| Differential Impairment Mechanism of Sperm Production via Induction of miR-34c-Activated Apoptosis and Spermatogenesis Pathway in Diet-Induced Obesity and Resistant Mice and GC-1 Spg Cells. | Differential Impairment Mechanism of Sperm Production via Induction of miR-34c-Activated Apoptosis and Spermatogenesis Pathway in Diet-Induced Obesity and Resistant Mice and GC-1 Spg Cells.
Li M, Zhao Q, Wang S, Song Y, Zhai L, Zhao J., Free PMC Article | 08/9/2024 |
| Inhibition of microRNA-34c reduces detrusor ROCK2 expression and urinary bladder inflammation in experimental cystitis. | Inhibition of microRNA-34c reduces detrusor ROCK2 expression and urinary bladder inflammation in experimental cystitis.
Mandal M, Rakib A, Kiran S, Al Mamun MA, Raghavan S, Kumar S, Singla B, Park F, Leo MD, Singh UP., | 01/3/2024 |
| The MIR34B/C genomic region contains multiple potential regulators of multiciliogenesis. | The MIR34B/C genomic region contains multiple potential regulators of multiciliogenesis.
Cavard A, Redman E, Mercey O, Abelanet S, Plaisant M, Arguel MJ, Magnone V, Ruiz García S, Rios G, Deprez M, Lebrigand K, Ponzio G, Caballero I, Barbry P, Zaragosi LE, Marcet B. | 08/24/2023 |
| Sperm-borne microRNA-34c regulates maternal mRNA degradation and preimplantation embryonic development in mice. | Sperm-borne microRNA-34c regulates maternal mRNA degradation and preimplantation embryonic development in mice.
Cui L, Fang L, Zhuang L, Shi B, Lin CP, Ye Y., Free PMC Article | 05/3/2023 |
| Downregulation of miR-34c-5p alleviates chronic intermittent hypoxia-induced myocardial damage by targeting sirtuin 1. | Downregulation of miR-34c-5p alleviates chronic intermittent hypoxia-induced myocardial damage by targeting sirtuin 1.
Zhang J, Xie B, Tang Y, Zhou B, Wang Q, Ge Q, Zhou Y, Gu T. | 10/22/2022 |
| Protective Role of miR-34c in Hypoxia by Activating Autophagy through BCL2 Repression. | Protective Role of miR-34c in Hypoxia by Activating Autophagy through BCL2 Repression.
Kim S, Han J, Ahn YH, Ha CH, Hwang JJ, Lee SE, Kim JJ, Kim N., Free PMC Article | 06/18/2022 |
| Up-regulation of miR-34b/c by JNK and FOXO3 protects from liver fibrosis. | Up-regulation of miR-34b/c by JNK and FOXO3 protects from liver fibrosis.
Piccolo P, Ferriero R, Barbato A, Attanasio S, Monti M, Perna C, Borel F, Annunziata P, Carissimo A, De Cegli R, Quagliata L, Terracciano LM, Housset C, Teckman JH, Mueller C, Brunetti-Pierri N., Free PMC Article | 08/21/2021 |
| Effects of miR-34c-5p on Sodium, Potassium, and Calcium Channel Currents in C2C12 Myotubes. | Effects of miR-34c-5p on Sodium, Potassium, and Calcium Channel Currents in C2C12 Myotubes.
Jin B, Gu X, Li D, Qi Z, Jiang B, Yin X. | 06/12/2021 |
| Increased miR-34c mediates synaptic deficits by targeting synaptotagmin 1 through ROS-JNK-p53 pathway in Alzheimer's Disease. | Increased miR-34c mediates synaptic deficits by targeting synaptotagmin 1 through ROS-JNK-p53 pathway in Alzheimer's Disease.
Shi Z, Zhang K, Zhou H, Jiang L, Xie B, Wang R, Xia W, Yin Y, Gao Z, Cui D, Zhang R, Xu S., Free PMC Article | 05/15/2021 |
| miR-34b/c regulates doxorubicin-induced myocardial cell injury through ITCH. | miR-34b/c regulates doxorubicin-induced myocardial cell injury through ITCH.
Zhang WC, Yang JH, Liu GH, Yang F, Gong JL, Jia MG, Zhang MJ, Zhao LS., Free PMC Article | 09/19/2020 |
| MicroRNA-34 Family Enhances Wound Inflammation by Targeting LGR4. | MicroRNA-34 Family Enhances Wound Inflammation by Targeting LGR4.
Wu J, Li X, Li D, Ren X, Li Y, Herter EK, Qian M, Toma MA, Wintler AM, Sérézal IG, Rollman O, Ståhle M, Wikstrom JD, Ye X, Landén NX. | 09/19/2020 |
| Oviductosomes can deliver to sperm miRNAs, including miR-34c-5p which is essential for the first cleavage and is solely sperm-derived in the zygote. | Murine Oviductosomes (OVS) microRNA profiling during the estrous cycle: Delivery of OVS-borne microRNAs to sperm where miR-34c-5p localizes at the centrosome.
Fereshteh Z, Schmidt SA, Al-Dossary AA, Accerbi M, Arighi C, Cowart J, Song JL, Green PJ, Choi K, Yoo S, Martin-DeLeon PA., Free PMC Article | 11/30/2019 |
| In this study , miR-34c was found to affect the growth of trigeminal sensory neurons and the repair of diabetic corneal nerve endings by acting directly on Atg4B. | MiR-34c Participates in Diabetic Corneal Neuropathy Via Regulation of Autophagy.
Hu J, Hu X, Kan T. | 06/29/2019 |
| miR-34b/c modulates Wnt1 expression, promotes cell cycle exit, and induces dopaminergic differentiation. | miR-34b/c Regulates Wnt1 and Enhances Mesencephalic Dopaminergic Neuron Differentiation.
De Gregorio R, Pulcrano S, De Sanctis C, Volpicelli F, Guatteo E, von Oerthel L, Latagliata EC, Esposito R, Piscitelli RM, Perrone-Capano C, Costa V, Greco D, Puglisi-Allegra S, Smidt MP, di Porzio U, Caiazzo M, Mercuri NB, Li M, Bellenchi GC., Free PMC Article | 04/27/2019 |
| ncreased miR-34c-5p expression induced leukemia stem cells (LSCs) senescence ex vivo, prevented leukemia development and promoted the eradication of LSCs in immune deficient mice. | miR-34c-5p promotes eradication of acute myeloid leukemia stem cells by inducing senescence through selective RAB27B targeting to inhibit exosome shedding.
Peng D, Wang H, Li L, Ma X, Chen Y, Zhou H, Luo Y, Xiao Y, Liu L. | 03/16/2019 |
| Results showed that miR-34c suppressed the activity of the NLRP3 inflammasome (NLRP3, ASC, and Caspase-1), thereby alleviating chronic constriction injury-induced neuropathic pain in mice through downregulation of NLRP3 by directly binding the 3'-untranslated region. Overexpression of miR-34c decreased the protein levels of NLRP3, ASC, caspase-1, IL-1beta, and IL-18 in the spinal cord. | MiR-34c Ameliorates Neuropathic Pain by Targeting NLRP3 in a Mouse Model of Chronic Constriction Injury.
Xu L, Wang Q, Jiang W, Yu S, Zhang S. | 03/16/2019 |
| the miR-34-dependent modulation of CRFR1 expression may be involved in the dorsal raphe nuclei regulation of stress-coping strategies. | MicroRNA-34 Contributes to the Stress-related Behavior and Affects 5-HT Prefrontal/GABA Amygdalar System through Regulation of Corticotropin-releasing Factor Receptor 1.
Andolina D, Di Segni M, Accoto A, Lo Iacono L, Borreca A, Ielpo D, Berretta N, Perlas E, Puglisi-Allegra S, Ventura R. | 02/9/2019 |
| The study was aimed at assessing if the control of gene expression mediated by miRNAs, namely miRs-34, has any roles in driving neuronal cell response to 50-Hz (1 mT) magnetic field in vitro. | Fifty-Hertz Magnetic Field Affects the Epigenetic Modulation of the miR-34b/c in Neuronal Cells.
Consales C, Cirotti C, Filomeni G, Panatta M, Butera A, Merla C, Lopresto V, Pinto R, Marino C, Benassi B. | 02/9/2019 |
| Data show that miR-34c up-regulated Nanos2 in mouse model of cryptorchidism. | miR-34c disrupts spermatogonial stem cell homeostasis in cryptorchid testes by targeting Nanos2.
Huang Z, Tang D, Gao J, Dou X, Cheng P, Peng D, Zhang Y, Mao J, Zhang L, Zhang X., Free PMC Article | 12/22/2018 |
| we supposed that miR-34c, through its effects on dendritic spine density, influences synaptic plasticity and plays a key role in Alzheimer's disease pathogenesis. | miRNA-34c Overexpression Causes Dendritic Loss and Memory Decline.
Kao YC, Wang IF, Tsai KJ., Free PMC Article | 12/22/2018 |
| miR-34c, which is edited frequently at all stages during spermatogenesis, regulates its target genes through the RNA structure changing and shows dysfunction when it is edited. | miRNA editing landscape reveals miR-34c regulated spermatogenesis through structure and target change in pig and mouse.
Wang X, Zhang P, Li L, Che D, Li T, Li H, Li Q, Jia H, Tao S, Hua J, Zeng W, Liao M. | 11/10/2018 |
| persistent distention/stretch on colonic smooth muscle cells could suppress SCF production probably through Ca(2+) -ERK-AP-1-miR-34c deregulation. | Persistent distention of colon damages interstitial cells of Cajal through Ca(2+) -ERK-AP-1-miR-34c-SCF deregulation.
Yang S, Dong F, Li D, Sun H, Wu B, Sun T, Wang Y, Shen P, Ji F, Zhou D., Free PMC Article | 06/2/2018 |
| This study provides novel evidence for a role of miR-34c in inhibiting myoblasts proliferation by repressing YY1. | miRNA-34c inhibits myoblasts proliferation by targeting YY1.
Wang M, Liu C, Su Y, Zhang K, Zhang Y, Chen M, Ge M, Gu L, Lu T, Li N, Yu Z, Meng Q., Free PMC Article | 06/2/2018 |
| vaspin could inhibit the osteogenic differentiation in vitro, and the PI3K-Akt/miR-34c loop might be the underlying mechanism. | Vaspin regulates the osteogenic differentiation of MC3T3-E1 through the PI3K-Akt/miR-34c loop.
Liu Y, Xu F, Pei HX, Zhu X, Lin X, Song CY, Liang QH, Liao EY, Yuan LQ., Free PMC Article | 03/31/2018 |
| Study suggests that miR-34c contributes to osteoclast differentiation by targeting LGR4, providing novel insights into understanding the molecular mechanism underlying osteoclast differentiation. | MicroRNA-34c promotes osteoclast differentiation through targeting LGR4.
Cong F, Wu N, Tian X, Fan J, Liu J, Song T, Fu H. | 03/18/2017 |