| Loss of TRIM29 mitigates viral myocarditis by attenuating PERK-driven ER stress response in male mice. | Loss of TRIM29 mitigates viral myocarditis by attenuating PERK-driven ER stress response in male mice.
Wang J, Lu W, Zhang J, Du Y, Fang M, Zhang A, Sungcad G, Chon S, Xing J., Free PMC Article | 04/29/2024 |
| TRIM29 promotes podocyte pyroptosis in diabetic nephropathy through the NF-kB/NLRP3 inflammasome pathway. | TRIM29 promotes podocyte pyroptosis in diabetic nephropathy through the NF-kB/NLRP3 inflammasome pathway.
Xu X, Qin Z, Zhang C, Mi X, Zhang C, Zhou F, Wang J, Zhang L, Hua F. | 05/11/2023 |
| TRIM29 (Tripartite Motif Containing 29) Alleviates NLRC4 (NLR Family CARD Domain Containing Protein 4) Inflammasome Related Cerebral Injury via Promoting Proteasomal Degradation of NLRC4 in Ischemic Stroke. | TRIM29 (Tripartite Motif Containing 29) Alleviates NLRC4 (NLR Family CARD Domain Containing Protein 4) Inflammasome Related Cerebral Injury via Promoting Proteasomal Degradation of NLRC4 in Ischemic Stroke.
Deng Y, Li Z, Sun X, Ma N, Song L, Chen D, Gao F. | 04/28/2023 |
| Reduced Tripartite Motif-Containing Protein 29 Deteriorates the Severity of Severe Acute Pancreatitis. | Reduced Tripartite Motif-Containing Protein 29 Deteriorates the Severity of Severe Acute Pancreatitis.
Ji S, Wang L. | 08/27/2022 |
| results identify TRIM29 as a negative regulator of NK cell functions | Identification of the E3 Ligase TRIM29 as a Critical Checkpoint Regulator of NK Cell Functions.
Dou Y, Xing J, Kong G, Wang G, Lou X, Xiao X, Vivier E, Li XC, Zhang Z., Free PMC Article | 04/11/2020 |
| deletion of the Atdc (Trim29) gene, whose human homolog is upregulated in the majority of pancreatic adenocarcinoma, prevents pancreatic adenocarcinoma development in the context of oncogenic KRAS; findings show ATDC (Trim29) promotes acinar-ductal metaplasia progression to pancreatic intraepithelial neoplasia through activation of beta-catenin signaling and subsequent SOX9 up-regulation | ATDC is required for the initiation of KRAS-induced pancreatic tumorigenesis.
Wang L, Yang H, Zamperone A, Diolaiti D, Palmbos PL, Abel EV, Purohit V, Dolgalev I, Rhim AD, Ljungman M, Hadju CH, Halbrook CJ, Bar-Sagi D, di Magliano MP, Crawford HC, Simeone DM., Free PMC Article | 09/7/2019 |
| TRIM29 regulates negatively the host innate immune response to RNA virus, which could be employed by RNA viruses for viral pathogenesis. | TRIM29 Negatively Regulates the Type I IFN Production in Response to RNA Virus.
Xing J, Zhang A, Minze LJ, Li XC, Zhang Z., Free PMC Article | 06/1/2019 |
| Knockdown of tripartite motif-containing 29 protein (TRIM29) enhanced the production of type I interferon in human and mouse dendritic cells by up to fourfold in response to intracellular herpes simplex virus. | TRIM29 promotes DNA virus infections by inhibiting innate immune response.
Xing J, Zhang A, Zhang H, Wang J, Li XC, Zeng MS, Zhang Z., Free PMC Article | 03/10/2018 |
| this study shows that deletion of TRIM29 enhanced macrophage production of type I interferons and protected mice from infection with influenza virus, while challenge of Trim29-/- mice with Haemophilus influenzae resulted in lethal lung inflammation due to massive production of proinflammatory cytokines by macrophages | Identification of a role for TRIM29 in the control of innate immunity in the respiratory tract.
Xing J, Weng L, Yuan B, Wang Z, Jia L, Jin R, Lu H, Li XC, Liu YJ, Zhang Z., Free PMC Article | 06/3/2017 |
| Findings established a role for ATDC/TRIM29 as a robust pathogenic driver of bladder cancer development, identified downstream effector pathways, and implicated ATDC as a candidate biomarker and therapeutic target. | ATDC/TRIM29 Drives Invasive Bladder Cancer Formation through miRNA-Mediated and Epigenetic Mechanisms.
Palmbos PL, Wang L, Yang H, Wang Y, Leflein J, Ahmet ML, Wilkinson JE, Kumar-Sinha C, Ney GM, Tomlins SA, Daignault S, Kunju LP, Wu XR, Lotan Y, Liebert M, Ljungman ME, Simeone DM., Free PMC Article | 04/30/2016 |
| ATDC up-regulates CD44 in mouse and human PanIN lesions via activation of beta-catenin signaling, leading to the induction of an epithelial-to-mesenchymal transition (EMT) phenotype characterized by expression of Zeb1 and Snail1. | ATDC induces an invasive switch in KRAS-induced pancreatic tumorigenesis.
Wang L, Yang H, Abel EV, Ney GM, Palmbos PL, Bednar F, Zhang Y, Leflein J, Waghray M, Owens S, Wilkinson JE, Prasad J, Ljungman M, Rhim AD, Pasca di Magliano M, Simeone DM., Free PMC Article | 03/7/2015 |
| Histone deacetylase 9 (HDAC9) regulates the functions of the ATDC (TRIM29) protein | Histone deacetylase 9 (HDAC9) regulates the functions of the ATDC (TRIM29) protein.
Yuan Z, Peng L, Radhakrishnan R, Seto E., Free PMC Article | 01/15/2011 |
| ATDC increases cell proliferation via inhibition of p53 nuclear activities. | The ATDC (TRIM29) protein binds p53 and antagonizes p53-mediated functions.
Yuan Z, Villagra A, Peng L, Coppola D, Glozak M, Sotomayor EM, Chen J, Lane WS, Seto E., Free PMC Article | 06/28/2010 |