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    TUBG1 tubulin gamma 1 [ Homo sapiens (human) ]

    Gene ID: 7283, updated on 5-May-2024

    GeneRIFs: Gene References Into Functions

    GeneRIFPubMed TitleDate
    TuBG1 promotes hepatocellular carcinoma via ATR/P53-apoptosis and cycling pathways.

    TuBG1 promotes hepatocellular carcinoma via ATR/P53-apoptosis and cycling pathways.
    Zhang Y, Wang ZZ, Han AQ, Yang MY, Zhu LX, Pan FM, Wang Y.

    03/11/2024
    Centrosome Movements Are TUBG1-Dependent.

    Centrosome Movements Are TUBG1-Dependent.
    Malycheva D, Alvarado-Kristensson M., Free PMC Article

    09/14/2023
    Upregulation of TUBG1 expression promotes hepatocellular carcinoma development.

    Upregulation of TUBG1 expression promotes hepatocellular carcinoma development.
    Wang ZJ, Dai ZZ, Hu MZ, Liu JN, Liang H, Shen MM, Zhu SJ, Sheng HJ, Gao J, Huang AL, Tang KF.

    02/23/2023
    Microtubule-associated proteins promote microtubule generation in the absence of gamma-tubulin in human colon cancer cells.

    Microtubule-associated proteins promote microtubule generation in the absence of γ-tubulin in human colon cancer cells.
    Tsuchiya K, Goshima G., Free PMC Article

    12/25/2021
    Biochemical reconstitutions reveal principles of human gamma-TuRC assembly and function.

    Biochemical reconstitutions reveal principles of human γ-TuRC assembly and function.
    Wieczorek M, Ti SC, Urnavicius L, Molloy KR, Aher A, Chait BT, Kapoor TM., Free PMC Article

    09/11/2021
    Gravin-associated kinase signaling networks coordinate gamma-tubulin organization at mitotic spindle poles.

    Gravin-associated kinase signaling networks coordinate γ-tubulin organization at mitotic spindle poles.
    Bucko PJ, Garcia I, Manocha R, Bhat A, Wordeman L, Scott JD., Free PMC Article

    02/6/2021
    TACC3 phosphorylation stabilizes gamma- tubulin ring complex assembly and thereby regulates formation of centrosomal asters.

    Aurora A site specific TACC3 phosphorylation regulates astral microtubule assembly by stabilizing γ-tubulin ring complex.
    Rajeev R, Singh P, Asmita A, Anand U, Manna TK., Free PMC Article

    05/9/2020
    Data present two patients with novel de novo tubulin gamma 1 (TUBG1) mutations with milder neurodevelopmental disorders.

    Case reports: novel TUBG1 mutations with milder neurodevelopmental presentations.
    Yuen YTK, Guella I, Roland E, Sargent M, Boelman C., Free PMC Article

    10/5/2019
    Study investigated the consequences of four human malformations of cortical development-related TUBG1 variants by using in utero electroporation and a knock-in Tubg1Y92C/+ mouse model and show that pathogenic TUBG1 variants affect neuronal positioning by disrupting neuronal migration and affecting microtubule dynamics rather than centrosomal positioning or nucleation ability.

    TUBG1 missense variants underlying cortical malformations disrupt neuronal locomotion and microtubule dynamics but not neurogenesis.
    Ivanova EL, Gilet JG, Sulimenko V, Duchon A, Rudolf G, Runge K, Collins SC, Asselin L, Broix L, Drouot N, Tilly P, Nusbaum P, Vincent A, Magnant W, Skory V, Birling MC, Pavlovic G, Godin JD, Yalcin B, Hérault Y, Dráber P, Chelly J, Hinckelmann MV., Free PMC Article

    06/15/2019
    Our findings suggest that level of gamma-tubulin expression may have an impact on patient survival at more advanced non-small cell lung cancer stages

    Expression of γ-tubulin in non-small cell lung cancer and effect on patient survival.
    Maounis NF, Dráberová E, Trakas N, Chorti M, Riga D, Tzannis K, Kanakis M, Voralu K, Ellina E, Mahera E, Demonakou M, Lioulias A, Dráber P, Katsetos CD.

    05/11/2019
    Four novel heterozygous variants in TUBG1 were identified in patients with malformations of cortical development.

    Tubulinopathies continued: refining the phenotypic spectrum associated with variants in TUBG1.
    Brock S, Stouffs K, Scalais E, D'Hooghe M, Keymolen K, Guerrini R, Dobyns WB, Di Donato N, Jansen AC., Free PMC Article

    03/2/2019
    induced FBXL13 expression downregulates centrosomal gamma-tubulin and disrupts centrosomal microtubule arrays. In addition, depletion of FBXL13 induces high levels of CEP192 and gamma-tubulin at the centrosomes with the consequence of defects in cell motility.

    FBXL13 directs the proteolysis of CEP192 to regulate centrosome homeostasis and cell migration.
    Fung E, Richter C, Yang HB, Schäffer I, Fischer R, Kessler BM, Bassermann F, D'Angiolella V., Free PMC Article

    02/9/2019
    CCT actively promotes the formation of conformationally different aggregates of gamma-tubulin, a non-amyloidogenic CCT client protein, which are mediated by specific CCT-gamma-tubulin interactions.

    The chaperonin CCT promotes the formation of fibrillar aggregates of γ-tubulin.
    Pouchucq L, Lobos-Ruiz P, Araya G, Valpuesta JM, Monasterio O.

    06/16/2018
    that in the face of predominant gamma-tubulin-1 expression, the accumulation of gamma-tubulin-2 in mature neurons and neuroblastoma cells during oxidative stress may denote a prosurvival role of gamma-tubulin-2 in neurons

    Differential expression of human γ-tubulin isotypes during neuronal development and oxidative stress points to a γ-tubulin-2 prosurvival function.
    Dráberová E, Sulimenko V, Vinopal S, Sulimenko T, Sládková V, D'Agostino L, Sobol M, Hozák P, Křen L, Katsetos CD, Dráber P.

    10/7/2017
    All GCPs are incorporated into the helix via lateral interactions between their N-terminal domains, whereas the C-terminal domains mediate longitudinal interactions with gamma-tubulin.

    Functional Analysis of γ-Tubulin Complex Proteins Indicates Specific Lateral Association via Their N-terminal Domains.
    Farache D, Jauneau A, Chemin C, Chartrain M, Rémy MH, Merdes A, Haren L., Free PMC Article

    09/30/2017
    While binding to gamma-tubulin may help target APC to the site of microtubule nucleation complexes, additional C-terminal sequences of APC are required to stimulate and stabilize microtubule growth.

    APC functions at the centrosome to stimulate microtubule growth.
    Lui C, Ashton C, Sharma M, Brocardo MG, Henderson BR.

    10/8/2016
    a causative link between altered function of AURKA-HMMR-TPX2-TUBG1 and breast carcinogenesis in BRCA1/2 mutation carriers

    Assessing associations between the AURKA-HMMR-TPX2-TUBG1 functional module and breast cancer risk in BRCA1/2 mutation carriers.
    Blanco I, Kuchenbaecker K, Cuadras D, Wang X, Barrowdale D, de Garibay GR, Librado P, Sánchez-Gracia A, Rozas J, Bonifaci N, McGuffog L, Pankratz VS, Islam A, Mateo F, Berenguer A, Petit A, Català I, Brunet J, Feliubadaló L, Tornero E, Benítez J, Osorio A, Ramón y Cajal T, Nevanlinna H, Aittomäki K, Arun BK, Toland AE, Karlan BY, Walsh C, Lester J, Greene MH, Mai PL, Nussbaum RL, Andrulis IL, Domchek SM, Nathanson KL, Rebbeck TR, Barkardottir RB, Jakubowska A, Lubinski J, Durda K, Jaworska-Bieniek K, Claes K, Van Maerken T, Díez O, Hansen TV, Jønson L, Gerdes AM, Ejlertsen B, de la Hoya M, Caldés T, Dunning AM, Oliver C, Fineberg E, Cook M, Peock S, McCann E, Murray A, Jacobs C, Pichert G, Lalloo F, Chu C, Dorkins H, Paterson J, Ong KR, Teixeira MR, Teixeira, Hogervorst FB, van der Hout AH, Seynaeve C, van der Luijt RB, Ligtenberg MJ, Devilee P, Wijnen JT, Rookus MA, Meijers-Heijboer HE, Blok MJ, van den Ouweland AM, Aalfs CM, Rodriguez GC, Phillips KA, Piedmonte M, Nerenstone SR, Bae-Jump VL, O'Malley DM, Ratner ES, Schmutzler RK, Wappenschmidt B, Rhiem K, Engel C, Meindl A, Ditsch N, Arnold N, Plendl HJ, Niederacher D, Sutter C, Wang-Gohrke S, Steinemann D, Preisler-Adams S, Kast K, Varon-Mateeva R, Gehrig A, Bojesen A, Pedersen IS, Sunde L, Jensen UB, Thomassen M, Kruse TA, Foretova L, Peterlongo P, Bernard L, Peissel B, Scuvera G, Manoukian S, Radice P, Ottini L, Montagna M, Agata S, Maugard C, Simard J, Soucy P, Berger A, Fink-Retter A, Singer CF, Rappaport C, Geschwantler-Kaulich D, Tea MK, Pfeiler G, BCFR, John EM, Miron A, Neuhausen SL, Terry MB, Chung WK, Daly MB, Goldgar DE, Janavicius R, Dorfling CM, van Rensburg EJ, Fostira F, Konstantopoulou I, Garber J, Godwin AK, Olah E, Narod SA, Rennert G, Paluch SS, Laitman Y, Friedman E, SWE-BRCA, Liljegren A, Rantala J, Stenmark-Askmalm M, Loman N, Imyanitov EN, Hamann U, kConFab Investigators, Spurdle AB, Healey S, Weitzel JN, Herzog J, Margileth D, Gorrini C, Esteller M, Gómez A, Sayols S, Vidal E, Heyn H, GEMO, Stoppa-Lyonnet D, Léoné M, Barjhoux L, Fassy-Colcombet M, de Pauw A, Lasset C, Ferrer SF, Castera L, Berthet P, Cornelis F, Bignon YJ, Damiola F, Mazoyer S, Sinilnikova OM, Maxwell CA, Vijai J, Robson M, Kauff N, Corines MJ, Villano D, Cunningham J, Lee A, Lindor N, Lázaro C, Easton DF, Offit K, Chenevix-Trench G, Couch FJ, Antoniou AC, Pujana MA., Free PMC Article

    12/26/2015
    Results show that CUL4A- and CUL4B-mediated polyubiquitination of gamma-tubulin for its degradation.

    Cullin 4A and 4B ubiquitin ligases interact with γ-tubulin and induce its polyubiquitination.
    Thirunavukarasou A, Govindarajalu G, Singh P, Bandi V, Muthu K, Baluchamy S.

    10/3/2015
    In this study, the molecular basis of interaction between two lateral gamma-tubulin units within the gamma-tubulin ring complex were elucidated by making extensive use of molecular mechanics and molecular dynamics techniques.

    Molecular insight into γ-γ tubulin lateral interactions within the γ-tubulin ring complex (γ-TuRC).
    Suri C, Hendrickson TW, Joshi HC, Naik PK.

    05/30/2015
    Gamma tubulin expression was associated with patients' age, astrocytoma grade, respectability, patient survival and performance. These factors may be important prognostic indicators for patients with astrocytomas.

    Association of Aurora A and gamma-tubulin expression in astrocytomas and patient survival.
    Tsai HP, Tsai CY, Lieu AS, Chai CY, Kwan AL, Howng SL, Loh JK.

    02/28/2015
    Recombinant gamma-tubulin can be phosphorylated by Cdk1-cyclin B or Brsk1 and dephosphorylated by Ppp4c-R2-R3A in vitro.

    Protein phosphatase 4 is phosphorylated and inactivated by Cdk in response to spindle toxins and interacts with γ-tubulin.
    Voss M, Campbell K, Saranzewa N, Campbell DG, Hastie CJ, Peggie MW, Martin-Granados C, Prescott AR, Cohen PT., Free PMC Article

    03/22/2014
    Nek9 phosphorylates NEDD1 on Ser377 driving its recruitment and thereby that of gamma-tubulin to the centrosome in mitotic cells.

    Nek9 phosphorylation of NEDD1/GCP-WD contributes to Plk1 control of γ-tubulin recruitment to the mitotic centrosome.
    Sdelci S, Schütz M, Pinyol R, Bertran MT, Regué L, Caelles C, Vernos I, Roig J.

    01/12/2013
    Our results reveal for the first time an increased expression of TUBG1 and TUBG2 in lung cancer

    Overexpression of γ-tubulin in non-small cell lung cancer.
    Maounis NF, Dráberová E, Mahera E, Chorti M, Caracciolo V, Sulimenko T, Riga D, Trakas N, Emmanouilidou A, Giordano A, Dráber P, Katsetos CD.

    11/17/2012
    overexpression of Cdk1 or BRCA1 greatly expands the gamma-tubulin coating of microtubules, suggesting that the microtubule-bound gamma-tubulin is involved in DNA damage response.

    Cdk1 and BRCA1 target γ-tubulin to microtubule domains.
    Hubert T, Vandekerckhove J, Gettemans J.

    12/17/2011
    in transformed as well as in non-transformed interphase mammalian cells gamma-tubulin is present not only in cytoplasm but also in nuclei and nucleoli where it can be translocated during mitosis

    Nuclear γ-tubulin associates with nucleoli and interacts with tumor suppressor protein C53.
    Hořejší B, Vinopal S, Sládková V, Dráberová E, Sulimenko V, Sulimenko T, Vosecká V, Philimonenko A, Hozák P, Katsetos CD, Dráber P.

    12/10/2011
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