| Thrombospondin-1 Regulates Trophoblast Necroptosis via NEDD4-Mediated Ubiquitination of TAK1 in Preeclampsia. | Thrombospondin-1 Regulates Trophoblast Necroptosis via NEDD4-Mediated Ubiquitination of TAK1 in Preeclampsia.
Hu H, Ma J, Peng Y, Feng R, Luo C, Zhang M, Tao Z, Chen L, Zhang T, Chen W, Yin Q, Zhai J, Chen J, Yin A, Wang CC, Zhong M., Free PMC Article | 06/13/2024 |
| TR4 worsen urosepsis by regulating GSDMD. | TR4 worsen urosepsis by regulating GSDMD.
Wang H, Zhu S, Zhou Z, Wang Z, Zhuang W, Xue D, Lu Z, Zheng Q, Ding L, Ren L, Luo W, Wang R, Ge G, Xia L, Li G, Wu H., Free PMC Article | 03/7/2024 |
| Structures of human TR4LBD-JAZF1 and TR4DBD-DNA complexes reveal the molecular basis of transcriptional regulation. | Structures of human TR4LBD-JAZF1 and TR4DBD-DNA complexes reveal the molecular basis of transcriptional regulation.
Liu Y, Ma L, Li M, Tian Z, Yang M, Wu X, Wang X, Shang G, Xie M, Chen Y, Liu X, Jiang L, Wu W, Xu C, Xia L, Li G, Dai S, Chen Z., Free PMC Article | 02/28/2023 |
| HDAC6-dependent deacetylation of TAK1 enhances sIL-6R release to promote macrophage M2 polarization in colon cancer. | HDAC6-dependent deacetylation of TAK1 enhances sIL-6R release to promote macrophage M2 polarization in colon cancer.
Xu G, Niu L, Wang Y, Yang G, Zhu X, Yao Y, Zhao G, Wang S, Li H., Free PMC Article | 10/29/2022 |
| Effects of transforming growth factor beta-activated kinase 1 (TAK1) on apoptosis of HK-2 cells in the high glucose environment. | Effects of transforming growth factor beta-activated kinase 1 (TAK1) on apoptosis of HK-2 cells in the high glucose environment.
Wang Y, Zhao L, Qiu D, Shi Y, Duan H., Free PMC Article | 07/16/2022 |
| Small extracellular vesicle-mediated miR-320e transmission promotes osteogenesis in OPLL by targeting TAK1. | Small extracellular vesicle-mediated miR-320e transmission promotes osteogenesis in OPLL by targeting TAK1.
Xu C, Zhang Z, Liu N, Li L, Zhong H, Wang R, Shi Q, Zhang Z, Wei L, Hu B, Zhang H, Shen X, Wang Y, Liu Y, Yuan W., Free PMC Article | 05/14/2022 |
| The stabilization of yes-associated protein by TGFbeta-activated kinase 1 regulates the self-renewal and oncogenesis of gastric cancer stem cells. | The stabilization of yes-associated protein by TGFβ-activated kinase 1 regulates the self-renewal and oncogenesis of gastric cancer stem cells.
Wang G, Sun Q, Zhu H, Bi Y, Zhu H, Xu A., Free PMC Article | 02/5/2022 |
| Takinib Inhibits Inflammation in Human Rheumatoid Arthritis Synovial Fibroblasts by Targeting the Janus Kinase-Signal Transducer and Activator of Transcription 3 (JAK/STAT3) Pathway. | Takinib Inhibits Inflammation in Human Rheumatoid Arthritis Synovial Fibroblasts by Targeting the Janus Kinase-Signal Transducer and Activator of Transcription 3 (JAK/STAT3) Pathway.
Panipinto PM, Singh AK, Shaikh FS, Siegel RJ, Chourasia M, Ahmed S., Free PMC Article | 12/18/2021 |
| Use of miR145 and testicular nuclear receptor 4 inhibition to reduce chemoresistance to docetaxel in prostate cancer. | Use of miR‑145 and testicular nuclear receptor 4 inhibition to reduce chemoresistance to docetaxel in prostate cancer.
Zhu J, Qin P, Cao C, Dai G, Xu L, Yang D., Free PMC Article | 10/23/2021 |
| LncRNA H19 aggravates TNF-alpha-induced inflammatory injury via TAK1 pathway in MH7A cells. | LncRNA H19 aggravates TNF-α-induced inflammatory injury via TAK1 pathway in MH7A cells.
Yang J, Li Y, Wang L, Zhang Z, Li Z, Jia Q. | 07/31/2021 |
| Farnesoid X receptor activation inhibits TGFBR1/TAK1-mediated vascular inflammation and calcification via miR-135a-5p. | Farnesoid X receptor activation inhibits TGFBR1/TAK1-mediated vascular inflammation and calcification via miR-135a-5p.
Li C, Zhang S, Chen X, Ji J, Yang W, Gui T, Gai Z, Li Y., Free PMC Article | 06/26/2021 |
| Targeting the radiation-induced TR4 nuclear receptor-mediated QKI/circZEB1/miR-141-3p/ZEB1 signaling increases prostate cancer radiosensitivity. | Targeting the radiation-induced TR4 nuclear receptor-mediated QKI/circZEB1/miR-141-3p/ZEB1 signaling increases prostate cancer radiosensitivity.
Chen D, Chou FJ, Chen Y, Tian H, Wang Y, You B, Niu Y, Huang CP, Yeh S, Xing N, Chang C. | 03/28/2021 |
| Essential role of the linear ubiquitin chain assembly complex and TAK1 kinase in A20 mutant Hodgkin lymphoma. | Essential role of the linear ubiquitin chain assembly complex and TAK1 kinase in A20 mutant Hodgkin lymphoma.
Song Z, Wei W, Xiao W, Al-Saleem ED, Nejati R, Chen L, Yin J, Fabrizio J, Petrus MN, Waldmann TA, Yang Y., Free PMC Article | 02/2/2021 |
| TAB3 upregulates PIM1 expression by directly activating the TAK1-STAT3 complex to promote colorectal cancer growth. | TAB3 upregulates PIM1 expression by directly activating the TAK1-STAT3 complex to promote colorectal cancer growth.
Li Q, Chen L, Luo C, ChenYan, Ge J, Zhu Z, Wang K, Yu X, Lei J, Liu T, Peng X, Liu X, Yuan R. | 12/12/2020 |
| Targeting TR4 nuclear receptor with antagonist bexarotene increases docetaxel sensitivity to better suppress the metastatic castration-resistant prostate cancer progression. | Targeting TR4 nuclear receptor with antagonist bexarotene increases docetaxel sensitivity to better suppress the metastatic castration-resistant prostate cancer progression.
Hu L, Sun Y, Luo J, He X, Ye M, Li G, Zhang Y, Bai J, Zhang D, Chang C., Free PMC Article | 11/28/2020 |
| [Transforming growth factor-beta-activated kinase 1 and pathological myocardial hypertrophy]. | [Transforming growth factor-β-activated kinase 1 and pathological myocardial hypertrophy].
Li Y, Chen Y, Zhang DM. | 09/26/2020 |
| CPEB1 and CPEB4 are involved in the regulation of the TAK1 and Smad signalings in human macrophages and dermal fibroblasts | CPEB1 or CPEB4 knockdown suppresses the TAK1 and Smad signalings in THP-1 macrophage-like cells and dermal fibroblasts.
Cui HS, Joo SY, Cho YS, Kim JB, Seo CH. | 07/25/2020 |
| dampening oxidative stress with N-acetylcysteine (NAC) lowered hypertrophy in MTG1 KO to WT levels. Collectively, our data indicate that MTG1 protects against pressure overload-induced cardiac hypertrophy and dysfunction by preserving mitochondrial function and reducing oxidative stress and downstream TAK1 stress signaling. | Novel role of mitochondrial GTPases 1 in pathological cardiac hypertrophy.
Xu D, Zhao Y, Weng X, Lu Y, Li W, Tang K, Chen W, Liu Z, Qi X, Zheng J, Fassett J, Zhang Y, Xu Y. | 06/20/2020 |
| Cell hypoxia increases TR4, which plays a critical role in regulating renal cell carcinoma (RCC) resistance to sunitinib through transcriptional regulation of lncTASR (ENST00000600671.1) which might then increase AXL protein expression via enhancing the stability of AXL mRNA to increase the sunitinib resistance. | Targeting the TR4 nuclear receptor-mediated lncTASR/AXL signaling with tretinoin increases the sunitinib sensitivity to better suppress the RCC progression.
Shi H, Sun Y, He M, Yang X, Hamada M, Fukunaga T, Zhang X, Chang C., Free PMC Article | 06/20/2020 |
| TAK1 governs p62 action, switching it from an autophagy receptor to a signaling platform. This ability of TAK1 to disable p62 as an autophagy receptor may allow certain autophagic substrates to accumulate when needed for cellular functions. | TAK1 converts Sequestosome 1/p62 from an autophagy receptor to a signaling platform.
Kehl SR, Soos BA, Saha B, Choi SW, Herren AW, Johansen T, Mandell MA., Free PMC Article | 06/6/2020 |
| TR4 may function as a suppressor of hepatocellular carcinoma metastasis by down-regulating the expression of EphA2. | TR(4) nuclear receptor suppresses HCC cell invasion via downregulating the EphA2 expression.
Jin R, Lin H, Li G, Xu J, Shi L, Chang C, Cai X., Free PMC Article | 04/11/2020 |
| IL-1beta regulates the expression of NGF and COX-2, rotator cuff tear pain-related molecules in the subacromial bursa cells, through TAK1. | IL-1β mediates NGF and COX-2 expression through transforming growth factor-activating kinase 1 in subacromial bursa cells derived from rotator cuff tear patients.
Nagura N, Uchida K, Kenmoku T, Inoue G, Nakawaki M, Miyagi M, Takaso M. | 02/29/2020 |
| This study demonstrated that the NR2C2-upstream open reading frame impaired the pivotal roles that UCA1-miR-627-5p-NR2C2 feedback loop had in regulating the malignancies of glioma cells by targeting NR2C2 directly. | NR2C2-uORF targeting UCA1-miR-627-5p-NR2C2 feedback loop to regulate the malignant behaviors of glioma cells.
Fan Z, Zheng J, Xue Y, Liu X, Wang D, Yang C, Ma J, Liu L, Ruan X, Wang Z, Liu Y., Free PMC Article | 11/30/2019 |
| TAK1, receptor-interacting kinase 1 (RIPK1) as well as canonical and non-canonical NF-kappaB signaling are differentially involved in SM-induced cell death in breast cancer cells. | Differential involvement of TAK1, RIPK1 and NF-κB signaling in Smac mimetic-induced cell death in breast cancer cells.
Schmidt N, Kowald L, van Wijk SJL, Fulda S. | 10/5/2019 |
| Taken together, these results suggest that enterohemorrhagic Escherichia coli Tir negatively regulates proinflammatory responses by inhibiting the activation of TAK1, which is essential for immune evasion. | Enterohemorrhagic Escherichia coli Tir inhibits TAK1 activation and mediates immune evasion.
Zhou R, Chen Z, Hao D, Wang Y, Zhang Y, Yi X, Lyu LD, Liu H, Zou Q, Chu Y, Ge B, Yan D., Free PMC Article | 08/31/2019 |