| Endothelial PDGF-D contributes to neurovascular protection after ischemic stroke by rescuing pericyte functions. | Endothelial PDGF-D contributes to neurovascular protection after ischemic stroke by rescuing pericyte functions.
Bernard M, Menet R, Lecordier S, ElAli A., Free PMC Article | 05/28/2024 |
| PDGF-D Is Dispensable for the Development and Progression of Murine Alport Syndrome. | PDGF-D Is Dispensable for the Development and Progression of Murine Alport Syndrome.
Firat EAM, Buhl EM, Bouteldja N, Smeets B, Eriksson U, Boor P, Klinkhammer BM. | 04/25/2024 |
| Molecular mechanisms of coronary artery disease risk at the PDGFD locus. | Molecular mechanisms of coronary artery disease risk at the PDGFD locus.
Kim HJ, Cheng P, Travisano S, Weldy C, Monteiro JP, Kundu R, Nguyen T, Sharma D, Shi H, Lin Y, Liu B, Haldar S, Jackson S, Quertermous T., Free PMC Article | 02/23/2023 |
| PDGFD switches on stem cell endothelial commitment. | PDGFD switches on stem cell endothelial commitment.
Lu W, Xu P, Deng B, Zhang J, Zhan Y, Lin X, Xu X, Xia Z, Yang X, Zeng X, Huang L, Xie B, Wang C, Wang S, Kuang H, Han X, Mora A, Cao Y, Jiang Q, Li X., Free PMC Article | 01/14/2023 |
| PDGF-D-PDGFRbeta signaling enhances IL-15-mediated human natural killer cell survival. | PDGF-D-PDGFRβ signaling enhances IL-15-mediated human natural killer cell survival.
Ma S, Tang T, Wu X, Mansour AG, Lu T, Zhang J, Wang LS, Caligiuri MA, Yu J., Free PMC Article | 02/26/2022 |
| Inhibiting PDGF-D alleviates the symptoms of HELLP by suppressing NF-kappaB activation. | Inhibiting PDGF-D alleviates the symptoms of HELLP by suppressing NF-κB activation.
Wang H, Nian L, Li Z, Lu C. | 12/11/2021 |
| PDGF-D activation by macrophage-derived uPA promotes AngII-induced cardiac remodeling in obese mice. | PDGF-D activation by macrophage-derived uPA promotes AngII-induced cardiac remodeling in obese mice.
Cheng YW, Zhang ZB, Lan BD, Lin JR, Chen XH, Kong LR, Xu L, Ruan CC, Gao PJ., Free PMC Article | 11/27/2021 |
| Data (including data from studies using transgenic/mutant mice and cells from such mice) suggest that Pdgfd promotes cell proliferation, cell migration, and expression of inflammatory factors in adventitial fibroblasts; in obese mice, inhibition of Pdgfd significantly reduces aortic aneurysm formation (induced by infusion of angiotensin II). | Perivascular Adipose Tissue-Derived PDGF-D Contributes to Aortic Aneurysm Formation During Obesity.
Zhang ZB, Ruan CC, Lin JR, Xu L, Chen XH, Du YN, Fu MX, Kong LR, Zhu DL, Gao PJ. | 07/28/2018 |
| upregulated in kidney fibrosis, may mediate renal scarring, and is dispensable for normal kidney development and physiological functions | The role of PDGF-D in healthy and fibrotic kidneys.
Buhl EM, Djudjaj S, Babickova J, Klinkhammer BM, Folestad E, Borkham-Kamphorst E, Weiskirchen R, Hudkins K, Alpers CE, Eriksson U, Floege J, Boor P. | 02/4/2017 |
| Inactivation of the Pdgfd gene resulted in a mild phenotype in C57BL/6 mice, and the offspring was viable, fertile and generally in good health. | Mice Lacking Platelet-Derived Growth Factor D Display a Mild Vascular Phenotype.
Gladh H, Folestad EB, Muhl L, Ehnman M, Tannenberg P, Lawrence AL, Betsholtz C, Eriksson U., Free PMC Article | 08/13/2016 |
| PDGF-D intensifies fibrogenesis by interfering with the fibrolytic activity of the TIMP-1/MMP-2/MMP-9 system, and PDGF-D signaling is mediated through both PDGF-alpha and -beta receptors. | Platelet-derived growth factor-D modulates extracellular matrix homeostasis and remodeling through TIMP-1 induction and attenuation of MMP-2 and MMP-9 gelatinase activities.
Borkham-Kamphorst E, Alexi P, Tihaa L, Haas U, Weiskirchen R. | 07/25/2015 |
| Radial glia require PDGFD-PDGFRbeta signalling in human but not mouse neocortex | Radial glia require PDGFD-PDGFRβ signalling in human but not mouse neocortex.
Lui JH, Nowakowski TJ, Pollen AA, Javaherian A, Kriegstein AR, Oldham MC., Free PMC Article | 12/20/2014 |
| PDGF D represents a potentially promising target for prostate carcinoma treatment resistance in the absence of PTEN function, and warrants further laboratory evaluation and clinical study. | A critical role of the PTEN/PDGF signaling network for the regulation of radiosensitivity in adenocarcinoma of the prostate.
Christensen M, Najy AJ, Snyder M, Movilla LS, Kim HR., Free PMC Article | 02/15/2014 |
| Data indicate that the proteolytic processing of full-length PDGF-D is required for PDGF-D activation of preosteoclasts, and that beta-PDGFR is present in activated osteoclasts. | A novel function for platelet-derived growth factor D: induction of osteoclastic differentiation for intraosseous tumor growth.
Huang W, Fridman Y, Bonfil RD, Ustach CV, Conley-LaComb MK, Wiesner C, Saliganan A, Cher ML, Kim HR., Free PMC Article | 01/26/2013 |
| identified PDGF-DD as an important target gene for antiangiogenic therapy due to its pleiotropic effects on vascular and non-vascular cells. PDGF-DD inhibition may offer new therapeutic options to treat neovascular diseases | Platelet-derived growth factor-DD targeting arrests pathological angiogenesis by modulating glycogen synthase kinase-3beta phosphorylation.
Kumar A, Hou X, Lee C, Li Y, Maminishkis A, Tang Z, Zhang F, Langer HF, Arjunan P, Dong L, Wu Z, Zhu LY, Wang L, Min W, Colosi P, Chavakis T, Li X., Free PMC Article | 06/28/2010 |
| Failure of laminin alpha4-mediated down-regulation of PDGF activity contributes to the progressive renal lesions in this animal model. | Laminin alpha4-null mutant mice develop chronic kidney disease with persistent overexpression of platelet-derived growth factor.
Abrass CK, Hansen KM, Patton BL., Free PMC Article | 03/22/2010 |
| PDGF-DD, a novel mediator of smooth muscle cell phenotypic modulation, is upregulated in endothelial cells exposed to atherosclerosis-prone flow patterns. | PDGF-DD, a novel mediator of smooth muscle cell phenotypic modulation, is upregulated in endothelial cells exposed to atherosclerosis-prone flow patterns.
Thomas JA, Deaton RA, Hastings NE, Shang Y, Moehle CW, Eriksson U, Topouzis S, Wamhoff BR, Blackman BR, Owens GK., Free PMC Article | 01/21/2010 |
| splicing variant results in significant differences in peptide expression and function | A novel murine PDGF-D splicing variant results in significant differences in peptide expression and function.
Zhuo Y, Hoyle GW, Zhang J, Morris G, Lasky JA. | 01/21/2010 |
| These results suggest that PDGF-D induce cellular transformation and promote tumour growth by accelerating the proliferation rate of the tumour cells, and by stimulation of tumour neovascularization. | PDGF-D is a potent transforming and angiogenic growth factor.
Li H, Fredriksson L, Li X, Eriksson U. | 01/21/2010 |
| PDGF-D plays an important role in the pathogenesis of tubulointerstitial injury through binding of PDGF-Rbeta in obstructive ureteral nephropathy | Obstructive uropathy in mice and humans: potential role for PDGF-D in the progression of tubulointerstitial injury.
Taneda S, Hudkins KL, Topouzis S, Gilbertson DG, Ophascharoensuk V, Truong L, Johnson RJ, Alpers CE. | 01/21/2010 |