake SB., Free PMC Article | 09/23/2017 |
| PHB has an unexpected nuclear role in human embryonic stem cells that is required for self-renewal and that it acts with HIRA in chromatin organization to link epigenetic organization to a metabolic circuit. | PHB Associates with the HIRA Complex to Control an Epigenetic-Metabolic Circuit in Human ESCs.
Zhu Z, Li C, Zeng Y, Ding J, Qu Z, Gu J, Ge L, Tang F, Huang X, Zhou C, Wang P, Zheng D, Jin Y. | 08/5/2017 |
| The abnormal lower expression of the HIRA gene in the myocardium may participate in the pathogenesis of Tetralogy of Fallot. | HIRA Gene is Lower Expressed in the Myocardium of Patients with Tetralogy of Fallot.
Ju ZR, Wang HJ, Ma XJ, Ma D, Huang GY., Free PMC Article | 03/4/2017 |
| These results support a model in which OGT modifies HIRA to regulate HIRA-H3.3 complex formation and H3.3 nucleosome assembly and reveal the mechanism by which OGT functions in cellular senescence. | O-linked N-acetylglucosamine transferase (OGT) interacts with the histone chaperone HIRA complex and regulates nucleosome assembly and cellular senescence.
Lee JS, Zhang Z., Free PMC Article | 01/28/2017 |
| HIRA controls a specialized, dynamic H4K16ac-decorated chromatin landscape in senescent cells and enforces tumor suppression. | HIRA orchestrates a dynamic chromatin landscape in senescence and is required for suppression of neoplasia.
Rai TS, Cole JJ, Nelson DM, Dikovskaya D, Faller WJ, Vizioli MG, Hewitt RN, Anannya O, McBryan T, Manoharan I, van Tuyn J, Morrice N, Pchelintsev NA, Ivanov A, Brock C, Drotar ME, Nixon C, Clark W, Sansom OJ, Anderson KI, King A, Blyth K, Adams PD., Free PMC Article | 02/14/2015 |
| Mechanistic studies reveal that HIRA accumulates at sites of UVC irradiation upon detection of DNA damage prior to repair and deposits newly synthesized H3.3 histones. This local action of HIRA depends on ubiquitylation events associated with damage recognition. | Transcription recovery after DNA damage requires chromatin priming by the H3.3 histone chaperone HIRA.
Adam S, Polo SE, Almouzni G. | 11/30/2013 |