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    TTF1 transcription termination factor 1 [ Homo sapiens (human) ]

    Gene ID: 7270, updated on 2-Nov-2024

    GeneRIFs: Gene References Into Functions

    GeneRIFPubMed TitleDate
    TTF-1: A Well-Favored Addition to the Immunohistochemistry Armamentarium as a Diagnostic Marker of SEGA.

    TTF-1: A Well-Favored Addition to the Immunohistochemistry Armamentarium as a Diagnostic Marker of SEGA.
    Dutta R, Sharma MC, Suri V, Sarkar C, Garg A, Suri A, Kale SS.

    04/23/2022
    Exploring immunoreactivity of TTF-1 and AVP in hypothalamic hamartoma.

    Exploring immunoreactivity of TTF-1 and AVP in hypothalamic hamartoma.
    Rao S, Sunitha K, Lanka V, Kulanthaivelu K, Arivazhagan A, Chowdary R, Raghavendra K, Rao R, Nandeesh BN, Bharath RD, Saini J, Sinha S, Santosh V, Yasha TC, Rajeswaran J, Malla BR, Mahadevan A.

    02/5/2022
    TTF1 expression is an independent predictor of survival of patients with advanced lung adenocarcinoma

    Prognostic Value of Thyroid Transcription Factor-1 Expression in Patients with Advanced Lung Adenocarcinoma.
    Zablockis R, Žurauskas E, Danila E, Gruslys V., Free PMC Article

    01/26/2019
    the TTF-1 protein and mRNA are specifically expressed in schwannomas

    Aberrant expression of thyroid transcription factor-1 in schwannomas.
    Wang DZ, Liu P, Yao L, Hao YH, Zhu RJ, Zhang T, Tang XB.

    12/22/2018
    Human TTF-I localizes in the nucleolus and N-terminus (1-224) of hTTF-I which include nucleolus localization sequence and the expression of Human TTF-I 521-732 increased HIV-I production by regulating transactivation of the LTR promoter.

    Investigation of functional roles of transcription termination factor-1 (TTF-I) in HIV-1 replication.
    Park SH, Yu KL, Jung YM, Lee SD, Kim MJ, You JC., Free PMC Article

    10/27/2018
    These findings collectively suggest that the triple combination of survivin knockdown with ABT-263 and trametinib treatment, may be a potential strategy for the treatment of KRAS-mutant lung adenocarcinoma. Furthermore, our findings indicate that the welldifferentiated type of KRAS-mutant lung tumors depends, at least in part, on TTF1 for growth.

    Survivin knockdown induces senescence in TTF‑1-expressing, KRAS-mutant lung adenocarcinomas.
    Sumi T, Hirai S, Yamaguchi M, Tanaka Y, Tada M, Yamada G, Hasegawa T, Miyagi Y, Niki T, Watanabe A, Takahashi H, Sakuma Y., Free PMC Article

    10/6/2018
    TTF-1 expression may serve as a predictive marker to identify lung cancer patients who may benefit from the addition of bevacizumab to platinum doublet therapy.

    TTF-1 Expression Predicts the Merit of Additional Antiangiogenic Treatment in Non-squamous Non-small Cell Lung Cancer.
    Takeuchi A, Oguri T, Yamashita Y, Sone K, Fukuda S, Takakuwa O, Uemura T, Maeno K, Fukumitsu K, Kanemitsu Y, Ohkubo H, Takemura M, Ito Y, Niimi A.

    09/22/2018
    Our results showed that an approach of using only a two-antibody panel (p40 and TTF-1) might help in reduction of diagnostic category of NSCLC-NOS significantly and contribute in saving tissue for future molecular testing

    p40 & thyroid transcription factor-1 immunohistochemistry: A useful panel to characterize non-small cell lung carcinoma-not otherwise specified (NSCLC-NOS) category.
    Walia R, Jain D, Madan K, Sharma MC, Mathur SR, Mohan A, Iyer VK, Kumar L., Free PMC Article

    07/14/2018
    Single nucleotide polymorphism in TTF1 gene is associated with Systemic lupus erythematosus

    Novel linkage disequilibrium clustering algorithm identifies new lupus genes on meta-analysis of GWAS datasets.
    Saeed M., Free PMC Article

    09/9/2017
    Case Report: KRAS mutation-positive bronchial surface epithelium type lung adenocarcinoma with strong expression of TTF-1.

    KRAS mutation-positive bronchial surface epithelium (BSE)-type lung adenocarcinoma with strong expression of TTF-1: a case providing a further insight as for the role of TTF-1 in the oncogenesis.
    Takanashi Y, Tajima S, Hayakawa T, Neyatani H, Funai K., Free PMC Article

    10/29/2016
    Overexpression of Transcription Termination Factor 1 is Associated with Colorectal Cancer

    Overexpression of Transcription Termination Factor 1 is Associated with a Poor Prognosis in Patients with Colorectal Cancer.
    Ueda M, Iguchi T, Nambara S, Saito T, Komatsu H, Sakimura S, Hirata H, Uchi R, Takano Y, Shinden Y, Eguchi H, Masuda T, Sugimachi K, Yamamoto H, Doki Y, Mori M, Mimori K.

    10/8/2016
    Depletion of TTF-I recapitulates the effects of ARF on ribosomal RNA synthesis and is rescued by the introduction of a TTF-I transgene.

    The ARF tumor suppressor controls ribosome biogenesis by regulating the RNA polymerase I transcription factor TTF-I.
    Lessard F, Morin F, Ivanchuk S, Langlois F, Stefanovsky V, Rutka J, Moss T.

    06/14/2010
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