| LncRNA TMPO-AS1 promotes esophageal squamous cell carcinoma progression by forming biomolecular condensates with FUS and p300 to regulate TMPO transcription. | LncRNA TMPO-AS1 promotes esophageal squamous cell carcinoma progression by forming biomolecular condensates with FUS and p300 to regulate TMPO transcription.
Luo XJ, He MM, Liu J, Zheng JB, Wu QN, Chen YX, Meng Q, Luo KJ, Chen DL, Xu RH, Zeng ZL, Liu ZX, Luo HY., Free PMC Article | 07/16/2022 |
| LncRNA TMPO-AS1 Aggravates the Development of Hepatocellular Carcinoma via miR-429/GOT1 Axis. | LncRNA TMPO-AS1 Aggravates the Development of Hepatocellular Carcinoma via miR-429/GOT1 Axis.
Liu X, Shen Z. | 01/2/2021 |
| TMPO-AS1 contributes to lung carcinogenesis, which may be partially through upregulation TMPO. | Long noncoding RNA TMPO-AS1 promotes progression of non-small cell lung cancer through regulating its natural antisense transcript TMPO.
Qin Z, Zheng X, Fang Y. | 07/4/2020 |
| Study found TMPO is significantly upregulated in glioblastoma tissues.TMPO knockdown promoted cell apoptosis by upregulation of the cleavage of caspase-3 and PARP protein levels. | Depletion of thymopoietin inhibits proliferation and induces cell cycle arrest/apoptosis in glioblastoma cells.
Zhang L, Wang G, Chen S, Ding J, Ju S, Cao H, Tian H., Free PMC Article | 04/29/2017 |
| Results suggest that TMPObeta and -gamma isoforms could provide a potential reliable diagnostic marker for breast cancer. | Thymopoietin Beta and Gamma Isoforms as a Potential Diagnostic Molecular Marker for Breast Cancer: Preliminary Data.
Marrero-Rodríguez D, Taniguchi-Ponciano K, Lopez-Sleman J, Romero-Morelos P, Mendoza-Rodríguez M, Garcia I, Huerta-Padilla V, Mantilla A, Duarte A, Piña P, Rodriguez-Esquivel M, Lopez-Romero R, Parrazal-Romero J, Tobias-Alonso S, Jimenez-Vega F, Alvarez-Blanco M, Salcedo M. | 07/16/2016 |
| The findings unveil a unique mechanism where the nuclear periphery proteins lamin-A/C, LAP2alpha and BAF1 are assembled into a protein complex during mitosis in order to regulate assembly and positioning of the mitotic spindle. | The lamin-A/C-LAP2α-BAF1 protein complex regulates mitotic spindle assembly and positioning.
Qi R, Xu N, Wang G, Ren H, Li S, Lei J, Lin Q, Wang L, Gu X, Zhang H, Jiang Q, Zhang C. | 06/28/2016 |
| The authors find that LAP2alpha (lamina-associated polypeptide-alpha) interacts with lamin A, while its interaction with progerin is significantly reduced. | Progerin reduces LAP2α-telomere association in Hutchinson-Gilford progeria.
Chojnowski A, Ong PF, Wong ES, Lim JS, Mutalif RA, Navasankari R, Dutta B, Yang H, Liow YY, Sze SK, Boudier T, Wright GD, Colman A, Burke B, Stewart CL, Dreesen O., Free PMC Article | 06/11/2016 |
| LAP2alpha can regulate extracellular matrix components independently of lamins A/C, which may help explain the proliferation-promoting function of LAP2alpha in cells expressing progerin. | Proliferation of progeria cells is enhanced by lamina-associated polypeptide 2α (LAP2α) through expression of extracellular matrix proteins.
Vidak S, Kubben N, Dechat T, Foisner R., Free PMC Article | 01/16/2016 |
| Results highlight the interactions at the nuclear envelope where mutations in the EMD and TMPO gene in combination with mutations in SUN1 have an impact on several components of the network. | Contribution of SUN1 mutations to the pathomechanism in muscular dystrophies.
Li P, Meinke P, Huong le TT, Wehnert M, Noegel AA. | 01/31/2015 |
| Data indicate that cells lacking either high mobility group protein N5 (HMGN5) and lamina-associated polypeptide 2alpha (LAP2alpha) showed that loss of either protein affects the genome-wide distribution of the remaining partner. | High mobility group protein N5 (HMGN5) and lamina-associated polypeptide 2α (LAP2α) interact and reciprocally affect their genome-wide chromatin organization.
Zhang S, Schones DE, Malicet C, Rochman M, Zhou M, Foisner R, Bustin M., Free PMC Article | 09/7/2013 |
| this study provides evidence for elevated LAP2alpha expression in cervical cancer and suggests that E2F and p53 activities associate with the positive and negative regulation of LAP2alpha expression, respectively | Deregulated LAP2α expression in cervical cancer associates with aberrant E2F and p53 activities.
Ward MC, van der Watt PJ, Tzoneva G, Leaner VD. | 02/18/2012 |
| Observational study of gene-disease association, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator) | Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study.
Bailey SD, Xie C, Do R, Montpetit A, Diaz R, Mohan V, Keavney B, Yusuf S, Gerstein HC, Engert JC, Anand S, DREAM investigators., Free PMC Article | 09/15/2010 |
| Observational study of gene-disease association. (HuGE Navigator) | See all PubMed (2) articlesNew genetic associations detected in a host response study to hepatitis B vaccine.
Davila S, Froeling FE, Tan A, Bonnard C, Boland GJ, Snippe H, Hibberd ML, Seielstad M. Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip.
Talmud PJ, Drenos F, Shah S, Shah T, Palmen J, Verzilli C, Gaunt TR, Pallas J, Lovering R, Li K, Casas JP, Sofat R, Kumari M, Rodriguez S, Johnson T, Newhouse SJ, Dominiczak A, Samani NJ, Caulfield M, Sever P, Stanton A, Shields DC, Padmanabhan S, Melander O, Hastie C, Delles C, Ebrahim S, Marmot MG, Smith GD, Lawlor DA, Munroe PB, Day IN, Kivimaki M, Whittaker J, Humphries SE, Hingorani AD, ASCOT investigators, NORDIL investigators, BRIGHT Consortium. | 04/7/2010 |
| Observational study and genome-wide association study of gene-disease association. (HuGE Navigator) | Genome-wide SNP genotyping study using pooled DNA to identify candidate markers mediating susceptibility to end-stage renal disease attributed to Type 1 diabetes.
Craig DW, Millis MP, DiStefano JK. | 01/20/2010 |
| Co-expression of LAP2beta and LAP2zeta results in inhibition of LAP2beta-induced gene silencing while overexpression of LAP2zeta alone leads to a small increase in transcriptional activity of various transcription factors. | LAP2zeta binds BAF and suppresses LAP2beta-mediated transcriptional repression.
Shaklai S, Somech R, Gal-Yam EN, Deshet-Unger N, Moshitch-Moshkovitz S, Hirschberg K, Amariglio N, Simon AJ, Rechavi G. | 01/21/2010 |
| Results indicate that in vitro, the interaction between HA95 and LAP2beta is influenced by a PKA-mediated phosphorylation of HA95 rather than by CDK1- or PKC-mediated phosphorylation of LAP2beta | In vitro modulation of the interaction between HA95 and LAP2beta by cAMP signaling.
Martins SB, Marstad A, Collas P. | 01/21/2010 |
| Results suggest that LAP2alpha and lamin A/C are involved in controlling retinoblastoma protein localization and phosphorylation, and a lack or mislocalization of either protein leads to cell cycle arrest in fibroblasts. | Nucleoplasmic LAP2alpha-lamin A complexes are required to maintain a proliferative state in human fibroblasts.
Pekovic V, Harborth J, Broers JL, Ramaekers FC, van Engelen B, Lammens M, von Zglinicki T, Foisner R, Hutchison C, Markiewicz E., Free PMC Article | 01/21/2010 |
| LAP2alpha forms higher order structures containing multiple LAP2alpha molecules in vivo and that complex formation is mediated by the C terminus. | Lamina-associated polypeptide 2-alpha forms homo-trimers via its C terminus, and oligomerization is unaffected by a disease-causing mutation.
Snyers L, Vlcek S, Dechat T, Skegro D, Korbei B, Gajewski A, Mayans O, Schöfer C, Foisner R. | 01/21/2010 |
| Lamina associated protein 2Beta (LAP2beta) is expressed in acute hematopoietic malignant cells, but not in chronic hematopoietic malignant cells. | Enhanced expression of the nuclear envelope LAP2 transcriptional repressors in normal and malignant activated lymphocytes.
Somech R, Gal-Yam EN, Shaklai S, Geller O, Amariglio N, Rechavi G, Simon AJ. | 01/21/2010 |
| A predicted Arg690Cys substitution within the LAP2 gene is implicated in the pathogenesis of genetic forms of dilated cardiomyopathy. | Thymopoietin (lamina-associated polypeptide 2) gene mutation associated with dilated cardiomyopathy.
Taylor MR, Slavov D, Gajewski A, Vlcek S, Ku L, Fain PR, Carniel E, Di Lenarda A, Sinagra G, Boucek MM, Cavanaugh J, Graw SL, Ruegg P, Feiger J, Zhu X, Ferguson DA, Bristow MR, Gotzmann J, Foisner R, Mestroni L, Familial Cardiomyopathy Registry Research Group. | 01/21/2010 |
| LAP2alpha and BAF transiently localize to telomeres and specific regions on chromatin during nuclear assembly | LAP2alpha and BAF transiently localize to telomeres and specific regions on chromatin during nuclear assembly.
Dechat T, Gajewski A, Korbei B, Gerlich D, Daigle N, Haraguchi T, Furukawa K, Ellenberg J, Foisner R. | 01/21/2010 |
| data suggest that hypophosphorylated Rb is anchored in the nucleus by the interaction of pocket C with LAP2alpha-lamin A/C complexes | Lamin A/C binding protein LAP2alpha is required for nuclear anchorage of retinoblastoma protein.
Markiewicz E, Dechat T, Foisner R, Quinlan RA, Hutchison CJ., Free PMC Article | 01/21/2010 |
| In agreement with its regulation by E2F, LAP2alpha over expression in primary tumors was found to be correlated with tumor proliferation rate | Lap2alpha expression is controlled by E2F and deregulated in various human tumors.
Parise P, Finocchiaro G, Masciadri B, Quarto M, Francois S, Mancuso F, Muller H. | 01/21/2010 |
| The effects of LAP2alpha on cell cycle progression and differentiation may be highly relevant for the cell- and tissue-specific phenotypes observed in laminopathic diseases. | Lamina-associated polypeptide 2alpha regulates cell cycle progression and differentiation via the retinoblastoma-E2F pathway.
Dorner D, Vlcek S, Foeger N, Gajewski A, Makolm C, Gotzmann J, Hutchison CJ, Foisner R., Free PMC Article | 01/21/2010 |