| Shared behavioural impairments in visual perception and place avoidance across different autism models are driven by periaqueductal grey hypoexcitability in Setd5 haploinsufficient mice. | Shared behavioural impairments in visual perception and place avoidance across different autism models are driven by periaqueductal grey hypoexcitability in Setd5 haploinsufficient mice.
Burnett LE, Koppensteiner P, Symonova O, Masson T, Vega-Zuniga T, Contreras X, Rülicke T, Shigemoto R, Novarino G, Joesch M., Free PMC Article | 07/10/2024 |
| SETD5 haploinsufficiency affects mitochondrial compartment in neural cells. | SETD5 haploinsufficiency affects mitochondrial compartment in neural cells.
Zaghi M, Longo F, Massimino L, Rubio A, Bido S, Mazzara PG, Bellini E, Banfi F, Podini P, Maltecca F, Zippo A, Broccoli V, Sessa A., Free PMC Article | 06/7/2023 |
| Setd5, but not Setd2, is indispensable for retinal cell survival and proliferation. | Setd5, but not Setd2, is indispensable for retinal cell survival and proliferation.
Iwagawa T, Kawabata R, Fukushima M, Kuribayashi H, Watanabe S. | 02/24/2023 |
| Setd5 is required in cardiopharyngeal mesoderm for heart development and its haploinsufficiency is associated with outflow tract defects in mouse. | Setd5 is required in cardiopharyngeal mesoderm for heart development and its haploinsufficiency is associated with outflow tract defects in mouse.
Cheung MY, Roberts C, Scambler P, Stathopoulou A., Free PMC Article | 02/19/2022 |
| Spatiotemporal dynamics of SETD5-containing NCoR-HDAC3 complex determines enhancer activation for adipogenesis. | Spatiotemporal dynamics of SETD5-containing NCoR-HDAC3 complex determines enhancer activation for adipogenesis.
Matsumura Y, Ito R, Yajima A, Yamaguchi R, Tanaka T, Kawamura T, Magoori K, Abe Y, Uchida A, Yoneshiro T, Hirakawa H, Zhang J, Arai M, Yang C, Yang G, Takahashi H, Fujihashi H, Nakaki R, Yamamoto S, Ota S, Tsutsumi S, Inoue SI, Kimura H, Wada Y, Kodama T, Inagaki T, Osborne TF, Aburatani H, Node K, Sakai J., Free PMC Article | 01/8/2022 |
| Setd5 haploinsufficiency impairs the proliferative dynamics of neural progenitors and synaptic wiring of neurons, ultimately resulting in behavioral deficits in mice. Setd5 gene loss leads to abnormal transcription, with impaired RNA maturation causing detrimental effects on gene integrity and splicing. | SETD5 Regulates Chromatin Methylation State and Preserves Global Transcriptional Fidelity during Brain Development and Neuronal Wiring.
Sessa A, Fagnocchi L, Mastrototaro G, Massimino L, Zaghi M, Indrigo M, Cattaneo S, Martini D, Gabellini C, Pucci C, Fasciani A, Belli R, Taverna S, Andreazzoli M, Zippo A, Broccoli V. | 04/11/2020 |
| A specific subpopulation of fetal Setd5(+/-) cortical neurons showed altered gene expression of neurodevelopment-related genes. Setd5(+/-) animals manifested several autism-like behaviors, including hyperactivity, cognitive deficit, and altered social interactions. Anatomical differences were observed in Setd5(+/-) adult brains, accompanied by a deficit of deep-layer cortical neurons in the developing brain. | Setd5 haploinsufficiency alters neuronal network connectivity and leads to autistic-like behaviors in mice.
Moore SM, Seidman JS, Ellegood J, Gao R, Savchenko A, Troutman TD, Abe Y, Stender J, Lee D, Wang S, Voytek B, Lerch JP, Suh H, Glass CK, Muotri AR., Free PMC Article | 05/25/2019 |
| Setd5-haploinsufficient mice present abnormal brain-to-body weight ratios and neural crest defect-associated phenotypes. Setd5-mutant mice show impairments in cognitive tasks, enhanced LTP, delayed ontogenetic profile of ultrasonic vocalization, and behavioral inflexibility. Behavioral issues are accompanied by abnormal expression of postsynaptic density proteins previously associated with cognition. | Haploinsufficiency of the intellectual disability gene SETD5 disturbs developmental gene expression and cognition.
Deliu E, Arecco N, Morandell J, Dotter CP, Contreras X, Girardot C, Käsper EL, Kozlova A, Kishi K, Chiaradia I, Noh KM, Novarino G. | 05/18/2019 |
| Both SetD5 and BRD2 bind to the transcription start site and to upstream promoter regions of the Sema3a locus and BRD2 is necessary for the regulation of Sema3A expression by SetD5. | miR-126-5p promotes retinal endothelial cell survival through SetD5 regulation in neurons.
Villain G, Poissonnier L, Noueihed B, Bonfils G, Rivera JC, Chemtob S, Soncin F, Mattot V. | 03/31/2018 |
| The findings suggest that SETD5 is essential for regulating histone acetylation during gene transcription and plays a vital role in mammalian embryonic development, and cell cycle progression. | Setd5 is essential for mammalian development and the co-transcriptional regulation of histone acetylation.
Osipovich AB, Gangula R, Vianna PG, Magnuson MA., Free PMC Article | 09/16/2017 |
| our data suggest that Setd5 is required for maintaining PGC-associated genes and Setd5-associated protein complexes containing Tbl1xr1 and Ctr9, which in turn are likely involved in regulating germ cell-related genes in mESCs | SET domain-containing protein 5 is required for expression of primordial germ cell specification-associated genes in murine embryonic stem cells.
Yu SE, Kim MS, Park SH, Yoo BC, Kim KH, Jang YK. | 08/19/2017 |