| Genetic polymorphisms of rs73620203 in the transforming growth interacting factor gene associated with rheumatoid arthritis in a Chinese population. | Genetic polymorphisms of rs73620203 in the transforming growth interacting factor gene associated with rheumatoid arthritis in a Chinese population.
Tan H, Ren R, Wang X, Hu W, Yang B. | 01/3/2024 |
| TGIF1 overexpression promotes glioma progression and worsens patient prognosis. | TGIF1 overexpression promotes glioma progression and worsens patient prognosis.
Wang B, Ma Q, Wang X, Guo K, Liu Z, Li G., Free PMC Article | 12/24/2022 |
| Allelic Variants in Established Hypopituitarism Genes Expand Our Knowledge of the Phenotypic Spectrum. | Allelic Variants in Established Hypopituitarism Genes Expand Our Knowledge of the Phenotypic Spectrum.
Nakaguma M, Ferreira NGBP, Benedetti AFF, Madi MC, Silva JM, Li JZ, Ma Q, Bilge Ozel A, Fang Q, Narcizo AM, Cardoso LC, Montenegro LR, Funari MFA, Nishi MY, Arnhold IJP, Jorge AAL, Mendonca BB, Camper SA, Carvalho LR., Free PMC Article | 02/12/2022 |
| Structural Insight into the Binding of TGIF1 to SIN3A PAH2 Domain through a C-Terminal Amphipathic Helix. | Structural Insight into the Binding of TGIF1 to SIN3A PAH2 Domain through a C-Terminal Amphipathic Helix.
He X, Nie Y, Zhou H, Hu R, Li Y, He T, Zhu J, Yang Y, Liu M., Free PMC Article | 01/1/2022 |
| TGIF1 plays a carcinogenic role in esophageal squamous cell carcinoma through the Wnt/betacatenin and Akt/mTOR signaling pathways. | TGIF1 plays a carcinogenic role in esophageal squamous cell carcinoma through the Wnt/β‑catenin and Akt/mTOR signaling pathways.
Kong L, Yu Y, Guan H, Jiang L, Sun F, Li X, Huang W, Li B., Free PMC Article | 11/13/2021 |
| TGFB-induced factor homeobox 1 (TGIF) expression in breast cancer. | TGFB-induced factor homeobox 1 (TGIF) expression in breast cancer.
Stürken C, Möbus V, Milde-Langosch K, Schmatloch S, Fasching PA, Rüschoff J, Stickeler E, Henke RP, Denkert C, Hanker L, Schem C, Vladimirova V, Karn T, Nekljudova V, Köhne CH, Marmé F, Schumacher U, Loibl S, Müller V., Free PMC Article | 10/23/2021 |
| HDAC3 deteriorates colorectal cancer progression via microRNA-296-3p/TGIF1/TGFbeta axis. | HDAC3 deteriorates colorectal cancer progression via microRNA-296-3p/TGIF1/TGFβ axis.
Li J, Hu M, Liu N, Li H, Yu Z, Yan Q, Zhou M, Wang Y, Song Y, Pan G, Liang F, Chen R., Free PMC Article | 07/31/2021 |
| XTP8 stimulates migration and invasion of gastric carcinoma through interacting with TGIF1. | XTP8 stimulates migration and invasion of gastric carcinoma through interacting with TGIF1.
Jia K, Wen QH, Zhao X, Cheng JM, Cheng L, Xi M. | 03/20/2021 |
| Breast cancer bone metastases are attenuated in a Tgif1-deficient bone microenvironment. | Breast cancer bone metastases are attenuated in a Tgif1-deficient bone microenvironment.
Haider MT, Saito H, Zarrer J, Uzhunnumpuram K, Nagarajan S, Kari V, Horn-Glander M, Werner S, Hesse E, Taipaleenmäki H., Free PMC Article | 10/3/2020 |
| Study report that TGIF1 is appreciably inactivated during pancreatic ductal adenocarcinoma (PDAC) progression and suggest that TGIF1 might serve as a potential prognostic indicator for PDAC progression. Also, TGIF1 loss accelerates PDAC development with reduced survival and increased metastatic behaviors in cooperation with KrasG12D. | Loss of the transcriptional repressor TGIF1 results in enhanced Kras-driven development of pancreatic cancer.
Weng CC, Hsieh MJ, Wu CC, Lin YC, Shan YS, Hung WC, Chen LT, Cheng KH., Free PMC Article | 04/18/2020 |
| Findings pinpoint TGIF1 as a potential tumor suppressor in pancreatic ductal adenocarcinoma and further suggest that sustained activation of TGF-b signaling might act to accelerate PDAC progression rather than to suppress its initiation. | TGIF1 functions as a tumor suppressor in pancreatic ductal adenocarcinoma.
Parajuli P, Singh P, Wang Z, Li L, Eragamreddi S, Ozkan S, Ferrigno O, Prunier C, Razzaque MS, Xu K, Atfi A., Free PMC Article | 12/28/2019 |
| Overexpression of TGIF1 lowers levels of cholesterol, triglycerides, and apoB. Overexpression of TGIF2 has more limited effects on lipid metabolism. | Effects on hepatic lipid metabolism in human hepatoma cells following overexpression of TGFβ induced factor homeobox 1 or 2.
Härdfeldt J, Hodson L, Larsson L, Pedrelli M, Pramfalk C. | 12/7/2019 |
| TGIF1 represses Niemann-Pick C1 like 1 (Npc1l1) promoter activity in intestines, lowering intestinal cholesterol absorption. | Overexpression of transforming growth factor β induced factor homeobox 1 represses NPC1L1 and lowers markers of intestinal cholesterol absorption.
Parini P, Melhuish TA, Wotton D, Larsson L, Ahmed O, Eriksson M, Pramfalk C. | 10/26/2019 |
| Chronic otitis media is associated with the TGIF1 and FBXO11 loci that are involved in TGF-beta signaling, suggesting this pathway may be important in the transition from acute to chronic middle ear inflammation, and a potential molecular target. | A mouse-to-man candidate gene study identifies association of chronic otitis media with the loci TGIF1 and FBXO11.
Bhutta MF, Lambie J, Hobson L, Goel A, Hafrén L, Einarsdottir E, Mattila PS, Farrall M, Brown S, Burton MJ., Free PMC Article | 07/20/2019 |
| TGIF1 homeodomain interacts with Smad2/Smad4 MH1 domains and represses TGF-beta signaling. | TGIF1 homeodomain interacts with Smad MH1 domain and represses TGF-β signaling.
Guca E, Suñol D, Ruiz L, Konkol A, Cordero J, Torner C, Aragon E, Martin-Malpartida P, Riera A, Macias MJ., Free PMC Article | 06/29/2019 |
| Results suggest that silencing TGIF inhibited migration, invasion and metastasis of the human breast cancer cell line of MDAMB231 in vitro and in vivo. | Silencing TGIF suppresses migration, invasion and metastasis of MDA‑MB‑231 human breast cancer cells.
Wang Y, Li L, Wang H, Li J, Yang H. | 09/8/2018 |
| Data suggest that expression of TGIF is up-regulated by carcinogen BaP [benzo(a)pyrene]; this process is involved in BaP-induced cell proliferation, cell migration, tumor invasiveness, and tumor metastasis of lung adenocarcinoma cells. | Benzo(a)pyrene promotes migration, invasion and metastasis of lung adenocarcinoma cells by upregulating TGIF.
Yang H, Zhang H, Pan T, Wang H, Wang Y. | 07/21/2018 |
| Based on the analysis of the TGIF1-homeodomain (HD) NMR structure determined here, the roles of two holoprosencephaly-related residues P192 and R219 in sufficient folding of TGIF1-HD were revealed. Mutations of these two residues, P192A and R219C found in holoprosence patients previously, resulted in structural change and less folding of TGIF1-HD, and thereby severely impaired the DNA-binding affinity of TGIF1-HD. | Structural insights into the impact of two holoprosencephaly-related mutations on human TGIF1 homeodomain.
Zhu J, Li S, Ramelot TA, Kennedy MA, Liu M, Yang Y. | 03/10/2018 |
| High TGIF-1 expression is associated with fetal growth restriction. | Homeobox gene TGIF-1 is increased in placental endothelial cells of human fetal growth restriction.
Gunatillake T, Yong HE, Dunk CE, Keogh RJ, Borg AJ, Cartwright JE, Whitley GS, Murthi P. | 11/4/2017 |
| Tgifs regulate ciliogenesis and suggests that Evi5l mediates at least part of this effect. | Tgif1 and Tgif2 Repress Expression of the RabGAP Evi5l.
Anderson AE, Taniguchi K, Hao Y, Melhuish TA, Shah A, Turner SD, Sutherland AE, Wotton D., Free PMC Article | 07/15/2017 |
| Knockdown of TGIF1 resulted in decreased protein expression of HOXD10 and increased resistance to colistin cytotoxicity in renal cells. | Genetic Variants Contributing to Colistin Cytotoxicity: Identification of TGIF1 and HOXD10 Using a Population Genomics Approach.
Eadon MT, Hause RJ, Stark AL, Cheng YH, Wheeler HE, Burgess KS, Benson EA, Cunningham PN, Bacallao RL, Dagher PC, Skaar TC, Dolan ME., Free PMC Article | 04/29/2017 |
| Data show that the silencing of TG-interacting factor (TGIF) inhibited A549 lung cancer cell proliferation, growth of tumor xenograft in vivo, and arrested the cell cycle in the G1 phase. | Silencing of TGIF attenuates the tumorigenicity of A549 cells in vitro and in vivo.
Wang Y, Pan T, Wang H, Li L, Li J, Zhang C, Yang H. | 02/25/2017 |
| we suggest that TGIF plays an important role in low-dose arsenic-induced malignant transformation of HaCaT cells, which is regulated by c-Src/EGFR/AKT/FOXO3A pathway and redox signaling. | TG-interacting factor mediates arsenic-induced malignant transformation of keratinocytes via c-Src/EGFR/AKT/FOXO3A and redox signalings.
Liu ZM, Tseng HY, Yeh BW, Wu WJ, Huang HS. | 09/17/2016 |
| Corneal fibroblasts demonstrate the expression of TGIF1 and TGIF2 transcription factors. These transcriptional repressors are critical, at least partially, in mediating the antifibrotic effect of vorinostat in the cornea. | Role of 5'TG3'-interacting factors (TGIFs) in Vorinostat (HDAC inhibitor)-mediated Corneal Fibrosis Inhibition.
Sharma A, Sinha NR, Siddiqui S, Mohan RR., Free PMC Article | 06/4/2016 |
| Our results suggested that elevated expression of TGIF was involved in lung carcinogenesis. | Elevated expression of TGIF is involved in lung carcinogenesis.
Wang Y, Wang H, Gao H, Xu B, Zhai W, Li J, Zhang C. | 04/23/2016 |