| Novel Mutations of TSPY1 Gene Associate Spermatogenic Failure Among Men. | Novel Mutations of TSPY1 Gene Associate Spermatogenic Failure Among Men.
Paladhi P, Dutta S, Pal S, Bose G, Ghosh P, Chattopadhyay R, Chakravarty B, Saha I, Ghosh S. | 07/23/2022 |
| Epigenetic modification-dependent androgen receptor occupancy facilitates the ectopic TSPY1 expression in prostate cancer cells. | Epigenetic modification-dependent androgen receptor occupancy facilitates the ectopic TSPY1 expression in prostate cancer cells.
Leng X, Liu M, Tao D, Yang B, Zhang Y, He T, Xie S, Wang Z, Liu Y, Yang Y., Free PMC Article | 03/6/2021 |
| Compared to n-TSPY, all other PCR assays had poor performance to detect semen exposure. The n-TSPY is an accessible assay that may have great utility in assessing semen exposure in studies where many factors are expected to accelerate biomarkers' clearance. | A novel nested polymerase chain reaction targeting the testis-specific protein Y-encoded family of genes for high sensitivity of recent semen exposure detection: Comparison with four other assays of semen detection.
Giguère K, Leblond FA, Goma-Matsétsé E, Dave V, Béhanzin L, Guédou FA, Alary M., Free PMC Article | 04/4/2020 |
| Experimental evidence establishes TSPY1 as an oncogenic factor that facilitates tumor progression and causes poor prognosis in male patients with lung adenocarcinoma or hepatocellular carcinoma. These findings revealed that TSPY1 strongly promotes the activation of the PI3K/AKT and RAS signaling pathways through suppressing IGFBP3 gene transcription. | Testis-specific protein, Y-linked 1 activates PI3K/AKT and RAS signaling pathways through suppressing IGFBP3 expression during tumor progression.
Tu W, Yang B, Leng X, Pei X, Xu J, Liu M, Dong Q, Tao D, Lu Y, Liu Y, Yang Y., Free PMC Article | 05/18/2019 |
| The expression of spermatogenic phenotypes of TSPY1 defects is independent of variations in TSPYL1 and TSPYL5 in the Han Chinese population. | Spermatogenic phenotype of testis-specific protein, Y-encoded, 1 (TSPY1) dosage deficiency is independent of variations in TSPY-like 1 (TSPYL1) and TSPY-like 5 (TSPYL5): a case-control study in a Han Chinese population.
Yang X, Leng X, Tu W, Liu Y, Xu J, Pei X, Ma Y, Yang D, Yang Y. | 09/8/2018 |
| TSPY and TSPX exert opposing effects on the transactivation functions of AR and AR-Vs important for various physiological and disease processes sensitive to male sex hormone actions, thereby not only affecting the pathogenesis of male-specific prostate cancer but also likely contributing to sex differences in the health and diseases of man. | The Y-located proto-oncogene TSPY exacerbates and its X-homologue TSPX inhibits transactivation functions of androgen receptor and its constitutively active variants.
Li Y, Zhang DJ, Qiu Y, Kido T, Lau YC., Free PMC Article | 05/20/2017 |
| The aim of this study was to compare two Y chromosome markers-SRY and DYS14-for their utility in the diagnosis of fetal gender. | Noninvasive Diagnosis of Fetal Gender: Utility of Combining DYS14 and SRY.
Jacob RR, Saxena R, Verma IC. | 07/16/2016 |
| Studies indicate that TSPY1 (testis-specific protein, Y-linked 1) gene has been identified to be the most important candidate gene for gonadoblastoma. | [Research progress of TSPY1 gene family].
Shen Y, Liu Y, Yang Y. | 02/14/2015 |
| Over-expression of Testis-specific Protein Y-encoded 1 is associated with male hepatocellular carcinoma. | Over-expressed Testis-specific Protein Y-encoded 1 as a novel biomarker for male hepatocellular carcinoma.
Li S, Mo C, Huang S, Yang S, Lu Y, Peng Q, Wang J, Deng Y, Qin X, Liu Y., Free PMC Article | 01/31/2015 |
| The oncogenic events leading to an ectopic activation of TSPY and/or inactivating mutation/epigenetic silencing of TSPX could collectively contribute to the sexual dimorphism(s) in HCC and related liver cancers in male-biased manners. | The potential contributions of a Y-located protooncogene and its X homologue in sexual dimorphisms in hepatocellular carcinoma.
Kido T, Lo RC, Li Y, Lee J, Tabatabai ZL, Ng IO, Lau YF. | 11/22/2014 |
| TSPY could bind directly to the chromatin/DNA at exon 1 of its own gene, and greatly enhance the transcriptional activities of the endogenous gene in LNCaP prostate cancer cells | The Y-located gonadoblastoma gene TSPY amplifies its own expression through a positive feedback loop in prostate cancer cells.
Kido T, Lau YF. | 06/14/2014 |
| A combined genetic analysis of the TSPY1 copy number and the gr/gr deletion could inform the clinical counselling of infertile couples. | A significant effect of the TSPY1 copy number on spermatogenesis efficiency and the phenotypic expression of the gr/gr deletion.
Shen Y, Yan Y, Liu Y, Zhang S, Yang D, Zhang P, Li L, Wang Y, Ma Y, Tao D, Yang Y. | 09/7/2013 |
| evaluate TSPY (testis specific protein on the Y chromosome) gene and 5'UTR (UnTranslated Region) polymorphisms in men with impaired fertility compared to fertile controls | Sequence recombination in exon 1 of the TSPY gene in men with impaired fertility.
Svacinova V, Vodicka R, Vrtel R, Godava M, Kvapilova M, Krejcirikova E, Dusek L, Bortlicek Z, Santavy J. | 05/26/2012 |
| a potential role(s) of TSPY in development and/or physiology of the nervous system | Expression of the human TSPY gene in the brains of transgenic mice suggests a potential role of this Y chromosome gene in neural functions.
Kido T, Schubert S, Schmidtke J, Chris Lau YF. | 02/25/2012 |
| Besides its role in mitotic cycle of spermatogonial renewal, TSPY could play significant roles in progression of prophase I and meiotic divisions during spermatogenesis. | Role of the Y-located putative gonadoblastoma gene in human spermatogenesis.
Lau YF, Li Y, Kido T. | 05/7/2011 |
| The expression analysis of genes OCT4, SRY, and TSPY in the dysgenetic gonads of Turner syndrome patients may allow introducing modifications in the microenvironment that could contributed to a malignant transformation process. | OCT4 gonadal gene expression related to the presence of Y-chromosome sequences in Turner syndrome.
Bianco B, Oliveira KC, Guedes AD, Barbosa CP, Lipay MV, Verreschi IT. | 12/11/2010 |
| Interphase fluorescence in situ hybridization targeting TSPY1 is a straightforward approach that can be used in the evaluation of Y-associated intersex disorders in women who develop gonadoblastoma. | The chromosome Y-linked testis-specific protein locus TSPY1 is characteristically present in gonadoblastoma.
Hertel JD, Huettner PC, Dehner LP, Pfeifer JD. | 11/13/2010 |
| TSPY copy number appears to have no functional consequences for semen quality. | Y chromosome TSPY copy numbers and semen quality.
Nickkholgh B, Noordam MJ, Hovingh SE, van Pelt AM, van der Veen F, Repping S. | 11/6/2010 |
| The chromosomal marker TSPY1 is not responsible for Mullerian aplasia syndrome in a cohort of Finnish patients. | Does the Y chromosome have a role in Müllerian aplasia?
Sandbacka M, Painter J, Puhakka M, Halttunen M, Laivuori H, Aittomäki K. | 06/28/2010 |
| Observational study of gene-disease association. (HuGE Navigator) | TSPY1 copy number variation influences spermatogenesis and shows differences among Y lineages.
Giachini C, Nuti F, Turner DJ, Laface I, Xue Y, Daguin F, Forti G, Tyler-Smith C, Krausz C, Giachini C, Nuti F, Turner DJ, Laface I, Xue Y, Daguin F, Forti G, Tyler-Smith C, Krausz C., Free PMC Articles: PMC3330747, PMC3330747 | 12/2/2009 |
| TSPY copy number variation significantly influences spermatogenic efficiency. Low TSPY1 copy number is a new risk factor for male infertility with potential clinical consequences. | TSPY1 copy number variation influences spermatogenesis and shows differences among Y lineages.
Giachini C, Nuti F, Turner DJ, Laface I, Xue Y, Daguin F, Forti G, Tyler-Smith C, Krausz C, Giachini C, Nuti F, Turner DJ, Laface I, Xue Y, Daguin F, Forti G, Tyler-Smith C, Krausz C., Free PMC Articles: PMC3330747, PMC3330747 | 01/21/2010 |
| DYS-14 copy number variations on extracellular fetal DNA is not an optimal marker for differentiation between normal and complicated pregnancies. | The effect of DYS-14 copy number variations on extracellular fetal DNA quantification in maternal circulation.
Hromadnikova I, Benesova M, Zejskova L, Stehnova J, Doucha J, Sedlacek P, Dlouha K, Krofta L. | 01/21/2010 |
| TSPY and its X-encoded homologue interact with cyclin B but exert contrasting functions on cyclin-dependent kinase 1 activities. | TSPY and its X-encoded homologue interact with cyclin B but exert contrasting functions on cyclin-dependent kinase 1 activities.
Li Y, Lau YF. | 01/21/2010 |
| TSPY could exert its oncogenic function(s) by interacting with eEF1As and stimulating gene expression via its enhancements in protein synthesis and gene transcription | The human Y-encoded testis-specific protein interacts functionally with eukaryotic translation elongation factor eEF1A, a putative oncoprotein.
Kido T, Lau YF. | 01/21/2010 |
| Patients with complete Sertoli cell-only syndrome (SCOS) did not exhibit TSPY gene expression. | Quantification of DDX3Y, RBMY1, DAZ and TSPY mRNAs in testes of patients with severe impairment of spermatogenesis.
Lardone MC, Parodi DA, Valdevenito R, Ebensperger M, Piottante A, Madariaga M, Smith R, Pommer R, Zambrano N, Castro A. | 01/21/2010 |