| Complement C1QC as a potential prognostic marker and therapeutic target in colon carcinoma based on single-cell RNA sequencing and immunohistochemical analysis. | Complement C1QC as a potential prognostic marker and therapeutic target in colon carcinoma based on single-cell RNA sequencing and immunohistochemical analysis.
Deng H, Chen Y, Liu Y, Liu L, Xu R., Free PMC Article | 01/14/2023 |
| Neuroinflammation and psychiatric disorders: Relevance of C1q, translocator protein (18 kDa) (TSPO), and neurosteroids. | Neuroinflammation and psychiatric disorders: Relevance of C1q, translocator protein (18 kDa) (TSPO), and neurosteroids.
Rupprecht R, Rupprecht C, Di Benedetto B, Rammes G. | 11/5/2022 |
| C1q-binding DSA and allograft outcomes in pediatric kidney transplant recipients. | C1q-binding DSA and allograft outcomes in pediatric kidney transplant recipients.
Hayde N, Solomon S, Caglar E, Ge J, Qama E, Colovai A. | 01/8/2022 |
| Clinical and prognostic significance of C1q deposition in IgAN patients-a retrospective study. | Clinical and prognostic significance of C1q deposition in IgAN patients-a retrospective study.
Tian S, Yang X, Luo J, Guo H. | 05/29/2021 |
| C1QA was associated with later onset, whereas C1QC may have a double role: variants may confer earlier or later age-at-onset | C1QA and C1QC modify age-at-onset in familial amyloid polyneuropathy patients.
Dias A, Santos D, Coelho T, Alves-Ferreira M, Sequeiros J, Alonso I, Sousa A, Lemos C., Free PMC Article | 02/22/2020 |
| Neuromyelitis optica patients had higher levels of C3a and anti-C1q antibodies than healthy controls. | Complement activation in patients with neuromyelitis optica.
Nytrova P, Potlukova E, Kemlink D, Woodhall M, Horakova D, Waters P, Havrdova E, Zivorova D, Vincent A, Trendelenburg M. | 11/22/2014 |
| C1q deficiency due to a Gly164Ser mutation may have a role in Rothmund-Thomson syndrome and glomerulonephritis [case report] | Rothmund-Thomson syndrome and glomerulonephritis in a homozygous C1q-deficient patient due to a Gly164Ser C1qC mutation.
López-Lera A, Torres-Canizales JM, Garrido S, Morales A, López-Trascasa M. | 05/31/2014 |
| Data indicate that Cna binds to C1q. | Collagen-binding microbial surface components recognizing adhesive matrix molecule (MSCRAMM) of Gram-positive bacteria inhibit complement activation via the classical pathway.
Kang M, Ko YP, Liang X, Ross CL, Liu Q, Murray BE, Höök M., Free PMC Article | 09/28/2013 |
| Analysis of its interaction properties by surface plasmon resonance shows that rC1q retains the ability of serum C1q to associate with the C1s-C1r-C1r-C1s tetramer, to recognize physiological C1q ligands such as IgG and pentraxin 3 | Expression of recombinant human complement C1q allows identification of the C1r/C1s-binding sites.
Bally I, Ancelet S, Moriscot C, Gonnet F, Mantovani A, Daniel R, Schoehn G, Arlaud GJ, Thielens NM., Free PMC Article | 08/10/2013 |
| Single nucleotide polymorphisms in and around the C1q genes, C1qA, C1qB and C1qC, correlated with C1q serum levels and may be a risk for the development of rheumatoid arthritis. | Genetic variants in the region of the C1q genes are associated with rheumatoid arthritis.
Trouw LA, Daha N, Kurreeman FA, Böhringer S, Goulielmos GN, Westra HJ, Zhernakova A, Franke L, Stahl EA, Levarht EW, Stoeken-Rijsbergen G, Verduijn W, Roos A, Li Y, Houwing-Duistermaat JJ, Huizinga TW, Toes RE., Free PMC Article | 08/10/2013 |
| We identified a major linear epitope of C1q that is the target of anti-C1q in systemic lupus erythematosus. | Identification of a major linear C1q epitope allows detection of systemic lupus erythematosus anti-C1q antibodies by a specific peptide-based enzyme-linked immunosorbent assay.
Vanhecke D, Roumenina LT, Wan H, Osthoff M, Schaller M, Trendelenburg M. | 01/12/2013 |
| C1q and C1q receptor interaction may be responsible for the C1q-mediated migration of mesenchymal stromal cells. | Mesenchymal stromal cells derived from umbilical cord blood migrate in response to complement C1q.
Qiu Y, Marquez-Curtis LA, Janowska-Wieczorek A. | 06/2/2012 |
| analysis of the molecular mechanisms for synchronized transcription of three complement C1q subunit genes (A, B and C) in dendritic cells and macrophages | Molecular mechanisms for synchronized transcription of three complement C1q subunit genes in dendritic cells and macrophages.
Chen G, Tan CS, Teh BK, Lu J., Free PMC Article | 12/10/2011 |
| Three single nucleotide polymorphisms (STAT6 rs703817, C1qG rs17433222, and MBP rs3794845) were found to be significantly associated with childhood leukemia risk in Koreans. | Polymorphisms in innate immunity genes and risk of childhood leukemia.
Han S, Lan Q, Park AK, Lee KM, Park SK, Ahn HS, Shin HY, Kang HJ, Koo HH, Seo JJ, Choi JE, Ahn YO, Chanock SJ, Kim H, Rothman N, Kang D, Han S, Lan Q, Park AK, Lee KM, Park SK, Ahn HS, Shin HY, Kang HJ, Koo HH, Seo JJ, Choi JE, Ahn YO, Chanock SJ, Kim H, Rothman N, Kang D., Free PMC Articles: PMC2967770, PMC2967770 | 01/15/2011 |
| These results suggest a novel pathway in which C1q and MBL influence removal and metabolism of atherogenic forms of LDL in the early stages of atherosclerosis. | Innate immune proteins C1q and mannan-binding lectin enhance clearance of atherogenic lipoproteins by human monocytes and macrophages.
Fraser DA, Tenner AJ., Free PMC Article | 10/23/2010 |
| Observational study of gene-disease association, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator) | Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study.
Bailey SD, Xie C, Do R, Montpetit A, Diaz R, Mohan V, Keavney B, Yusuf S, Gerstein HC, Engert JC, Anand S, DREAM investigators., Free PMC Article | 09/15/2010 |
| prevents monocyte-derived dendritic cell differentiation | Evidence that a C1q/C1qR system regulates monocyte-derived dendritic cell differentiation at the interface of innate and acquired immunity.
Hosszu KK, Santiago-Schwarz F, Peerschke EI, Ghebrehiwet B., Free PMC Article | 09/13/2010 |
| In a large family-based association study of C1Q gene cluster polymorphisms no evidence for a genetic role of C1Q locus SNP in systemic lupus erythematosus risk predisposition was obtained in patients of European ancestry. | Assessing association of common variation in the C1Q gene cluster with systemic lupus erythematosus.
Rafiq S, Frayling TM, Vyse TJ, Cunninghame Graham DS, Eggleton P., Free PMC Article | 08/30/2010 |
| Observational study of gene-disease association and gene-gene interaction. (HuGE Navigator) | Polymorphisms in innate immunity genes and risk of childhood leukemia.
Han S, Lan Q, Park AK, Lee KM, Park SK, Ahn HS, Shin HY, Kang HJ, Koo HH, Seo JJ, Choi JE, Ahn YO, Chanock SJ, Kim H, Rothman N, Kang D, Han S, Lan Q, Park AK, Lee KM, Park SK, Ahn HS, Shin HY, Kang HJ, Koo HH, Seo JJ, Choi JE, Ahn YO, Chanock SJ, Kim H, Rothman N, Kang D., Free PMC Articles: PMC2967770, PMC2967770 | 06/30/2010 |
| Data show that C1q, C4, C3, and C9 bind to thrombin receptor-activating peptide-activated platelets in lepirudin-anticoagulated platelet-rich plasma (PRP) and whole blood. | Complement component C3 binds to activated normal platelets without preceding proteolytic activation and promotes binding to complement receptor 1.
Hamad OA, Nilsson PH, Wouters D, Lambris JD, Ekdahl KN, Nilsson B., Free PMC Article | 05/10/2010 |
| C1QC (rs9434) correlates with later age of onset in TTR Val30Met familial amyloidotic polyneuropathy. C1QC (rs15940) does not. | Complement C1Q polymorphisms modulate onset in familial amyloidotic polyneuropathy TTR Val30Met.
Dardiotis E, Koutsou P, Zamba-Papanicolaou E, Vonta I, Hadjivassiliou M, Hadjigeorgiou G, Cariolou M, Christodoulou K, Kyriakides T. | 01/21/2010 |
| C1q deficiency is such a strong risk factor for systemic lupus erythematosus. | C1q inhibits immune complex-induced interferon-alpha production in plasmacytoid dendritic cells: a novel link between C1q deficiency and systemic lupus erythematosus pathogenesis.
Lood C, Gullstrand B, Truedsson L, Olin AI, Alm GV, Rönnblom L, Sturfelt G, Eloranta ML, Bengtsson AA. | 01/21/2010 |
| C1q polymorphisms are associated with SLE, serum C1q and CH50 levels in a stable founder population of patients with SLE. | Analysis of C1q polymorphisms suggests association with systemic lupus erythematosus, serum C1q and CH50 levels and disease severity.
Martens HA, Zuurman MW, de Lange AH, Nolte IM, van der Steege G, Navis GJ, Kallenberg CG, Seelen MA, Bijl M. | 01/21/2010 |
| Complement protein C1q and anti-hexon antibodies together can mediate efficient adenovirus infection in coxsackie and adenovirus receptor-negative cell types. | Complement component C1q and anti-hexon antibody mediate adenovirus infection of a CAR-negative cell line.
Tsai V, Varghese R, Ravindran S, Ralston R, Vellekamp G. | 01/21/2010 |
| Complement C1q chemoattracts human dendritic cells and enhances migration of mature dendritic cells to CCL19 via activation of AKT and MAPK pathways.( | Complement C1q chemoattracts human dendritic cells and enhances migration of mature dendritic cells to CCL19 via activation of AKT and MAPK pathways.
Liu S, Wu J, Zhang T, Qian B, Wu P, Li L, Yu Y, Cao X. | 01/21/2010 |