| Variants in tropomyosins TPM2 and TPM3 causing muscle hypertonia. | Variants in tropomyosins TPM2 and TPM3 causing muscle hypertonia.
Wallgren-Pettersson C, Jokela M, Lehtokari VL, Tyynismaa H, Sainio MT, Ylikallio E, Tynninen O, Pelin K, Auranen M. | 02/28/2024 |
| A recurrent pathogenic variant in TPM2 reveals further phenotypic and genetic heterogeneity in multiple pterygium syndrome-related disorders. | A recurrent pathogenic variant in TPM2 reveals further phenotypic and genetic heterogeneity in multiple pterygium syndrome-related disorders.
Vogt J, Al-Saedi A, Willis T, Male A, McKie A, Kiely N, Maher ER. | 06/5/2021 |
| Mutations Q93H and E97K in TPM2 Disrupt Ca-Dependent Regulation of Actin Filaments. | Mutations Q93H and E97K in TPM2 Disrupt Ca-Dependent Regulation of Actin Filaments.
Śliwinska M, Robaszkiewicz K, Wasąg P, Moraczewska J., Free PMC Article | 05/15/2021 |
| Looking for Targets to Restore the Contractile Function in Congenital Myopathy Caused by Gln(147)Pro Tropomyosin. | Looking for Targets to Restore the Contractile Function in Congenital Myopathy Caused by Gln(147)Pro Tropomyosin.
Karpicheva OE, Simonyan AO, Rysev NA, Redwood CS, Borovikov YS., Free PMC Article | 02/27/2021 |
| [Expression of tropomyosin 2 in aortic dissection tissue]. | [Expression of tropomyosin 2 in aortic dissection tissue].
Zhong XX, Wei X, Jiang DS, Zhu XH, Liu LG. | 09/26/2020 |
| TPM2 as a potential predictive biomarker for atherosclerosis. | TPM2 as a potential predictive biomarker for atherosclerosis.
Meng LB, Shan MJ, Qiu Y, Qi R, Yu ZM, Guo P, Di CY, Gong T., Free PMC Article | 09/5/2020 |
| Structural and functional properties of alpha-beta-Tpm heterodimers with myopathic mutations Q147P and K49del in the beta-chain differ significantly from the properties of beta-beta-Tpm homodimers with the same substitutions in both beta-chains. Mutations Q147P and K49del strongly increased the stability of calorimetric domain previously assigned to the N-terminal part of Tpm molecule. | Structural and functional properties of αβ-heterodimers of tropomyosin with myopathic mutations Q147P and K49del in the β-chain.
Matyushenko AM, Shchepkin DV, Susorov DS, Nefedova VV, Kopylova GV, Berg VY, Kleymenov SY, Levitsky DI. | 11/23/2019 |
| Novel mutations in TPM2 and PIEZO2 are responsible for distal arthrogryposis (DA) 2B and mild DA in two Chinese families. | Novel mutations in TPM2 and PIEZO2 are responsible for distal arthrogryposis (DA) 2B and mild DA in two Chinese families.
Li S, You Y, Gao J, Mao B, Cao Y, Zhao X, Zhang X., Free PMC Article | 05/25/2019 |
| Tropomyosin Tpm 2.1 loss induces glioblastoma spreading in soft brain-like environments. Study demonstrate that Tpm 2.1 depletion by siRNA induces cell spreading and elongation in soft 3D hydrogels, irrespective of matrix composition. | Tropomyosin Tpm 2.1 loss induces glioblastoma spreading in soft brain-like environments.
Mitchell CB, Black B, Sun F, Chrzanowski W, Cooper-White J, Maisonneuve B, Stringer B, Day B, Biro M, O'Neill GM. | 04/20/2019 |
| Hypoxia may regulate cell invasiveness partly by TPM2 down-regulation mediated changes of MMP2 expression, which is also a new pathway by which hypoxia regulates cancer progression. TPM2 is a potential novel tumour suppressor gene in breast cancer. | Hypoxia-Induced TPM2 Methylation is Associated with Chemoresistance and Poor Prognosis in Breast Cancer.
Zhang J, Zhang J, Xu S, Zhang X, Wang P, Wu H, Xia B, Zhang G, Lei B, Wan L, Zhang D, Pang D. | 03/31/2018 |
| Stress fibre formation and up-regulation of alpha-smooth muscle actin (alphaSMA) induced by TGFbeta2 could be reversed by Tpm1/2 knock-down by siRNA. | FGF2 antagonizes aberrant TGFβ regulation of tropomyosin: role for posterior capsule opacity.
Kubo E, Shibata S, Shibata T, Kiyokawa E, Sasaki H, Singh DP., Free PMC Article | 10/14/2017 |
| The increased expression of TPM1lambda and the decreased expression of TPM1delta RNA and TPM2beta may lead to decreased stress fiber formation and malignant transformation in human breast epithelial cells. | Expression of tropomyosin 2 gene isoforms in human breast cancer cell lines.
Dube S, Thomas A, Abbott L, Benz P, Mitschow C, Dube DK, Poiesz BJ., Free PMC Article | 03/18/2017 |
| Promoter variants in HOXA9, TPM1, and TPM2, alter promoter expression suggesting that they have a functional role in clubfoot. | Functional Assessment of Clubfoot Associated HOXA9, TPM1, and TPM2 Variants Suggests a Potential Gene Regulation Mechanism.
Weymouth KS, Blanton SH, Powell T, Patel CV, Savill SA, Hecht JT., Free PMC Article | 02/25/2017 |
| TPM2 appears to be commonly silenced by aberrant DNA methylation in colon cancer. TPM2 loss is associated with RhoA activation and tumor proliferation. | Epigenetic silencing of TPM2 contributes to colorectal cancer progression upon RhoA activation.
Cui J, Cai Y, Hu Y, Huang Z, Luo Y, Kaz AM, Yang Z, Chen D, Fan X, Grady WM, Wang J. | 02/18/2017 |
| Despite its reduced affinity for actin in co-sedimentation assay, the Q147P mutant incorporates into the muscle fiber ..Q147P tropomyosin (TPM2)binds to actin in ghost muscle fiber. | Myopathy-causing Q147P TPM2 mutation shifts tropomyosin strands further towards the open position and increases the proportion of strong-binding cross-bridges during the ATPase cycle.
Karpicheva OE, Simonyan AO, Kuleva NV, Redwood CS, Borovikov YS. | 06/28/2016 |
| tropomyosin 2.1 acts as a suppressor of growth on soft matrices by supporting proper rigidity sensing | Tropomyosin controls sarcomere-like contractions for rigidity sensing and suppressing growth on soft matrices.
Wolfenson H, Meacci G, Liu S, Stachowiak MR, Iskratsch T, Ghassemi S, Roca-Cusachs P, O'Shaughnessy B, Hone J, Sheetz MP., Free PMC Article | 05/14/2016 |
| Myo1c significantly increases the frequency of kinesin-1-driven microtubule-based runs that begin at actin/microtubule intersections. The actin-binding protein tropomyosin 2 abolishes Myo1c-specific effects on both run initiation and run termination. | Control of the initiation and termination of kinesin-1-driven transport by myosin-Ic and nonmuscle tropomyosin.
McIntosh BB, Holzbaur EL, Ostap EM., Free PMC Article | 12/5/2015 |
| Changes for CRMP2, TCP1epsilon, TPM2 and 14-3-3gamma were confirmed in experimental tumors and in a series of 28 human SI-NETs. | Mechanisms of local invasion in enteroendocrine tumors: identification of novel candidate cytoskeleton-associated proteins in an experimental mouse model by a proteomic approach and validation in human tumors.
Couderc C, Bollard J, Couté Y, Massoma P, Poncet G, Lepinasse F, Hervieu V, Gadot N, Sanchez JC, Scoazec JY, Diaz JJ, Roche C. | 08/8/2015 |
| Patients with TPM2 mutations tended to present with milder symptoms than those with TPM3 mutations, DA being present only in the TPM2 group. | Mutation update and genotype-phenotype correlations of novel and previously described mutations in TPM2 and TPM3 causing congenital myopathies.
Marttila M, Lehtokari VL, Marston S, Nyman TA, Barnerias C, Beggs AH, Bertini E, Ceyhan-Birsoy O, Cintas P, Gerard M, Gilbert-Dussardier B, Hogue JS, Longman C, Eymard B, Frydman M, Kang PB, Klinge L, Kolski H, Lochmüller H, Magy L, Manel V, Mayer M, Mercuri E, North KN, Peudenier-Robert S, Pihko H, Probst FJ, Reisin R, Stewart W, Taratuto AL, de Visser M, Wilichowski E, Winer J, Nowak K, Laing NG, Winder TL, Monnier N, Clarke NF, Pelin K, Grönholm M, Wallgren-Pettersson C., Free PMC Article | 01/24/2015 |
| in a cohort of 94 patients with congenital myopathy, 2 related female patients and 2 sporadic male patients were found to carry mutations in TPM2 and TPM3 genes respectively; clinical presentation and muscle morphological findings differed in the patients | Frequency and phenotype of patients carrying TPM2 and TPM3 gene mutations in a cohort of 94 patients with congenital myopathy.
Citirak G, Witting N, Duno M, Werlauff U, Petri H, Vissing J. | 01/17/2015 |
| Histopathological phenotype association of muscle fibers expressing Beta-tropomyosin mutational variants that occur in human myopathies. | Phenotypes of myopathy-related beta-tropomyosin mutants in human and mouse tissue cultures.
Abdul-Hussein S, Rahl K, Moslemi AR, Tajsharghi H., Free PMC Article | 06/14/2014 |
| effect of the skeletal myopathy-causing E117K mutation in human beta-tropomyosin on actomyosin structure during the ATPase cycle | The E117K mutation in β-tropomyosin disturbs concerted conformational changes of actomyosin in muscle fibers.
Karpicheva OE, Redwood CS, Borovikov YS. | 06/14/2014 |
| In addition to CLIC1 and TPM1, which were the proteins initially discovered in a xenograft mouse model, CLIC4, TPM2, TPM3, and TPM4 were present in ovarian cancer patient sera at significantly elevated levels compared with controls. | Protein isoform-specific validation defines multiple chloride intracellular channel and tropomyosin isoforms as serological biomarkers of ovarian cancer.
Tang HY, Beer LA, Tanyi JL, Zhang R, Liu Q, Speicher DW., Free PMC Article | 03/22/2014 |
| We showed that TPM2, CLU, and COL4A6 mRNA levels are downregulated in prostate cancer. | Identification of new genes downregulated in prostate cancer and investigation of their effects on prognosis.
Varisli L. | 02/15/2014 |
| The p.R133W mutation in TPM2 is associated with Sheldon-Hall syndrome. | First Korean family with a mutation in TPM2 associated with Sheldon-Hall syndrome.
Ko JM, Choi IH, Baek GH, Kim KW., Free PMC Article | 12/14/2013 |