| Senescent cells perturb intestinal stem cell differentiation through Ptk7 induced noncanonical Wnt and YAP signaling. | Senescent cells perturb intestinal stem cell differentiation through Ptk7 induced noncanonical Wnt and YAP signaling.
Yun J, Hansen S, Morris O, Madden DT, Libeu CP, Kumar AJ, Wehrfritz C, Nile AH, Zhang Y, Zhou L, Liang Y, Modrusan Z, Chen MB, Overall CC, Garfield D, Campisi J, Schilling B, Hannoush RN, Jasper H., Free PMC Article | 02/10/2023 |
| Protein Tyrosine Kinase 7 (PTK7) Promotes Metastasis in Hepatocellular Carcinoma via SOX9 Regulation and TGF-beta Signaling. | Protein Tyrosine Kinase 7 (PTK7) Promotes Metastasis in Hepatocellular Carcinoma via SOX9 Regulation and TGF-β Signaling.
Wong TLM, Wong TL, Zhou L, Man K, Purcell J, Lee TK, Yun JP, Ma S., Free PMC Article | 12/31/2022 |
| PTK7 regulates extracellular matrix integrity and the activity levels of RAC1 and myosin II, which in turn regulates Wolffian duct morphogenesis and therefore, epididymal function. | Protein tyrosine kinase 7 regulates extracellular matrix integrity and mesenchymal intracellular RAC1 and myosin II activities during Wolffian duct morphogenesis.
Xu B, Santos SAA, Hinton BT., Free PMC Article | 06/2/2018 |
| In a Ptk7-deficient mouse strain, loss of Ptk7 leads to a diminished pool of hematopoietic stem cells but does not affect in vitro or in vivo differentiation. This is correlated with increased quiescence and reduced homing abilities of Ptk7-deficient hematopoietic stem and progenitor cells. | Ptk7-Deficient Mice Have Decreased Hematopoietic Stem Cell Pools as a Result of Deregulated Proliferation and Migration.
Lhoumeau AC, Arcangeli ML, De Grandis M, Giordano M, Orsoni JC, Lembo F, Bardin F, Marchetto S, Aurrand-Lions M, Borg JP. | 07/1/2017 |
| Data suggest that protein tyrosine kinase 7 (PTK7) is essential for Wolffian duct morphogenesis and male fertility. | Protein tyrosine kinase 7 is essential for tubular morphogenesis of the Wolffian duct.
Xu B, Washington AM, Domeniconi RF, Ferreira Souza AC, Lu X, Sutherland A, Hinton BT., Free PMC Article | 09/10/2016 |
| data demonstrates that PTK7 regulates the activity of KDR biphasically by inducing oligomerization of KDR molecules at lower concentrations and by surrounding KDR molecules at higher concentrations. | Biphasic effect of PTK7 on KDR activity in endothelial cells and angiogenesis.
Shin WS, Na HW, Lee ST. | 12/5/2015 |
| PTK7 expression plays an important role in the invasiveness of intrahepatic cholangiocarcinoma cells. | High expression of protein tyrosine kinase 7 significantly associates with invasiveness and poor prognosis in intrahepatic cholangiocarcinoma.
Jin J, Ryu HS, Lee KB, Jang JJ., Free PMC Article | 11/8/2014 |
| Planar polarity of neural cell motility and intercalation requires Ptk7 function. | Distinct apical and basolateral mechanisms drive planar cell polarity-dependent convergent extension of the mouse neural plate.
Williams M, Yen W, Lu X, Sutherland A., Free PMC Article | 06/21/2014 |
| acts in conjunction with the noncanonical Wnt pathway to orient epithelial planar cell polarity through modulation of myosin II-based contractile tension between supporting cells and hair cells | PTK7 regulates myosin II activity to orient planar polarity in the mammalian auditory epithelium.
Lee J, Andreeva A, Sipe CW, Liu L, Cheng A, Lu X., Free PMC Article | 10/20/2012 |
| The tyrosine kinase receptor, PTK7, is implicated in beta-catenin-dependent developmental processes. | PTK7: a cell polarity receptor with multiple facets.
Lhoumeau AC, Puppo F, Prébet T, Kodjabachian L, Borg JP. | 09/3/2011 |
| These findings illustrate a novel and pivotal role for Cdx function upstream of Ptk7 and neural tube closure in vertebrates. | Cdx mediates neural tube closure through transcriptional regulation of the planar cell polarity gene Ptk7.
Savory JG, Mansfield M, Rijli FM, Lohnes D. | 05/14/2011 |
| Chuzhoi mutation, that causes multiple abnormalities maps, to Chromosome 17 and carries a splice site mutation in Ptk7 and causes disruption of Ptk7 protein expression. | The novel mouse mutant, chuzhoi, has disruption of Ptk7 protein and exhibits defects in neural tube, heart and lung development and abnormal planar cell polarity in the ear.
Paudyal A, Damrau C, Patterson VL, Ermakov A, Formstone C, Lalanne Z, Wells S, Lu X, Norris DP, Dean CH, Henderson DJ, Murdoch JN., Free PMC Article | 11/27/2010 |
| polarized cell behaviors underlying CE in the mouse, clearly define specific roles for planar polarity and for the novel planar cell polarity gene, Ptk7, as essential regulators of mediolateral cell intercalation during mammalian CE. | PTK7 is essential for polarized cell motility and convergent extension during mouse gastrulation.
Yen WW, Williams M, Periasamy A, Conaway M, Burdsal C, Keller R, Lu X, Sutherland A., Free PMC Article | 01/21/2010 |
| Ptk7 mRNA was expressed at high levels in lung and un-pregnant uterus among adult tissues, and in the tail, limbs, somites, gut, and craniofacial regions among embryonic tissues, and suggest that PTK7 plays multiple roles in embryonic development. | Cloning and characterization of the full-length mouse Ptk7 cDNA encoding a defective receptor protein tyrosine kinase.
Jung JW, Shin WS, Song J, Lee ST. | 01/21/2010 |
| a mutation disrupts neural tube closure and stereociliary bundle orientation, and shows genetic interactions with a mutation in the mouse Van Gogh homologue vangl2 | PTK7/CCK-4 is a novel regulator of planar cell polarity in vertebrates.
Lu X, Borchers AG, Jolicoeur C, Rayburn H, Baker JC, Tessier-Lavigne M. | 01/21/2010 |