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    TJP1 tight junction protein 1 [ Homo sapiens (human) ]

    Gene ID: 7082, updated on 6-May-2024

    GeneRIFs: Gene References Into Functions

    GeneRIFPubMed TitleDate
    circRNA-PTPN4 mediated regulation of FOXO3 and ZO-1 expression: implications for blood-brain barrier integrity and cognitive function in uremic encephalopathy.

    circRNA-PTPN4 mediated regulation of FOXO3 and ZO-1 expression: implications for blood-brain barrier integrity and cognitive function in uremic encephalopathy.
    Liu Y, Qin Y, Zhang Y., Free PMC Article

    05/1/2024
    CLDN6 inhibits colorectal cancer proliferation dependent on restraining p53 ubiquitination via ZO-1/PTEN axis.

    CLDN6 inhibits colorectal cancer proliferation dependent on restraining p53 ubiquitination via ZO-1/PTEN axis.
    Dong Y, Xu W, Qi D, Qu H, Jin Q, Sun M, Wang X, Quan C.

    11/3/2023
    Rabeprazole destroyed gastric epithelial barrier function through FOXF1/STAT3-mediated ZO-1 expression.

    Rabeprazole destroyed gastric epithelial barrier function through FOXF1/STAT3-mediated ZO-1 expression.
    Yang F, Li L, Zhou Y, Pan W, Liang X, Huang L, Huang J, Cheng Y, Geng L, Xu W, Gong S.

    10/26/2023
    Loss of TJP1 disrupts gastrulation patterning and increases differentiation toward the germ cell lineage in human pluripotent stem cells.

    Loss of TJP1 disrupts gastrulation patterning and increases differentiation toward the germ cell lineage in human pluripotent stem cells.
    Vasic I, Libby ARG, Maslan A, Bulger EA, Zalazar D, Krakora Compagno MZ, Streets A, Tomoda K, Yamanaka S, McDevitt TC.,

    08/30/2023
    ZO-1 expression in normal human macula densa: Immunohistochemical and immunofluorescence investigations.

    ZO-1 expression in normal human macula densa: Immunohistochemical and immunofluorescence investigations.
    Tossetta G, Fantone S, Senzacqua M, Galosi AB, Marzioni D, Morroni M.,

    05/17/2023
    Hypoxic nasopharyngeal carcinoma-derived exosomal miR-455 increases vascular permeability by targeting ZO-1 to promote metastasis.

    Hypoxic nasopharyngeal carcinoma-derived exosomal miR-455 increases vascular permeability by targeting ZO-1 to promote metastasis.
    Xie L, Zhang K, You B, Yin H, Zhang P, Shan Y, Gu Z, Zhang Q.

    05/15/2023
    [Porphyromonas gingivalis infection causes umbilical vein endothelial barrier dysfunction in vitro by down-regulating ZO-1, occludin and VE-cadherin expression].

    [Porphyromonas gingivalis infection causes umbilical vein endothelial barrier dysfunction in vitro by down-regulating ZO-1, occludin and VE-cadherin expression].
    Zeng J, Li X, Yin L, Chen T, Hou J., Free PMC Article

    03/27/2023
    Does the Blood-Brain Barrier Integrity Change in Regard to the Onset of Fetal Growth Restriction?

    Does the Blood-Brain Barrier Integrity Change in Regard to the Onset of Fetal Growth Restriction?
    Misan N, Michalak S, Kapska K, Osztynowicz K, Ropacka-Lesiak M, Kawka-Paciorkowska K., Free PMC Article

    02/28/2023
    Zonula occludens-1 expression is reduced in nasal epithelial cells of allergic rhinitis patients.

    Zonula occludens-1 expression is reduced in nasal epithelial cells of allergic rhinitis patients.
    Siti Sarah CO, Nur Husna SM, Md Shukri N, Wong KK, Mohd Ashari NS., Free PMC Article

    01/14/2023
    Suppression of milk-derived miR-148a caused by stress plays a role in the decrease in intestinal ZO-1 expression in infants.

    Suppression of milk-derived miR-148a caused by stress plays a role in the decrease in intestinal ZO-1 expression in infants.
    Chiba T, Takaguri A, Kooka A, Kowatari K, Yoshizawa M, Fukushi Y, Hongo F, Sato H, Fujisawa M, Wada S, Maeda T.

    12/10/2022
    Circular RNA circCCNB1 inhibits the migration and invasion of nasopharyngeal carcinoma through binding and stabilizing TJP1 mRNA.

    Circular RNA circCCNB1 inhibits the migration and invasion of nasopharyngeal carcinoma through binding and stabilizing TJP1 mRNA.
    Zhao M, Wang Y, Tan F, Liu L, Hou X, Fan C, Tang L, Mo Y, Wang Y, Yan Q, Gong Z, Li Z, Liao Q, Guo C, Huang H, Zeng X, Li G, Zeng Z, Xiong W, Wang F.

    11/26/2022
    TJP1, a Membrane-Expressed Protein, is a Potential Therapeutic and Prognostic Target for Lung Cancer.

    TJP1, a Membrane-Expressed Protein, is a Potential Therapeutic and Prognostic Target for Lung Cancer.
    Pu J, Ai T, Weng W, Wang L, Yang Y, Ma L, Hu Z, Meng X., Free PMC Article

    07/9/2022
    GLTSCR1 coordinates alternative splicing and transcription elongation of ZO1 to regulate colorectal cancer progression.

    GLTSCR1 coordinates alternative splicing and transcription elongation of ZO1 to regulate colorectal cancer progression.
    Han F, Yang B, Zhou M, Huang Q, Mai M, Huang Z, Lai M, Xu E, Zhang H., Free PMC Article

    06/18/2022
    Direct inhibition of the first PDZ domain of ZO-1 by glycyrrhizin is a possible mechanism of tight junction opening of Caco-2 cells.

    Direct inhibition of the first PDZ domain of ZO-1 by glycyrrhizin is a possible mechanism of tight junction opening of Caco-2 cells.
    Hibino E, Goda N, Hisada M, Tenno T, Hiroaki H.

    03/19/2022
    The Tight Junction Protein ZO-1 Is Dispensable for Barrier Function but Critical for Effective Mucosal Repair.

    The Tight Junction Protein ZO-1 Is Dispensable for Barrier Function but Critical for Effective Mucosal Repair.
    Kuo WT, Zuo L, Odenwald MA, Madha S, Singh G, Gurniak CB, Abraham C, Turner JR., Free PMC Article

    01/22/2022
    Zonula occludens-1 demonstrates a unique appearance in buccal mucosa over several layers.

    Zonula occludens-1 demonstrates a unique appearance in buccal mucosa over several layers.
    Imafuku K, Kamaguchi M, Natsuga K, Nakamura H, Shimizu H, Iwata H.

    12/11/2021
    Molecular docking of SARS-COV-2 Spike epitope sequences identifies heterodimeric peptide-protein complex formation with human Zo-1, TLR8 and brain specific glial proteins.

    Molecular docking of SARS-COV-2 Spike epitope sequences identifies heterodimeric peptide-protein complex formation with human Zo-1, TLR8 and brain specific glial proteins.
    Dasgupta S, Bandyopadhyay M., Free PMC Article

    12/4/2021
    PLP2 drives collective cell migration via ZO-1-mediated cytoskeletal remodeling at the leading edge in human colorectal cancer cells.

    PLP2 drives collective cell migration via ZO-1-mediated cytoskeletal remodeling at the leading edge in human colorectal cancer cells.
    Ghosh D, Dutta A, Kashyap A, Upmanyu N, Datta S.

    10/30/2021
    Par3 and ZO-1 Membrane Clustering is an Indicator of Poor Prognosis in Lung Squamous Cell Carcinoma.

    Par3 and ZO-1 Membrane Clustering is an Indicator of Poor Prognosis in Lung Squamous Cell Carcinoma.
    Nito M, Takekoshi S, Kitatani K, Matsuzaki T, Yagasaki H, Tsuboi T, Nakano K, Shioyama K, Masuda R, Iwazaki M.

    10/30/2021
    Tight junction protein ZO-1 in Kawasaki disease.

    Tight junction protein ZO-1 in Kawasaki disease.
    Lai WT, Lee HC, Huang YH, Lo MH, Kuo HC., Free PMC Article

    07/10/2021
    SARS-CoV-2 Envelope (E) protein interacts with PDZ-domain-2 of host tight junction protein ZO1.

    SARS-CoV-2 Envelope (E) protein interacts with PDZ-domain-2 of host tight junction protein ZO1.
    Shepley-McTaggart A, Sagum CA, Oliva I, Rybakovsky E, DiGuilio K, Liang J, Bedford MT, Cassel J, Sudol M, Mullin JM, Harty RN., Free PMC Article

    07/10/2021
    Targeting TJP1 attenuates cell-cell aggregation and modulates chemosensitivity against doxorubicin in leiomyosarcoma.

    Targeting TJP1 attenuates cell-cell aggregation and modulates chemosensitivity against doxorubicin in leiomyosarcoma.
    Lee EY, Yu JY, Paek AR, Lee SH, Jang H, Cho SY, Kim JH, Kang HG, Yun T, Oh SE, Park SY, You HJ.

    06/12/2021
    Serum exosomal miR-638 is a prognostic marker of HCC via downregulation of VE-cadherin and ZO-1 of endothelial cells.

    Serum exosomal miR-638 is a prognostic marker of HCC via downregulation of VE-cadherin and ZO-1 of endothelial cells.
    Yokota Y, Noda T, Okumura Y, Kobayashi S, Iwagami Y, Yamada D, Tomimaru Y, Akita H, Gotoh K, Takeda Y, Tanemura M, Murakami T, Umeshita K, Doki Y, Eguchi H., Free PMC Article

    03/20/2021
    Exposure to Zinc Oxide Nanoparticles Disrupts Endothelial Tight and Adherens Junctions and Induces Pulmonary Inflammatory Cell Infiltration.

    Exposure to Zinc Oxide Nanoparticles Disrupts Endothelial Tight and Adherens Junctions and Induces Pulmonary Inflammatory Cell Infiltration.
    Chen CM, Wu ML, Ho YC, Gung PY, Tsai MH, Orekhov AN, Sobenin IA, Lin P, Yet SF., Free PMC Article

    02/13/2021
    HIV Tat-mediated induction of autophagy regulates the disruption of ZO-1 in brain endothelial cells.

    HIV Tat-mediated induction of autophagy regulates the disruption of ZO-1 in brain endothelial cells.
    Liao K, Niu F, Hu G, Guo ML, Sil S, Buch S., Free PMC Article

    12/12/2020
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