| Faim2 up-regulation may contribute to the neuroprotective effects of low-dose erythropoietin in transient brain ischemia | Faim2 contributes to neuroprotection by erythropoietin in transient brain ischemia.
Komnig D, Gertz K, Habib P, Nolte KW, Meyer T, Brockmann MA, Endres M, Rathkolb B, Hrabě de Angelis M, German Mouse Clinic Consortium, Schulz JB, Falkenburger BH, Reich A. | 05/11/2019 |
| that FAIM2 is an intrinsic neuroprotective factor activated by stress in photoreceptors and delays FAS-mediated photoreceptor apoptosis | FAS apoptotic inhibitory molecule 2 is a stress-induced intrinsic neuroprotective factor in the retina.
Pawar M, Busov B, Chandrasekhar A, Yao J, Zacks DN, Besirli CG., Free PMC Article | 06/23/2018 |
| Increased degeneration of dopaminergic neurons was found in animals with Faim2 deficiency. | Mice lacking Faim2 show increased cell death in the MPTP mouse model of Parkinson disease.
Komnig D, Schulz JB, Reich A, Falkenburger BH. | 06/24/2017 |
| MiR-3202 can promote EC apoptosis in hyperglycemic conditions, which demonstrated that EC apoptosis induced by high-glucose conditions partly depends on miR-3202 targeting FAIM2. | MiR-3202 - Promoted H5V Cell Apoptosis by Directly Targeting Fas Apoptotic Inhibitory Molecule 2 (FAIM2) in High Glucose Condition.
Huang X, Xie H, Xue G, Ye M, Zhang L., Free PMC Article | 06/24/2017 |
| LFG plays a role in protecting T cells from apoptosis during antiviral immune response. | Antiapoptotic Role for Lifeguard in T Cell Mediated Immune Response.
Hurtado de Mendoza T, Liu F, Verma IM., Free PMC Article | 06/28/2016 |
| Data suggest Faim2/LFG (lifeguard protein) protects against FasL-/Fas ligand-induced apoptosis by down-regulating calcium release from endoplasmic reticulum in cortical neurons. | Lifeguard Inhibits Fas Ligand-mediated Endoplasmic Reticulum-Calcium Release Mandatory for Apoptosis in Type II Apoptotic Cells.
Urresti J, Ruiz-Meana M, Coccia E, Arévalo JC, Castellano J, Fernández-Sanz C, Galenkamp KM, Planells-Ferrer L, Moubarak RS, Llecha-Cano N, Reix S, García-Dorado D, Barneda-Zahonero B, Comella JX., Free PMC Article | 06/4/2016 |
| In Faim2-deficient mice, there was increased hippocampal cell death during acute bacterial meningitis. | Modulation of hippocampal neuroplasticity by Fas/CD95 regulatory protein 2 (Faim2) in the course of bacterial meningitis.
Tauber SC, Harms K, Falkenburger B, Weis J, Sellhaus B, Nau R, Schulz JB, Reich A., Free PMC Article | 03/1/2014 |
| Expression of Faim2 is triggered, at least in part, by Fas-receptor activation and subsequent ERK signaling. | ERK-mediated activation of Fas apoptotic inhibitory molecule 2 (Faim2) prevents apoptosis of 661W cells in a model of detachment-induced photoreceptor cell death.
Besirli CG, Zheng QD, Reed DM, Zacks DN., Free PMC Article | 02/23/2013 |
| mechanism of action of LFG as an inhibitor of the Fas pathway and evidence of the neuroprotective role of LFG in cerebellar granule neurons and Purkinje cells in an organotypic cerebellar culture system | Antiapoptotic protein Lifeguard is required for survival and maintenance of Purkinje and granular cells.
Hurtado de Mendoza T, Perez-Garcia CG, Kroll TT, Hoong NH, O'Leary DD, Verma IM., Free PMC Article | 12/17/2011 |
| This study demonistrated that lack of Faim2 caused an increase in susceptibility to combined oxygen-glucose deprivation in primary neurons as well as in caspase-associated cell death, stroke volume, and neurological impairment after cerebral ischemia. | Fas/CD95 regulatory protein Faim2 is neuroprotective after transient brain ischemia.
Reich A, Spering C, Gertz K, Harms C, Gerhardt E, Kronenberg G, Nave KA, Schwab M, Tauber SC, Drinkut A, Harms K, Beier CP, Voigt A, Göbbels S, Endres M, Schulz JB., Free PMC Article | 02/5/2011 |
| LFG is an endogenous inhibitor of FasL-mediated neuronal death detected in lipid rafts microdomains, and it mediates the FasL resistance of CNS differentiated neurons | Lifeguard/neuronal membrane protein 35 regulates Fas ligand-mediated apoptosis in neurons via microdomain recruitment.
Fernández M, Segura MF, Solé C, Colino A, Comella JX, Ceña V. | 01/21/2010 |