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    TPO thyroid peroxidase [ Homo sapiens (human) ]

    Gene ID: 7173, updated on 2-Nov-2024

    GeneRIFs: Gene References Into Functions

    GeneRIFPubMed TitleDate
    Disulfide Bonds of Thyroid Peroxidase Are Critical Elements for Subcellular Localization, Proteasome-Dependent Degradation, and Enzyme Activity.

    Disulfide Bonds of Thyroid Peroxidase Are Critical Elements for Subcellular Localization, Proteasome-Dependent Degradation, and Enzyme Activity.
    Iwasaki H, Suwanai H, Yakou F, Sakai H, Ishii K, Hara N, Buckle AM, Kanekura K, Miyagi T, Narumi S, Suzuki R.

    06/7/2024
    Is There a Link between Thyroid Peroxidase Gene Promoter Polymorphisms and Autoimmune Thyroiditis in the Polish Population?

    Is There a Link between Thyroid Peroxidase Gene Promoter Polymorphisms and Autoimmune Thyroiditis in the Polish Population?
    Lacka K, Maciejewski A, Jarecki P, Herman W, Lacki JK, Żaba R, Kowalczyk MJ., Free PMC Article

    04/2/2024
    Homozygous Mutations in Thyroid Peroxidase (TPO) in Hypothyroidism with Intellectual Disability, Developmental Delay, and Hearing and Ocular Anomalies in Two Families: Severe Manifestation of Untreated TPO-deficiency Poses a Diagnostic Dilemma.

    Homozygous Mutations in Thyroid Peroxidase (TPO) in Hypothyroidism with Intellectual Disability, Developmental Delay, and Hearing and Ocular Anomalies in Two Families: Severe Manifestation of Untreated TPO-deficiency Poses a Diagnostic Dilemma.
    Naqvi SF, Yıldız-Bölükbaşı E, Afzal M, Nalbant G, Mumtaz S, Tolun A, Malik S., Free PMC Article

    11/1/2023
    TPO as an indicator of lymph node metastasis and recurrence in papillary thyroid carcinoma.

    TPO as an indicator of lymph node metastasis and recurrence in papillary thyroid carcinoma.
    Li X, Cheng R., Free PMC Article

    07/10/2023
    Variants in TPO rs2048722, PTCSC2 rs925489 and SEMA4G rs4919510 affect thyroid carcinoma susceptibility risk.

    Variants in TPO rs2048722, PTCSC2 rs925489 and SEMA4G rs4919510 affect thyroid carcinoma susceptibility risk.
    Shen Z, Sun Y, Niu G., Free PMC Article

    06/24/2023
    Longitudinal Associations Between TPO Gene Variants and Thyroid Peroxidase Antibody Seroconversion in a Population-Based Study: Tehran Thyroid Study.

    Longitudinal Associations Between TPO Gene Variants and Thyroid Peroxidase Antibody Seroconversion in a Population-Based Study: Tehran Thyroid Study.
    Ghanooni AH, Zadeh-Vakili A, Rezvankhah B, Jafari Nodushan S, Akbarzadeh M, Amouzegar A, Daneshpour MS, Khalili D, Mehrabi Y, Ebadi SA, Azizi F.

    04/4/2023
    Cryo-electron microscopy structures of human thyroid peroxidase (TPO) in complex with TPO antibodies.

    Cryo-electron microscopy structures of human thyroid peroxidase (TPO) in complex with TPO antibodies.
    Baker S, Miguel RN, Thomas D, Powell M, Furmaniak J, Smith BR., Free PMC Article

    02/4/2023
    Hypomethylation of Thyroid Peroxidase as a Biomarker for Hepatocellular Carcinoma with Tumor Thrombosis.

    Hypomethylation of Thyroid Peroxidase as a Biomarker for Hepatocellular Carcinoma with Tumor Thrombosis.
    Xie RT, Li QY, Sun XC, Zhi QJ, Huang XX, Zhu XC, Miao QZ, Zhou DZ, Han DY.

    01/11/2023
    Mutational screening of the TPO and DUOX2 genes in Argentinian children with congenital hypothyroidism due to thyroid dyshormonogenesis.

    Mutational screening of the TPO and DUOX2 genes in Argentinian children with congenital hypothyroidism due to thyroid dyshormonogenesis.
    Molina MF, Papendieck P, Sobrero G, Balbi VA, Belforte FS, Martínez EB, Adrover E, Olcese MC, Chiesa A, Miras MB, González VG, Pio MG, González-Sarmiento R, Targovnik HM, Rivolta CM.

    07/9/2022
    TSH stimulation of human thyroglobulin and thyroid peroxidase gene transcription is partially dependent on internalization.

    TSH stimulation of human thyroglobulin and thyroid peroxidase gene transcription is partially dependent on internalization.
    Jang D, Eliseeva E, Klubo-Gwiezdzinska J, Neumann S, Gershengorn MC., Free PMC Article

    04/9/2022
    Novel DIO1 Gene Mutation Acting as Phenotype Modifier for Novel Compound Heterozygous TPO Gene Mutations Causing Congenital Hypothyroidism.

    Novel DIO1 Gene Mutation Acting as Phenotype Modifier for Novel Compound Heterozygous TPO Gene Mutations Causing Congenital Hypothyroidism.
    Furman A, Hannoush Z, Echegoyen FB, Dumitrescu A, Refetoff S, Weiss RE., Free PMC Article

    03/26/2022
    Screening and Functional Analysis of TPO Gene Mutations in a Cohort of Chinese Patients With Congenital Hypothyroidism.

    Screening and Functional Analysis of TPO Gene Mutations in a Cohort of Chinese Patients With Congenital Hypothyroidism.
    Wang H, Wang W, Chen X, Shi H, Shi Y, Ding G., Free PMC Article

    02/19/2022
    Congenital hypothyroidism and hearing loss without inner ear malformation: Think TPO.

    Congenital hypothyroidism and hearing loss without inner ear malformation: Think TPO.
    Ziegler A, Denommé-Pichon AS, Boucher S, Bouzamondo N, Colin E, Dieu X, Jean Yves T, Bouhours N, Rouleau S, Coutant R, Rodien P, Prunier D, Bonneau D.

    01/22/2022
    Association of Thyroid Peroxidase Gene Polymorphisms and Serum Anti- TPO Levels in Egyptian Patients with Autoimmune Hypothyroidism.

    Association of Thyroid Peroxidase Gene Polymorphisms and Serum Anti- TPO Levels in Egyptian Patients with Autoimmune Hypothyroidism.
    Ahmed HS, Nsrallah AAM, Abdel-Fatah AH, Mahmoud AA, Fikry AA.

    12/4/2021
    Functional analysis of thyroid peroxidase gene mutations resulting in congenital hypothyroidism.

    Functional analysis of thyroid peroxidase gene mutations resulting in congenital hypothyroidism.
    Zhao D, Li Y, Shan Z, Teng W, Li J, Teng X.

    09/25/2021
    Homology between TSH-R/Tg/TPO and Hashimoto's encephalopathy autoantigens.

    Homology between TSH-R/Tg/TPO and Hashimoto's encephalopathy autoantigens.
    Benvenga S, Guarneri F.

    06/19/2021
    The TPO mutation screening and genotype-phenotype analysis in 230 Chinese patients with congenital hypothyroidism.

    The TPO mutation screening and genotype-phenotype analysis in 230 Chinese patients with congenital hypothyroidism.
    Zhang RJ, Sun F, Chen F, Fang Y, Yan CY, Zhang CR, Ying YX, Wang Z, Zhang CX, Wu FY, Han B, Liang J, Zhao SX, Song HD.

    05/8/2021
    Increased Prevalence of TG and TPO Mutations in Sudanese Children With Congenital Hypothyroidism.

    Increased Prevalence of TG and TPO Mutations in Sudanese Children With Congenital Hypothyroidism.
    Bruellman RJ, Watanabe Y, Ebrhim RS, Creech MK, Abdullah MA, Dumitrescu AM, Refetoff S, Weiss RE., Free PMC Article

    02/13/2021
    Thyroid Peroxidase Antibody (TPO) as a Predictor of Radiation Induced Thyroid Dysfunction Among Nurses and Technicians Working in Mansoura Specialized Medical Hospital: Cross Sectional Study.

    Thyroid Peroxidase Antibody (TPO) as a Predictor of Radiation Induced Thyroid Dysfunction Among Nurses and Technicians Working in Mansoura Specialized Medical Hospital: Cross Sectional Study.
    Albehairy A, Fathy S, Bahriz R.

    11/21/2020
    can exist as both a monomer and a dimer; autoantibody preferentially binds the TPO monomer

    Structural Studies of Thyroid Peroxidase Show the Monomer Interacting With Autoantibodies in Thyroid Autoimmune Disease.
    Williams DE, Le SN, Hoke DE, Chandler PG, Gora M, Godlewska M, Banga JP, Buckle AM.

    07/18/2020
    study of differences in the galectin-3 and TPO expression between some oncocytic and non-oncocytic thyroid tumors

    Combined use of galectin-3 and thyroid peroxidase improves the differential diagnosis of thyroid tumors.
    Kalfert D, Ludvikova M, Kholova I, Ludvik J, Topolocan O, Plzak J.

    03/14/2020
    the substitutions mutations, namely, p.Ala373Ser, p.Ser398Thr, and p.Thr725Pro, had been involved in Bangladeshi patients with TDH and molecular docking-based study revealed that these mutations had damaging effect on the TPO protein activity

    Mutation Spectrum in TPO Gene of Bangladeshi Patients with Thyroid Dyshormonogenesis and Analysis of the Effects of Different Mutations on the Structural Features and Functions of TPO Protein through In Silico Approach.
    Begum MN, Islam MT, Hossain SR, Bhuyan GS, Halim MA, Shahriar I, Sarker SK, Haque S, Konika TK, Islam MS, Rahat A, Qadri SK, Sultana R, Begum S, Sultana S, Saha N, Hasan M, Hasanat MA, Banu H, Shekhar HU, Chowdhury EK, Sajib AA, Islam ABMMK, Qadri SS, Qadri F, Akhteruzzaman S, Mannoor K., Free PMC Article

    07/27/2019
    genetic association studies in population in Japan: Data suggest that SNPs in TPO (rs2071400 C/T, rs2071403 A/G) are associated with development of Hashimoto's disease and Graves' disease, but not with the prognosis of individual patients in the population studied.

    The polymorphisms in the thyroid peroxidase gene were associated with the development of autoimmune thyroid disease and the serum levels of anti-thyroid peroxidase antibody.
    Tomari S, Watanabe M, Inoue N, Mizuma T, Yamanaka C, Hidaka Y, Iwatani Y.

    07/14/2018
    Biochemical properties of the TPO protein expressed in cancer and normal breast tissue are similar to those observed for the thyroid TPO. Nevertheless, there are some differences in comparison with the thyroid-tissue expressed protein, such as a lower N-glycan content, a slightly smaller polypeptide length, a decreased enzymatic activity, and undetectable dimer formation.

    Biochemical properties of thyroid peroxidase (TPO) expressed in human breast and mammary-derived cell lines.
    Godlewska M, Krasuska W, Czarnocka B., Free PMC Article

    06/30/2018
    For the first time, we have isolated thyroid peroxidase by immunocytochemistry in the granulosa cumulus cells of the human ovarian follicle, thereby supporting the hypothesis that the human ovarian follicle may be an independent thyroid-hormone producing unit.

    Thyroid peroxidase identified in human granulosa cells: another piece to the thyroid-ovary puzzle?
    Monteleone P, Faviana P, Artini PG.

    05/12/2018
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