| The transcription factor OCT6 promotes the dissolution of the naive pluripotent state by repressing Nanog and activating a formative state gene regulatory network. | The transcription factor OCT6 promotes the dissolution of the naïve pluripotent state by repressing Nanog and activating a formative state gene regulatory network.
Waisman A, Sevlever F, Saulnier D, Francia M, Blanco R, Amín G, Lombardi A, Biani C, Palma MB, Scarafía A, Smucler J, La Greca A, Moro L, Sevlever G, Guberman A, Miriuka S., Free PMC Article | 05/23/2024 |
| Single-molecule tracking of Nanog and Oct4 in living mouse embryonic stem cells uncovers a feedback mechanism of pluripotency maintenance. | Single-molecule tracking of Nanog and Oct4 in living mouse embryonic stem cells uncovers a feedback mechanism of pluripotency maintenance.
Okamoto K, Fujita H, Okada Y, Shinkai S, Onami S, Abe K, Fujimoto K, Sasaki K, Shioi G, Watanabe TM., Free PMC Article | 09/20/2023 |
| Embryonic stem cell ERK, AKT, plus STAT3 response dynamics combinatorics are heterogeneous but NANOG state independent. | Embryonic stem cell ERK, AKT, plus STAT3 response dynamics combinatorics are heterogeneous but NANOG state independent.
Reimann A, Kull T, Wang W, Dettinger P, Loeffler D, Schroeder T., Free PMC Article | 06/19/2023 |
| Epigenetic regulation of pluripotency inducer genes NANOG and SOX2 in human prostate cancer. | Epigenetic regulation of pluripotency inducer genes NANOG and SOX2 in human prostate cancer.
Niharika, Roy A, Mishra J, Chakraborty S, Singh SP, Patra SK. | 04/10/2023 |
| Trim28 citrullination maintains mouse embryonic stem cell pluripotency via regulating Nanog and Klf4 transcription. | Trim28 citrullination maintains mouse embryonic stem cell pluripotency via regulating Nanog and Klf4 transcription.
Zhang Y, Wan X, Qiu L, Zhou L, Huang Q, Wei M, Liu X, Liu S, Zhang B, Han J. | 03/27/2023 |
| H3K9 tri-methylation at Nanog times differentiation commitment and enables the acquisition of primitive endoderm fate. | H3K9 tri-methylation at Nanog times differentiation commitment and enables the acquisition of primitive endoderm fate.
Dubois A, Vincenti L, Chervova A, Greenberg MVC, Vandormael-Pournin S, Bourc'his D, Cohen-Tannoudji M, Navarro P., Free PMC Article | 09/24/2022 |
| LC3B upregulation by NANOG promotes immune resistance and stem-like property through hyperactivation of EGFR signaling in immune-refractory tumor cells. | LC3B upregulation by NANOG promotes immune resistance and stem-like property through hyperactivation of EGFR signaling in immune-refractory tumor cells.
Kim S, Cho H, Hong SO, Oh SJ, Lee HJ, Cho E, Woo SR, Song JS, Chung JY, Son SW, Yoon SM, Jeon YM, Jeon S, Yee C, Lee KM, Hewitt SM, Kim JH, Song KH, Kim TW., Free PMC Article | 01/22/2022 |
| Long noncoding RNA lnc-NAP sponges mmu-miR-139-5p to modulate Nanog functions in mouse ESCs and embryos. | Long noncoding RNA lnc-NAP sponges mmu-miR-139-5p to modulate Nanog functions in mouse ESCs and embryos.
Xie D, Tong M, Xia B, Feng G, Wang L, Li A, Luo G, Wan H, Zhang Z, Zhang H, Yang YG, Zhou Q, Wang M, Wang XJ., Free PMC Article | 11/27/2021 |
| Genome editing demonstrates that the -5 kb Nanog enhancer regulates Nanog expression by modulating RNAPII initiation and/or recruitment. | Genome editing demonstrates that the -5 kb Nanog enhancer regulates Nanog expression by modulating RNAPII initiation and/or recruitment.
Agrawal P, Blinka S, Pulakanti K, Reimer MH Jr, Stelloh C, Meyer AE, Rao S., Free PMC Article | 09/4/2021 |
| Effect of Nanog overexpression on the metastatic potential of a mouse melanoma cell line B16-BL6. | Effect of Nanog overexpression on the metastatic potential of a mouse melanoma cell line B16-BL6.
Saito M, Kishi R, Sasai T, Hatakenaka T, Matsuki N, Minagawa S., Free PMC Article | 07/31/2021 |
| Phosphorylation of NANOG by casein kinase I regulates embryonic stem cell self-renewal. | Phosphorylation of NANOG by casein kinase I regulates embryonic stem cell self-renewal.
Mullin NP, Varghese J, Colby D, Richardson JM, Findlay GM, Chambers I., Free PMC Article | 07/10/2021 |
| BACH1 recruits NANOG and histone H3 lysine 4 methyltransferase MLL/SET1 complexes to regulate enhancer-promoter activity and maintains pluripotency. | BACH1 recruits NANOG and histone H3 lysine 4 methyltransferase MLL/SET1 complexes to regulate enhancer-promoter activity and maintains pluripotency.
Niu C, Wang S, Guo J, Wei X, Jia M, Chen Z, Gong W, Qin Y, Wang X, Zhi X, Lu M, Chen S, Gu M, Zhang J, Han JJ, Lan F, Meng D., Free PMC Article | 03/13/2021 |
| TET1 Interacts Directly with NANOG via Independent Domains Containing Hydrophobic and Aromatic Residues. | TET1 Interacts Directly with NANOG via Independent Domains Containing Hydrophobic and Aromatic Residues.
Pantier R, Mullin N, Hall-Ponsele E, Chambers I., Free PMC Article | 03/6/2021 |
| Pluripotency factor NANOG promotes germ cell maintenance in vitro without triggering dedifferentiation of spermatogonial stem cells. | Pluripotency factor NANOG promotes germ cell maintenance in vitro without triggering dedifferentiation of spermatogonial stem cells.
Yang M, Deng B, Geng L, Li L, Wu X. | 02/6/2021 |
| Low-Level Nanog Expression in the Regulation of Quiescent Endothelium. | Low-Level Nanog Expression in the Regulation of Quiescent Endothelium.
Baruah J, Chaudhuri S, Mastej V, Axen C, Hitzman R, Ribeiro IMB, Wary KK., Free PMC Article | 10/10/2020 |
| Low intensity pulsed ultrasound (LIPUS) maintains osteogenic potency by the increased expression and stability of Nanog through spleen tyrosine kinase (Syk) activation. | Low intensity pulsed ultrasound (LIPUS) maintains osteogenic potency by the increased expression and stability of Nanog through spleen tyrosine kinase (Syk) activation.
Kusuyama J, Seong C, Makarewicz NS, Ohnishi T, Shima K, Semba I, Bandow K, Matsuguchi T. | 08/22/2020 |
| Compression force, which is generated by the 3D-SAC, promotes colony growth and expression of Nanog and Oct4 in mESCs and blastocyst development of mouse embryos. | Compression Generated by a 3D Supracellular Actomyosin Cortex Promotes Embryonic Stem Cell Colony Growth and Expression of Nanog and Oct4.
Du J, Fan Y, Guo Z, Wang Y, Zheng X, Huang C, Liang B, Gao L, Cao Y, Chen Y, Zhang X, Li L, Xu L, Wu C, Weitz DA, Feng X. | 08/12/2020 |
| essential role in the activation of pulmonary fibroblasts | Epithelial cell senescence induces pulmonary fibrosis through Nanog-mediated fibroblast activation.
Chen X, Xu H, Hou J, Wang H, Zheng Y, Li H, Cai H, Han X, Dai J., Free PMC Article | 07/11/2020 |
| Study shows that TET2 binds to the transcription factor NANOG suggesting that TET2 and NANOG co-localize on chromatin to regulate enhancers associated with naive pluripotency genes. | Endogenous epitope-tagging of Tet1, Tet2 and Tet3 identifies TET2 as a naïve pluripotency marker.
Pantier R, Tatar T, Colby D, Chambers I., Free PMC Article | 07/4/2020 |
| Nanog supports pluripotency in naive cells, while Nodal supports pluripotency in primed cells, but the handover from Nanog to Nodal does not proceed seamlessly, opening up the risk of aberrant differentiation if FGF is activated before Nodal. Here, we report that Id1 acts as a sensor to detect delays in Nodal activation after the downregulation of Nanog. | Id1 Stabilizes Epiblast Identity by Sensing Delays in Nodal Activation and Adjusting the Timing of Differentiation.
Malaguti M, Migueles RP, Blin G, Lin CY, Lowell S., Free PMC Article | 05/16/2020 |
| Fluorescence correlation spectroscopy analyses suggest a more compact chromatin organization in K6b-/- cells and impaired interactions of Oct4 and Nanog with chromatin. | Kat6b Modulates Oct4 and Nanog Binding to Chromatin in Embryonic Stem Cells and Is Required for Efficient Neural Differentiation.
Cosentino MS, Oses C, Vázquez Echegaray C, Solari C, Waisman A, Álvarez Y, Petrone MV, Francia M, Schultz M, Sevlever G, Miriuka S, Levi V, Guberman A. | 03/28/2020 |
| Nanog expression in adults prevents the maturation of erythroid cells | The pluripotency factor NANOG controls primitive hematopoiesis and directly regulates Tal1.
Sainz de Aja J, Menchero S, Rollan I, Barral A, Tiana M, Jawaid W, Cossio I, Alvarez A, Carreño-Tarragona G, Badia-Careaga C, Nichols J, Göttgens B, Isern J, Manzanares M., Free PMC Article | 01/4/2020 |
| The results suggest that Nanog represses Gsr gene expression in embryonic stem cells, evidencing a role of this crucial pluripotency transcription factor in preservation of redox homeostasis in stem cells. | The pluripotency transcription factor Nanog represses glutathione reductase gene expression in mouse embryonic stem cells.
Solari C, Petrone MV, Toro A, Vazquez Echegaray C, Cosentino MS, Waisman A, Francia M, Barañao L, Miriuka S, Guberman A., Free PMC Article | 12/14/2019 |
| Hmga2 transcriptionally up-regulates expression of stem cell factors, Sox2 and Nanog. They were co-localized with Hmga2 in the germs, but differentially distributed at enamel organ and mesenchyme in Hmga2-/- mice. | Hmga2 regulation of tooth formation and association with Sox2 and Nanog expression.
Kodama Y, Harinath D, Mihara-Tomiyama N, Tominaga N, Ide Y, Nakahara T, Maeda M, Igarashi M, D'Armiento J, Chada K, Imai K. | 11/9/2019 |
| Targeting dCas9 to an Oct4 site in the Nanog promoter displaced Oct4 from this site, reduced Nanog expression, and slowed division. In contrast, disrupting the Oct4 binding site adjacent to Pax6 upregulated Pax6 transcription and disrupting Nanog binding its own promoter upregulated its transcription | Reversible Disruption of Specific Transcription Factor-DNA Interactions Using CRISPR/Cas9.
Shariati SA, Dominguez A, Xie S, Wernig M, Qi LS, Skotheim JM., Free PMC Article | 10/26/2019 |