| Expression of thimet oligopeptidase (THOP) modulated by oxidative stress in human multidrug resistant (MDR) leukemia cells. | Expression of thimet oligopeptidase (THOP) modulated by oxidative stress in human multidrug resistant (MDR) leukemia cells.
Neves RL, Marem A, Carmona B, Arata JG, Cyrillo Ramos MP, Justo GZ, Machado de Melo FH, Oliveira V, Icimoto MY. | 11/1/2023 |
| Data suggest that three new candidate genes involved in the development of rheumatoid arthritis (RA): ERBB2, TP53 and THOP1. | Discovery of new candidate genes for rheumatoid arthritis through integration of genetic association data with expression pathway analysis.
Shchetynsky K, Diaz-Gallo LM, Folkersen L, Hensvold AH, Catrina AI, Berg L, Klareskog L, Padyukov L., Free PMC Article | 11/11/2017 |
| THOP1 may have clinical potentials to be employed as a promising biomarker to identify individuals with better prognosis and a novel antitumor agent for therapy of patients with NSCLC | Expression of THOP1 and its relationship to prognosis in non-small cell lung cancer.
Qi L, Li SH, Si LB, Lu M, Tian H., Free PMC Article | 11/7/2015 |
| Low THOP1 expression levels are associated with recurrence of hepatocellular carcinoma. | Expression analysis of THOP1 in background liver, a prognostic predictive factor in hepatocellular carcinoma, extracted by multiarray analysis.
Nomoto S, Hishida M, Inokawa Y, Takano N, Kanda M, Nishikawa Y, Fujii T, Koike M, Sugimoto H, Kodera Y. | 01/24/2015 |
| TCEP. Data indicate that THIMET-oligopeptidase (TOP) oxidation by H2O2 and high valence states of hemeproteins does not lead to enzyme oligomerization. | Recycling of the high valence States of heme proteins by cysteine residues of THIMET-oligopeptidase.
Ferreira JC, Icimoto MY, Marcondes MF, Oliveira V, Nascimento OR, Nantes IL., Free PMC Article | 08/30/2014 |
| shear-dependent TOP induction down-regulates MHC1 levels, pointing to a role for TOP in the flow-mediated regulation of endothelial immunogenicity | Shear stress is a positive regulator of thimet oligopeptidase (EC3.4.24.15) in vascular endothelial cells: consequences for MHC1 levels.
Guinan AF, Rochfort KD, Fitzpatrick PA, Walsh TG, Pierotti AR, Phelan S, Murphy RP, Cummins PM. | 03/1/2014 |
| The semi-quantitative intracellular peptidome analyses of siRNA-transfected HEK293 cells shows that the levels of specific intracellular peptides are either increased or decreased upon EP24.15 inhibition. | Inhibition of thimet oligopeptidase by siRNA alters specific intracellular peptides and potentiates isoproterenol signal transduction.
Russo LC, Castro LM, Gozzo FC, Ferro ES. | 12/8/2012 |
| mediates antigen processing that generates cytotoxic T cell epitopes | Antigen processing by nardilysin and thimet oligopeptidase generates cytotoxic T cell epitopes.
Kessler JH, Khan S, Seifert U, Le Gall S, Chow KM, Paschen A, Bres-Vloemans SA, de Ru A, van Montfoort N, Franken KL, Benckhuijsen WE, Brooks JM, van Hall T, Ray K, Mulder A, Doxiadis II, van Swieten PF, Overkleeft HS, Prat A, Tomkinson B, Neefjes J, Kloetzel PM, Rodgers DW, Hersh LB, Drijfhout JW, van Veelen PA, Ossendorp F, Melief CJ. | 05/14/2011 |
| interaction between EP24.15 and calmodulin is regulated within cells and is important for the stimulated secretion of EP24.15 from HEK293 cells. | Interaction with calmodulin is important for the secretion of thimet oligopeptidase following stimulation.
Russo LC, Goñi CN, Castro LM, Asega AF, Camargo AC, Trujillo CA, Ulrich H, Glucksman MJ, Scavone C, Ferro ES., Free PMC Article | 01/21/2010 |
| Over 100 peptides were identified in human embryonic kidney 293 (HEK293) cells that are derived from intracellular proteins; many but not all of these peptides are substrates or products of EP24.15. | Analysis of intracellular substrates and products of thimet oligopeptidase in human embryonic kidney 293 cells.
Berti DA, Morano C, Russo LC, Castro LM, Cunha FM, Zhang X, Sironi J, Klitzke CF, Ferro ES, Fricker LD., Free PMC Article | 01/21/2010 |
| increase in THOP1 expression might be part of a compensatory defense mechanism of the brain against an increased Abeta load. | Increased expression of the oligopeptidase THOP1 is a neuroprotective response to Abeta toxicity.
Pollio G, Hoozemans JJ, Andersen CA, Roncarati R, Rosi MC, van Haastert ES, Seredenina T, Diamanti D, Gotta S, Fiorentini A, Magnoni L, Raggiaschi R, Rozemuller AJ, Casamenti F, Caricasole A, Terstappen GC. | 01/21/2010 |
| THIMET has a role in degradation of peptides generated by proteasomes | Pathway for degradation of peptides generated by proteasomes: a key role for thimet oligopeptidase and other metallopeptidases.
Saric T, Graef CI, Goldberg AL. | 01/21/2010 |
| human thimet oligopeptidase crystal structure shows substrate recognition, regulation, and localization | Crystal structure of human thimet oligopeptidase provides insight into substrate recognition, regulation, and localization.
Ray K, Hines CS, Coll-Rodriguez J, Rodgers DW. | 01/21/2010 |
| EP24.15 associates with AT1 and B2 receptors both at the plasma membrane and after receptor internalization | EP24.15 interacts with the angiotensin II type I receptor and bradykinin B2 receptor.
Shivakumar BR, Wang Z, Hammond TG, Harris RC. | 01/21/2010 |
| Mutations at only two residues (Glu-469 and Arg-498) are required to swap specificity with neurolysin, a result that is confirmed by testing the two-mutant constructs. | Swapping the substrate specificities of the neuropeptidases neurolysin and thimet oligopeptidase.
Lim EJ, Sampath S, Coll-Rodriguez J, Schmidt J, Ray K, Rodgers DW. | 01/21/2010 |