| CircTOP1 targeted regulation of PTBP1 expression promotes the progression of coronary artery calcification. | CircTOP1 targeted regulation of PTBP1 expression promotes the progression of coronary artery calcification.
Hu H, Shen S, Wu J, Ma L. | 08/12/2024 |
| Levels of anti-topoisomerase I antibody correlated with short onset of cardiopulmonary involvement in Thai systemic sclerosis patients. | Levels of anti-topoisomerase I antibody correlated with short onset of cardiopulmonary involvement in Thai systemic sclerosis patients.
Mulalin K, Mahakkanukrauh A, Suwannaroj S, Pongkulkiat P, Onchan T, Kasa S, Foocharoen C., Free PMC Article | 07/8/2024 |
| Human DNA topoisomerase I poisoning causes R loop-mediated genome instability attenuated by transcription factor IIS. | Human DNA topoisomerase I poisoning causes R loop-mediated genome instability attenuated by transcription factor IIS.
Duardo RC, Marinello J, Russo M, Morelli S, Pepe S, Guerra F, Gómez-González B, Aguilera A, Capranico G., Free PMC Article | 06/7/2024 |
| G-quadruplexes on chromosomal DNA negatively regulates topoisomerase 1 activity. | G-quadruplexes on chromosomal DNA negatively regulates topoisomerase 1 activity.
Liang HT, Yan JY, Yao HJ, Zhang XN, Xing ZM, Liu L, Chen YQ, Li GR, Huang J, He YD, Zheng KW., Free PMC Article | 03/26/2024 |
| Coinhibition of topoisomerase 1 and BRD4-mediated pause release selectively kills pancreatic cancer via readthrough transcription. | Coinhibition of topoisomerase 1 and BRD4-mediated pause release selectively kills pancreatic cancer via readthrough transcription.
Cameron DP, Grosser J, Ladigan S, Kuzin V, Iliopoulou E, Wiegard A, Benredjem H, Jackson K, Liffers ST, Lueong S, Cheung PF, Vangala D, Pohl M, Viebahn R, Teschendorf C, Wolters H, Usta S, Geng K, Kutter C, Arsenian-Henriksson M, Siveke JT, Tannapfel A, Schmiegel W, Hahn SA, Baranello L., Free PMC Article | 11/30/2023 |
| Topoisomerase 1 inhibits MYC promoter activity by inducing G-quadruplex formation. | Topoisomerase 1 inhibits MYC promoter activity by inducing G-quadruplex formation.
Keller JG, Hymøller KM, Thorsager ME, Hansen NY, Erlandsen JU, Tesauro C, Simonsen AKW, Andersen AB, Vandsø Petersen K, Holm LL, Stougaard M, Andresen BS, Kristensen P, Frøhlich R, Knudsen BR., Free PMC Article | 08/27/2022 |
| Signatures of TOP1 transcription-associated mutagenesis in cancer and germline. | Signatures of TOP1 transcription-associated mutagenesis in cancer and germline.
Reijns MAM, Parry DA, Williams TC, Nadeu F, Hindshaw RL, Rios Szwed DO, Nicholson MD, Carroll P, Boyle S, Royo R, Cornish AJ, Xiang H, Ridout K, Genomics England Research Consortium, Colorectal Cancer Domain UK 100,000 Genomes Project, Schuh A, Aden K, Palles C, Campo E, Stankovic T, Taylor MS, Jackson AP., Free PMC Article | 06/11/2022 |
| Topoisomerase 1 activity during mitotic transcription favors the transition from mitosis to G1. | Topoisomerase 1 activity during mitotic transcription favors the transition from mitosis to G1.
Wiegard A, Kuzin V, Cameron DP, Grosser J, Ceribelli M, Mehmood R, Ballarino R, Valant F, Grochowski R, Karabogdan I, Crosetto N, Lindqvist A, Bizard AH, Kouzine F, Natsume T, Baranello L. | 02/19/2022 |
| Topoisomerase I (TOP1) dynamics: conformational transition from open to closed states. | Topoisomerase I (TOP1) dynamics: conformational transition from open to closed states.
Takahashi DT, Gadelle D, Agama K, Kiselev E, Zhang H, Yab E, Petrella S, Forterre P, Pommier Y, Mayer C., Free PMC Article | 01/29/2022 |
| TDP1 and TOP1 as targets in anticancer treatment of NSCLC: Activity and protein level in normal and tumor tissue from 150 NSCLC patients correlated to clinical data. | TDP1 and TOP1 as targets in anticancer treatment of NSCLC: Activity and protein level in normal and tumor tissue from 150 NSCLC patients correlated to clinical data.
Jakobsen AK, Yuusufi S, Madsen LB, Meldgaard P, Knudsen BR, Stougaard M. | 01/29/2022 |
| PARylation prevents the proteasomal degradation of topoisomerase I DNA-protein crosslinks and induces their deubiquitylation. | PARylation prevents the proteasomal degradation of topoisomerase I DNA-protein crosslinks and induces their deubiquitylation.
Sun Y, Chen J, Huang SN, Su YP, Wang W, Agama K, Saha S, Jenkins LM, Pascal JM, Pommier Y., Free PMC Article | 09/18/2021 |
| Implications of Topoisomerase (TOP1 and TOP2alpha) Expression in Patients With Breast Cancer. | Implications of Topoisomerase (TOP1 and TOP2α) Expression in Patients With Breast Cancer.
Ogino M, Fujii T, Nakazawa Y, Higuchi T, Koibuchi Y, Oyama T, Horiguchi J, Shirabe K., Free PMC Article | 07/10/2021 |
| RNases H1 and H2: guardians of the stability of the nuclear genome when supply of dNTPs is limiting for DNA synthesis. | RNases H1 and H2: guardians of the stability of the nuclear genome when supply of dNTPs is limiting for DNA synthesis.
Cerritelli SM, El Hage A., Free PMC Article | 06/5/2021 |
| TOP1 inhibition therapy protects against SARS-CoV-2-induced lethal inflammation. | TOP1 inhibition therapy protects against SARS-CoV-2-induced lethal inflammation.
Ho JSY, Mok BW, Campisi L, Jordan T, Yildiz S, Parameswaran S, Wayman JA, Gaudreault NN, Meekins DA, Indran SV, Morozov I, Trujillo JD, Fstkchyan YS, Rathnasinghe R, Zhu Z, Zheng S, Zhao N, White K, Ray-Jones H, Malysheva V, Thiecke MJ, Lau SY, Liu H, Zhang AJ, Lee AC, Liu WC, Jangra S, Escalera A, Aydillo T, Melo BS, Guccione E, Sebra R, Shum E, Bakker J, Kaufman DA, Moreira AL, Carossino M, Balasuriya UBR, Byun M, Albrecht RA, Schotsaert M, Garcia-Sastre A, Chanda SK, Miraldi ER, Jeyasekharan AD, TenOever BR, Spivakov M, Weirauch MT, Heinz S, Chen H, Benner C, Richt JA, Marazzi I., Free PMC Article | 05/29/2021 |
| Natural Products as Anti-Cancerous Therapeutic Molecules Targeted towards Topoisomerases. | Natural Products as Anti-Cancerous Therapeutic Molecules Targeted towards Topoisomerases.
Singh S, Pandey VP, Yadav K, Yadav A, Dwivedi UN. | 05/29/2021 |
| [The Efficacy of topo -pS10 Expression in Gastric Cancer as a Predictive Biomarker for Irinotecan Use]. | [The Efficacy of topo Ⅰ-pS10 Expression in Gastric Cancer as a Predictive Biomarker for Irinotecan Use].
Ando K, Hu Q, Fujimoto Y, Jogo T, Nakanishi R, Hisamatsu Y, Kimura Y, Oki E, Bharti A, Mori M. | 04/13/2021 |
| Proteome dynamics at broken replication forks reveal a distinct ATM-directed repair response suppressing DNA double-strand break ubiquitination. | Proteome dynamics at broken replication forks reveal a distinct ATM-directed repair response suppressing DNA double-strand break ubiquitination.
Nakamura K, Kustatscher G, Alabert C, Hödl M, Forne I, Völker-Albert M, Satpathy S, Beyer TE, Mailand N, Choudhary C, Imhof A, Rappsilber J, Groth A., Free PMC Article | 03/20/2021 |
| Topoisomerase 1 prevents replication stress at R-loop-enriched transcription termination sites. | Topoisomerase 1 prevents replication stress at R-loop-enriched transcription termination sites.
Promonet A, Padioleau I, Liu Y, Sanz L, Biernacka A, Schmitz AL, Skrzypczak M, Sarrazin A, Mettling C, Rowicka M, Ginalski K, Chedin F, Chen CL, Lin YL, Pasero P., Free PMC Article | 09/26/2020 |
| Dual Processing of R-Loops and Topoisomerase I Induces Transcription-Dependent DNA Double-Strand Breaks. | Dual Processing of R-Loops and Topoisomerase I Induces Transcription-Dependent DNA Double-Strand Breaks.
Cristini A, Ricci G, Britton S, Salimbeni S, Huang SN, Marinello J, Calsou P, Pommier Y, Favre G, Capranico G, Gromak N, Sordet O., Free PMC Article | 09/12/2020 |
| Topoisomerase I-driven repair of UV-induced damage in NER-deficient cells. | Topoisomerase I-driven repair of UV-induced damage in NER-deficient cells.
Saha LK, Wakasugi M, Akter S, Prasad R, Wilson SH, Shimizu N, Sasanuma H, Huang SN, Agama K, Pommier Y, Matsunaga T, Hirota K, Iwai S, Nakazawa Y, Ogi T, Takeda S., Free PMC Article | 08/29/2020 |
| Colorectal carcinoma patients at early stage had higher frequency of positive levels of TOP1 fragment autoantibody and CRC patients with positive autoantibody levels had higher overall survival rate than CRC patients with negative autoantibody levels. | A specific autoantibody against a novel tumour-association antigen derived from human DNA-topoiomerase I is a potential biomarker for early diagnosis and favourable prognosis in patients with colorectal carcinoma.
Zhao F, Cao M, Jiang XH, Xie K, Ye SR, Yie SM. | 07/25/2020 |
| In this study, molecular dynamics simulation was performed on the complexes of Top1 peptide with various HLA-DR subtypes divided into ATASSc-associated alleles (HLA-DRB1*08:02, HLA-DRB1*11:01 and HLA-DRB1*11:04), suspected allele (HLA-DRB5*01:02), and non-associated allele (HLA-DRB1*01:01). | Interactions of HLA-DR and Topoisomerase I Epitope Modulated Genetic Risk for Systemic Sclerosis.
Kongkaew S, Rungrotmongkol T, Punwong C, Noguchi H, Takeuchi F, Kungwan N, Wolschann P, Hannongbua S., Free PMC Article | 07/25/2020 |
| NC and TOP1 inhibitors are able to exert anti-inflammatory action through enhancing Akt-mediated IL-10 production. | Nitidine chloride exerts anti-inflammatory action by targeting Topoisomerase I and enhancing IL-10 production.
Yang N, Yue R, Ma J, Li W, Zhao Z, Li H, Shen Y, Hu Z, Lv C, Xu X, Yang Y, Dai X, Liu X, Yu Y, Zhang W. | 07/4/2020 |
| TEX264 recognises both unmodified and SUMO1-modifed TOP1 and initiates TOP1cc repair by recruiting p97 and SPRTN. | TEX264 coordinates p97- and SPRTN-mediated resolution of topoisomerase 1-DNA adducts.
Fielden J, Wiseman K, Torrecilla I, Li S, Hume S, Chiang SC, Ruggiano A, Narayan Singh A, Freire R, Hassanieh S, Domingo E, Vendrell I, Fischer R, Kessler BM, Maughan TS, El-Khamisy SF, Ramadan K., Free PMC Article | 07/4/2020 |
| DNA topoisomerase I (TOP1) interacts with cyclic cGMP-AMP synthase (cGAS) to enhance the binding of cGAS to DNA. Retention of TOP1cc to cytoplasmic chromatin depends on its stabilization by the chromatin architecture protein HMGB2. Functionally, the HMGB2-TOP1cc-cGAS axis determines the response of orthotopically transplanted ex vivo therapy-induced senescent cells to immune checkpoint blockade in vivo. | Topoisomerase 1 cleavage complex enables pattern recognition and inflammation during senescence.
Zhao B, Liu P, Fukumoto T, Nacarelli T, Fatkhutdinov N, Wu S, Lin J, Aird KM, Tang HY, Liu Q, Speicher DW, Zhang R., Free PMC Article | 05/2/2020 |