| Tyrosine hydroxylase variants influence protein expression, cellular localization, stability, enzymatic activity and the physical interaction between tyrosine hydroxylase and GTP cyclohydrolase 1. | Tyrosine hydroxylase variants influence protein expression, cellular localization, stability, enzymatic activity and the physical interaction between tyrosine hydroxylase and GTP cyclohydrolase 1.
Jung-Klawitter S, Richter P, Yuan Y, Welzel K, Kube M, Bähr S, Leibner A, Flory E, Opladen T. | 06/3/2024 |
| Association of tyrosine hydroxylase 01 (TH01) microsatellite and insulin gene (INS) variable number of tandem repeat (VNTR) with type 2 diabetes and fasting insulin secretion in Mexican population. | Association of tyrosine hydroxylase 01 (TH01) microsatellite and insulin gene (INS) variable number of tandem repeat (VNTR) with type 2 diabetes and fasting insulin secretion in Mexican population.
Berumen J, Orozco L, Gallardo-Rincón H, Juárez-Torres E, Barrera E, Cruz-López M, Benuto RE, Ramos-Martinez E, Marin-Madina M, Alvarado-Silva A, Valladares-Salgado A, Peralta-Romero JJ, García-Ortiz H, Martinez-Juarez LA, Montoya A, Alvarez-Hernández DA, Alegre-Diaz J, Kuri-Morales P, Tapia-Conyer R., Free PMC Article | 03/13/2024 |
| [Clinical and genetic analysis of tyrosine hydroxylase deficiency of six cases]. | [Clinical and genetic analysis of tyrosine hydroxylase deficiency of six cases].
Zhang H, Zhang B, Zhao B, Zhang TX, Zhao CP, Liu YM, Yan CZ, Zhao YY. | 11/3/2023 |
| [Clinical and genetic characteristics of children with dopa-responsive dystonia caused by tyrosine hydroxylase gene variations]. | [Clinical and genetic characteristics of children with dopa-responsive dystonia caused by tyrosine hydroxylase gene variations].
Zhang GY, Cai ZJ, Zhang XL, Yang L, Li YZ, Wei LK, Zhang YP, Chang PP, Zhu DN. | 04/10/2023 |
| Aging accentuates decrease in tyrosine hydroxylase immunoreactivity associated with the increase in the motor impairment in a model of reserpine-induced parkinsonism. | Aging accentuates decrease in tyrosine hydroxylase immunoreactivity associated with the increase in the motor impairment in a model of reserpine-induced parkinsonism.
Melo JEC, Santos TFO, Santos RS, Franco HS, Monteiro MCN, Bispo JMM, Mendonça MS, Ribeiro AM, Silva RH, Gois AM, Marchioro M, Lins LCRF, Santos JR. | 11/12/2022 |
| Expression Quantitative Trait Locus rs6356 Is Associated with Susceptibility to Heroin Addiction by Potentially Influencing TH Gene Expression in the Hippocampus and Nucleus Accumbens. | Expression Quantitative Trait Locus rs6356 Is Associated with Susceptibility to Heroin Addiction by Potentially Influencing TH Gene Expression in the Hippocampus and Nucleus Accumbens.
Wang K, Zhang H, Ji J, Zhang R, Dang W, Xie Q, Zhu Y, Zhang J. | 05/7/2022 |
| Immunohistochemical Expression of Choline Acetyltransferase and Catecholamine-Synthesizing Enzymes in Head-and-Neck and Thoracoabdominal Paragangliomas and Pheochromocytomas. | Immunohistochemical Expression of Choline Acetyltransferase and Catecholamine-Synthesizing Enzymes in Head-and-Neck and Thoracoabdominal Paragangliomas and Pheochromocytomas.
Kimura N, Shiga K, Kaneko KI, Oki Y, Sugisawa C, Saito J, Tawara S, Akahori H, Sogabe S, Yamashita T, Takekoshi K, Naruse M, Katabami T. | 03/26/2022 |
| Tyrosine hydroxylase activity is regulated through the modification of the 176th cysteine residue. | Tyrosine hydroxylase activity is regulated through the modification of the 176th cysteine residue.
Inukai S, Hara S, Ichinose H. | 02/12/2022 |
| Structural mechanism for tyrosine hydroxylase inhibition by dopamine and reactivation by Ser40 phosphorylation. | Structural mechanism for tyrosine hydroxylase inhibition by dopamine and reactivation by Ser40 phosphorylation.
Bueno-Carrasco MT, Cuéllar J, Flydal MI, Santiago C, Kråkenes TA, Kleppe R, López-Blanco JR, Marcilla M, Teigen K, Alvira S, Chacón P, Martinez A, Valpuesta JM., Free PMC Article | 01/29/2022 |
| Post-translational and post-transcriptional mechanisms of activity regulation of tyrosine hydroxylase in the central nervous system - the effect of physical exercise", trans "Post-translacyjne i post-transkrypcyjne mechanizmy regulacji aktywnosci hydroksylazy tyrozynowej w osrodkowym ukladzie nerwowym-wplyw wysilku fizycznego. | [Post-translational and post-transcriptional mechanisms of activity regulation of tyrosine hydroxylase in the central nervous system – the effect of physical exercise].
Przybylska I, Kania D, Tymosiewicz P, Langfort J, Chalimoniuk M. | 12/18/2021 |
| Tyrosine Hydroxylase Gene Polymorphisms Contribute to Opioid Dependence and Addiction by Affecting Promoter Region Function. | Tyrosine Hydroxylase Gene Polymorphisms Contribute to Opioid Dependence and Addiction by Affecting Promoter Region Function.
Liu JL, Li SQ, Zhu F, Zhang YX, Wu YN, Yang JS, Zhang B, Yan CX. | 10/9/2021 |
| beta-Methylphenylalanine exerts neuroprotective effects in a Parkinson's disease model by protecting against tyrosine hydroxylase depletion. | β-Methylphenylalanine exerts neuroprotective effects in a Parkinson's disease model by protecting against tyrosine hydroxylase depletion.
Feng Y, Ma J, Yuan L., Free PMC Article | 09/18/2021 |
| Stimulation of L-type calcium channels increases tyrosine hydroxylase and dopamine in ventral midbrain cells induced from somatic cells. | Stimulation of L-type calcium channels increases tyrosine hydroxylase and dopamine in ventral midbrain cells induced from somatic cells.
Jefri M, Bell S, Peng H, Hettige N, Maussion G, Soubannier V, Wu H, Silveira H, Theroux JF, Moquin L, Zhang X, Aouabed Z, Krishnan J, O'Leary LA, Antonyan L, Zhang Y, McCarty V, Mechawar N, Gratton A, Schuppert A, Durcan TM, Fon EA, Ernst C., Free PMC Article | 07/3/2021 |
| Levalbuterol lowers the feedback inhibition by dopamine and delays misfolding and aggregation in tyrosine hydroxylase. | Levalbuterol lowers the feedback inhibition by dopamine and delays misfolding and aggregation in tyrosine hydroxylase.
Flydal MI, Kråkenes TA, Tai MDS, Tran MPA, Teigen K, Martinez A. | 06/12/2021 |
| Neuroblastoma patient-derived cultures are enriched for a mesenchymal gene signature and reflect individual drug response. | Neuroblastoma patient-derived cultures are enriched for a mesenchymal gene signature and reflect individual drug response.
Hee E, Wong MK, Tan SH, Choo Z, Kuick CH, Ling S, Yong MH, Jain S, Lian DWQ, Ng EHQ, Yong YFL, Ren MH, Syed Sulaiman N, Low SYY, Chua YW, Syed MF, Lim TKH, Soh SY, Iyer P, Seng MSF, Lam JCM, Tan EEK, Chan MY, Tan AM, Chen Y, Chen Z, Chang KTE, Loh AHP., Free PMC Article | 12/19/2020 |
| Subcellular distribution of human tyrosine hydroxylase isoforms 1 and 4 in SH-SY5Y cells. | Subcellular distribution of human tyrosine hydroxylase isoforms 1 and 4 in SH-SY5Y cells.
Kunzler A, Garcia Sobrinho P, Smith T, Gelain DP, Moreira JCF, Dunkley PR, Dickson PW. | 11/21/2020 |
| Dopa-responsive dystonia caused by tyrosine hydroxylase deficiency: Three cases report and literature review. | Dopa-responsive dystonia caused by tyrosine hydroxylase deficiency: Three cases report and literature review.
Dong HY, Feng JY, Yue XJ, Shan L, Jia FY., Free PMC Article | 09/19/2020 |
| Promoter-activity assays confirmed that exposure of cells to full-length Nurr1 fusion protein activated not only its cognate human tyrosine hydroxylase promoter but also the corresponding mouse sequence, although at a reduced efficiency. | Lethal Factor Domain-Mediated Delivery of Nurr1 Transcription Factor Enhances Tyrosine Hydroxylase Activity and Protects from Neurotoxin-Induced Degeneration of Dopaminergic Cells.
Paliga D, Raudzus F, Leppla SH, Heumann R, Neumann S., Free PMC Article | 08/17/2019 |
| Study provide evidence that the enhancer at IGF2 regulates the rate-limiting enzyme in dopamine synthesis tyrosine hydroxylase (TH). This work suggests a mechanism for epigenetic regulation of dopamine levels in the brain. Epigenetic misregulation of an enhancer at IGF2 may underlie the dopaminergic abnormalities that drives psychotic symptoms. | Differential methylation of enhancer at IGF2 is associated with abnormal dopamine synthesis in major psychosis.
Pai S, Li P, Killinger B, Marshall L, Jia P, Liao J, Petronis A, Szabó PE, Labrie V., Free PMC Article | 06/8/2019 |
| This study provides original evidence that obesity-associated stimuli induce a TH upregulation in periodontal cells and tissues. | Regulation of tyrosine hydroxylase in periodontal fibroblasts and tissues by obesity-associated stimuli.
Memmert S, Damanaki A, Nogueira AVB, Nokhbehsaim M, Götz W, Cirelli JA, Rath-Deschner B, Jäger A, Deschner J. | 06/1/2019 |
| High levels of bone marrow TH and PHOX2B and of peripheral blood PHOX2B at diagnosis allow early identification of a group of high-risk infant and toddlers with neuroblastoma who may be candidates for alternative treatments | Event-free survival of infants and toddlers enrolled in the HR-NBL-1/SIOPEN trial is associated with the level of neuroblastoma mRNAs at diagnosis.
Corrias MV, Parodi S, Tchirkov A, Lammens T, Vicha A, Pasqualini C, Träger C, Yáñez Y, Dallorso S, Varesio L, Luksch R, Laureys G, Valteau-Couanet D, Canete A, Pöetschger U, Ladenstein R, Burchill SA. | 05/11/2019 |
| conserved regions recruit transcription factors that are established regulators of Th transcription | Conserved Upstream Regulatory Regions in Mammalian Tyrosine Hydroxylase.
Wang M, Fones L, Cave JW., Free PMC Article | 02/9/2019 |
| These results provide a novel mechanism of how NO can modulate TH's enzymatic activity through S-nitrosylation. | Novel enhancement mechanism of tyrosine hydroxylase enzymatic activity by nitric oxide through S-nitrosylation.
Wang Y, Sung CC, Chung KK., Free PMC Article | 11/10/2018 |
| It is a genetic risk for Parkinson's disease. | Study of GCH1 and TH genes in Chinese patients with Parkinson's disease.
Yan YP, Zhang B, Shen T, Si XL, Guo ZY, Tian J, Xu CY, Zhang BR. | 10/20/2018 |
| One novel mutation of c.679A>G (p.T227A) in GCH1 and 3 known mutations of c.457C>T (p.R153X), c.739G>A (p.G247S), and c.698G>A (p.R227H) in tyrosine hydroxylase (TH) have been found and predicted to be damaging or deleterious. | Dopa-Responsive Dystonia in Han Chinese Patients: One Novel Heterozygous Mutation in GTP Cyclohydrolase 1 (GCH1) and Three Known Mutations in TH.
Yang K, Yin R, Lan X, Zhang Y, Cheng H, Wang S, Wang C, Lu Y, Xi J, Lu Q, Huang J, Chen Y., Free PMC Article | 08/18/2018 |