| CWH43 Is a Novel Tumor Suppressor Gene with Negative Regulation of TTK in Colorectal Cancer. | CWH43 Is a Novel Tumor Suppressor Gene with Negative Regulation of TTK in Colorectal Cancer.
Lee CC, Tsai KY, Lee AW, Wei PL, Huang CY, Batzorig U, Chang YJ., Free PMC Article | 11/1/2023 |
| TTK is a potential regulator of tumor progression correlated with dedifferentiation and immune cell infiltration in papillary thyroid cancer. | TTK is a potential regulator of tumor progression correlated with dedifferentiation and immune cell infiltration in papillary thyroid cancer.
Ma JJ, Xiang C, Wang JW., Free PMC Article | 10/24/2023 |
| TTK Protein Kinase promotes temozolomide resistance through inducing autophagy in glioblastoma. | TTK Protein Kinase promotes temozolomide resistance through inducing autophagy in glioblastoma.
Yu J, Gao G, Wei X, Wang Y., Free PMC Article | 07/23/2022 |
| TTK predicts triple positive breast cancer prognosis and regulates tumor proliferation and invasion. | TTK predicts triple positive breast cancer prognosis and regulates tumor proliferation and invasion.
Gao YH, Qu SS, Cao LQ, Yao M. | 04/16/2022 |
| Hsp90 regulates the tumorigenic function of tyrosine protein kinase in osteosarcoma. | Hsp90 regulates the tumorigenic function of tyrosine protein kinase in osteosarcoma.
Yao ZP, Zhu H, Shen F, Gong D. | 03/26/2022 |
| Identification of hub genes associated with prognosis, diagnosis, immune infiltration and therapeutic drug in liver cancer by integrated analysis. | Identification of hub genes associated with prognosis, diagnosis, immune infiltration and therapeutic drug in liver cancer by integrated analysis.
Lei X, Zhang M, Guan B, Chen Q, Dong Z, Wang C., Free PMC Article | 02/5/2022 |
| Frequent expression of a novel cancer testis antigen, protein kinase human monopolar spindle 1 (hMps1/TTK) in human urinary bladder transitional cell carcinoma. | Frequent expression of a novel cancer testis antigen, protein kinase human monopolar spindle 1 (hMps1/TTK) in human urinary bladder transitional cell carcinoma.
Singh PK, Bhatt MLB, Singh P, Rath SK, Dalela D, Goel MM. | 01/22/2022 |
| Overexpressed MPS-1 contributes to endometrioma development through the NF-kappaB signaling pathway. | Overexpressed MPS-1 contributes to endometrioma development through the NF-κB signaling pathway.
Liu Y, Ma J, Zhang L, Lin J, Liu X., Free PMC Article | 01/1/2022 |
| TTK (threonine tyrosine kinase) regulates the malignant behaviors of cancer cells and is regulated by microRNA-582-5p in ovarian cancer. | TTK (threonine tyrosine kinase) regulates the malignant behaviors of cancer cells and is regulated by microRNA-582-5p in ovarian cancer.
Lu N, Ren L., Free PMC Article | 01/1/2022 |
| CENPE, PRC1, TTK, and PLK4 May Play Crucial Roles in the Osteosarcoma Progression. | CENPE, PRC1, TTK, and PLK4 May Play Crucial Roles in the Osteosarcoma Progression.
Wang F, Zhao Q, Liu W, Kong D., Free PMC Article | 11/27/2021 |
| TTK regulates proliferation and apoptosis of gastric cancer cells through the Akt-mTOR pathway. | TTK regulates proliferation and apoptosis of gastric cancer cells through the Akt-mTOR pathway.
Huang H, Yang Y, Zhang W, Liu X, Yang G., Free PMC Article | 11/6/2021 |
| Mass-spectrometry-based proteomic correlates of grade and stage reveal pathways and kinases associated with aggressive human cancers. | Mass-spectrometry-based proteomic correlates of grade and stage reveal pathways and kinases associated with aggressive human cancers.
Monsivais D, Vasquez YM, Chen F, Zhang Y, Chandrashekar DS, Faver JC, Masand RP, Scheurer ME, Varambally S, Matzuk MM, Creighton CJ., Free PMC Article | 10/16/2021 |
| Mps1 dimerization and multisite interactions with Ndc80 complex enable responsive spindle assembly checkpoint signaling. | Mps1 dimerization and multisite interactions with Ndc80 complex enable responsive spindle assembly checkpoint signaling.
Gui P, Sedzro DM, Yuan X, Liu S, Hei M, Tian W, Zohbi N, Wang F, Yao Y, Aikhionbare FO, Gao X, Wang D, Yao X, Dou Z., Free PMC Article | 08/14/2021 |
| TTK, CDC25A, and ESPL1 as Prognostic Biomarkers for Endometrial Cancer. | TTK, CDC25A, and ESPL1 as Prognostic Biomarkers for Endometrial Cancer.
Yang Q, Yu B, Sun J., Free PMC Article | 05/8/2021 |
| Bioinformatics analysis and experimental validation of TTK as a biomarker for prognosis in non-small cell lung cancer. | Bioinformatics analysis and experimental validation of TTK as a biomarker for prognosis in non-small cell lung cancer.
Chen J, Wu R, Xuan Y, Jiang M, Zeng Y., Free PMC Article | 04/17/2021 |
| Inhibition of mitotic kinase Mps1 promotes cell death in neuroblastoma. | Inhibition of mitotic kinase Mps1 promotes cell death in neuroblastoma.
Simon Serrano S, Sime W, Abassi Y, Daams R, Massoumi R, Jemaà M., Free PMC Article | 12/12/2020 |
| Upregulation of Thr/Tyr kinase Increases the Cancer Progression by Neurotensin and Dihydropyrimidinase-Like 3 in Lung Cancer. | Upregulation of Thr/Tyr kinase Increases the Cancer Progression by Neurotensin and Dihydropyrimidinase-Like 3 in Lung Cancer.
Tsai YM, Wu KL, Chang YY, Hung JY, Chang WA, Chang CY, Jian SF, Tsai PH, Huang YC, Chong IW, Hsu YL., Free PMC Article | 11/28/2020 |
| TTK inhibition radiosensitizes basal-like breast cancer through impaired homologous recombination. | TTK inhibition radiosensitizes basal-like breast cancer through impaired homologous recombination.
Chandler BC, Moubadder L, Ritter CL, Liu M, Cameron M, Wilder-Romans K, Zhang A, Pesch AM, Michmerhuizen AR, Hirsh N, Androsiglio M, Ward T, Olsen E, Niknafs YS, Merajver S, Thomas DG, Brown PH, Lawrence TS, Nyati S, Pierce LJ, Chinnaiyan A, Speers C., Free PMC Article | 09/19/2020 |
| The expression of CDK2 and CCNE1 decreased after TTK was knocked out. | Silencing TTK expression inhibits the proliferation and progression of prostate cancer.
Chen S, Wang J, Wang L, Peng H, Xiao L, Li C, Lin D, Yang K. | 06/20/2020 |
| Studied the role of monopolar spindle 1 kinase (TTK) in colon cancer patient tissues and cell line; results show TTK promotes colon cancer cell proliferation through activation of PKCalpha/ERK1/2 and inhibits the differentiation by inactivation of PI3K/Akt pathway. | Mitotic checkpoint kinase Mps1/TTK predicts prognosis of colon cancer patients and regulates tumor proliferation and differentiation via PKCα/ERK1/2 and PI3K/Akt pathway.
Zhang L, Jiang B, Zhu N, Tao M, Jun Y, Chen X, Wang Q, Luo C. | 05/2/2020 |
| A helical fragment within the kinetochore-targeting N-terminal extension (NTE) module of MPS1 is required for interactions with kinetochores and forms intramolecular interactions with its adjacent tetratricopeptide repeat (TPR) domain. | Interactions between N-terminal Modules in MPS1 Enable Spindle Checkpoint Silencing.
Pachis ST, Hiruma Y, Tromer EC, Perrakis A, Kops GJPL. | 04/11/2020 |
| This study presents a 2.4 A resolution crystal structure of an "extended" version of the Mps1 kinase domain, which shows an ordered activation loop. | A crystal structure of the human protein kinase Mps1 reveals an ordered conformation of the activation loop.
Roorda JC, Joosten RP, Perrakis A, Hiruma Y., Free PMC Article | 04/4/2020 |
| study reveals a molecular mechanism by which HPV16E7 perturbs host mitotic progression by interfering Mps1-MAP4 signaling cascade, which results in an extended infection window and may facilitate the persistent HPV16 infection | Human Papillomavirus 16 oncoprotein E7 retards mitotic progression by blocking Mps1-MAP4 signaling cascade.
Guo Y, Zhang X, Xu Q, Gong F, Shi X, Li C, Huang R, Nie F, Zhu W, Li J, Tang J, Li R, Zhang L, Chen L, Ma RZ. | 02/15/2020 |
| TTK affected the progression of clear cell renal cell carcinoma; its expression level was associated with tumor stage and lymphatic metastasis | TTK contributes to tumor growth and metastasis of clear cell renal cell carcinoma by inducing cell proliferation and invasion.
Liu XD, Yao DW, Xin F. | 12/7/2019 |
| Authors show that Mps1 regulates chromosome alignment through MCRS1, a spindle assembly factor that controls the dynamics of the minus end of kinetochore microtubules. Mps1 binds and phosphorylates MCRS1. | Mps1 regulates spindle morphology through MCRS1 to promote chromosome alignment.
Yang H, Zhang F, Huang CJ, Liao J, Han Y, Hao P, Chu Y, Lu X, Li W, Yu H, Kang J., Free PMC Article | 09/14/2019 |