Optineurin regulates osteoblast function in an age-dependent fashion in a mouse model of Paget's disease of bone.
Hu X, Foster BL, Zhao B, Tseng HC, Wu YC, Ko CC.,

Deciphering the mitophagy receptor network identifies a crucial role for OPTN (optineurin) in acute myeloid leukemia.
Meyer LM, Koschade SE, Vischedyk JB, Thoelken M, Gubas A, Wegner M, Basoglu M, Knapp S, Kaulich M, Eimer S, Shaid S, Brandts CH., Free PMC Article

Optineurin deficiency impairs autophagy to cause interferon beta overproduction and increased survival of mice following viral infection.
Fukushi M, Ohsawa R, Okinaka Y, Oikawa D, Kiyono T, Moriwaki M, Irie T, Oda K, Kamei Y, Tokunaga F, Sotomaru Y, Maruyama H, Kawakami H, Sakaguchi T., Free PMC Article

Optineurin regulates NRF2-mediated antioxidant response in a mouse model of Paget's disease of bone.
Hu X, Wong SW, Liang K, Wu TH, Wang S, Wang L, Liu J, Yamauchi M, Foster BL, Ting JP, Zhao B, Tseng HC, Ko CC., Free PMC Article

OPTN attenuates the neurotoxicity of abnormal Tau protein by restoring autophagy.
Xu Y, Liu Y, Chen X, Xu Q, Liu L, Liu H, Guo R, Qin Y., Free PMC Article

Knockdown of optineurin controls C2C12 myoblast differentiation via regulating myogenin and MyoD expressions.
Ishikawa K, Araki M, Nagano Y, Motoda A, Shishido T, Kurashige T, Takahashi T, Morino H, Kawakami H, Matsumoto M, Maruyama H.

Optineurin promotes myogenesis during muscle regeneration in mice by autophagic degradation of GSK3β.
Shi XC, Xia B, Zhang JF, Zhang RX, Zhang DY, Liu H, Xie BC, Wang YL, Wu JW., Free PMC Article

Age-related visual impairments and retinal ganglion cells axonal degeneration in a mouse model harboring OPTN (E50K) mutation.
Hou M, Shao Z, Zhang S, Liu X, Fan P, Jiang M, Zhao Y, Xiao R, Yuan H., Free PMC Article

Autophagy receptor OPTN (optineurin) regulates mesenchymal stem cell fate and bone-fat balance during aging by clearing FABP3.
Liu ZZ, Hong CG, Hu WB, Chen ML, Duan R, Li HM, Yue T, Cao J, Wang ZX, Chen CY, Hu XK, Wu B, Liu HM, Tan YJ, Liu JH, Luo ZW, Zhang Y, Rao SS, Luo MJ, Yin H, Wang YY, Xia K, Xu L, Tang SY, Hu RG, Xie H., Free PMC Article

Deficiency of optineurin enhances osteoclast differentiation by attenuating the NRF2-mediated antioxidant response.
Xue P, Hu X, Chang E, Wang L, Chen M, Wu TH, Lee DJ, Foster BL, Tseng HC, Ko CC., Free PMC Article

TRIM14 inhibits OPTN-mediated autophagic degradation of KDM4D to epigenetically regulate inflammation.
Liu D, Zhao Z, She Y, Zhang L, Chen X, Ma L, Cui J., Free PMC Article

Proteomic analysis of aged and OPTN E50K retina in the development of normal tension glaucoma.
Liu X, Wang Q, Shao Z, Zhang S, Hou M, Jiang M, Du M, Li J, Yuan H.

Intrinsic Antiviral Activity of Optineurin Prevents Hyperproliferation of a Primary Herpes Simplex Virus Type 2 Infection.
Patil CD, Suryawanshi R, Ames J, Koganti R, Agelidis A, Kapoor D, Yadavalli T, Koujah L, Tseng HC, Shukla D., Free PMC Article

Optineurin defects cause TDP43-pathology with autophagic vacuolar formation.
Kurashige T, Kuramochi M, Ohsawa R, Yamashita Y, Shioi G, Morino H, Kamada M, Ayaki T, Ito H, Sotomaru Y, Maruyama H, Kawakami H.

Optineurin modulates the maturation of dendritic cells to regulate autoimmunity through JAK2-STAT3 signaling.
Wang J, Wang J, Hong W, Zhang L, Song L, Shi Q, Shao Y, Hao G, Fang C, Qiu Y, Yang L, Yang Z, Wang J, Cao J, Yang B, He Q, Weng Q., Free PMC Article

Neuroprotective effects of bone marrow Sca-1(+) cells against age-related retinal degeneration in OPTN E50K mice.
Liu X, Hou M, Zhang S, Zhao Y, Wang Q, Jiang M, Du M, Shao Z, Yuan H., Free PMC Article

OPTN is a host intrinsic restriction factor against neuroinvasive HSV-1 infection.
Ames J, Yadavalli T, Suryawanshi R, Hopkins J, Agelidis A, Patil C, Fredericks B, Tseng H, Valyi-Nagy T, Shukla D., Free PMC Article

Respiratory pathology in the Optn(-/-) mouse model of Amyotrophic Lateral Sclerosis.
McCall AL, Dhindsa JS, Pucci LA, Kahn AF, Fusco AF, Biswas DD, Strickland LM, Tseng HC, ElMallah MK., Free PMC Article

iTRAQ-Based Quantitative Proteomics Indicated Nrf2/OPTN-Mediated Mitophagy Inhibits NLRP3 Inflammasome Activation after Intracerebral Hemorrhage.
Cheng Y, Liu M, Tang H, Chen B, Yang G, Zhao W, Cai Y, Shang H., Free PMC Article

The PINK1/PARK2/optineurin pathway of mitophagy is activated for protection in septic acute kidney injury.
Wang Y, Zhu J, Liu Z, Shu S, Fu Y, Liu Y, Cai J, Tang C, Liu Y, Yin X, Dong Z., Free PMC Article

Optineurin deletion disrupts metabotropic glutamate receptor 5-mediated regulation of ERK1/2, GSK3β/ZBTB16, mTOR/ULK1 signaling in autophagy.
Ibrahim KS, McLaren CJ, Abd-Elrahman KS, Ferguson SSG.

Optineurin modulates ER stress-induced signaling pathways and cell death.
Ramachandran G, Moharir SC, Raghunand TR, Swarup G.

Global deletion of Optineurin results in altered type I IFN signaling and abnormal bone remodeling in a model of Paget's disease.
Wong SW, Huang BW, Hu X, Ho Kim E, Kolb JP, Padilla RJ, Xue P, Wang L, Oguin TH 3rd, Miguez PA, Tseng HC, Ko CC, Martinez J., Free PMC Article

ALS-Related Mutant SOD1 Aggregates Interfere with Mitophagy by Sequestering the Autophagy Receptor Optineurin.
Tak YJ, Park JH, Rhim H, Kang S., Free PMC Article

Optineurin regulates osteoblastogenesis through STAT1.
Mizuno N, Iwata T, Ohsawa R, Ouhara K, Matsuda S, Kajiya M, Matsuda Y, Kume K, Tada Y, Morino H, Yoshimoto T, Ueki Y, Mihara K, Sotomaru Y, Takeda K, Munenaga S, Fujita T, Kawaguchi H, Shiba H, Kawakami H, Kurihara H.